UniProtKB - Q3UIJ9 (MYZAP_MOUSE)
Myocardial zonula adherens protein
Myzap
Functioni
Plays a role in cellular signaling via Rho-related GTP-binding proteins and activation of transcription factor SRF. Targets TJP1 to cell junctions (By similarity).
In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).
By similarity1 PublicationGO - Biological processi
- intracellular signal transduction Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Myocardial zonula adherens protein |
Gene namesi | Name:Myzap Synonyms:Myozap |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2142908, Myzap |
VEuPathDBi | HostDB:ENSMUSG00000041361 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Plasma membrane
- Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Other locations
- I band 1 Publication
- Z line 1 Publication
- Cell junction By similarity
Note: Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disks. Colocalizes with F-actin. Colocalizes with cortical actin.
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Nucleus
- nuclear envelope Source: MGI
- RNA polymerase II, core complex Source: MGI
- RNA polymerase II, holoenzyme Source: MGI
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
Other locations
- cell junction Source: UniProtKB-SubCell
- I band Source: UniProtKB
- membrane Source: MGI
- Z disc Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_0000326226 | 17 – 466 | Myocardial zonula adherens proteinAdd BLAST | 450 |
Proteomic databases
MaxQBi | Q3UIJ9 |
PaxDbi | Q3UIJ9 |
PRIDEi | Q3UIJ9 |
ProteomicsDBi | 287551 |
PTM databases
iPTMneti | Q3UIJ9 |
PhosphoSitePlusi | Q3UIJ9 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000041361, Expressed in myocardium of ventricle and 218 other tissues |
ExpressionAtlasi | Q3UIJ9, baseline and differential |
Genevisiblei | Q3UIJ9, MM |
Interactioni
Subunit structurei
Interacts with DSP, MPRIP and TJP1/ZO1. Interaction with MPRIP inhibits the activation of transcription factor SRF.
Interacts with GRIN1.
Interacts with DYNLL1 (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000091342 |
Miscellaneous databases
RNActi | Q3UIJ9, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 68 | DisorderedSequence analysisAdd BLAST | 68 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 95 – 137 | Sequence analysisAdd BLAST | 43 | |
Coiled coili | 187 – 415 | Sequence analysisAdd BLAST | 229 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 16 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 44 – 59 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, SignalPhylogenomic databases
eggNOGi | ENOG502QSEE, Eukaryota |
GeneTreei | ENSGT00950000183065 |
HOGENOMi | CLU_022112_0_0_1 |
InParanoidi | Q3UIJ9 |
OMAi | RKEQHPD |
OrthoDBi | 639997at2759 |
PhylomeDBi | Q3UIJ9 |
TreeFami | TF331627 |
Family and domain databases
InterProi | View protein in InterPro IPR028273, Myozap |
PANTHERi | PTHR23171:SF2, PTHR23171:SF2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MLRSTSTVTL FSGGGAKSPG TPSRRANVCR LRLTVPPENP VPQQTEKKIE
60 70 80 90 100
RKDQPPELSN GESTKRLPQG VVYGVVRRSD PNQQKEMVVY GWSTNQLKEE
110 120 130 140 150
MNYIKDVRAT LEKVRKRMYG DYDEMRQKIR QLTQDLSVSH AQQDYLDSHI
160 170 180 190 200
QAQASALDSF NAMNAALASD SVGLQKTLVD VTLENSHIKD QIRHLQQTYE
210 220 230 240 250
ASMDKLREKQ RQLEAAQMEN QLLKMRVESS QEANAEVMRE MTRKLYSQYE
260 270 280 290 300
EKLQEAQRKH SAEKEVLLEE TNSFLKAIEE ANKKMEAAEL SLEEKDQKIG
310 320 330 340 350
ELDRLIERME KERHQLQLQL LEHETEMSGE MADSDKNRYQ QLEEASASLR
360 370 380 390 400
ERIRHLDDMV HCQQKKVKQM VEEIESLKKK VQQKQLLILQ LLEKISFLEG
410 420 430 440 450
ENNELQSRLD YLTETQPKTE VETREIGVGC DLLPSPTGRT REITMPSRSY
460
TPYTRVLELS SKKTLT
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q565 | E9Q565_MOUSE | Myocardial zonula adherens protein | Myzap | 438 | Annotation score: | ||
E9Q4R0 | E9Q4R0_MOUSE | Myocardial zonula adherens protein | Myzap | 99 | Annotation score: | ||
E9PWY8 | E9PWY8_MOUSE | Myocardial zonula adherens protein | Myzap | 93 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK146889 mRNA Translation: BAE27507.1 CH466522 Genomic DNA Translation: EDL26227.1 BC139077 mRNA Translation: AAI39078.1 BC139078 mRNA Translation: AAI39079.1 |
CCDSi | CCDS23327.1 |
RefSeqi | NP_001028380.1, NM_001033208.4 |
Genome annotation databases
Ensembli | ENSMUST00000093823; ENSMUSP00000091342; ENSMUSG00000041361 |
GeneIDi | 102371 |
KEGGi | mmu:102371 |
UCSCi | uc009qpa.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK146889 mRNA Translation: BAE27507.1 CH466522 Genomic DNA Translation: EDL26227.1 BC139077 mRNA Translation: AAI39078.1 BC139078 mRNA Translation: AAI39079.1 |
CCDSi | CCDS23327.1 |
RefSeqi | NP_001028380.1, NM_001033208.4 |
3D structure databases
SMRi | Q3UIJ9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000091342 |
PTM databases
iPTMneti | Q3UIJ9 |
PhosphoSitePlusi | Q3UIJ9 |
Proteomic databases
MaxQBi | Q3UIJ9 |
PaxDbi | Q3UIJ9 |
PRIDEi | Q3UIJ9 |
ProteomicsDBi | 287551 |
Genome annotation databases
Ensembli | ENSMUST00000093823; ENSMUSP00000091342; ENSMUSG00000041361 |
GeneIDi | 102371 |
KEGGi | mmu:102371 |
UCSCi | uc009qpa.1, mouse |
Organism-specific databases
CTDi | 100820829 |
MGIi | MGI:2142908, Myzap |
VEuPathDBi | HostDB:ENSMUSG00000041361 |
Phylogenomic databases
eggNOGi | ENOG502QSEE, Eukaryota |
GeneTreei | ENSGT00950000183065 |
HOGENOMi | CLU_022112_0_0_1 |
InParanoidi | Q3UIJ9 |
OMAi | RKEQHPD |
OrthoDBi | 639997at2759 |
PhylomeDBi | Q3UIJ9 |
TreeFami | TF331627 |
Miscellaneous databases
BioGRID-ORCSi | 102371, 1 hit in 63 CRISPR screens |
ChiTaRSi | Myzap, mouse |
PROi | PR:Q3UIJ9 |
RNActi | Q3UIJ9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041361, Expressed in myocardium of ventricle and 218 other tissues |
ExpressionAtlasi | Q3UIJ9, baseline and differential |
Genevisiblei | Q3UIJ9, MM |
Family and domain databases
InterProi | View protein in InterPro IPR028273, Myozap |
PANTHERi | PTHR23171:SF2, PTHR23171:SF2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MYZAP_MOUSE | |
Accessioni | Q3UIJ9Primary (citable) accession number: Q3UIJ9 Secondary accession number(s): B2RT00 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 23, 2022 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families