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Protein

Protein GREB1

Gene

Greb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in estrogen-stimulated cell proliferation.By similarity

Enzyme and pathway databases

ReactomeiR-MMU-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GREB1
Gene namesi
Name:Greb1
Synonyms:Kiaa0575
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2149712 Greb1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1873 – 1893HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003209451 – 1954Protein GREB1Add BLAST1954

Proteomic databases

PaxDbiQ3UHK3
PRIDEiQ3UHK3

PTM databases

iPTMnetiQ3UHK3
PhosphoSitePlusiQ3UHK3

Expressioni

Gene expression databases

BgeeiENSMUSG00000036523 Expressed in 165 organ(s), highest expression level in female gonad
ExpressionAtlasiQ3UHK3 baseline and differential
GenevisibleiQ3UHK3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044454

Structurei

3D structure databases

ProteinModelPortaliQ3UHK3
SMRiQ3UHK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1228 – 1235Poly-Ser8

Sequence similaritiesi

Belongs to the GREB1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF9T Eukaryota
ENOG410Z1PN LUCA
GeneTreeiENSGT00390000008041
HOGENOMiHOG000090251
HOVERGENiHBG107963
InParanoidiQ3UHK3
OMAiNYELVTG
OrthoDBiEOG091G009I
PhylomeDBiQ3UHK3
TreeFamiTF329531

Family and domain databases

InterProiView protein in InterPro
IPR028422 GREB1
PANTHERiPTHR15720 PTHR15720, 1 hit
PfamiView protein in Pfam
PF15782 GREB1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q3UHK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNSYAGQLK STRFEEVLHN SIEASLRSNT LVPRPIFSQL YLEAEQQLSS
60 70 80 90 100
LEGGSRADNE EEEEDGEGGL EPSSPPNAYQ LPPPPEGCCT TDGFCQAGKD
110 120 130 140 150
LRLVSISSEP IEVPAGFLLV GAKSPSLPDH LLVCAVDKRF LPDDNGHNAL
160 170 180 190 200
LGFSGNCVGC GKKGFCYFTE FSNHINLKLT TQPKKQKHLK YYLVRNAQGA
210 220 230 240 250
LTKGPLICWK GSEFRGRQNS TNTCSSSLFP PLESSGSLAA FPTEPVPGTN
260 270 280 290 300
PSVPVGAQQA GPASDHPSVT TATGPAVFNG KDSPKHPQLV KSSLSALPRP
310 320 330 340 350
SALGILPNSG PPKKRHKGWS PESKSTTDGG FIQGGGNRAK HEGTSIPCVP
360 370 380 390 400
QAGLVGPASV TFPVVASGEP VSVPDNLLKI CKAKPVIFKG HGNFPYLCGN
410 420 430 440 450
LNDVVVSPLL YTCYQNSQSL ARAYEQHGAS TMQPISEETQ LLLTVYYLVQ
460 470 480 490 500
LAADQVPLME DLEQIFLRSW RESHLTEIRQ YQQAPPQPFP PATSTAAPVT
510 520 530 540 550
SAQLPWLAGL AASSCNDSVH VIECAYSLAE GLSEMFRLLI EGKLSKTNYV
560 570 580 590 600
VIICACRNAA IDSCIAVTGK YQARILSESL LSPAEYQREV HYELVTGKVD
610 620 630 640 650
SLGTFFSSLC PEGDIDILLD KFHQENQGHV SSSFTASSTK KTAVLDASGV
660 670 680 690 700
PVCTSYHQEP RGVRPFQLAV AQKLLSHVCS IADSSTQNLD LGSFEKVDFL
710 720 730 740 750
ICIPPSEVTY QQTVFHVWHS GVLLELGLEK EPVTKQRAEQ HVLKLDTEAQ
760 770 780 790 800
ARFKAFLQNS FQNPHTLFVL IHDHAHWDLV SSAVHNIYSQ SDPSVGLVDR
810 820 830 840 850
LLNCREVKEA PNIVTLHVTS FPYALQTQHT LISPYNEIHW PISFSNGVDL
860 870 880 890 900
YHESKKYFGL SEFIDSTLSG HSLPLLRYDS SFEAMVTALG KRFPRLHSAV
910 920 930 940 950
IRTFVLVQHY AAAMMAVSGL PQMKNHTSVE TLEITQNLLN SPKQCPCGHG
960 970 980 990 1000
LMVLLRVPCS PLAAVAYERL AHVRARLALE EHFEIILGHP SSGITVGKHF
1010 1020 1030 1040 1050
VKQLKMWQKI EDAEWRPQTY LELEGLPCIL IFSGMDPHGE SLPRSLRYCD
1060 1070 1080 1090 1100
LRLINSSCLV RTALEQELGL AAYFVSNDIP LEKGPKNEAL ESDGEKLSST
1110 1120 1130 1140 1150
DEDEEAGTEG CFEAGSTSEQ RGPVKRERSH SHDSASSSLS SRASGSVLYG
1160 1170 1180 1190 1200
ESLAQPSGPP QGELTRSPPS CGPAEEGRAP GEIQRLRVSQ GSTVISRHSP
1210 1220 1230 1240 1250
GLVPQPDSSL RTGRRSLQVP AAPSSQLSSS SGSSSTCAVP TANVLVLQAS
1260 1270 1280 1290 1300
QCSMAKACRQ PPIVFLPKLV YDMLLSTDSS GLPKSASLLP SPSVMWTSSF
1310 1320 1330 1340 1350
RPLLSKMMTS TEQSLYYRQW TVPRPSHMDY GNRAEGRVDS FHPRRLLLSG
1360 1370 1380 1390 1400
PPQIGKTGAY LQFLSILSRM LIRLTEVDVY DEEEINTSFR EESEWRYLQL
1410 1420 1430 1440 1450
ADPWPDLELF QKMPFDYIIH DPKYEDASLI CSHPQTIKSE DRGMSRKPED
1460 1470 1480 1490 1500
LYVRRQTARM RLSKYAAYNT YHHCEQCQQY MGFHPHYQLS ESTLHVFAFS
1510 1520 1530 1540 1550
CSMLGEEVQL HFIIPKSKEH HFVFSQPGGQ LESMRLPLVT DKSHEHIKSP
1560 1570 1580 1590 1600
TFTPTTGRHE HGLFNLYHAM DGANHLHVLV VKEYEMAIYK KYWPNHIMLV
1610 1620 1630 1640 1650
LPSIFNSAGV GAAHFLIKEL CYHNLELERN RQEELGVKPQ DVWPFIVIAD
1660 1670 1680 1690 1700
DSCVMWNVAD VDCAGERSRE FSWSERNVSL KYIMLHIEAS PNITHYALLG
1710 1720 1730 1740 1750
MRKWASKTRG REVQEPFSRC HVHDFIILNV DLTQNVQYNQ NRFTCDDVDF
1760 1770 1780 1790 1800
NLRVHSAGLL LCRFNRFSVM KKQIAVGGHR SFHITSKVSD SSVAIVPSQY
1810 1820 1830 1840 1850
ICAPDSKHTF LAAPAQLLLE KFLQYHSHRF FPLSLKNHSH PVLSVDCYLN
1860 1870 1880 1890 1900
LGPQISVCYV SSRPHSLNIS CSDMVFSGLL LYLCDSFVGA SFLKKFHFLK
1910 1920 1930 1940 1950
GATLCVICQD RNSLRQTVVR LELEDEWQFR LRDEFQTANA KEDRPLFFLT

ARHI
Length:1,954
Mass (Da):216,927
Last modified:July 27, 2011 - v2
Checksum:i9EBBC2FF6F011E06
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CXG4E0CXG4_MOUSE
Protein GREB1
Greb1
1,926Annotation score:
E0CYD8E0CYD8_MOUSE
Protein GREB1
Greb1
151Annotation score:
F6TVY7F6TVY7_MOUSE
Protein GREB1
Greb1
123Annotation score:
F6U5E3F6U5E3_MOUSE
Protein GREB1
Greb1
121Annotation score:

Sequence cautioni

The sequence BAC41432 differs from that shown. Partially unspliced pre-RNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti230P → T in AAF44295 (PubMed:10644441).Curated1
Sequence conflicti230P → T in BAE27854 (PubMed:16141072).Curated1
Sequence conflicti260A → V in AAF44295 (PubMed:10644441).Curated1
Sequence conflicti360V → A in AAF44295 (PubMed:10644441).Curated1
Sequence conflicti659E → G in BAE27854 (PubMed:16141072).Curated1
Sequence conflicti844F → Y in AAF44295 (PubMed:10644441).Curated1
Sequence conflicti1154A → V in AAF44295 (PubMed:10644441).Curated1
Sequence conflicti1154A → V in BAE27854 (PubMed:16141072).Curated1
Sequence conflicti1154A → V in BAC41432 (PubMed:12465718).Curated1
Sequence conflicti1170S → P in AAF44295 (PubMed:10644441).Curated1
Sequence conflicti1170S → P in BAE27854 (PubMed:16141072).Curated1
Sequence conflicti1170S → P in BAC41432 (PubMed:12465718).Curated1
Sequence conflicti1201G → D in AAF44295 (PubMed:10644441).Curated1
Sequence conflicti1201G → D in BAE27854 (PubMed:16141072).Curated1
Sequence conflicti1417Y → C in AAF44295 (PubMed:10644441).Curated1
Sequence conflicti1749D → N in BAC28368 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180470 mRNA Translation: AAF44295.1
AK033573 mRNA Translation: BAC28368.1
AK147337 mRNA Translation: BAE27854.1
AC122228 Genomic DNA No translation available.
AC157352 Genomic DNA No translation available.
AB093248 Transcribed RNA Translation: BAC41432.2 Sequence problems.
CCDSiCCDS36408.1
RefSeqiNP_056579.2, NM_015764.4
XP_006515156.1, XM_006515093.2
XP_006515157.1, XM_006515094.3
XP_006515158.1, XM_006515095.3
XP_006515159.1, XM_006515096.2
XP_006515160.1, XM_006515097.3
XP_006515161.1, XM_006515098.2
UniGeneiMm.428062
Mm.490218

Genome annotation databases

EnsembliENSMUST00000048064; ENSMUSP00000044454; ENSMUSG00000036523
ENSMUST00000162112; ENSMUSP00000124348; ENSMUSG00000036523
GeneIDi268527
KEGGimmu:268527
UCSCiuc029rrb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180470 mRNA Translation: AAF44295.1
AK033573 mRNA Translation: BAC28368.1
AK147337 mRNA Translation: BAE27854.1
AC122228 Genomic DNA No translation available.
AC157352 Genomic DNA No translation available.
AB093248 Transcribed RNA Translation: BAC41432.2 Sequence problems.
CCDSiCCDS36408.1
RefSeqiNP_056579.2, NM_015764.4
XP_006515156.1, XM_006515093.2
XP_006515157.1, XM_006515094.3
XP_006515158.1, XM_006515095.3
XP_006515159.1, XM_006515096.2
XP_006515160.1, XM_006515097.3
XP_006515161.1, XM_006515098.2
UniGeneiMm.428062
Mm.490218

3D structure databases

ProteinModelPortaliQ3UHK3
SMRiQ3UHK3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044454

PTM databases

iPTMnetiQ3UHK3
PhosphoSitePlusiQ3UHK3

Proteomic databases

PaxDbiQ3UHK3
PRIDEiQ3UHK3

Protocols and materials databases

DNASUi268527
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048064; ENSMUSP00000044454; ENSMUSG00000036523
ENSMUST00000162112; ENSMUSP00000124348; ENSMUSG00000036523
GeneIDi268527
KEGGimmu:268527
UCSCiuc029rrb.1 mouse

Organism-specific databases

CTDi9687
MGIiMGI:2149712 Greb1
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IF9T Eukaryota
ENOG410Z1PN LUCA
GeneTreeiENSGT00390000008041
HOGENOMiHOG000090251
HOVERGENiHBG107963
InParanoidiQ3UHK3
OMAiNYELVTG
OrthoDBiEOG091G009I
PhylomeDBiQ3UHK3
TreeFamiTF329531

Enzyme and pathway databases

ReactomeiR-MMU-9018519 Estrogen-dependent gene expression

Miscellaneous databases

PROiPR:Q3UHK3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036523 Expressed in 165 organ(s), highest expression level in female gonad
ExpressionAtlasiQ3UHK3 baseline and differential
GenevisibleiQ3UHK3 MM

Family and domain databases

InterProiView protein in InterPro
IPR028422 GREB1
PANTHERiPTHR15720 PTHR15720, 1 hit
PfamiView protein in Pfam
PF15782 GREB1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGREB1_MOUSE
AccessioniPrimary (citable) accession number: Q3UHK3
Secondary accession number(s): E0CYB3
, Q8BZT6, Q8CHE7, Q9JLG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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