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Entry version 96 (07 Apr 2021)
Sequence version 1 (11 Oct 2005)
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Protein

Fibronectin

Gene

Fn1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-bindingARBA annotation
Biological processAcute phaseARBA annotation, Cell adhesionARBA annotation, Cell shapeARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FibronectinARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fn1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:95566, Fn1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Disulfide bondARBA annotation, OxidationARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q3UHR1

PRoteomics IDEntifications database

More...
PRIDEi
Q3UHR1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 45Fibronectin type-IInterPro annotationAdd BLAST44
Domaini50 – 92Fibronectin type-IInterPro annotationAdd BLAST43
Domaini93 – 136Fibronectin type-IInterPro annotationAdd BLAST44
Domaini144 – 251Fibronectin type-IIIInterPro annotationAdd BLAST108
Domaini255 – 345Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini346 – 437Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini442 – 531Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini532 – 621Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini622 – 708Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini709 – 799Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini802 – 894Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini895 – 982Fibronectin type-IIIInterPro annotationAdd BLAST88
Domaini983 – 1076Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1077 – 1168Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini1169 – 1256Fibronectin type-IIIInterPro annotationAdd BLAST88
Domaini1257 – 1350Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1351 – 1437Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini1438 – 1528Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini1636 – 1730Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini1737 – 1781Fibronectin type-IInterPro annotationAdd BLAST45
Domaini1782 – 1824Fibronectin type-IInterPro annotationAdd BLAST43
Domaini1826 – 1866Fibronectin type-IInterPro annotationAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1104 – 1127DisorderedSequence analysisAdd BLAST24

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00061, FN1, 6 hits
cd00063, FN3, 16 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 16 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000083, Fibronectin_type1
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00039, fn1, 6 hits
PF00041, fn3, 16 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00058, FN1, 6 hits
SM00060, FN3, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01253, FN1_1, 2 hits
PS51091, FN1_2, 6 hits
PS50853, FN3, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q3UHR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
EVICTTNEGV MYRIGDQWDK QHDLGHMMRC TCVGNGRGEW ACIPYSQLRD
60 70 80 90 100
QCIVDDITYN VNDTFHKRHE EGHMLNCTCF GQGRGRWKCD PIDQCQDSET
110 120 130 140 150
RTFYQIGDSW EKFVHGVRYQ CYCYGRGIGE WHCQPLQTYP GTTGPVQVII
160 170 180 190 200
TETPSQPNSH PIQWNAPEPS HITKYILRWR PKTSTGRWKE ATIPGHLNSY
210 220 230 240 250
TIKGLTPGVI YEGQLISIQQ YGHREVTRFD FTTSASTPVT SNTVTGETAP
260 270 280 290 300
YSPVVATSES VTEITASSFV VSWVSASDTV SGFRVEYELS EEGDEPQYLD
310 320 330 340 350
LPSTATSVNI PDLLPGRKYI VNVYQISEEG KQSLILSTSQ TTAPDAPPDP
360 370 380 390 400
TVDQVDDTSI VVRWSRPQAP ITGYRIVYSP SVEGSSTELN LPETANSVTL
410 420 430 440 450
SDLQPGVQYN ITIYAVEENQ ESTPVFIQQE TTGTPRSDNV PPPTDLQFVE
460 470 480 490 500
LTDVKVTIMW TPPDSVVSGY RVEVLPVSLP GEHGQRLPVN RNTFAEITGL
510 520 530 540 550
SPGVTYLFKV FAVHQGRESN PLTAQQTTKL DAPTNLQFVN ETDRTVLVTW
560 570 580 590 600
TPPRARIAGY RLTAGLTRGG QPKQYNVGPL ASKYPLRNLQ PGSEYTVTLV
610 620 630 640 650
AVKGNQQSPK ATGVFTTLQP LRSIPPYNTE VTETTIVITW TPAPRIGFKL
660 670 680 690 700
GVRPSQGGEA PREVTSDSGS IVVSGLTPGV EYTYTIQVLR DGQERDAPIV
710 720 730 740 750
NRVVTPLSPP TNLHLEANPD TGVLTVSWER STTPDITGYR ITTTPTNGQQ
760 770 780 790 800
GTSLEEVVHA DQSSCTFENL NPGLEYNVSV YTVKDDKESA PISDTVVPAV
810 820 830 840 850
PPPTDLRFTN IGPDTMRVTW APPPSIELTN LLVRYSPVKN EEDVAELSIS
860 870 880 890 900
PSDNAVVLTN LLPGTEYLVS VSSVYEQHES IPLRGRQKTG LDSPTGFDSS
910 920 930 940 950
DITANSFTVH WVAPRAPITG YIIRHHAEHS VGRPRQDRVP PSRNSITLTN
960 970 980 990 1000
LNPGTEYVVS IIAVNGREES PPLIGQQATV SDIPRDLEVI ASTPTSLLIS
1010 1020 1030 1040 1050
WEPPAVSVRY YRITYGETGG NSPVQEFTVP GSKSTATINN IKPGADYTIT
1060 1070 1080 1090 1100
LYAVTGRGDS PASSKPVSIN YKTEIDKPSQ MQVTDVQDNS ISVRWLPSTS
1110 1120 1130 1140 1150
PVTGYRVTTT PKNGLGPSKT KTASPDQTEM TIEGLQPTVE YVVSVYAQNR
1160 1170 1180 1190 1200
NGESQPLVQT AVTNIDRPKG LAFTDVDVDS IKIAWESPQG QVSRYRVTYS
1210 1220 1230 1240 1250
SPEDGIRELF PAPDGEDDTA ELQGLRPGSE YTVSVVALHD DMESQPLIGI
1260 1270 1280 1290 1300
QSTAIPAPTN LKFSQVTPTS FTAQWIAPSV QLTGYRVRVN PKEKTGPMKE
1310 1320 1330 1340 1350
INLSPDSSSV IVSGLMVATK YEVSVYALKD TLTSRPAQGV ITTLENVSPP
1360 1370 1380 1390 1400
RRARVTDATE TTITISWRTK TETITGFQVD AIPANGQTPV QRSISPDVRS
1410 1420 1430 1440 1450
YTITGLQPGT DYKIHLYTLN DNARSSPVII DASTAIDAPS NLRFLTTTPN
1460 1470 1480 1490 1500
SLLVSWQAPR ARITGYIIKY EKPGSPPREV VPRPRPGVTE ATITGLEPGT
1510 1520 1530 1540 1550
EYTIYVIALK NNQKSEPLIG RKKTDELPQL VTLPHPNLHG PEILDVPSTV
1560 1570 1580 1590 1600
QKTPFITNPG YDTENGIQLP GTTHQQPSVG QQMIFEEHGF SRTTPPTAAT
1610 1620 1630 1640 1650
PVRLRPRPYL PNVDEEVQIG HVPRGDVDYH LYPHVPGLNP NASTGQEALS
1660 1670 1680 1690 1700
QTTISWTPFQ ESSEYIISCQ PVGTDEEPLQ FQVPGTSTSA TLTGLTRGVT
1710 1720 1730 1740 1750
YNIIVEALQN QRRHKVREEV VTVGNAVSEG LNQPTDDSCF DPYTVSHYAI
1760 1770 1780 1790 1800
GEEWERLSDA GFKLTCQCLG FGSGHFRCDS SKWCHDNGVN YKIGEKWDRQ
1810 1820 1830 1840 1850
GENGQRMSCT CLGNGKGEFK CDPHEATCYD DGKTYHVGEQ WQKEYLGAIC
1860 1870 1880 1890 1900
SCTCFGGQRG WRCDNCRRPG AAEPSPDGTT GHTYNQYTQR YNQRTNTNVN
1910 1920
CPIECFMPLD VQADRDDSRE
Length:1,920
Mass (Da):211,106
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i688FDC456CC6D334
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK147249 mRNA Translation: BAE27796.1

NCBI Reference Sequences

More...
RefSeqi
NP_001263337.1, NM_001276408.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
14268

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147249 mRNA Translation: BAE27796.1
RefSeqiNP_001263337.1, NM_001276408.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ3UHR1
PRIDEiQ3UHR1

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
14268

Genome annotation databases

GeneIDi14268

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2335
MGIiMGI:95566, Fn1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
14268, 1 hit in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Fn1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

CDDicd00061, FN1, 6 hits
cd00063, FN3, 16 hits
Gene3Di2.60.40.10, 16 hits
InterProiView protein in InterPro
IPR000083, Fibronectin_type1
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
PfamiView protein in Pfam
PF00039, fn1, 6 hits
PF00041, fn3, 16 hits
SMARTiView protein in SMART
SM00058, FN1, 6 hits
SM00060, FN3, 16 hits
SUPFAMiSSF49265, SSF49265, 10 hits
PROSITEiView protein in PROSITE
PS01253, FN1_1, 2 hits
PS51091, FN1_2, 6 hits
PS50853, FN3, 16 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3UHR1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UHR1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: April 7, 2021
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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