UniProtKB - Q3UHH0 (Q3UHH0_MOUSE)
Protein
Calcium-transporting ATPase
Gene
Atp2b2
Organism
Mus musculus (Mouse)
Status
Functioni
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
Catalytic activityi
- EC:7.2.2.10UniRule annotationARBA annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- calcium transmembrane transporter activity, phosphorylative mechanism Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | TranslocaseARBA annotation |
Biological process | Calcium transportUniRule annotationARBA annotation, Ion transport, Transport |
Ligand | ATP-bindingUniRule annotationARBA annotation, Calcium, MagnesiumARBA annotation, Metal-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Atp2b2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:105368, Atp2b2 |
Subcellular locationi
Other locations
- Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 98 – 121 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 151 – 170 | HelicalUniRule annotationAdd BLAST | 20 | |
Transmembranei | 357 – 378 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 398 – 424 | HelicalUniRule annotationAdd BLAST | 27 | |
Transmembranei | 906 – 924 | HelicalUniRule annotationAdd BLAST | 19 | |
Transmembranei | 982 – 1002 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 1014 – 1035 | HelicalUniRule annotationAdd BLAST | 22 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembraneExpressioni
Gene expression databases
Bgeei | ENSMUSG00000030302, Expressed in striatum and 194 other tissues |
Genevisiblei | Q3UHH0, MM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 123 | Cation_ATPase_NInterPro annotationAdd BLAST | 77 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 296 – 328 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 1145 – 1194 | DisorderedSequence analysisAdd BLAST | 50 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 21 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1146 – 1194 | PolarSequence analysisAdd BLAST | 49 |
Sequence similaritiesi
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. [View classification]UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000161461 |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR030322, ATP2B2 IPR022141, ATP_Ca_trans_C IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006408, P-type_ATPase_IIB IPR001757, P_typ_ATPase |
PANTHERi | PTHR24093:SF377, PTHR24093:SF377, 2 hits |
Pfami | View protein in Pfam PF12424, ATP_Ca_trans_C, 1 hit PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01517, ATPase-IIB_Ca, 1 hit TIGR01494, ATPase_P-type, 3 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q3UHH0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGDMTNSDFY SKNQRNESSH GGEFGCTMEE LRSLMELRGT EAVVKIKETY
60 70 80 90 100
GDTEAICRRL KTSPVEGLPG TAPDLEKRKQ IFGQNFIPPK KPKTFLQLVW
110 120 130 140 150
EALQDVTLII LEIAAIISLG LSFYHPPGES NEGCATAQGG AEDEGEAEAG
160 170 180 190 200
WIEGAAILLS VICVVLVTAF NDWSKEKQFR GLQSRIEQEQ KFTVVRAGQV
210 220 230 240 250
VQIPVAEIVV GDIAQIKYGD LLPADGLFIQ GNDLKIDESS LTGESDQVRK
260 270 280 290 300
SVDKDPMLLS GTHVMEGSGR MVVTAVGVNS QTGIIFTLLG AGGEEEEKKD
310 320 330 340 350
KKAKQQDGAA AMEMQPLKSA EGGDADDKKK ANMHKKEKSV LQGKLTKLAV
360 370 380 390 400
QIGKAGLVMS AITVIILVLY FTVDTFVVNK KPWLTECTPV YVQYFVKFFI
410 420 430 440 450
IGVTVLVVAV PEGLPLAVTI SLAYSVKKMM KDNNLVRHLD ACETMGNATA
460 470 480 490 500
ICSDKTGTLT TNRMTVVQAY VGDVHYKEIP DPSSINAKTL ELLVNAIAIN
510 520 530 540 550
SAYTTKILPP EKEGALPRQV GNKTECGLLG FVLDLRQDYE PVRSQMPEEK
560 570 580 590 600
LYKVYTFNSV RKSMSTVIKM PDESFRMYSK GASEIVLKKC CKILSGAGEA
610 620 630 640 650
RVFRPRDRDE MVKKVIEPMA CDGLRTICVA YRDFPSSPEP DWDNENDILN
660 670 680 690 700
ELTCICVVGI EDPVPEAIRK CQRAGITVRM VTGDNINTAR AIAIKCGIIH
710 720 730 740 750
PGEDFLCLEG KEFNRRIRNE KGEIEQERID KIWPKLRVLA RSSPTDKHTL
760 770 780 790 800
VKGIIDSTHT EQRQVVAVTG DGTNDGPALK KADVGFAMGI AGTDVAKEAS
810 820 830 840 850
DIILTDDNFS SIVKAVMWGR NVYDSISKFL QFQLTVNVVA VIVAFTGACI
860 870 880 890 900
TQDSPLKAVQ MLWVNLIMDT FASLALATEP PTETLLLRKP YGRNKPLISR
910 920 930 940 950
TMMKNILGHA VYQLTLIFTL LFVGEKMFQI DSGRNAPLHS PPSEHYTIIF
960 970 980 990 1000
NTFVMMQLFN EINARKIHGE RNVFDGIFRN PIFCTIVLGT FAIQIVIVQF
1010 1020 1030 1040 1050
GGKPFSCSPL QLDQWMWCIF IGLGELVWGQ VIATIPTSRL KFLKEAGRLT
1060 1070 1080 1090 1100
QKEEIPEEEL NEDVEEIDHA ERELRRGQIL WFRGLNRIQT QIRVVKAFRS
1110 1120 1130 1140 1150
SLYEGLEKPE SRTSIHNFMA HPEFRIEDSQ PHIPLIDDTD LEEDAALKQN
1160 1170 1180 1190
SSPPSSLNKN NSAIDSGINL TTDTSKSATS SSPGSPIHSL ETSL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9R0K7 | AT2B2_MOUSE | Plasma membrane calcium-transportin... | Atp2b2 Pmca2 | 1,198 | Annotation score: | ||
F8WHB1 | F8WHB1_MOUSE | Calcium-transporting ATPase | Atp2b2 | 1,243 | Annotation score: | ||
S4R1C4 | S4R1C4_MOUSE | Calcium-transporting ATPase | Atp2b2 | 1,154 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC117596 Genomic DNA No translation available. AC153590 Genomic DNA No translation available. AK147399 mRNA Translation: BAE27887.1 |
RefSeqi | NP_001031761.1, NM_001036684.3 |
Genome annotation databases
Ensembli | ENSMUST00000205052; ENSMUSP00000145174; ENSMUSG00000030302 |
GeneIDi | 11941 |
KEGGi | mmu:11941 |
UCSCi | uc012eqi.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC117596 Genomic DNA No translation available. AC153590 Genomic DNA No translation available. AK147399 mRNA Translation: BAE27887.1 |
RefSeqi | NP_001031761.1, NM_001036684.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q3UHH0, 1 interactor |
Protocols and materials databases
Antibodypediai | 26012, 120 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000205052; ENSMUSP00000145174; ENSMUSG00000030302 |
GeneIDi | 11941 |
KEGGi | mmu:11941 |
UCSCi | uc012eqi.1, mouse |
Organism-specific databases
CTDi | 491 |
MGIi | MGI:105368, Atp2b2 |
Phylogenomic databases
GeneTreei | ENSGT00940000161461 |
Miscellaneous databases
BioGRID-ORCSi | 11941, 1 hit in 17 CRISPR screens |
ChiTaRSi | Atp2b2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030302, Expressed in striatum and 194 other tissues |
Genevisiblei | Q3UHH0, MM |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR030322, ATP2B2 IPR022141, ATP_Ca_trans_C IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR006408, P-type_ATPase_IIB IPR001757, P_typ_ATPase |
PANTHERi | PTHR24093:SF377, PTHR24093:SF377, 2 hits |
Pfami | View protein in Pfam PF12424, ATP_Ca_trans_C, 1 hit PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01517, ATPase-IIB_Ca, 1 hit TIGR01494, ATPase_P-type, 3 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3UHH0_MOUSE | |
Accessioni | Q3UHH0Primary (citable) accession number: Q3UHH0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |