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Protein

Serine-rich coiled-coil domain-containing protein 2

Gene

Ccser2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-binding protein which might play a role in microtubule bundling.1 Publication

GO - Molecular functioni

  • microtubule binding Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-rich coiled-coil domain-containing protein 2
Alternative name(s):
Coiled-coil serine-rich protein 2
Granule cell antiserum positive protein 14
Protein GCAP14
Gene namesi
Name:Ccser2
Synonyms:Fam190b, Gcap14, Kiaa1128
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:101859 Ccser2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003094621 – 833Serine-rich coiled-coil domain-containing protein 2Add BLAST833

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei222PhosphoserineBy similarity1
Modified residuei451PhosphoserineCombined sources1
Isoform 2 (identifier: Q3UHI0-2)
Modified residuei843PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UHI0
PaxDbiQ3UHI0
PRIDEiQ3UHI0

PTM databases

iPTMnetiQ3UHI0
PhosphoSitePlusiQ3UHI0

Expressioni

Tissue specificityi

Expressed in brain (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000058690 Expressed in 275 organ(s), highest expression level in dorsal root ganglion
CleanExiMM_GCAP14
ExpressionAtlasiQ3UHI0 baseline and differential
GenevisibleiQ3UHI0 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215684, 9 interactors
IntActiQ3UHI0, 9 interactors

Structurei

3D structure databases

ProteinModelPortaliQ3UHI0
SMRiQ3UHI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili711 – 747Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi603 – 615His-richAdd BLAST13

Sequence similaritiesi

Belongs to the CCSER family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGH2 Eukaryota
ENOG410XT5P LUCA
GeneTreeiENSGT00730000111195
HOGENOMiHOG000060196
InParanoidiQ3UHI0
OMAiHSFNWRT
OrthoDBiEOG091G0TIG
PhylomeDBiQ3UHI0
TreeFamiTF331021

Family and domain databases

InterProiView protein in InterPro
IPR029627 CCSER
IPR029629 CCSER2
PANTHERiPTHR22461 PTHR22461, 1 hit
PTHR22461:SF2 PTHR22461:SF2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3UHI0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEKTQIKTF LGSKLPKYGM KSVRSTLQPM PNGATVTLLG TSKSSNVKSY
60 70 80 90 100
IKNNGSDCSL SHSFNWRKTN KYQLGSQNTA ELNNIQSTHD KLIEPEQHAP
110 120 130 140 150
APGTLDGHGI KGGLKSASLF TSKLARPSTM FVSSAEELSQ KSFSGPSNLG
160 170 180 190 200
KFTKGTLLGR TSYSSVNAKS HLNAFYGNRS SGNVQKPRVN SCASRSSSGE
210 220 230 240 250
SLAQSPDNAK SITCEKMVRS QSFSHSIQNV FLPPSSITRS HSFNRAVDLT
260 270 280 290 300
KPYQNQQLPV RVPLRSGMLT RSSLQSEVLN GNEHVGFGFN RPYAAAGKKL
310 320 330 340 350
ALSNGPAVSS TLVYRMAHPP LLKSSRPPFS GPMTVDSNKN PPADMCVEEE
360 370 380 390 400
GMVSAQDSSP GKDQELIENE SYRRDNDQTG KNESKVRYLS DDVDDISLSS
410 420 430 440 450
LSSSDKNDLS EDFSDDFIDL EDSNRTRITP EEMTLKEEKH ESRPSKDIFD
460 470 480 490 500
SPKESEQAFS KAEEWIDISV SDRSECTKHT SGNNLISPDT DYRAGSSFEL
510 520 530 540 550
SPSDSSDGTY MWDEEGLEPI GSVHPVGSYE SSEMNSIDIL NNLESCDLED
560 570 580 590 600
DDLMLDVDLP EDAPLENVEC DNMNRFDRTD RNVRQSQDGF WKRPPQRWSG
610 620 630 640 650
QDHYHLSHPG HYHHHGQSDL SRGSPYRESP LGHFESYGGT PFFQAQKMFV
660 670 680 690 700
DVPDNTVILD EMTLRHMVQD CTAVKTQLLK LKRLLHQHDG SGSLHDVQLS
710 720 730 740 750
LPSSPEPEDG DQIYKNEDLL NEITQLKEEI KKKDEKIQLL EQQLATRCNC
760 770 780 790 800
QQKSKEEKCT YADKYTQTPW RRIPGGYCAP SFSPWQGSFQ GMPRTVPPHR
810 820 830
RQTSSTTAFQ QPSQIYRPRP GKTNKATTYR GPQ
Length:833
Mass (Da):92,932
Last modified:October 11, 2005 - v1
Checksum:i18C871932C925CA8
GO
Isoform 2 (identifier: Q3UHI0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     775-833: GGYCAPSFSP...NKATTYRGPQ → PQVLQPSSSL...YSRLPKPKIH

Show »
Length:1,038
Mass (Da):114,976
Checksum:i1DEA61EA24EB38EE
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J2A7A0A0R4J2A7_MOUSE
Granule cell antiserum positive 14,...
Ccser2 Gcap14, mCG_6694
485Annotation score:
S4R211S4R211_MOUSE
Serine-rich coiled-coil domain-cont...
Ccser2
261Annotation score:
S4R170S4R170_MOUSE
Serine-rich coiled-coil domain-cont...
Ccser2
204Annotation score:
S4R2U3S4R2U3_MOUSE
Serine-rich coiled-coil domain-cont...
Ccser2
277Annotation score:
S4R1Q3S4R1Q3_MOUSE
Serine-rich coiled-coil domain-cont...
Ccser2
83Annotation score:
A0A286YEB1A0A286YEB1_MOUSE
Serine-rich coiled-coil domain-cont...
Ccser2
375Annotation score:

Sequence cautioni

The sequence BAB24323 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61S → P in BAC98105 (PubMed:14621295).Curated1
Sequence conflicti94E → D in BAC98105 (PubMed:14621295).Curated1
Sequence conflicti108H → Y in BAE42850 (PubMed:16141072).Curated1
Sequence conflicti129T → A in BAC98105 (PubMed:14621295).Curated1
Sequence conflicti181S → P in BAC98105 (PubMed:14621295).Curated1
Sequence conflicti212I → M in BAC98105 (PubMed:14621295).Curated1
Sequence conflicti307A → N in BAE42850 (PubMed:16141072).Curated1
Sequence conflicti307A → N in BAC98105 (PubMed:14621295).Curated1
Sequence conflicti353V → I in BAC98105 (PubMed:14621295).Curated1
Sequence conflicti382N → S in BAC98105 (PubMed:14621295).Curated1
Sequence conflicti424N → K in BAC98105 (PubMed:14621295).Curated1
Sequence conflicti433M → V in BAC98105 (PubMed:14621295).Curated1
Sequence conflicti449F → L in BAC98105 (PubMed:14621295).Curated1
Sequence conflicti460S → G in BAC98105 (PubMed:14621295).Curated1
Sequence conflicti479H → Q in BAE42850 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029183775 – 833GGYCA…YRGPQ → PQVLQPSSSLPRSTDHAQGK LIKPQRTEAHSDYTVQGVCP GGAHPDGSCTHGLQQDNSRG LQERPSSSSPQLTVDVVKYI PSETDLSMTLDAQEPHHLAE KKPSDLQFVTPPPQTPSQSS TVDQTKRGGRNQCPQPKSLQ LLKPSNLSSLTPPPDSDSSP SRTSTCKKAPGITPCHSKHQ PTSNQNNPANHLNLKTSKLR PPSGSFKQKQISNPQVEPQN FQAKTSIPRPLARPKELHAP HSGLHSGDCVASNRYSRLPK PKIH in isoform 2. 2 PublicationsAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005931 mRNA Translation: BAB24323.1 Different initiation.
AK147383 mRNA Translation: BAE27877.1
AK172153 mRNA Translation: BAE42850.1
BC111465 mRNA Translation: AAI11466.1
BC139090 mRNA Translation: AAI39091.1
AK129295 mRNA Translation: BAC98105.1
CCDSiCCDS26948.1 [Q3UHI0-1]
CCDS84113.1 [Q3UHI0-2]
RefSeqiNP_001334431.1, NM_001347502.1 [Q3UHI0-2]
NP_001334432.1, NM_001347503.1
NP_081321.1, NM_027045.1 [Q3UHI0-1]
NP_082683.2, NM_028407.3
UniGeneiMm.27621

Genome annotation databases

EnsembliENSMUST00000067700; ENSMUSP00000068550; ENSMUSG00000058690 [Q3UHI0-2]
ENSMUST00000090024; ENSMUSP00000087478; ENSMUSG00000058690 [Q3UHI0-1]
GeneIDi72972
KEGGimmu:72972
UCSCiuc007tbn.1 mouse [Q3UHI0-2]
uc007tbo.1 mouse [Q3UHI0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005931 mRNA Translation: BAB24323.1 Different initiation.
AK147383 mRNA Translation: BAE27877.1
AK172153 mRNA Translation: BAE42850.1
BC111465 mRNA Translation: AAI11466.1
BC139090 mRNA Translation: AAI39091.1
AK129295 mRNA Translation: BAC98105.1
CCDSiCCDS26948.1 [Q3UHI0-1]
CCDS84113.1 [Q3UHI0-2]
RefSeqiNP_001334431.1, NM_001347502.1 [Q3UHI0-2]
NP_001334432.1, NM_001347503.1
NP_081321.1, NM_027045.1 [Q3UHI0-1]
NP_082683.2, NM_028407.3
UniGeneiMm.27621

3D structure databases

ProteinModelPortaliQ3UHI0
SMRiQ3UHI0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215684, 9 interactors
IntActiQ3UHI0, 9 interactors

PTM databases

iPTMnetiQ3UHI0
PhosphoSitePlusiQ3UHI0

Proteomic databases

MaxQBiQ3UHI0
PaxDbiQ3UHI0
PRIDEiQ3UHI0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067700; ENSMUSP00000068550; ENSMUSG00000058690 [Q3UHI0-2]
ENSMUST00000090024; ENSMUSP00000087478; ENSMUSG00000058690 [Q3UHI0-1]
GeneIDi72972
KEGGimmu:72972
UCSCiuc007tbn.1 mouse [Q3UHI0-2]
uc007tbo.1 mouse [Q3UHI0-1]

Organism-specific databases

CTDi54462
MGIiMGI:101859 Ccser2
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IGH2 Eukaryota
ENOG410XT5P LUCA
GeneTreeiENSGT00730000111195
HOGENOMiHOG000060196
InParanoidiQ3UHI0
OMAiHSFNWRT
OrthoDBiEOG091G0TIG
PhylomeDBiQ3UHI0
TreeFamiTF331021

Miscellaneous databases

PROiPR:Q3UHI0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058690 Expressed in 275 organ(s), highest expression level in dorsal root ganglion
CleanExiMM_GCAP14
ExpressionAtlasiQ3UHI0 baseline and differential
GenevisibleiQ3UHI0 MM

Family and domain databases

InterProiView protein in InterPro
IPR029627 CCSER
IPR029629 CCSER2
PANTHERiPTHR22461 PTHR22461, 1 hit
PTHR22461:SF2 PTHR22461:SF2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCSE2_MOUSE
AccessioniPrimary (citable) accession number: Q3UHI0
Secondary accession number(s): B2RT11
, Q2NKY3, Q3TA20, Q6ZPX3, Q9DAD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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