UniProtKB - Q3UIB2 (Q3UIB2_MOUSE)
Protein
Mitogen-activated protein kinase
Gene
Mapk13
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
Cofactori
Mg2+SAAS annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- MAP kinase activity Source: UniProtKB-EC
GO - Biological processi
- cellular response to anisomycin Source: Ensembl
- cellular response to hydrogen peroxide Source: Ensembl
- cellular response to interleukin-1 Source: Ensembl
- cellular response to sodium arsenite Source: Ensembl
- cellular response to sorbitol Source: Ensembl
- cellular response to UV Source: Ensembl
- peptidyl-serine phosphorylation Source: Ensembl
- positive regulation of interleukin-6 production Source: Ensembl
- response to osmotic stress Source: Ensembl
- stress-activated MAPK cascade Source: Ensembl
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase |
Ligand | ATP-bindingSAAS annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Mapk13Imported ORF Names:mCG_18522Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:1346864 Mapk13 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000004864 Expressed in 194 organ(s), highest expression level in intestine |
ExpressionAtlasi | Q3UIB2 baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 308 | Protein kinaseInterPro annotationAdd BLAST | 284 |
Phylogenomic databases
eggNOGi | KOG0660 Eukaryota ENOG410XNY0 LUCA |
KOi | K04441 |
OMAi | TMSSGAM |
OrthoDBi | 683132at2759 |
Family and domain databases
CDDi | cd07879 STKc_p38delta, 1 hit |
InterProi | View protein in InterPro IPR011009 Kinase-like_dom_sf IPR003527 MAP_kinase_CS IPR008352 MAPK_p38-like IPR038785 p38delta IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS |
Pfami | View protein in Pfam PF00069 Pkinase, 1 hit |
PRINTSi | PR01773 P38MAPKINASE |
SMARTi | View protein in SMART SM00220 S_TKc, 1 hit |
SUPFAMi | SSF56112 SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351 MAPK, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3UIB2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLTRKRGFY KQDINKTAWE LPKTYLAPAH VGSGAYGAVC SAIDKRTGEK
60 70 80 90 100
VAIKKLSRPF QSEIFAKRAY RELLLLKHMH HENVIGLLDV FTPASSLRSF
110 120 130 140 150
HDFYLVMPFM QTDLQKIMGM EFSEDKVQYL VYQMLKGLKY IHSAGIVHRD
160 170 180 190 200
LKPGNLAVNE DCELKILDFG LARHTDTEMT GYVVTRWYRA PEVILSWMHY
210 220 230 240 250
NQTVDIWSVG CIMAEMLTGK TLFKGKDYLD QLTQILKVTG VPGAEFVQKL
260 270 280 290 300
KDKAAKSYIQ SLPQSPKKDF TQLFPRASPQ AADLLDKMLE LDVDKRLTAA
310 320 330 340 350
QALAHPFFEP FRDPEEETEA QQPFDDALEH EKLSVDEWKQ HIYKEISNFS
360
PIARKDSRRR SGMKLQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK146993 mRNA Translation: BAE27594.1 CH466606 Genomic DNA Translation: EDL22588.1 |
RefSeqi | NP_036080.2, NM_011950.2 |
Genome annotation databases
GeneIDi | 26415 |
KEGGi | mmu:26415 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK146993 mRNA Translation: BAE27594.1 CH466606 Genomic DNA Translation: EDL22588.1 |
RefSeqi | NP_036080.2, NM_011950.2 |
3D structure databases
SMRi | Q3UIB2 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | Q3UIB2 |
PRIDEi | Q3UIB2 |
Genome annotation databases
GeneIDi | 26415 |
KEGGi | mmu:26415 |
Organism-specific databases
CTDi | 5603 |
MGIi | MGI:1346864 Mapk13 |
Phylogenomic databases
eggNOGi | KOG0660 Eukaryota ENOG410XNY0 LUCA |
KOi | K04441 |
OMAi | TMSSGAM |
OrthoDBi | 683132at2759 |
Miscellaneous databases
ChiTaRSi | Mapk13 mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000004864 Expressed in 194 organ(s), highest expression level in intestine |
ExpressionAtlasi | Q3UIB2 baseline and differential |
Family and domain databases
CDDi | cd07879 STKc_p38delta, 1 hit |
InterProi | View protein in InterPro IPR011009 Kinase-like_dom_sf IPR003527 MAP_kinase_CS IPR008352 MAPK_p38-like IPR038785 p38delta IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS |
Pfami | View protein in Pfam PF00069 Pkinase, 1 hit |
PRINTSi | PR01773 P38MAPKINASE |
SMARTi | View protein in SMART SM00220 S_TKc, 1 hit |
SUPFAMi | SSF56112 SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS01351 MAPK, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3UIB2_MOUSE | |
Accessioni | Q3UIB2Primary (citable) accession number: Q3UIB2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | October 16, 2019 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |