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UniProtKB - Q3UIT2 (Q3UIT2_MOUSE)
Protein
COP9 signalosome complex subunit 6
Gene
Cops6
Organism
Mus musculus (Mouse)
Status
Functioni
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
UniRule annotationGO - Molecular functioni
- isopeptidase activity Source: InterPro
- metallopeptidase activity Source: InterPro
GO - Biological processi
- protein deneddylation Source: UniProtKB-UniRule
Names & Taxonomyi
Protein namesi | Recommended name: COP9 signalosome complex subunit 6UniRule annotationARBA annotation |
Gene namesi | Name:Cops6Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:1349439, Cops6 |
VEuPathDBi | HostDB:ENSMUSG00000019494 |
Subcellular locationi
Nucleus
- COP9 signalosome Source: UniProtKB-UniRule
- nucleoplasm Source: Ensembl
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotation, NucleusUniRule annotation, SignalosomeUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000019494, Expressed in brain and 334 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 171 | MPNInterPro annotationAdd BLAST | 134 |
Sequence similaritiesi
Phylogenomic databases
OMAi | DLVGWYT |
OrthoDBi | 1455324at2759 |
PhylomeDBi | Q3UIT2 |
Family and domain databases
CDDi | cd08063, MPN_CSN6, 1 hit |
InterProi | View protein in InterPro IPR000555, JAMM/MPN+_dom IPR037518, MPN IPR033859, MPN_CSN6 IPR024969, Rpn11/EIF3F_C |
Pfami | View protein in Pfam PF01398, JAB, 1 hit PF13012, MitMem_reg, 1 hit |
SMARTi | View protein in SMART SM00232, JAB_MPN, 1 hit |
PROSITEi | View protein in PROSITE PS50249, MPN, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3UIT2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAAAAAGAN GSGGSSGMEV DAAVPSVMAS GVTGSVSVAL HPLVILNISD
60 70 80 90 100
HWIRMRSQEG RPMQVIGALI GKQEGRNIEV MNSFELLSHT VEEKIIIDKE
110 120 130 140 150
YYYTKEEQFK QVFKELEFLG WYTTGGPPDP SDIHVHKQVC EIIESPLFLK
160 170 180 190 200
LNPMTKHTDL PVSVFESVID IINGEATMLF AELTYTLATE EAERIGVDHV
210 220 230 240 250
ARMTATGSGE NSTVAEHLIA QHSAIKMLHS RVKLILEYVK ASEAGEVPFN
260 270 280 290 300
HEILREAYAL CHCLPVLSTD KFKTDFYDQC NDVGLMAYLG TITKTCNTMN
310 320
QFVNKFNVLY DRQGIGRRMR GLFF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK146775 mRNA Translation: BAE27424.1 |
RefSeqi | NP_036132.1, NM_012002.3 |
Genome annotation databases
GeneIDi | 26893 |
KEGGi | mmu:26893 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK146775 mRNA Translation: BAE27424.1 |
RefSeqi | NP_036132.1, NM_012002.3 |
3D structure databases
SMRi | Q3UIT2 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q3UIT2 |
Protocols and materials databases
Antibodypediai | 30510, 209 antibodies from 24 providers |
DNASUi | 26893 |
Genome annotation databases
GeneIDi | 26893 |
KEGGi | mmu:26893 |
Organism-specific databases
CTDi | 10980 |
MGIi | MGI:1349439, Cops6 |
VEuPathDBi | HostDB:ENSMUSG00000019494 |
Phylogenomic databases
OMAi | DLVGWYT |
OrthoDBi | 1455324at2759 |
PhylomeDBi | Q3UIT2 |
Miscellaneous databases
BioGRID-ORCSi | 26893, 28 hits in 65 CRISPR screens |
ChiTaRSi | Cops6, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000019494, Expressed in brain and 334 other tissues |
Family and domain databases
CDDi | cd08063, MPN_CSN6, 1 hit |
InterProi | View protein in InterPro IPR000555, JAMM/MPN+_dom IPR037518, MPN IPR033859, MPN_CSN6 IPR024969, Rpn11/EIF3F_C |
Pfami | View protein in Pfam PF01398, JAB, 1 hit PF13012, MitMem_reg, 1 hit |
SMARTi | View protein in SMART SM00232, JAB_MPN, 1 hit |
PROSITEi | View protein in PROSITE PS50249, MPN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3UIT2_MOUSE | |
Accessioni | Q3UIT2Primary (citable) accession number: Q3UIT2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | January 19, 2022 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |