Pdap1

Functionⁱ

GO - Molecular functionⁱ

platelet-derived growth factor binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

platelet-derived growth factor receptor signaling pathway Source: MGI

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 28 kDa heat- and acid-stable phosphoprotein Alternative name(s): PDGF-associated protein Short name: PAP PDGFA-associated protein 1 Short name: PAP1
Gene namesⁱ	Name:Pdap1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:2448536 Pdap1

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000083898	1 – 181	28 kDa heat- and acid-stable phosphoproteinAdd BLAST		181

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	18	PhosphothreonineBy similarity	1
Modified residueⁱ	19	PhosphoserineBy similarity	1
Cross-linkⁱ	52	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	57	PhosphoserineCombined sources	1
Modified residueⁱ	60	PhosphoserineCombined sources	1
Modified residueⁱ	63	PhosphoserineCombined sources	1
Modified residueⁱ	70	PhosphotyrosineCombined sources	1
Modified residueⁱ	126	N6-methyllysineBy similarity	1
Modified residueⁱ	132	N6-acetyllysineBy similarity	1
Modified residueⁱ	164	N6-acetyllysineCombined sources	1
Modified residueⁱ	176	PhosphoserineBy similarity	1
Modified residueⁱ	178	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylated by several kinases in vitro. In vivo, can be phosphorylated by CK2.

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q3UHX2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3UHX2
PaxDbⁱ	Q3UHX2
PRIDEⁱ	Q3UHX2
TopDownProteomicsⁱ	Q3UHX2

PTM databases

iPTMnetⁱ	Q3UHX2
PhosphoSitePlusⁱ	Q3UHX2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000029623 Expressed in 291 organ(s), highest expression level in ear
CleanExⁱ	MM_PDAP1
ExpressionAtlasⁱ	Q3UHX2 baseline and differential
Genevisibleⁱ	Q3UHX2 MM

Interactionⁱ

GO - Molecular functionⁱ

platelet-derived growth factor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	231191, 1 interactor

BioGridⁱ

231191, 1 interactor

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3UHX2
SMRⁱ	Q3UHX2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the PDAP1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3375 Eukaryota ENOG4111T3A LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018509
HOGENOMⁱ	HOG000241539
HOVERGENⁱ	HBG000319
InParanoidⁱ	Q3UHX2
OMAⁱ	AIIKQHR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G16GX
PhylomeDBⁱ	Q3UHX2
TreeFamⁱ	TF324338

Family and domain databases

InterProⁱ	View protein in InterPro IPR019380 Casein_kinase_sb_PP28 IPR039876 HAP28
PANTHERⁱ	PTHR22055 PTHR22055, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10252 PP28, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q3UHX2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPKGGRKGGH KGRVRQYTSP EEIDAQLQAE KQKANEEDEQ EEGGDGASGD 
        60         70         80         90        100
PKKEKKSLDS DESEDEDDDY QQKRKGVEGL IDIENPNRVA QTTKKVTQLD 
       110        120        130        140        150
LDGPKELSRR EREEIEKQKA KERYMKMHLA GKTEQAKADL ARLAIIRKQR 
       160        170        180 
EEAARKKEEE RKAKDDATLS GKRMQSLSLN K

Length:181

Mass (Da):20,605

Last modified:October 11, 2005 - v1

Checksum:ⁱC9A74B7C41174F87

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK147170 mRNA Translation: BAE27734.1 BC007162 mRNA Translation: AAH07162.1 BC106168 mRNA Translation: AAI06169.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS39384.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001028485.1, NM_001033313.3
UniGeneⁱ	Mm.188851

Genome annotation databases

Ensemblⁱ	ENSMUST00000031627; ENSMUSP00000031627; ENSMUSG00000029623
GeneIDⁱ	231887
KEGGⁱ	mmu:231887
UCSC genome browser More...UCSCⁱ	uc009ame.1 mouse

Protein	Similar proteins		Species	Score	Length	Source
Q3UHX2	28 kDa heat- and acid-stable phosphoprotein		RAT		181	UniRef100_Q3UHX2
MCG17262		MOUSE		181
28 kDa heat- and acid-stable phosphoprotein		MESAU		181
28 kDa heat-and acid-stable phosphoprotein		CRIGR		181

Protein	Similar proteins		Species	Score	Length	Source
Q3UHX2	28 kDa heat- and acid-stable phosphoprotein		HUMAN		181	UniRef90_Q13442
28 kDa heat- and acid-stable phosphoprotein		RAT		181
PDAP1 isoform 2		PANTR		181
Uncharacterized protein		COLAP		181
Uncharacterized protein		CERAT		181
+47

Protein	Similar proteins		Species	Score	Length	Source
Q3UHX2	28 kDa heat- and acid-stable phosphoprotein		HUMAN		181	UniRef50_Q13442
28 kDa heat- and acid-stable phosphoprotein		RAT		181
PDAP1 isoform 2		PANTR		181
Uncharacterized protein		COLAP		181
Uncharacterized protein		CERAT		181
+192

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK147170 mRNA Translation: BAE27734.1 BC007162 mRNA Translation: AAH07162.1 BC106168 mRNA Translation: AAI06169.1
CCDSⁱ	CCDS39384.1
RefSeqⁱ	NP_001028485.1, NM_001033313.3
UniGeneⁱ	Mm.188851

3D structure databases

ProteinModelPortalⁱ	Q3UHX2
SMRⁱ	Q3UHX2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	231191, 1 interactor

BioGridⁱ

231191, 1 interactor

PTM databases

iPTMnetⁱ	Q3UHX2
PhosphoSitePlusⁱ	Q3UHX2

Proteomic databases

EPDⁱ	Q3UHX2
MaxQBⁱ	Q3UHX2
PaxDbⁱ	Q3UHX2
PRIDEⁱ	Q3UHX2
TopDownProteomicsⁱ	Q3UHX2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000031627; ENSMUSP00000031627; ENSMUSG00000029623
GeneIDⁱ	231887
KEGGⁱ	mmu:231887
UCSCⁱ	uc009ame.1 mouse

Organism-specific databases

CTDⁱ	11333
MGIⁱ	MGI:2448536 Pdap1

Phylogenomic databases

eggNOGⁱ	KOG3375 Eukaryota ENOG4111T3A LUCA
GeneTreeⁱ	ENSGT00390000018509
HOGENOMⁱ	HOG000241539
HOVERGENⁱ	HBG000319
InParanoidⁱ	Q3UHX2
OMAⁱ	AIIKQHR
OrthoDBⁱ	EOG091G16GX
PhylomeDBⁱ	Q3UHX2
TreeFamⁱ	TF324338

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSⁱ	Pdap1 mouse
Protein Ontology More...PROⁱ	PR:Q3UHX2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000029623 Expressed in 291 organ(s), highest expression level in ear
CleanExⁱ	MM_PDAP1
ExpressionAtlasⁱ	Q3UHX2 baseline and differential
Genevisibleⁱ	Q3UHX2 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR019380 Casein_kinase_sb_PP28 IPR039876 HAP28
PANTHERⁱ	PTHR22055 PTHR22055, 1 hit
Pfamⁱ	View protein in Pfam PF10252 PP28, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HAP28_MOUSE
Accessionⁱ	Q3UHX2Primary (citable) accession number: Q3UHX2 Secondary accession number(s): A0JLS1, Q3KQJ5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
	Last sequence update:	October 11, 2005
	Last modified:	November 7, 2018
	This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3UHX2 (HAP28_MOUSE)

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28 kDa heat- and acid-stable phosphoprotein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Extracellular region or secreted

Plasma Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ