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Entry version 126 (17 Jun 2020)
Sequence version 1 (11 Oct 2005)
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Protein

Transcription factor HIVEP2

Gene

Hivep2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri189 – 211C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri217 – 239C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1783 – 1805C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1811 – 1835C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor HIVEP2
Alternative name(s):
Human immunodeficiency virus type I enhancer-binding protein 2 homolog
Myc intron-binding protein 1
Short name:
MIBP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hivep2
Synonyms:Mibp1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1338076 Hivep2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000473721 – 2430Transcription factor HIVEP2Add BLAST2430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei811PhosphoserineBy similarity1
Modified residuei942PhosphoserineCombined sources1
Modified residuei947PhosphoserineCombined sources1
Modified residuei1040PhosphoserineCombined sources1
Modified residuei1431PhosphoserineCombined sources1
Modified residuei1435PhosphoserineCombined sources1
Modified residuei2102PhosphoserineBy similarity1
Modified residuei2281PhosphoserineBy similarity1
Modified residuei2285PhosphoserineBy similarity1
Modified residuei2413PhosphoserineCombined sources1
Modified residuei2415PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3UHF7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3UHF7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3UHF7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3UHF7

PRoteomics IDEntifications database

More...
PRIDEi
Q3UHF7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3UHF7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3UHF7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, lung, skeletal muscle and liver. In the brain expressed in cerebral cortex, hippocampus, corpora amygdala and cerebellar cortex.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At 13.5 dpc and 15.5 dpc expressed in anterior neural tube over primordial frontal cortex, spinal cord, dorsal root glanglia and developing skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000015501 Expressed in CA1 field of hippocampus and 283 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q3UHF7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TCF4.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
200314, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000015645

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3UHF7 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati2037 – 204014
Repeati2043 – 204624
Repeati2055 – 205834
Repeati2067 – 207044
Repeati2073 – 207654
Repeati2090 – 209364
Repeati2096 – 209974
Repeati2102 – 210584
Repeati2114 – 211794
Repeati2129 – 2132104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2037 – 213210 X 4 AA tandem repeats of S-P-[RGMKC]-[RK]Add BLAST96

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi929 – 935Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi942 – 974Ser-richAdd BLAST33
Compositional biasi1499 – 1569Ser-richAdd BLAST71
Compositional biasi1883 – 1907Asp/Glu-rich (acidic)Add BLAST25
Compositional biasi2057 – 2132Arg-richAdd BLAST76

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri189 – 211C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri217 – 239C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1783 – 1805C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1811 – 1835C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156512

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000719_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3UHF7

KEGG Orthology (KO)

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KOi
K09239

Identification of Orthologs from Complete Genome Data

More...
OMAi
EHTGKKS

Database of Orthologous Groups

More...
OrthoDBi
212048at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3UHF7

TreeFam database of animal gene trees

More...
TreeFami
TF331837

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3UHF7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTGDTALGQ KATSRSGETD SVSGRWRQEQ SAVLKMSTFS SQEGPRQPQI
60 70 80 90 100
DPEQIGNAAS AQLFGSGKLA SPGEGLHQVT EKQYPPHRPS PYPCQHSLSF
110 120 130 140 150
PQHSLSQGMT HSHKPHQSLE GPPWLFPGPL PSVASEDLFP FPMHGHSGGY
160 170 180 190 200
PRKKISNLNP AYSQYSQKSI EQAEDAHKKE HKPKKPGKYI CPYCSRACAK
210 220 230 240 250
PSVLKKHIRS HTGERPYPCI PCGFSFKTKS NLYKHRKSHA HAIKAGLVPF
260 270 280 290 300
TESSVSKLDL EAGFIDVEAE IHSDGEQSTD TDEESSLFAE ASDKVSPGPP
310 320 330 340 350
VPLDIASRGG YHGSLEESLG GPMKVPILII PKSGIPLASE GSQYLSSEML
360 370 380 390 400
PNPSLNAKAD DSHTVKQKLA LRLSEKKGQD SEPSLNLLSP HSKGSTDSGY
410 420 430 440 450
FSRSESAEQQ ISPPNTNAKS YEEIIFGKYC RLSPRNTLSV TPTGQERTAM
460 470 480 490 500
GRRGIMEPLP HLNTRLEVKM FEDPISQLNP SKGEMDPGQI NMLKTTKFNS
510 520 530 540 550
ECRQPQAIPS SVRNEGKPYP GNFLGSNPML LEAPVDSSPL IRSNSMPTSS
560 570 580 590 600
ATNLSVPPSL RGSHSFDERM TGSDDVFYPG TVGIPPQRML RRQAAFELPS
610 620 630 640 650
VQEGHMESEH PARVSKGLAS PSLKEKKLLP GDRPGYDYDV CRKPYKKWED
660 670 680 690 700
SETLKQSYLG SFKQGGEYFM DPSVPVQGVP TMFGTTCENR KRRKEKSVGD
710 720 730 740 750
EEDVPMICGG MGNAPVGMMS SEYDPKLQDG GRSGFAMTAH ESLAHGHSDR
760 770 780 790 800
LDPARPQLPS RSPSLGSEDL PLAADPDKMT DLGKKPPGNV ISVIQHTNSL
810 820 830 840 850
SRPNSFERSE STEMVACPQD KTPSPAETCD SEVLEAPVSP EWAPPGDGGE
860 870 880 890 900
SGSKPTPSQQ VPQHSYHAQP RLVRQHNIQV PEIRVTEEPD KPEKEKEAPT
910 920 930 940 950
KEPEKPVEEF QWPQRSETLS QLPAEKLPPK KKRLRLADLE HSSGESSFES
960 970 980 990 1000
TGTGLSRSPS QESNLSHSSS FSMSFDREET VKLTAPPKQD ESGKHSEFLT
1010 1020 1030 1040 1050
VPAGSYSLSV PGHHHQKEMR RCSSEQMPCP HPTEVPEIRS KSFDYGNLSH
1060 1070 1080 1090 1100
APVAGTSPST LSPSRERKKC FLVRQASFSG SPEIAQGEAG VDPSVKQEHM
1110 1120 1130 1140 1150
EHLHAGLRAA WSSVLPPLPG DDPGKQVGTC GPLSSGPPLH LTQQQIMHMD
1160 1170 1180 1190 1200
SQESLRNPLI QPTSYMTSKH LPEQPHLFPH QDAVPFSPIQ NALFQFQYPT
1210 1220 1230 1240 1250
VCMVHLPAQQ PPWWQTHFPH PFAPHPQNSY SKPPFQADLH SSYPLEHVAE
1260 1270 1280 1290 1300
HTGKKSADYP HAKEQTYPCY SGTSGLHSKN LPLKFPSDPG SKSTETPTEQ
1310 1320 1330 1340 1350
LLREDFASEN AGPLQSLPGT VVPVRIQTHV PSYGSVMYTS ISQILGQNSP
1360 1370 1380 1390 1400
AIVICKVDEN MTQRTLVTNA AMQGIGLNIA QVLGQHTGLE KYPLWKVPQT
1410 1420 1430 1440 1450
LPLGLESSIP LCLPSTSDNA ASLGGSKRML SPASSLELFM ETKQQKRVKE
1460 1470 1480 1490 1500
EKMYGQIVEE LSAVELTNSD IKKGLSRPQK PQLVRQGCAS EPKDGCFQSR
1510 1520 1530 1540 1550
SSSFSSLSPS SSQDHPSASG PFPPNREILP GSRAPPRRKF SGPSESRESS
1560 1570 1580 1590 1600
DELDMDETSS DMSMSPQSSA LPTGGGQQEE EGKARKLPVS MLVHMASGPG
1610 1620 1630 1640 1650
GNVANSTLLF TDVADFQQIL QFPSLRTTTT VSWCFLNYTK PSFVQQATFK
1660 1670 1680 1690 1700
SSVYASWCIS SCNPNPSGLN TKTTLALLRS KQKITAEIYT LAAMHRPGAG
1710 1720 1730 1740 1750
KLTSSSVWKQ FAQMKPDAPF LFGNKLERKL AGNVLKERGK GEIHGDKDLG
1760 1770 1780 1790 1800
SKQTEPIRIK IFEGGYKSNE DYVYVRGRGR GKYICEECGI RCKKPSMLKK
1810 1820 1830 1840 1850
HIRTHTDVRP YVCKLCNFAF KTKGNLTKHM KSKAHMKKCL ELGVSMTSVD
1860 1870 1880 1890 1900
DTETEEAENM EELHKTSEKH SMSGISTDHQ FSDAEESDGE DGDDNDDDDE
1910 1920 1930 1940 1950
DDDDFDDQGD LTPKTRSRST SPQPPRFSSL PVNVGAVAHG VPSDSSLGHS
1960 1970 1980 1990 2000
SLISYLVTLP SIQVTQLMTP SDSCDDTQMT EYQRLFQSKS TDSEPDKDRL
2010 2020 2030 2040 2050
DIPSSMDEEA MLSSEPSSSP RDFSPSSYRS SPGYDSSPCR DNSPKRYLIP
2060 2070 2080 2090 2100
KGDLSPRRHL SPRRDLSPMR HLSPRKEAAL RREMSQGDAS PRRHLSPRRP
2110 2120 2130 2140 2150
LSPGKDITAR RDLSPRRERR YMTTIRAPSP RRALYPNPPL SMGQYLQTEP
2160 2170 2180 2190 2200
IVLGPPNLRR GIPQVPYFSL YGDQEGAYEH HGSSLFPEGP TDYVFSHLPL
2210 2220 2230 2240 2250
HSQQQVRAPI PMVPVGGIQM VHSLPPALSG LHPPPTLPLP TEGSEEKKGA
2260 2270 2280 2290 2300
PGEAFAKDPY ILSRRHEKQA PQVLQSSGLP SSPSSPRLLM KQSTSEDSLN
2310 2320 2330 2340 2350
STEREQEENI QTCTKAIASL RIATEEAALL GADPPTWVQE SPQKPLESAH
2360 2370 2380 2390 2400
VSIRHFGGPE PGQPCTSAAH PDLHDGEKDT FGTSQTAVAH PTFYSKSSVD
2410 2420 2430
EKRVDFQSSK ELSLSTEEGN EPSPEKNQLH
Length:2,430
Mass (Da):266,705
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i265694210C8A7024
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WQF9A0A087WQF9_MOUSE
Transcription factor HIVEP2
Hivep2
373Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti572G → E in CAA75868 (PubMed:10207097).Curated1
Sequence conflicti661S → P in CAA75868 (PubMed:10207097).Curated1
Sequence conflicti749D → N in CAA75868 (PubMed:10207097).Curated1
Sequence conflicti762S → G in CAA75868 (PubMed:10207097).Curated1
Sequence conflicti1112S → P in CAA75868 (PubMed:10207097).Curated1
Sequence conflicti1211P → S in CAA75868 (PubMed:10207097).Curated1
Sequence conflicti1223A → G in CAA75868 (PubMed:10207097).Curated1
Sequence conflicti1496C → S in CAA75868 (PubMed:10207097).Curated1
Sequence conflicti2001D → E in BAE23294 (PubMed:16141072).Curated1
Sequence conflicti2091P → A in CAA75868 (PubMed:10207097).Curated1
Sequence conflicti2122M → L in CAA75868 (PubMed:10207097).Curated1
Sequence conflicti2263S → C in BAE23336 (PubMed:16141072).Curated1
Sequence conflicti2294T → A in BAE23294 (PubMed:16141072).Curated1
Sequence conflicti2314T → A in CAA75868 (PubMed:10207097).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y15907 mRNA Translation: CAA75868.1
AK137291 mRNA Translation: BAE23294.1
AK137384 mRNA Translation: BAE23336.1
AK147244 mRNA Translation: BAE27792.1
AK147419 mRNA Translation: BAE27900.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS23704.1

NCBI Reference Sequences

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RefSeqi
NP_034567.2, NM_010437.2
XP_006512619.1, XM_006512556.1
XP_006512621.1, XM_006512558.2
XP_006512622.1, XM_006512559.2
XP_006512624.1, XM_006512561.3
XP_011241431.1, XM_011243129.2
XP_011241432.1, XM_011243130.2
XP_011241433.1, XM_011243131.2
XP_011241434.1, XM_011243132.2
XP_011241435.1, XM_011243133.2
XP_017169296.1, XM_017313807.1
XP_017169297.1, XM_017313808.1
XP_017169298.1, XM_017313809.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000015645; ENSMUSP00000015645; ENSMUSG00000015501
ENSMUST00000187083; ENSMUSP00000140290; ENSMUSG00000015501
ENSMUST00000191138; ENSMUSP00000140150; ENSMUSG00000015501

Database of genes from NCBI RefSeq genomes

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GeneIDi
15273

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:15273

UCSC genome browser

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UCSCi
uc007elg.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15907 mRNA Translation: CAA75868.1
AK137291 mRNA Translation: BAE23294.1
AK137384 mRNA Translation: BAE23336.1
AK147244 mRNA Translation: BAE27792.1
AK147419 mRNA Translation: BAE27900.1
CCDSiCCDS23704.1
RefSeqiNP_034567.2, NM_010437.2
XP_006512619.1, XM_006512556.1
XP_006512621.1, XM_006512558.2
XP_006512622.1, XM_006512559.2
XP_006512624.1, XM_006512561.3
XP_011241431.1, XM_011243129.2
XP_011241432.1, XM_011243130.2
XP_011241433.1, XM_011243131.2
XP_011241434.1, XM_011243132.2
XP_011241435.1, XM_011243133.2
XP_017169296.1, XM_017313807.1
XP_017169297.1, XM_017313808.1
XP_017169298.1, XM_017313809.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi200314, 1 interactor
STRINGi10090.ENSMUSP00000015645

PTM databases

iPTMnetiQ3UHF7
PhosphoSitePlusiQ3UHF7

Proteomic databases

EPDiQ3UHF7
jPOSTiQ3UHF7
MaxQBiQ3UHF7
PaxDbiQ3UHF7
PRIDEiQ3UHF7

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
46676 43 antibodies

Genome annotation databases

EnsembliENSMUST00000015645; ENSMUSP00000015645; ENSMUSG00000015501
ENSMUST00000187083; ENSMUSP00000140290; ENSMUSG00000015501
ENSMUST00000191138; ENSMUSP00000140150; ENSMUSG00000015501
GeneIDi15273
KEGGimmu:15273
UCSCiuc007elg.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3097
MGIiMGI:1338076 Hivep2

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000156512
HOGENOMiCLU_000719_0_0_1
InParanoidiQ3UHF7
KOiK09239
OMAiEHTGKKS
OrthoDBi212048at2759
PhylomeDBiQ3UHF7
TreeFamiTF331837

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
15273 3 hits in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Hivep2 mouse

Protein Ontology

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PROi
PR:Q3UHF7
RNActiQ3UHF7 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000015501 Expressed in CA1 field of hippocampus and 283 other tissues
GenevisibleiQ3UHF7 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZEP2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UHF7
Secondary accession number(s): O55140, Q3UVD4, Q3UVH5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 11, 2005
Last modified: June 17, 2020
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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