UniProtKB - Q3UHW8 (Q3UHW8_MOUSE)
Protein
Importin N-terminal domain-containing protein
Gene
Kpnb1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- small GTPase binding Source: InterPro
GO - Biological processi
- protein import into nucleus Source: InterPro
Keywordsi
Biological process | Protein transportARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Importin N-terminal domain-containing proteinInterPro annotation |
Gene namesi | Name:Kpnb1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:107532, Kpnb1 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Interactioni
GO - Molecular functioni
- small GTPase binding Source: InterPro
Protein-protein interaction databases
IntActi | Q3UHW8, 1 interactor |
MINTi | Q3UHW8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 101 | Importin N-terminalInterPro annotationAdd BLAST | 81 | |
Repeati | 409 – 446 | HEATPROSITE-ProRule annotationAdd BLAST | 38 |
Sequence similaritiesi
Phylogenomic databases
OMAi | KNHLTSK |
OrthoDBi | 769199at2759 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR021133, HEAT_type_2 IPR001494, Importin-beta_N IPR040122, Importin_beta |
PANTHERi | PTHR10527, PTHR10527, 1 hit |
Pfami | View protein in Pfam PF03810, IBN_N, 1 hit |
SMARTi | View protein in SMART SM00185, ARM, 3 hits SM00913, IBN_N, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50077, HEAT_REPEAT, 1 hit PS50166, IMPORTIN_B_NT, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3UHW8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MELITILEKT VSPDRLELEA AQKFLERAAV ENLPTFLVEL SRVLANPGNS
60 70 80 90 100
QVARVAAGLQ IKNSLTSKDP DIKAQYQQRW LAIDANARRE VKNYVLQTLG
110 120 130 140 150
TETYRPSSAS QCVAGIACAE IPVSQWPELI PQLVANVTNP NSTEHMKEST
160 170 180 190 200
LEAIGYICQD IDPEQLQDKS NEILTAIIQG MRKEEPSNNV KLAATNALLN
210 220 230 240 250
SLEFTKANFD KESERHFIMQ VVCEATQCPD TRVRVAALQN LVKIMSLYYQ
260 270 280 290 300
YMETYMGPAL FAITIEAMKS DIDEVALQGI EFWSNVCDEE MDLAIEASEA
310 320 330 340 350
AEQGRPPEHT SKFYAKGALQ YLVPILTQTL TKQDENDDDD DWNPCKAAGV
360 370 380 390 400
CLMLLSTCCE DDIVPHVLPF IKEHIKNPDW RYRDAAVMAF GSILEGPEPN
410 420 430 440 450
QLKPLVIQAM PTLIELMKDP SVVVRDTTAW TVGRICELLP EAAINDVYLA
460 470 480 490 500
PLLQCLIEGL SAEPRVASNV CWAFSSLAEA AYEAADVADD QEEPATYCLS
510 520 530 540 550
SSFELIVQKL LETTDRPDGH QNSLRSSAYE SLMEIVKNSA KDCYPAVQKT
560 570 580 590 600
TLVIMERLQQ VLQMESHIQS TSDRIQFNDL QSLLCATLQN VLRKVQHQDA
610 620 630 640 650
LQISDVVMAS LLRMFQSTAG SGGVQEDALM AVSTLVEVLG GEFLKYMEAF
660 670 680 690 700
KPFLGIGLKN YAEYQVCLAA VGLVGDLCRA LQSNILPFCD EVMQLLLENL
710 720 730 740 750
GNENVHRSVK PQILSVFGDI ALAIGGEFKK YLEVVLNTLQ QASQAQVDKS
760 770 780 790 800
DFDMVDYLNE LRESCLEAYT GIVQGLKGDQ ENVHPDVMLV QPRVEFILSF
810 820 830 840 850
IDHIAGDEDH TDGVVACAAG LIGDLCTAFG KDVLKLVEAR PMIHELLTEG
860 870
RRSKTNKAKT LATWATKELR KLKNQA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK147175 mRNA Translation: BAE27738.1 |
RefSeqi | NP_032405.3, NM_008379.3 |
Genome annotation databases
GeneIDi | 16211 |
KEGGi | mmu:16211 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK147175 mRNA Translation: BAE27738.1 |
RefSeqi | NP_032405.3, NM_008379.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q3UHW8, 1 interactor |
MINTi | Q3UHW8 |
Proteomic databases
PeptideAtlasi | Q3UHW8 |
PRIDEi | Q3UHW8 |
Protocols and materials databases
DNASUi | 16211 |
Genome annotation databases
GeneIDi | 16211 |
KEGGi | mmu:16211 |
Organism-specific databases
CTDi | 3837 |
MGIi | MGI:107532, Kpnb1 |
Phylogenomic databases
OMAi | KNHLTSK |
OrthoDBi | 769199at2759 |
Miscellaneous databases
BioGRID-ORCSi | 16211, 24 hits in 51 CRISPR screens |
ChiTaRSi | Kpnb1, mouse |
SOURCEi | Search... |
Gene expression databases
Genevisiblei | Q3UHW8, MM |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR021133, HEAT_type_2 IPR001494, Importin-beta_N IPR040122, Importin_beta |
PANTHERi | PTHR10527, PTHR10527, 1 hit |
Pfami | View protein in Pfam PF03810, IBN_N, 1 hit |
SMARTi | View protein in SMART SM00185, ARM, 3 hits SM00913, IBN_N, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50077, HEAT_REPEAT, 1 hit PS50166, IMPORTIN_B_NT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3UHW8_MOUSE | |
Accessioni | Q3UHW8Primary (citable) accession number: Q3UHW8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | April 7, 2021 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |