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Entry version 126 (31 Jul 2019)
Sequence version 2 (31 Jan 2018)
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Protein

Trinucleotide repeat-containing gene 6A protein

Gene

Tnrc6a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) (PubMed:22187428). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins (PubMed:22187428). As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processRNA-mediated gene silencing, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-426496 Post-transcriptional silencing by small RNAs
R-MMU-5578749 Transcriptional regulation by small RNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trinucleotide repeat-containing gene 6A protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tnrc6a
Synonyms:Kiaa1460
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2385292 Tnrc6a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Development up until embryonic stage 9.5 dpc is normal. After this point, mortality rates increase rapidly with less than 5% survival at stage 12.5 dpc. The yolk sac endoderm is abnormally thin with fewer mitotic cells. In addition there are fewer blood islands in the yolk sac, associated with impaired hematopoiesis. Expression of many miRNA-regulated genes in the yolk sac is abnormal, and in particular there is marked derepression of genes involved in regulation of apoptosis and the cell cycle. miRNA biogenesis is not affected.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003739801 – 1896Trinucleotide repeat-containing gene 6A proteinAdd BLAST1896

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei724PhosphoserineBy similarity1
Modified residuei863PhosphoserineBy similarity1
Modified residuei976PhosphoserineBy similarity1
Modified residuei1197PhosphoserineBy similarity1
Modified residuei1255PhosphoserineBy similarity1
Modified residuei1406PhosphothreonineBy similarity1
Modified residuei1520PhosphoserineBy similarity1
Modified residuei1804PhosphoserineBy similarity1
Modified residuei1825PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3UHK8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3UHK8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3UHK8

PRoteomics IDEntifications database

More...
PRIDEi
Q3UHK8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3UHK8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3UHK8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in the yolk sac endoderm at embryonic stage 9.5 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000052707 Expressed in 320 organ(s), highest expression level in gonadal ridge

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3UHK8 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AGO2.

Interacts with AGO1, AGO3 and AGO4.

Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT complex.

Interacts with ZC3H12A.

Interacts with SND1.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
231455, 1 interactor

Database of interacting proteins

More...
DIPi
DIP-60538N

Protein interaction database and analysis system

More...
IntActi
Q3UHK8, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000091595

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3UHK8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1716 – 1788RRMAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 917Interaction with argonaute family proteinsBy similarityAdd BLAST917
Regioni239 – 488Sufficient for interaction with AGO1, AGO3 and AGO4By similarityAdd BLAST250
Regioni255 – 331Sufficient for interaction with AGO2By similarityAdd BLAST77
Regioni303 – 384Sufficient for interaction with AGO2By similarityAdd BLAST82
Regioni325 – 424Sufficient for interaction with AGO2By similarityAdd BLAST100
Regioni394 – 480Sufficient for interaction with AGO2By similarityAdd BLAST87
Regioni487 – 736Sufficient for interaction with AGO2By similarityAdd BLAST250
Regioni551 – 1279Sufficient for interaction with AGO1 and AGO4By similarityAdd BLAST729
Regioni1059 – 1129Sufficient for interaction with AGO2By similarityAdd BLAST71
Regioni1605 – 1896Sufficient for interaction with AGO2By similarityAdd BLAST292

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi31 – 54Lys-richAdd BLAST24
Compositional biasi93 – 113Gln-richAdd BLAST21
Compositional biasi334 – 337Poly-Ser4
Compositional biasi1127 – 1130Poly-Glu4
Compositional biasi1332 – 1415Gln-richAdd BLAST84
Compositional biasi1592 – 1597Poly-Ser6
Compositional biasi1890 – 1893Poly-Gly4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GW182 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IF5S Eukaryota
ENOG41110AX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158180

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049171

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3UHK8

KEGG Orthology (KO)

More...
KOi
K18412

Identification of Orthologs from Complete Genome Data

More...
OMAi
AWGKPMD

Database of Orthologous Groups

More...
OrthoDBi
50428at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3UHK8

TreeFam database of animal gene trees

More...
TreeFami
TF329702

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12711 RRM_TNRC6A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019486 Argonaute_hook_dom
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR032226 TNRC6_PABC-bd
IPR033501 TNRC6A
IPR034924 TNRC6A_RRM

The PANTHER Classification System

More...
PANTHERi
PTHR13020:SF28 PTHR13020:SF28, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10427 Ago_hook, 1 hit
PF16608 TNRC6-PABC_bdg, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q3UHK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRELEAKATK DVERNLSRDL VQEEEQLMEE KKKKKDDKKK KEAAQKKATE
60 70 80 90 100
QKIKVPEQIK PSVSQPQPAN SDNGTSTATS TNNNAKRATA SNQQPPPPQQ
110 120 130 140 150
QQPQQEQQQQ QPQALPRYPR EVPPRFRHQE HKQLLKRGQH FPVIAANLGS
160 170 180 190 200
AVKVLNSQSE SSAVTNQQPQ NNGEVQNSKS QSDINHNTSG SHYENCQRGP
210 220 230 240 250
VSSTSDCSTS CKNAVNDLLE KEAWPSAPGS DPELAPECID ADSASNSESE
260 270 280 290 300
RNITVMASGN TGGEKDGLRN STGLGSQSKF VVGSSSNNVG HGSSTGPWGF
310 320 330 340 350
PHGALISTCQ VSVDAPESKP ESSNNRMNAW GTVSSSSNGG LNPSTLNSAS
360 370 380 390 400
NHGAWPVLEN NGLALKGPVG SGSSGINIQC STIGQMPNNQ NINSKVSGSS
410 420 430 440 450
THGTWGSLQE TCEPEVSGTQ KVSFSGQPQN ITTETTGPNN TTNFMTSSLP
460 470 480 490 500
NSGSVQNNEL PTSNPGAWRV STMNHPQIQA PSVMNGTSLS HLSNGESKTG
510 520 530 540 550
GSYGTTWGAY GSNYSGDKCA GPNGQANGDT VNATLMQPGI NGPMGTNFQV
560 570 580 590 600
NTNKGGGVWE PGTVNSQSSP WGSGNGANSG GSRRGWGSPA QNTGTGLSSV
610 620 630 640 650
EWNKLPSNQH SNDSANGNGK KLTNGWKSTE EDDQGSATSQ TNEQNSVWAK
660 670 680 690 700
AGGTVESDGS AESTGRLEEK VTGESQSRDR RKIDQHTLLQ SIVNRTDLDP
710 720 730 740 750
RVLSNSGWGQ TPIKQNTAWD TETSPRGERK TDNGTEAWGS SATQTFNSGA
760 770 780 790 800
CTDKTSPNSN DTSSVSGWGD PKPTLRWGDS KGSNCQGGWE DDSAATGMIK
810 820 830 840 850
SNQWGGCKED KSTWNDSQKS KQGWGDGQKS SQGWSISAGD NWGESSRSNH
860 870 880 890 900
WGEANKKSSS GGSDSDRSIS GWNELGKTSS FTWGNNINPN NSSGWDESSK
910 920 930 940 950
PNSSQGWGDP PKCNQSLGWG DSSKPVSSPD WNKQQDIVGS WGIPPATSKP
960 970 980 990 1000
PGTGWLGGPI PAPAKEEEPT GWEEPSPESI RRKMEIDDGT SAWGDPSKYN
1010 1020 1030 1040 1050
YKNVNMWNKN IPEASGRSDQ QAQMHRLLPA ASAVSSKETS SGSGWGEPWA
1060 1070 1080 1090 1100
EPSTPATTVD NGTSAWGKPI DSGPSWGEPI TAASNASTWG SSSVGPQSLS
1110 1120 1130 1140 1150
KSGPKSMQDG WCGDDMPLPG SRPTGWEEEE DVEIGMWNSN SSQELNSSLN
1160 1170 1180 1190 1200
WPPYTKKMSS KGLSGKKRRR ERGMMKGGNK QEDAWINPFV KQFSNISFSR
1210 1220 1230 1240 1250
DSPEENVQSN KMDLSGGMLQ DKRMEIDKHS LNIGDYNRTV GKGPGSRPQI
1260 1270 1280 1290 1300
SKESSMERNP YFDKNGNPNM FGVGNTAAQP RGMQQPPAQP LSSSQPNLRA
1310 1320 1330 1340 1350
QVPPPLLSPQ VPVSLLKYAP NNGGLNPLFG PQQVAMLNQL SQLNQLSQIS
1360 1370 1380 1390 1400
QLQRLLAQQQ RAQSQRSAPS ANRQQQDQQG RPLSVQQQMM QQSRQLDPSL
1410 1420 1430 1440 1450
LVKQQTPPSQ QPLHQPAMKS FLDNVMPHTT PELQKGPSPV NAFSNFPIGL
1460 1470 1480 1490 1500
NSNLNVNMDM NSIKEPQSRL RKWTTVDSMS VNTSLDQNSS KHGAISSGFR
1510 1520 1530 1540 1550
LEESPFVPYD FMNSSTSPAS PPGSIGDGWP RAKSPNGSSS VNWPPEFRPG
1560 1570 1580 1590 1600
EPWKGYPNID PETDPYVTPG SVINSLSINT VREVDHLRDR NSGSSSSLNT
1610 1620 1630 1640 1650
TLPSTSAWSS IRASNYNVPL SSTAQSTSAR NSDSKLTWSP GSVTNTSLAH
1660 1670 1680 1690 1700
ELWKVPLPPK NITAPSRPPP GLTGQKPPLS TWDNSPLRVG GGWGNSDARY
1710 1720 1730 1740 1750
TPGSSWGESS SGRITNWLVL KNLTPQIDGS TLRTLCMQHG PLITFHLNLP
1760 1770 1780 1790 1800
HGNALVRYSS KEEVVKAQKS LHMCVLGNTT ILAEFASEEE ISRFFAQSQS
1810 1820 1830 1840 1850
LTPSPGWQSL GSSQSRLGSL DCSHSFSSRT DVNHWNGAGL SGANCGDLHG
1860 1870 1880 1890
TSLWGTPHYS TSLWGPPSSD PRGISSPSPI NAFLSVDHLG GGGESM
Length:1,896
Mass (Da):203,150
Last modified:January 31, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58858C69497903BF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RQ65A0A0U1RQ65_MOUSE
Trinucleotide repeat-containing gen...
Tnrc6a
1,398Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQ94A0A0U1RQ94_MOUSE
Trinucleotide repeat-containing gen...
Tnrc6a
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RPF5A0A0U1RPF5_MOUSE
Trinucleotide repeat-containing gen...
Tnrc6a
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RPB4A0A0U1RPB4_MOUSE
Trinucleotide repeat-containing gen...
Tnrc6a
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti587G → E in BAE27849 (PubMed:16141072).1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK147327 mRNA Translation: BAE27849.1
AC138364 Genomic DNA No translation available.
AC141887 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS57583.1

NCBI Reference Sequences

More...
RefSeqi
NP_659174.3, NM_144925.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000094053; ENSMUSP00000091595; ENSMUSG00000052707

Database of genes from NCBI RefSeq genomes

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GeneIDi
233833

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:233833

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147327 mRNA Translation: BAE27849.1
AC138364 Genomic DNA No translation available.
AC141887 Genomic DNA No translation available.
CCDSiCCDS57583.1
RefSeqiNP_659174.3, NM_144925.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UMZX-ray1.90D/E1164-1172[»]
SMRiQ3UHK8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi231455, 1 interactor
DIPiDIP-60538N
IntActiQ3UHK8, 3 interactors
STRINGi10090.ENSMUSP00000091595

PTM databases

iPTMnetiQ3UHK8
PhosphoSitePlusiQ3UHK8

Proteomic databases

EPDiQ3UHK8
MaxQBiQ3UHK8
PaxDbiQ3UHK8
PRIDEiQ3UHK8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094053; ENSMUSP00000091595; ENSMUSG00000052707
GeneIDi233833
KEGGimmu:233833

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
27327
MGIiMGI:2385292 Tnrc6a

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiENOG410IF5S Eukaryota
ENOG41110AX LUCA
GeneTreeiENSGT00940000158180
HOGENOMiHOG000049171
InParanoidiQ3UHK8
KOiK18412
OMAiAWGKPMD
OrthoDBi50428at2759
PhylomeDBiQ3UHK8
TreeFamiTF329702

Enzyme and pathway databases

ReactomeiR-MMU-426496 Post-transcriptional silencing by small RNAs
R-MMU-5578749 Transcriptional regulation by small RNAs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tnrc6a mouse

Protein Ontology

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PROi
PR:Q3UHK8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000052707 Expressed in 320 organ(s), highest expression level in gonadal ridge
ExpressionAtlasiQ3UHK8 baseline and differential

Family and domain databases

CDDicd12711 RRM_TNRC6A, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR019486 Argonaute_hook_dom
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR032226 TNRC6_PABC-bd
IPR033501 TNRC6A
IPR034924 TNRC6A_RRM
PANTHERiPTHR13020:SF28 PTHR13020:SF28, 2 hits
PfamiView protein in Pfam
PF10427 Ago_hook, 1 hit
PF16608 TNRC6-PABC_bdg, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNR6A_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UHK8
Secondary accession number(s): F6ZMJ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: January 31, 2018
Last modified: July 31, 2019
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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