Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

28 kDa heat- and acid-stable phosphoprotein

Gene

Pdap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
28 kDa heat- and acid-stable phosphoprotein
Alternative name(s):
PDGF-associated protein
Short name:
PAP
PDGFA-associated protein 1
Short name:
PAP1
Gene namesi
Name:Pdap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2448536 Pdap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000838981 – 18128 kDa heat- and acid-stable phosphoproteinAdd BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphothreonineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Cross-linki52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei57PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei70PhosphotyrosineCombined sources1
Modified residuei126N6-methyllysineBy similarity1
Modified residuei132N6-acetyllysineBy similarity1
Modified residuei164N6-acetyllysineCombined sources1
Modified residuei176PhosphoserineBy similarity1
Modified residuei178PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by several kinases in vitro. In vivo, can be phosphorylated by CK2.

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ3UHX2
MaxQBiQ3UHX2
PaxDbiQ3UHX2
PRIDEiQ3UHX2
TopDownProteomicsiQ3UHX2

PTM databases

iPTMnetiQ3UHX2
PhosphoSitePlusiQ3UHX2

Expressioni

Gene expression databases

BgeeiENSMUSG00000029623 Expressed in 291 organ(s), highest expression level in ear
CleanExiMM_PDAP1
ExpressionAtlasiQ3UHX2 baseline and differential
GenevisibleiQ3UHX2 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231191, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ3UHX2
SMRiQ3UHX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PDAP1 family.Curated

Phylogenomic databases

eggNOGiKOG3375 Eukaryota
ENOG4111T3A LUCA
GeneTreeiENSGT00390000018509
HOGENOMiHOG000241539
HOVERGENiHBG000319
InParanoidiQ3UHX2
OMAiAIIKQHR
OrthoDBiEOG091G16GX
PhylomeDBiQ3UHX2
TreeFamiTF324338

Family and domain databases

InterProiView protein in InterPro
IPR019380 Casein_kinase_sb_PP28
IPR039876 HAP28
PANTHERiPTHR22055 PTHR22055, 1 hit
PfamiView protein in Pfam
PF10252 PP28, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UHX2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKGGRKGGH KGRVRQYTSP EEIDAQLQAE KQKANEEDEQ EEGGDGASGD
60 70 80 90 100
PKKEKKSLDS DESEDEDDDY QQKRKGVEGL IDIENPNRVA QTTKKVTQLD
110 120 130 140 150
LDGPKELSRR EREEIEKQKA KERYMKMHLA GKTEQAKADL ARLAIIRKQR
160 170 180
EEAARKKEEE RKAKDDATLS GKRMQSLSLN K
Length:181
Mass (Da):20,605
Last modified:October 11, 2005 - v1
Checksum:iC9A74B7C41174F87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147170 mRNA Translation: BAE27734.1
BC007162 mRNA Translation: AAH07162.1
BC106168 mRNA Translation: AAI06169.1
CCDSiCCDS39384.1
RefSeqiNP_001028485.1, NM_001033313.3
UniGeneiMm.188851

Genome annotation databases

EnsembliENSMUST00000031627; ENSMUSP00000031627; ENSMUSG00000029623
GeneIDi231887
KEGGimmu:231887
UCSCiuc009ame.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147170 mRNA Translation: BAE27734.1
BC007162 mRNA Translation: AAH07162.1
BC106168 mRNA Translation: AAI06169.1
CCDSiCCDS39384.1
RefSeqiNP_001028485.1, NM_001033313.3
UniGeneiMm.188851

3D structure databases

ProteinModelPortaliQ3UHX2
SMRiQ3UHX2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231191, 1 interactor

PTM databases

iPTMnetiQ3UHX2
PhosphoSitePlusiQ3UHX2

Proteomic databases

EPDiQ3UHX2
MaxQBiQ3UHX2
PaxDbiQ3UHX2
PRIDEiQ3UHX2
TopDownProteomicsiQ3UHX2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031627; ENSMUSP00000031627; ENSMUSG00000029623
GeneIDi231887
KEGGimmu:231887
UCSCiuc009ame.1 mouse

Organism-specific databases

CTDi11333
MGIiMGI:2448536 Pdap1

Phylogenomic databases

eggNOGiKOG3375 Eukaryota
ENOG4111T3A LUCA
GeneTreeiENSGT00390000018509
HOGENOMiHOG000241539
HOVERGENiHBG000319
InParanoidiQ3UHX2
OMAiAIIKQHR
OrthoDBiEOG091G16GX
PhylomeDBiQ3UHX2
TreeFamiTF324338

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiPdap1 mouse
PROiPR:Q3UHX2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029623 Expressed in 291 organ(s), highest expression level in ear
CleanExiMM_PDAP1
ExpressionAtlasiQ3UHX2 baseline and differential
GenevisibleiQ3UHX2 MM

Family and domain databases

InterProiView protein in InterPro
IPR019380 Casein_kinase_sb_PP28
IPR039876 HAP28
PANTHERiPTHR22055 PTHR22055, 1 hit
PfamiView protein in Pfam
PF10252 PP28, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHAP28_MOUSE
AccessioniPrimary (citable) accession number: Q3UHX2
Secondary accession number(s): A0JLS1, Q3KQJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again