Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Proton myo-inositol cotransporter

Gene

Slc2a13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

H+-myo-inositol cotransporter. Can also transport related stereoisomers (By similarity).By similarity

GO - Molecular functioni

  • carbohydrate:proton symporter activity Source: GO_Central
  • glucose transmembrane transporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-429593 Inositol transporters

Names & Taxonomyi

Protein namesi
Recommended name:
Proton myo-inositol cotransporter
Short name:
H(+)-myo-inositol cotransporter
Short name:
Hmit
Alternative name(s):
H(+)-myo-inositol symporter
Solute carrier family 2 member 13
Gene namesi
Name:Slc2a13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2146030 Slc2a13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 65CytoplasmicSequence analysisAdd BLAST65
Transmembranei66 – 86Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini87 – 114ExtracellularSequence analysisAdd BLAST28
Transmembranei115 – 135Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini136 – 137CytoplasmicSequence analysis2
Transmembranei138 – 158Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini159 – 167ExtracellularSequence analysis9
Transmembranei168 – 188Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini189 – 201CytoplasmicSequence analysisAdd BLAST13
Transmembranei202 – 222Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini223 – 228ExtracellularSequence analysis6
Transmembranei229 – 249Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini250 – 313CytoplasmicSequence analysisAdd BLAST64
Transmembranei314 – 334Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini335 – 352ExtracellularSequence analysisAdd BLAST18
Transmembranei353 – 373Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini374 – 382CytoplasmicSequence analysis9
Transmembranei383 – 403Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini404 – 497ExtracellularSequence analysisAdd BLAST94
Transmembranei498 – 518Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini519 – 538CytoplasmicSequence analysisAdd BLAST20
Transmembranei539 – 559Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini560 – 562ExtracellularSequence analysis3
Transmembranei563 – 583Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini584 – 637CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002613171 – 637Proton myo-inositol cotransporterAdd BLAST637

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Glycosylationi422N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi447N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi474N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei629PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ3UHK1
PaxDbiQ3UHK1
PeptideAtlasiQ3UHK1
PRIDEiQ3UHK1

PTM databases

iPTMnetiQ3UHK1
PhosphoSitePlusiQ3UHK1
SwissPalmiQ3UHK1

Expressioni

Gene expression databases

BgeeiENSMUSG00000036298 Expressed in 205 organ(s), highest expression level in nucleus accumbens
GenevisibleiQ3UHK1 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104906

Structurei

3D structure databases

ProteinModelPortaliQ3UHK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0254 Eukaryota
ENOG410XNQK LUCA
GeneTreeiENSGT00920000149002
HOGENOMiHOG000202868
HOVERGENiHBG031722
InParanoidiQ3UHK1
KOiK08150
OMAiSWGVVVW
OrthoDBiEOG091G046D
PhylomeDBiQ3UHK1
TreeFamiTF314916

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 2 hits
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UHK1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRKASEDVE YTLRSLSSLM GERRRRQPEP GAPGGERSLL AAESAASLQG
60 70 80 90 100
AELERAARRQ FQRDETPAFV YAAAAFSALG GFLFGYDTGV VSGAMLLLRR
110 120 130 140 150
QMRLGAMWQE LLVSGAVGAA AVAALAGGAL NGALGRRSAI LLASALCTVG
160 170 180 190 200
SAVLAAAANK ETLLAGRLVV GLGIGIASMT VPVYIAEVSP PNLRGRLVTI
210 220 230 240 250
NTLFITGGQF FASVVDGAFS YLQKDGWRYM LGLAAIPAVI QFLGFLFLPE
260 270 280 290 300
SPRWLIQKGQ TQKARRILSQ MRGNQTIDEE YDSIRNSIEE EEKEATAAGP
310 320 330 340 350
IICRMLSYPP TRRALVVGCG LQMFQQLSGI NTIMYYSATI LQMSGVEDDR
360 370 380 390 400
LAIWLASITA FTNFIFTLVG VWLVEKVGRR KLTFGSLAGT TVALIILALG
410 420 430 440 450
FLLSAQVSPR VTFRPTTPSD QNTTCTGYSY CNECMLDPDC GFCYKINGSA
460 470 480 490 500
VIDSSCVPVN KASTTEAAWG RCDNETKFKA EGAHWAYSFC PTPYSWTALV
510 520 530 540 550
GLVLYLVFFA PGMGPMPWTV NSEIYPLWAR STGNACSAGI NWIFNVLVSL
560 570 580 590 600
TFLHTAEYLT YYGAFFLYAG FAAVGLLFVY GCLPETKGKK LEEIESLFDH
610 620 630
RLCSCGAADS DEGRYIEYIR VKGSNYHLSD NDASDVE
Length:637
Mass (Da):69,062
Last modified:April 20, 2010 - v2
Checksum:iCF13253E46E934D2
GO

Sequence cautioni

The sequence BAE27856 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147341 mRNA Translation: BAE27856.1 Different initiation.
CCDSiCCDS27761.2
RefSeqiNP_001028805.2, NM_001033633.3
UniGeneiMm.360596

Genome annotation databases

EnsembliENSMUST00000109283; ENSMUSP00000104906; ENSMUSG00000036298
GeneIDi239606
KEGGimmu:239606
UCSCiuc007xhy.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147341 mRNA Translation: BAE27856.1 Different initiation.
CCDSiCCDS27761.2
RefSeqiNP_001028805.2, NM_001033633.3
UniGeneiMm.360596

3D structure databases

ProteinModelPortaliQ3UHK1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104906

PTM databases

iPTMnetiQ3UHK1
PhosphoSitePlusiQ3UHK1
SwissPalmiQ3UHK1

Proteomic databases

MaxQBiQ3UHK1
PaxDbiQ3UHK1
PeptideAtlasiQ3UHK1
PRIDEiQ3UHK1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109283; ENSMUSP00000104906; ENSMUSG00000036298
GeneIDi239606
KEGGimmu:239606
UCSCiuc007xhy.2 mouse

Organism-specific databases

CTDi114134
MGIiMGI:2146030 Slc2a13

Phylogenomic databases

eggNOGiKOG0254 Eukaryota
ENOG410XNQK LUCA
GeneTreeiENSGT00920000149002
HOGENOMiHOG000202868
HOVERGENiHBG031722
InParanoidiQ3UHK1
KOiK08150
OMAiSWGVVVW
OrthoDBiEOG091G046D
PhylomeDBiQ3UHK1
TreeFamiTF314916

Enzyme and pathway databases

ReactomeiR-MMU-429593 Inositol transporters

Miscellaneous databases

ChiTaRSiSlc2a13 mouse
PROiPR:Q3UHK1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036298 Expressed in 205 organ(s), highest expression level in nucleus accumbens
GenevisibleiQ3UHK1 MM

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 2 hits
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYCT_MOUSE
AccessioniPrimary (citable) accession number: Q3UHK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again