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Entry version 117 (31 Jul 2019)
Sequence version 1 (11 Oct 2005)
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Protein
Submitted name:

Splicing factor 3b, subunit 2

Gene

Sf3b2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72165 mRNA Splicing - Minor Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Splicing factor 3b, subunit 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sf3b2Imported
ORF Names:mCG_19856Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2441856 Sf3b2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000024853 Expressed in 282 organ(s), highest expression level in rostral migratory stream

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000025774

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 58SAPInterPro annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25DisorderedSequence analysisAdd BLAST25
Regioni67 – 136DisorderedSequence analysisAdd BLAST70
Regioni183 – 356DisorderedSequence analysisAdd BLAST174
Regioni383 – 436DisorderedSequence analysisAdd BLAST54
Regioni674 – 740DisorderedSequence analysisAdd BLAST67
Regioni827 – 878DisorderedSequence analysisAdd BLAST52

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili140 – 177Sequence analysisAdd BLAST38
Coiled coili516 – 539Sequence analysisAdd BLAST24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi10 – 24Pro-richSequence analysisAdd BLAST15
Compositional biasi86 – 136Pro-richSequence analysisAdd BLAST51
Compositional biasi208 – 234Pro-richSequence analysisAdd BLAST27
Compositional biasi261 – 283PolyampholyteSequence analysisAdd BLAST23
Compositional biasi305 – 321BasicSequence analysisAdd BLAST17
Compositional biasi327 – 342PolyampholyteSequence analysisAdd BLAST16
Compositional biasi383 – 412PolyampholyteSequence analysisAdd BLAST30
Compositional biasi678 – 695PolyampholyteSequence analysisAdd BLAST18
Compositional biasi696 – 715AcidicSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2330 Eukaryota
COG5182 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006734

Identification of Orthologs from Complete Genome Data

More...
OMAi
MYRQFYR

Database of Orthologous Groups

More...
OrthoDBi
1275099at2759

TreeFam database of animal gene trees

More...
TreeFami
TF300635

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007180 DUF382
IPR006568 PSP_pro-rich
IPR003034 SAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04037 DUF382, 1 hit
PF04046 PSP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00581 PSP, 1 hit
SM00513 SAP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50800 SAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3UJB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAEHPEPPK GELQLPPPPP PGHYGAWAAQ ELQARLAEIG APIQGSREEL
60 70 80 90 100
VERLQTYTRQ TGIVLNRPVL RGEDGDKAAP PPMSAQLSGI PMPPPPMGLP
110 120 130 140 150
PLQPPPPPPP PPPGLGLGFP MAHPPNLGPP PPLRVGEPVA LSEEERLKLA
160 170 180 190 200
QQQAALLMQQ EERAKQAAVL MEQERQQEIA KMGTAVPRPP QDMGQLGVRT
210 220 230 240 250
PLGPRVAAPV GPVVPTPTVL PMGAPVPRPR GPPPPPGDEN REMDDPSVGP
260 270 280 290 300
KIPQALEKIL QLKESRQEEM NSQQEEEEME TDTRSSLGQS ASETEEDTVS
310 320 330 340 350
ISKKEKNRKR RNRKKKKKPQ RVRAASSESS GDREKDSGRS RGSDPPAADV
360 370 380 390 400
EIEYVTEEPE IYEPNFIFFK RIFEAFKLTD DVKKEKEKEP EKLDKMESSA
410 420 430 440 450
VPKKKGFEEE HKDSDDDSSD DEQEKKPEAP KLSKKKLRRM NRFTVAELKQ
460 470 480 490 500
LVARPDVVEM HDVTAQDPKL LVHLKATRNS VPVPRHWCFK RKYLQGKRGI
510 520 530 540 550
EKPPFELPDF IKRTGIQEMR EALQEKEEQK TMKSKMREKV RPKMGKIDID
560 570 580 590 600
YQKLHDAFFK WQTKPKLTIH GDLYYEGKEF ETRLKEKKPG DLSDELRISL
610 620 630 640 650
GMPVGPNAHK VPPPWLIAMQ RYGPPPSYPN LKIPGLNSPI PESCSFGYHA
660 670 680 690 700
GGWGKPPVDE TGKPLYGDVF GTNAAEFQTK TEEEEIDRTP WGELEPSDEE
710 720 730 740 750
SSEEEEEEES DEDKPDETGF ITPADSGLIT PGGFSSVPAG METPELIELR
760 770 780 790 800
KKKIEEAMDG SETPQLFTVL PEKRTATVGG AMMGSTHIYD MSTVMSRKGP
810 820 830 840 850
APELQGVEVA LAPEELELDP MAMTQKYEEH VREQQAQVEK EDFSDMVAEH
860 870
AAKQKQKKRK AQPQDSRGGS KKYKEFKF
Length:878
Mass (Da):98,198
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5DC0DC32D9EF49E4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494B9S9A0A494B9S9_MOUSE
Splicing factor 3b, subunit 2
Sf3b2
308Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC125059 Genomic DNA No translation available.
AK146063 mRNA Translation: BAE26872.1
AK146540 mRNA Translation: BAE27245.1
AK147687 mRNA Translation: BAE28075.1
CH466612 Genomic DNA Translation: EDL33110.1

NCBI Reference Sequences

More...
RefSeqi
NP_084385.2, NM_030109.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000025774; ENSMUSP00000025774; ENSMUSG00000024853

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
319322

UCSC genome browser

More...
UCSCi
uc008gcm.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125059 Genomic DNA No translation available.
AK146063 mRNA Translation: BAE26872.1
AK146540 mRNA Translation: BAE27245.1
AK147687 mRNA Translation: BAE28075.1
CH466612 Genomic DNA Translation: EDL33110.1
RefSeqiNP_084385.2, NM_030109.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025774

Genome annotation databases

EnsembliENSMUST00000025774; ENSMUSP00000025774; ENSMUSG00000024853
GeneIDi319322
UCSCiuc008gcm.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10992
MGIiMGI:2441856 Sf3b2

Phylogenomic databases

eggNOGiKOG2330 Eukaryota
COG5182 LUCA
GeneTreeiENSGT00390000006734
OMAiMYRQFYR
OrthoDBi1275099at2759
TreeFamiTF300635

Enzyme and pathway databases

ReactomeiR-MMU-72163 mRNA Splicing - Major Pathway
R-MMU-72165 mRNA Splicing - Minor Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sf3b2 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000024853 Expressed in 282 organ(s), highest expression level in rostral migratory stream

Family and domain databases

InterProiView protein in InterPro
IPR007180 DUF382
IPR006568 PSP_pro-rich
IPR003034 SAP_dom
PfamiView protein in Pfam
PF04037 DUF382, 1 hit
PF04046 PSP, 1 hit
SMARTiView protein in SMART
SM00581 PSP, 1 hit
SM00513 SAP, 1 hit
PROSITEiView protein in PROSITE
PS50800 SAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3UJB0_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UJB0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: July 31, 2019
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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