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Entry version 118 (13 Nov 2019)
Sequence version 2 (15 May 2007)
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Protein

Pleckstrin homology domain-containing family A member 7

Gene

Plekha7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for zonula adherens biogenesis and maintenance. Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (By similarity). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleckstrin homology domain-containing family A member 7
Short name:
PH domain-containing family A member 7
Alternative name(s):
Heart adapter protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Plekha7
Synonyms:Hadp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2445094 Plekha7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002876931 – 1118Pleckstrin homology domain-containing family A member 7Add BLAST1118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei533PhosphoserineCombined sources1
Modified residuei542PhosphoserineCombined sources1
Modified residuei566PhosphoserineBy similarity1
Modified residuei601PhosphoserineCombined sources1
Modified residuei605PhosphoserineBy similarity1
Modified residuei609PhosphoserineCombined sources1
Modified residuei857PhosphoserineBy similarity1
Modified residuei864PhosphoserineCombined sources1
Modified residuei867PhosphothreonineBy similarity1
Modified residuei868PhosphoserineCombined sources1
Modified residuei900PhosphoserineCombined sources1
Modified residuei904PhosphoserineCombined sources1
Modified residuei983PhosphoserineBy similarity1
Isoform 4 (identifier: Q3UIL6-4)
Modified residuei990PhosphoserineCombined sources1
Isoform 6 (identifier: Q3UIL6-6)
Modified residuei1180PhosphoserineCombined sources1
Isoform 2 (identifier: Q3UIL6-2)
Modified residuei1226PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3UIL6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3UIL6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3UIL6

PeptideAtlas

More...
PeptideAtlasi
Q3UIL6

PRoteomics IDEntifications database

More...
PRIDEi
Q3UIL6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3UIL6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3UIL6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in kidney and lung (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000045659 Expressed in 245 organ(s), highest expression level in placenta labyrinth

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3UIL6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3UIL6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CAMSAP3 and CTNND1 (By similarity).

Interacts (via WW domains) with TSPAN33 (via cytoplasmic domain) and with PDZD11; the interaction with TSPAN33 is dependent on PDZD11 being bound to PLEKHA7 and facilitates the docking of ADAM10 to zonula adherens through interaction of TSPAN33 with ADAM10 (PubMed:30463011).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q3UIL6, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000081714

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3UIL6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 41WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini53 – 86WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini163 – 281PHPROSITE-ProRule annotationAdd BLAST119

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni535 – 693Interaction with CTNND1By similarityAdd BLAST159

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili697 – 798Sequence analysisAdd BLAST102
Coiled coili1064 – 1091Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi564 – 596Pro-richAdd BLAST33
Compositional biasi842 – 939Pro-richAdd BLAST98

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG1I Eukaryota
ENOG4111FBI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155817

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000077378

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3UIL6

Identification of Orthologs from Complete Genome Data

More...
OMAi
HLDRRSM

Database of Orthologous Groups

More...
OrthoDBi
71844at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3UIL6

TreeFam database of animal gene trees

More...
TreeFami
TF329090

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13248 PH_PEPP1_2_3, 1 hit
cd00201 WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR040392 PKHA4/5/6/7_PH
IPR001202 WW_dom
IPR036020 WW_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit
SM00456 WW, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51045 SSF51045, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3UIL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAVGRDTL PEHWSYGVCR DGRVFFINDQ LRCTTWLHPR TGEPVNSGHM
60 70 80 90 100
IRSDLPRGWE EGFTEEGASF FIDHNQQTTT FRHPVTGQFS SENSEYVLRE
110 120 130 140 150
EPHPHMSKPE RNQRPSSMVS ETSTAGTTST LEAKPGPKIV KSSSKVHSFG
160 170 180 190 200
KRDQAIRRNL NVPVVVRGWL HKQDSSGMRL WKRRWFVLAD YCLFYYKDSR
210 220 230 240 250
EEAVLGSIPL PSYVISPVAP EDRISRKYSF KAVHTGMRAL IYSTTTAGSQ
260 270 280 290 300
MEHSGMRTYY FSADTLEDMN AWVRAMNQAA QVLSRSSLRR DVDKVERQAM
310 320 330 340 350
PQANHTDACQ ECGHVGPGHS RDCPRRGYED SYGFNRREQE EERFRAQRDP
360 370 380 390 400
LEGRRDRSKA RSPYLPAEED ALFVDLPGGP RGQQAQPQRA EKNGVPPYGL
410 420 430 440 450
GEQNGTNGYQ RTAPPRANPE KHSQRKTGLA QAEHWTKAQK GDGRSLPLDQ
460 470 480 490 500
TLPRQGPSQP LSFPENYQSL PKSTRHLSGS SSPPPRNLPS DYKYAQDRAS
510 520 530 540 550
HLKMSSEERR AHRDGTVWQL YEWQQRQQFR HGSPTAPIGA GSPEFTEQGR
560 570 580 590 600
SRSLLEVPRS ISVPPSPSDI PPPGPPRPFP PRRPHTPAER VTVKPPEQRR
610 620 630 640 650
SVDISLGGSP RKARGHAAKN SSHVDRRSMP SMGYMTHTVS APSLHGKSAD
660 670 680 690 700
DTYLQLKKDL EYLDLKMTGR DLLKDRSLKP MKIAESDIDV KLSIFCEQDR
710 720 730 740 750
ILQDLEDKIR ALKENKDQLE SVLEVLHRQT EQYRDQPQHL EKITCQQRLL
760 770 780 790 800
QEDLVHIRAE LCRESTEMEN AWNEYLKLEK DVEQLKQTLQ EQHRRAFFFQ
810 820 830 840 850
EKSQIQKDLW RIEDVMAGLS ANKENYRVLV GSVKNPERKT VPLFPHPSVP
860 870 880 890 900
SLSPTESKPA LQPSPPTSPV RTPLEVRLFP QLQTYVPYRP HPPQLRKVMS
910 920 930 940 950
PLQSPTKAKP QAEDEAPPRP PLPELYSPED QPPAVPPLPR EATIIRHTSV
960 970 980 990 1000
RGLKRQSDER KRDREQGQCV NGDLKVELRS YVSEPELASL SGDVPQPSLS
1010 1020 1030 1040 1050
LVGSESRYQT LPGRGLSGST SRLQQSSTIA PYVTLRRGLN AENSSATFSR
1060 1070 1080 1090 1100
PKSALERLYS GDHQRGKMSA EEQLERMKRH QKALVRERKR TLSQGEKTGL
1110
LSARYLSQPL PGDLGSVC
Length:1,118
Mass (Da):126,742
Last modified:May 15, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6CCCE91B582ED368
GO
Isoform 2 (identifier: Q3UIL6-2) [UniParc]FASTAAdd to basket
Also known as: HADP1a

The sequence of this isoform differs from the canonical sequence as follows:
     1116-1118: SVC → SWKREQEFDL...QVAAQAITDP

Show »
Length:1,266
Mass (Da):143,817
Checksum:iEB37C5F5A7ED26B4
GO
Isoform 3 (identifier: Q3UIL6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-105: Missing.

Note: No experimental confirmation available.
Show »
Length:1,013
Mass (Da):114,660
Checksum:i9D297ACD309171F5
GO
Isoform 4 (identifier: Q3UIL6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-236: Missing.
     1116-1118: SVC → SWKREQEFDL...QVAAQAITDP

Note: No experimental confirmation available.Combined sources
Show »
Length:1,030
Mass (Da):116,896
Checksum:iE9EA2BEA661819C2
GO
Isoform 5 (identifier: Q3UIL6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.
     63-73: FTEEGASFFID → MSLRSTWATVC

Note: No experimental confirmation available.
Show »
Length:1,056
Mass (Da):119,670
Checksum:i2AA8F9A181A07C6C
GO
Isoform 6 (identifier: Q3UIL6-6) [UniParc]FASTAAdd to basket
Also known as: HADP1b

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: MAAAVGRDTL...TEEGASFFID → MEPWRCPPRDARPAALGFWGEPLAVCS
     1116-1118: SVC → SWKREQEFDL...QVAAQAITDP

Show »
Length:1,220
Mass (Da):138,503
Checksum:i9D804E13DE9819FC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SQ79A0A1L1SQ79_MOUSE
Pleckstrin homology domain-containi...
Plekha7
867Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RPA0A0A0U1RPA0_MOUSE
Pleckstrin homology domain-containi...
Plekha7
1,212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R243S4R243_MOUSE
Pleckstrin homology domain-containi...
Plekha7
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R190S4R190_MOUSE
Pleckstrin homology domain-containi...
Plekha7
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SU82A0A1L1SU82_MOUSE
Pleckstrin homology domain-containi...
Plekha7
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1SV63A0A1L1SV63_MOUSE
Pleckstrin homology domain-containi...
Plekha7
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RP25A0A0U1RP25_MOUSE
Pleckstrin homology domain-containi...
Plekha7
64Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE36027 differs from that shown. Reason: Frameshift.Curated
The sequence BAE36027 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0255931 – 236Missing in isoform 4. 1 PublicationAdd BLAST236
Alternative sequenceiVSP_0255951 – 105Missing in isoform 3. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_0395441 – 73MAAAV…SFFID → MEPWRCPPRDARPAALGFWG EPLAVCS in isoform 6. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_0446261 – 62Missing in isoform 5. CuratedAdd BLAST62
Alternative sequenceiVSP_04462763 – 73FTEEGASFFID → MSLRSTWATVC in isoform 5. CuratedAdd BLAST11
Alternative sequenceiVSP_0255961116 – 1118SVC → SWKREQEFDLQLLERAAQGD RKDKEEGWLKVQATPVMELD LEPQDYDLDISRELSKPEKV SIPERYVELDPEEPPSLEEL QARYQKAEKIRNILARSSMC NLQPLGQDRNSLADLDSQLQ EQERIINISYALASEASKRS KQVAAQAITDP in isoform 2, isoform 4 and isoform 6. 2 Publications3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
EU380771 mRNA Translation: ACB38003.1
EU380772 mRNA Translation: ACB38004.1
AK040271 mRNA Translation: BAC30557.1
AK146866 mRNA Translation: BAE27490.1
AK160810 mRNA Translation: BAE36027.1 Frameshift.
BC084587 mRNA Translation: AAH84587.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS40099.1 [Q3UIL6-4]
CCDS80791.1 [Q3UIL6-3]
CCDS85395.1 [Q3UIL6-5]
CCDS85396.1 [Q3UIL6-6]
CCDS85397.1 [Q3UIL6-2]

NCBI Reference Sequences

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RefSeqi
NP_001292114.1, NM_001305185.1 [Q3UIL6-2]
NP_001292115.1, NM_001305186.1 [Q3UIL6-6]
NP_001292118.1, NM_001305189.1 [Q3UIL6-3]
NP_001292119.1, NM_001305190.1 [Q3UIL6-5]
NP_766331.1, NM_172743.3 [Q3UIL6-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000084664; ENSMUSP00000081714; ENSMUSG00000045659 [Q3UIL6-4]
ENSMUST00000181981; ENSMUSP00000138766; ENSMUSG00000045659 [Q3UIL6-3]
ENSMUST00000181998; ENSMUSP00000138575; ENSMUSG00000045659 [Q3UIL6-2]
ENSMUST00000182487; ENSMUSP00000138214; ENSMUSG00000045659 [Q3UIL6-1]
ENSMUST00000182511; ENSMUSP00000138544; ENSMUSG00000045659 [Q3UIL6-5]
ENSMUST00000182834; ENSMUSP00000138257; ENSMUSG00000045659 [Q3UIL6-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
233765

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:233765

UCSC genome browser

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UCSCi
uc009jiy.2 mouse [Q3UIL6-4]
uc009jiz.3 mouse [Q3UIL6-2]
uc009jja.1 mouse [Q3UIL6-6]
uc009jjc.2 mouse [Q3UIL6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU380771 mRNA Translation: ACB38003.1
EU380772 mRNA Translation: ACB38004.1
AK040271 mRNA Translation: BAC30557.1
AK146866 mRNA Translation: BAE27490.1
AK160810 mRNA Translation: BAE36027.1 Frameshift.
BC084587 mRNA Translation: AAH84587.1
CCDSiCCDS40099.1 [Q3UIL6-4]
CCDS80791.1 [Q3UIL6-3]
CCDS85395.1 [Q3UIL6-5]
CCDS85396.1 [Q3UIL6-6]
CCDS85397.1 [Q3UIL6-2]
RefSeqiNP_001292114.1, NM_001305185.1 [Q3UIL6-2]
NP_001292115.1, NM_001305186.1 [Q3UIL6-6]
NP_001292118.1, NM_001305189.1 [Q3UIL6-3]
NP_001292119.1, NM_001305190.1 [Q3UIL6-5]
NP_766331.1, NM_172743.3 [Q3UIL6-4]

3D structure databases

SMRiQ3UIL6
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ3UIL6, 1 interactor
STRINGi10090.ENSMUSP00000081714

PTM databases

iPTMnetiQ3UIL6
PhosphoSitePlusiQ3UIL6

Proteomic databases

jPOSTiQ3UIL6
MaxQBiQ3UIL6
PaxDbiQ3UIL6
PeptideAtlasiQ3UIL6
PRIDEiQ3UIL6

Genome annotation databases

EnsembliENSMUST00000084664; ENSMUSP00000081714; ENSMUSG00000045659 [Q3UIL6-4]
ENSMUST00000181981; ENSMUSP00000138766; ENSMUSG00000045659 [Q3UIL6-3]
ENSMUST00000181998; ENSMUSP00000138575; ENSMUSG00000045659 [Q3UIL6-2]
ENSMUST00000182487; ENSMUSP00000138214; ENSMUSG00000045659 [Q3UIL6-1]
ENSMUST00000182511; ENSMUSP00000138544; ENSMUSG00000045659 [Q3UIL6-5]
ENSMUST00000182834; ENSMUSP00000138257; ENSMUSG00000045659 [Q3UIL6-6]
GeneIDi233765
KEGGimmu:233765
UCSCiuc009jiy.2 mouse [Q3UIL6-4]
uc009jiz.3 mouse [Q3UIL6-2]
uc009jja.1 mouse [Q3UIL6-6]
uc009jjc.2 mouse [Q3UIL6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
144100
MGIiMGI:2445094 Plekha7

Phylogenomic databases

eggNOGiENOG410IG1I Eukaryota
ENOG4111FBI LUCA
GeneTreeiENSGT00940000155817
HOGENOMiHOG000077378
InParanoidiQ3UIL6
OMAiHLDRRSM
OrthoDBi71844at2759
PhylomeDBiQ3UIL6
TreeFamiTF329090

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Plekha7 mouse

Protein Ontology

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PROi
PR:Q3UIL6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000045659 Expressed in 245 organ(s), highest expression level in placenta labyrinth
ExpressionAtlasiQ3UIL6 baseline and differential
GenevisibleiQ3UIL6 MM

Family and domain databases

CDDicd13248 PH_PEPP1_2_3, 1 hit
cd00201 WW, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR040392 PKHA4/5/6/7_PH
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00456 WW, 2 hits
SUPFAMiSSF51045 SSF51045, 2 hits
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPKHA7_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UIL6
Secondary accession number(s): B6RSP2
, B6RSP3, Q3TUE4, Q5XG70, Q8BYE3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 13, 2019
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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