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Protein

Myocardial zonula adherens protein

Gene

Myzap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in cellular signaling via Rho-related GTP-binding proteins and activation of transcription factor SRF. Targets TJP1 to cell junctions (By similarity). In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity).By similarity1 Publication

GO - Biological processi

  • intracellular signal transduction Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Myocardial zonula adherens protein
Gene namesi
Name:Myzap
Synonyms:Myozap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2142908 Myzap

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000032622617 – 466Myocardial zonula adherens proteinAdd BLAST450

Proteomic databases

MaxQBiQ3UIJ9
PaxDbiQ3UIJ9
PRIDEiQ3UIJ9

PTM databases

iPTMnetiQ3UIJ9
PhosphoSitePlusiQ3UIJ9

Expressioni

Tissue specificityi

Detected in heart myocardium and lung.1 Publication

Developmental stagei

Detected in embryonic vasculature at 8 dpc. Detected in endocardium and the primitive ventricle at 9 dpc. First detected in myocardium at 11.5 dpc. Highly expressed in heart and lung at 15.5 dpc and in neonates, wherease expression in vasculature is no longer detectable.1 Publication

Gene expression databases

BgeeiENSMUSG00000041361 Expressed in 186 organ(s), highest expression level in myocardium of ventricle
ExpressionAtlasiQ3UIJ9 baseline and differential
GenevisibleiQ3UIJ9 MM

Interactioni

Subunit structurei

Interacts with DSP, MPRIP and TJP1/ZO1. Interaction with MPRIP inhibits the activation of transcription factor SRF. Interacts with GRIN1. Interacts with DYNLL1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091342

Structurei

3D structure databases

ProteinModelPortaliQ3UIJ9
SMRiQ3UIJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili95 – 137Sequence analysisAdd BLAST43
Coiled coili187 – 415Sequence analysisAdd BLAST229

Sequence similaritiesi

Belongs to the MYZAP family.Curated

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiENOG410II7W Eukaryota
ENOG410ZUQB LUCA
GeneTreeiENSGT00530000063232
HOGENOMiHOG000060195
InParanoidiQ3UIJ9
KOiK22031
OrthoDBiEOG091G01MP
PhylomeDBiQ3UIJ9
TreeFamiTF331627

Family and domain databases

InterProiView protein in InterPro
IPR028273 Myozap
PANTHERiPTHR23171:SF2 PTHR23171:SF2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q3UIJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRSTSTVTL FSGGGAKSPG TPSRRANVCR LRLTVPPENP VPQQTEKKIE
60 70 80 90 100
RKDQPPELSN GESTKRLPQG VVYGVVRRSD PNQQKEMVVY GWSTNQLKEE
110 120 130 140 150
MNYIKDVRAT LEKVRKRMYG DYDEMRQKIR QLTQDLSVSH AQQDYLDSHI
160 170 180 190 200
QAQASALDSF NAMNAALASD SVGLQKTLVD VTLENSHIKD QIRHLQQTYE
210 220 230 240 250
ASMDKLREKQ RQLEAAQMEN QLLKMRVESS QEANAEVMRE MTRKLYSQYE
260 270 280 290 300
EKLQEAQRKH SAEKEVLLEE TNSFLKAIEE ANKKMEAAEL SLEEKDQKIG
310 320 330 340 350
ELDRLIERME KERHQLQLQL LEHETEMSGE MADSDKNRYQ QLEEASASLR
360 370 380 390 400
ERIRHLDDMV HCQQKKVKQM VEEIESLKKK VQQKQLLILQ LLEKISFLEG
410 420 430 440 450
ENNELQSRLD YLTETQPKTE VETREIGVGC DLLPSPTGRT REITMPSRSY
460
TPYTRVLELS SKKTLT
Length:466
Mass (Da):53,897
Last modified:October 11, 2005 - v1
Checksum:iFF6F99C1E486B717
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q565E9Q565_MOUSE
Myocardial zonula adherens protein
Myzap
438Annotation score:
E9PWY8E9PWY8_MOUSE
Myocardial zonula adherens protein
Myzap
93Annotation score:
E9Q4R0E9Q4R0_MOUSE
Myocardial zonula adherens protein
Myzap
99Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146889 mRNA Translation: BAE27507.1
CH466522 Genomic DNA Translation: EDL26227.1
BC139077 mRNA Translation: AAI39078.1
BC139078 mRNA Translation: AAI39079.1
CCDSiCCDS23327.1
RefSeqiNP_001028380.1, NM_001033208.4
UniGeneiMm.27585

Genome annotation databases

EnsembliENSMUST00000093823; ENSMUSP00000091342; ENSMUSG00000041361
GeneIDi102371
KEGGimmu:102371
UCSCiuc009qpa.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK146889 mRNA Translation: BAE27507.1
CH466522 Genomic DNA Translation: EDL26227.1
BC139077 mRNA Translation: AAI39078.1
BC139078 mRNA Translation: AAI39079.1
CCDSiCCDS23327.1
RefSeqiNP_001028380.1, NM_001033208.4
UniGeneiMm.27585

3D structure databases

ProteinModelPortaliQ3UIJ9
SMRiQ3UIJ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091342

PTM databases

iPTMnetiQ3UIJ9
PhosphoSitePlusiQ3UIJ9

Proteomic databases

MaxQBiQ3UIJ9
PaxDbiQ3UIJ9
PRIDEiQ3UIJ9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000093823; ENSMUSP00000091342; ENSMUSG00000041361
GeneIDi102371
KEGGimmu:102371
UCSCiuc009qpa.1 mouse

Organism-specific databases

CTDi100820829
MGIiMGI:2142908 Myzap

Phylogenomic databases

eggNOGiENOG410II7W Eukaryota
ENOG410ZUQB LUCA
GeneTreeiENSGT00530000063232
HOGENOMiHOG000060195
InParanoidiQ3UIJ9
KOiK22031
OrthoDBiEOG091G01MP
PhylomeDBiQ3UIJ9
TreeFamiTF331627

Miscellaneous databases

PROiPR:Q3UIJ9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041361 Expressed in 186 organ(s), highest expression level in myocardium of ventricle
ExpressionAtlasiQ3UIJ9 baseline and differential
GenevisibleiQ3UIJ9 MM

Family and domain databases

InterProiView protein in InterPro
IPR028273 Myozap
PANTHERiPTHR23171:SF2 PTHR23171:SF2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYZAP_MOUSE
AccessioniPrimary (citable) accession number: Q3UIJ9
Secondary accession number(s): B2RT00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 11, 2005
Last modified: September 12, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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