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UniProtKB - Q3UJP5 (CF418_MOUSE)
Protein
Cilia- and flagella-associated protein 418
Gene
Cfap418
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in photoreceptor outer segment disk morphogenesis.
1 PublicationGO - Biological processi
- photoreceptor cell morphogenesis Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Cilia- and flagella-associated protein 418 |
Gene namesi | Name:Cfap418 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914407, 2610301B20Rik |
VEuPathDBi | HostDB:ENSMUSG00000059482 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 2 Publications
Other locations
- Photoreceptor inner segment 1 Publication
Note: In the retina, located at the base of the primary cilium (PubMed:22177090). Expressed throughout photoreceptors cell body including the basal body, inner segment and synaptic terminus, but not in the outer segment (at the protein level).1 Publication
Cytosol
- cytosol Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cell junction Source: MGI
- ciliary base Source: MGI
- cytoplasm Source: UniProtKB
- photoreceptor inner segment Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Disruption phenotypei
No visible phenotype. However mice exhibit progressive and simultaneous degeneration of rod and cone photoreceptors (PubMed:29440555).1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000271059 | 1 – 209 | Cilia- and flagella-associated protein 418Add BLAST | 209 |
Proteomic databases
EPDi | Q3UJP5 |
MaxQBi | Q3UJP5 |
PaxDbi | Q3UJP5 |
PeptideAtlasi | Q3UJP5 |
PRIDEi | Q3UJP5 |
PTM databases
PhosphoSitePlusi | Q3UJP5 |
Expressioni
Tissue specificityi
Expressed in multiple tissues, including the brain, kidney, lung, spleen, heart, trachea and testis (PubMed:29440555). Expressed in the retina (at protein level) (PubMed:22177090, PubMed:29440555).2 Publications
Gene expression databases
Bgeei | ENSMUSG00000059482, Expressed in spermatocyte and 287 other tissues |
ExpressionAtlasi | Q3UJP5, baseline and differential |
Genevisiblei | Q3UJP5, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 211983, 1 interactor |
STRINGi | 10090.ENSMUSP00000103966 |
Miscellaneous databases
RNActi | Q3UJP5, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 24 – 58 | DisorderedSequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 43 – 58 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Phylogenomic databases
eggNOGi | ENOG502S1KM, Eukaryota |
GeneTreei | ENSGT00390000006173 |
HOGENOMi | CLU_092833_0_0_1 |
InParanoidi | Q3UJP5 |
OMAi | TACDFWV |
OrthoDBi | 1589583at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR029239, C8orf37 |
PANTHERi | PTHR33958, PTHR33958, 1 hit |
Pfami | View protein in Pfam PF14996, RMP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q3UJP5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAKDLDELLD EVETKFCRLD PLRLDLGERP KGDGGGGSHS GDRNGAQEKE
60 70 80 90 100
TLRSTETFKK EDDLDSLINE IFEEPDFDRK SFQKFKSKSS SNTCVRAPMQ
110 120 130 140 150
GVSKSCSPVY LSGSAIPCGI GTNTSQRACD RLRCVACDFR IVSYNDYMWD
160 170 180 190 200
KSCDYLFFRN NMPEFHKLKT KLIEKKGARA YACQCSWRTV EELTDLQTDH
QLRWVCGKH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB1AV75 | B1AV75_MOUSE | Cilia- and flagella-associated prot... | Cfap418 2610301B20Rik | 210 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 | E → D in AAH58777 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK146358 mRNA Translation: BAE27110.1 BC058777 mRNA Translation: AAH58777.1 |
CCDSi | CCDS17961.1 |
RefSeqi | NP_080281.3, NM_026005.3 |
Genome annotation databases
Ensembli | ENSMUST00000080517; ENSMUSP00000079361; ENSMUSG00000059482 |
GeneIDi | 67157 |
KEGGi | mmu:67157 |
UCSCi | uc012dam.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK146358 mRNA Translation: BAE27110.1 BC058777 mRNA Translation: AAH58777.1 |
CCDSi | CCDS17961.1 |
RefSeqi | NP_080281.3, NM_026005.3 |
3D structure databases
SMRi | Q3UJP5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 211983, 1 interactor |
STRINGi | 10090.ENSMUSP00000103966 |
PTM databases
PhosphoSitePlusi | Q3UJP5 |
Proteomic databases
EPDi | Q3UJP5 |
MaxQBi | Q3UJP5 |
PaxDbi | Q3UJP5 |
PeptideAtlasi | Q3UJP5 |
PRIDEi | Q3UJP5 |
Protocols and materials databases
Antibodypediai | 12959, 40 antibodies from 9 providers |
Genome annotation databases
Ensembli | ENSMUST00000080517; ENSMUSP00000079361; ENSMUSG00000059482 |
GeneIDi | 67157 |
KEGGi | mmu:67157 |
UCSCi | uc012dam.1, mouse |
Organism-specific databases
CTDi | 157657 |
MGIi | MGI:1914407, 2610301B20Rik |
VEuPathDBi | HostDB:ENSMUSG00000059482 |
Phylogenomic databases
eggNOGi | ENOG502S1KM, Eukaryota |
GeneTreei | ENSGT00390000006173 |
HOGENOMi | CLU_092833_0_0_1 |
InParanoidi | Q3UJP5 |
OMAi | TACDFWV |
OrthoDBi | 1589583at2759 |
Miscellaneous databases
BioGRID-ORCSi | 67157, 1 hit in 65 CRISPR screens |
PROi | PR:Q3UJP5 |
RNActi | Q3UJP5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000059482, Expressed in spermatocyte and 287 other tissues |
ExpressionAtlasi | Q3UJP5, baseline and differential |
Genevisiblei | Q3UJP5, MM |
Family and domain databases
InterProi | View protein in InterPro IPR029239, C8orf37 |
PANTHERi | PTHR33958, PTHR33958, 1 hit |
Pfami | View protein in Pfam PF14996, RMP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CF418_MOUSE | |
Accessioni | Q3UJP5Primary (citable) accession number: Q3UJP5 Secondary accession number(s): Q6PDD5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 23, 2022 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot