UniProtKB - Q3UHX2 (HAP28_MOUSE)
Protein
28 kDa heat- and acid-stable phosphoprotein
Gene
Pdap1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- platelet-derived growth factor binding Source: MGI
GO - Biological processi
Enzyme and pathway databases
Reactomei | R-MMU-6798695 Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: 28 kDa heat- and acid-stable phosphoproteinAlternative name(s): PDGF-associated protein Short name: PAP PDGFA-associated protein 1 Short name: PAP1 |
Gene namesi | Name:Pdap1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2448536 Pdap1 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Extracellular region or secreted
- extracellular space Source: MGI
Plasma Membrane
- plasma membrane Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000083898 | 1 – 181 | 28 kDa heat- and acid-stable phosphoproteinAdd BLAST | 181 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 18 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 19 | PhosphoserineBy similarity | 1 | |
Cross-linki | 52 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 57 | PhosphoserineCombined sources | 1 | |
Modified residuei | 60 | PhosphoserineCombined sources | 1 | |
Modified residuei | 63 | PhosphoserineCombined sources | 1 | |
Modified residuei | 70 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 126 | N6-methyllysineBy similarity | 1 | |
Modified residuei | 132 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 164 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 176 | PhosphoserineBy similarity | 1 | |
Modified residuei | 178 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylated by several kinases in vitro. In vivo, can be phosphorylated by CK2.
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q3UHX2 |
jPOSTi | Q3UHX2 |
MaxQBi | Q3UHX2 |
PaxDbi | Q3UHX2 |
PRIDEi | Q3UHX2 |
TopDownProteomicsi | Q3UHX2 |
PTM databases
iPTMneti | Q3UHX2 |
PhosphoSitePlusi | Q3UHX2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000029623 Expressed in 291 organ(s), highest expression level in ear |
ExpressionAtlasi | Q3UHX2 baseline and differential |
Genevisiblei | Q3UHX2 MM |
Interactioni
GO - Molecular functioni
- platelet-derived growth factor binding Source: MGI
Protein-protein interaction databases
BioGridi | 231191, 1 interactor |
STRINGi | 10090.ENSMUSP00000031627 |
Family & Domainsi
Sequence similaritiesi
Belongs to the PDAP1 family.Curated
Phylogenomic databases
eggNOGi | KOG3375 Eukaryota ENOG4111T3A LUCA |
GeneTreei | ENSGT00390000018509 |
HOGENOMi | HOG000241539 |
InParanoidi | Q3UHX2 |
OMAi | IGDPKKE |
OrthoDBi | 1572985at2759 |
PhylomeDBi | Q3UHX2 |
TreeFami | TF324338 |
Family and domain databases
InterProi | View protein in InterPro IPR019380 Casein_kinase_sb_PP28 IPR039876 HAP28 |
PANTHERi | PTHR22055 PTHR22055, 1 hit |
Pfami | View protein in Pfam PF10252 PP28, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3UHX2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKGGRKGGH KGRVRQYTSP EEIDAQLQAE KQKANEEDEQ EEGGDGASGD
60 70 80 90 100
PKKEKKSLDS DESEDEDDDY QQKRKGVEGL IDIENPNRVA QTTKKVTQLD
110 120 130 140 150
LDGPKELSRR EREEIEKQKA KERYMKMHLA GKTEQAKADL ARLAIIRKQR
160 170 180
EEAARKKEEE RKAKDDATLS GKRMQSLSLN K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK147170 mRNA Translation: BAE27734.1 BC007162 mRNA Translation: AAH07162.1 BC106168 mRNA Translation: AAI06169.1 |
CCDSi | CCDS39384.1 |
RefSeqi | NP_001028485.1, NM_001033313.3 |
Genome annotation databases
Ensembli | ENSMUST00000031627; ENSMUSP00000031627; ENSMUSG00000029623 |
GeneIDi | 231887 |
KEGGi | mmu:231887 |
UCSCi | uc009ame.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK147170 mRNA Translation: BAE27734.1 BC007162 mRNA Translation: AAH07162.1 BC106168 mRNA Translation: AAI06169.1 |
CCDSi | CCDS39384.1 |
RefSeqi | NP_001028485.1, NM_001033313.3 |
3D structure databases
SMRi | Q3UHX2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 231191, 1 interactor |
STRINGi | 10090.ENSMUSP00000031627 |
PTM databases
iPTMneti | Q3UHX2 |
PhosphoSitePlusi | Q3UHX2 |
Proteomic databases
EPDi | Q3UHX2 |
jPOSTi | Q3UHX2 |
MaxQBi | Q3UHX2 |
PaxDbi | Q3UHX2 |
PRIDEi | Q3UHX2 |
TopDownProteomicsi | Q3UHX2 |
Genome annotation databases
Ensembli | ENSMUST00000031627; ENSMUSP00000031627; ENSMUSG00000029623 |
GeneIDi | 231887 |
KEGGi | mmu:231887 |
UCSCi | uc009ame.1 mouse |
Organism-specific databases
CTDi | 11333 |
MGIi | MGI:2448536 Pdap1 |
Phylogenomic databases
eggNOGi | KOG3375 Eukaryota ENOG4111T3A LUCA |
GeneTreei | ENSGT00390000018509 |
HOGENOMi | HOG000241539 |
InParanoidi | Q3UHX2 |
OMAi | IGDPKKE |
OrthoDBi | 1572985at2759 |
PhylomeDBi | Q3UHX2 |
TreeFami | TF324338 |
Enzyme and pathway databases
Reactomei | R-MMU-6798695 Neutrophil degranulation |
Miscellaneous databases
ChiTaRSi | Pdap1 mouse |
PROi | PR:Q3UHX2 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029623 Expressed in 291 organ(s), highest expression level in ear |
ExpressionAtlasi | Q3UHX2 baseline and differential |
Genevisiblei | Q3UHX2 MM |
Family and domain databases
InterProi | View protein in InterPro IPR019380 Casein_kinase_sb_PP28 IPR039876 HAP28 |
PANTHERi | PTHR22055 PTHR22055, 1 hit |
Pfami | View protein in Pfam PF10252 PP28, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HAP28_MOUSE | |
Accessioni | Q3UHX2Primary (citable) accession number: Q3UHX2 Secondary accession number(s): A0JLS1, Q3KQJ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | October 16, 2019 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot