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Entry version 133 (12 Aug 2020)
Sequence version 1 (11 Oct 2005)
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Protein

Leucine-rich repeat serine/threonine-protein kinase 1

Gene

Lrrk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Binding of GTP stimulates kinase activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1270ATPPROSITE-ProRule annotationBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1386Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1248 – 1256ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, GTP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat serine/threonine-protein kinase 1 (EC:2.7.11.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lrrk1Imported
Synonyms:Kiaa1790
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2142227, Lrrk1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002333781 – 2014Leucine-rich repeat serine/threonine-protein kinase 1Add BLAST2014

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3UHC2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3UHC2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3UHC2

PeptideAtlas

More...
PeptideAtlasi
Q3UHC2

PRoteomics IDEntifications database

More...
PRIDEi
Q3UHC2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3UHC2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3UHC2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000015133, Expressed in lung and 246 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3UHC2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
231403, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q3UHC2, 3 interactors

Molecular INTeraction database

More...
MINTi
Q3UHC2

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000015277

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3UHC2, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati86 – 116ANK 1Sequence analysisAdd BLAST31
Repeati119 – 148ANK 2Sequence analysisAdd BLAST30
Repeati152 – 182ANK 3Sequence analysisAdd BLAST31
Repeati193 – 222ANK 4Sequence analysisAdd BLAST30
Repeati279 – 300LRR 1Add BLAST22
Repeati303 – 324LRR 2Add BLAST22
Repeati330 – 351LRR 3Add BLAST22
Repeati353 – 374LRR 4Sequence analysisAdd BLAST22
Repeati381 – 402LRR 5Add BLAST22
Repeati405 – 426LRR 6Add BLAST22
Repeati427 – 447LRR 7Add BLAST21
Repeati451 – 472LRR 8Add BLAST22
Repeati474 – 495LRR 9Add BLAST22
Repeati498 – 519LRR 10Sequence analysisAdd BLAST22
Repeati549 – 570LRR 11Add BLAST22
Repeati572 – 594LRR 12Sequence analysisAdd BLAST23
Repeati596 – 617LRR 13Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini632 – 826RocPROSITE-ProRule annotationAdd BLAST195
Domaini1242 – 1525Protein kinasePROSITE-ProRule annotationAdd BLAST284

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

ANK repeat, Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0192, Eukaryota
KOG0619, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160363

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001731_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3UHC2

KEGG Orthology (KO)

More...
KOi
K08843

Identification of Orthologs from Complete Genome Data

More...
OMAi
VPCHICA

Database of Orthologous Groups

More...
OrthoDBi
14978at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3UHC2

TreeFam database of animal gene trees

More...
TreeFami
TF313679

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR032171, COR
IPR011009, Kinase-like_dom_sf
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR027417, P-loop_NTPase
IPR000719, Prot_kinase_dom
IPR011044, Quino_amine_DH_bsu
IPR020859, ROC_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit
PF16095, COR, 1 hit
PF13855, LRR_8, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 4 hits
SM00369, LRR_TYP, 8 hits
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF50969, SSF50969, 1 hit
SSF52540, SSF52540, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS51450, LRR, 11 hits
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS51424, ROC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 12 Publications (identifier: Q3UHC2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGTSQRPPS MYWCVGTEGL AVCPGPAMET HNGAEDMGSK LSLPGGSSTV
60 70 80 90 100
QCPSMEEIHT AYKQRNLSRA RDLLRGVCEE SESSQEKGQL LSIAAAHGDL
110 120 130 140 150
ETVQFLLTEK RVELPTEPTD DNPAVVAAHF GHAEVVRELL ESLPGPCTPQ
160 170 180 190 200
RLLNWMLALA CQRGHLEVVK LLVLTHGADP ENYAVRKNEF PVIVRLPLYA
210 220 230 240 250
AIKAGNEDIA IFLLRHGAYF CSYILLDSPE PSKHLLRKYF IEASALPSSY
260 270 280 290 300
PGKIALRVKW SHLKLPWVDL DWLLDISCQI TELDLSANCL PSLPSIIPWG
310 320 330 340 350
LINLKKLNLS NNQLGELPCV QSSDEIICSR LLEIDISSNK LSHLPPGFLH
360 370 380 390 400
LSKLQKLTAS KNYLERLFEE ENATNWIGLR KLQELDLADN RLTELPVQFM
410 420 430 440 450
HSFKSLTSLN VSRNNLKSFP DPWSCPLKCC KASKNALESL PDKMAVFWKS
460 470 480 490 500
HLRDADFSEN SLKEVPLGLF QLDALMFLRL QGNQLLSLPP QEKWTCTQLK
510 520 530 540 550
TLDLSRNQLG KNEDGLKTKR ISLFTTRGRQ RSGTETASML EFPAFLSESL
560 570 580 590 600
EVLCLNDNHL DAVPPSVCLL KNLSELYLGN NPGLRELPPE LGQLGNLWQL
610 620 630 640 650
DIEDLNISNV PAEVRKEGPK ATLSFLRAQL RKAEKCKLMK MILVGPPRQG
660 670 680 690 700
KSTLLEILQT GKAPQLAHSE ATIRTTKWEL QRPAGSKAKV ESVEFNVWDI
710 720 730 740 750
GGPASMATVN QCFFTDKALY VVVWNLALGE EAVANLQFWL LNIEAKAPNA
760 770 780 790 800
VVLVVGTHLD LIEAKFRVER IATLRAYVLA LCRSPSGSRA TGFPDITFKH
810 820 830 840 850
LHEISCKNLE GQEGLRQLIF HVTCNMKDVG STIGCQKLAG RLIPRSYISL
860 870 880 890 900
QEAVLAEQQR RSLGDQVQYL TDRQLDQLVE QTPGNDIKDY EDLQSAISFL
910 920 930 940 950
IETGTLLHFP DTSHGLRNLY FLDPIWLSEC LQRIFNIKGS RSVAKNGVIQ
960 970 980 990 1000
AEDLRMLLVG TGFTQQTEEQ YFQFLAKFEI ALPVANDSYL LPHLLPSKPG
1010 1020 1030 1040 1050
LDTHSMRHPM ANTIQRVFKM SFVPVGFWQR FIARMLISLA EMDLQLFENK
1060 1070 1080 1090 1100
KNTKSRNRKV TIYSFTGSQR NRCSTFRVRR NQTIYWQEGL LVTFDGGYLS
1110 1120 1130 1140 1150
VESSDVNWKK KKSGGIKIIC QSEMRDFSAM AFITDHVNSL IDQWFPALTA
1160 1170 1180 1190 1200
TESDGTPLME QYVPCPVCEA SWAQHADPNE RSESVQYFDM EDCVLTAIER
1210 1220 1230 1240 1250
DFISCPRHPD LPVPLQELVP ELFMTDFPAR LFLENSKLEH TEGENSILGQ
1260 1270 1280 1290 1300
GGSGTVIYQA RYQGQPVAVK RFHIKKFKNS ANAPADTMLR HLRAMDAMKN
1310 1320 1330 1340 1350
FSDFRQEASM LHALQHPCIV SLIGISIHPL CFALELAPLG SLNTVLSENA
1360 1370 1380 1390 1400
KDSSFMPLGH MLTQKIAYQI ASGLAYLHKK NIIFCDLKSD NILVWSLSAK
1410 1420 1430 1440 1450
EHINIKLSDY GISRQSFHEG ALGVEGTPGY QAPEIRPRIV YDEKVDMFSY
1460 1470 1480 1490 1500
GMVLYELLSG QRPALGHHQL QIVKKLSKGI RPVLGQPEEV QFHRLQALMM
1510 1520 1530 1540 1550
ECWDTKPEKR PLALSVVSQM KDPTFATFMY MLPCGKQSAF FSSQSQEYTV
1560 1570 1580 1590 1600
VFWDGKEESR NYTVVNTEKG LLEVQRMTCP GMKLSCQLKV QSSVWIATED
1610 1620 1630 1640 1650
QKIYIYSLKG MCPLSVPQQA LDTPAVVTCF LAVPVIKKNS FLVLAGLADG
1660 1670 1680 1690 1700
LVAVFPVARG TPKESCSYLC SHTANRSKFC IPDEDARQNP YPVKAMEVVN
1710 1720 1730 1740 1750
SGSEVWYSNG PGLLVIDCTI LDISRRLEPY AAPSMVTSLV CSSDCRGEEM
1760 1770 1780 1790 1800
VWCLDDKANC LVMYHSATYQ LCARYFCGDP NPLRDTFSVQ PSVLETPGSH
1810 1820 1830 1840 1850
KTTSKGPVEE CIADVSIMYS EELGTQILTH QDSLTDYCSM SSYSSSPPHQ
1860 1870 1880 1890 1900
DPRSPSSLPS SLTSYSSVPF SANYEDSDRL QEPSVTSDRT EHDLSPMDGE
1910 1920 1930 1940 1950
TFSQHLQAVK VLAVKDLIWV PRHGGDIIVI GLEKDSGAQR GRVIAVLKAR
1960 1970 1980 1990 2000
ELNRHGVLVD AAVVAKDTVV CSFANENTEW CLAVWRGWGA REFDIFYQSY
2010
EELGRLEACT RKRR
Length:2,014
Mass (Da):225,470
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE33100F581779D0
GO
Isoform 21 Publication (identifier: Q3UHC2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1610: Missing.

Show »
Length:404
Mass (Da):44,456
Checksum:i2CC2B9DB95B439EA
GO
Isoform 31 Publication (identifier: Q3UHC2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     1153-1979: Missing.
     1999-2014: SYEELGRLEACTRKRR → LPHQLFQCAFLCQL

Show »
Length:1,149
Mass (Da):129,636
Checksum:iF07799A22B7421EB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6YIW9F6YIW9_MOUSE
Leucine-rich repeat serine/threonin...
Lrrk1
508Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH27199 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC36341 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC39743 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti66N → D in BAC34581 (PubMed:16141072).Curated1
Sequence conflicti950Q → R (PubMed:14621295).Curated1
Sequence conflicti1539A → T in BAE32558 (PubMed:16141072).Curated1
Sequence conflicti1539A → T (PubMed:14621295).Curated1
Sequence conflicti1751V → L in AAH27199 (PubMed:15489334).Curated1
Sequence conflicti1806G → E in BAE32558 (PubMed:16141072).Curated1
Sequence conflicti1806G → E in AAH80819 (PubMed:15489334).Curated1
Sequence conflicti1806G → E (PubMed:14621295).Curated1
Sequence conflicti1903S → N in BAE32558 (PubMed:16141072).Curated1
Sequence conflicti1903S → N in AAH80819 (PubMed:15489334).Curated1
Sequence conflicti1903S → N (PubMed:14621295).Curated1
Sequence conflicti1931G → S in BAE32558 (PubMed:16141072).Curated1
Sequence conflicti1931G → S in AAH80819 (PubMed:15489334).Curated1
Sequence conflicti1931G → S (PubMed:14621295).Curated1
Sequence conflicti1972S → G in BAE32558 (PubMed:16141072).Curated1
Sequence conflicti1972S → G in AAH27199 (PubMed:15489334).Curated1
Sequence conflicti1972S → G in AAH80819 (PubMed:15489334).Curated1
Sequence conflicti1972S → G (PubMed:14621295).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0520141 – 1610Missing in isoform 2. 1 PublicationAdd BLAST1610
Alternative sequenceiVSP_0520131 – 36Missing in isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_0520151153 – 1979Missing in isoform 3. 1 PublicationAdd BLAST827
Alternative sequenceiVSP_0520161999 – 2014SYEEL…TRKRR → LPHQLFQCAFLCQL in isoform 3. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK051264 mRNA Translation: BAC34581.1
AK076432 mRNA Translation: BAC36341.1 Different initiation.
AK081849 mRNA Translation: BAC38349.1
AK086795 mRNA Translation: BAC39743.1 Different initiation.
AK147469 mRNA Translation: BAE27935.1
AK154395 mRNA Translation: BAE32558.1
BC027199 mRNA Translation: AAH27199.1 Different initiation.
BC066159 mRNA Translation: AAH66159.1
BC072664 mRNA Translation: AAH72664.1
BC080819 mRNA Translation: AAH80819.1
AK129441 mRNA Translation: BAC98251.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS21344.1 [Q3UHC2-1]

NCBI Reference Sequences

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RefSeqi
NP_666303.3, NM_146191.3 [Q3UHC2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000015277; ENSMUSP00000015277; ENSMUSG00000015133 [Q3UHC2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
233328

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:233328

UCSC genome browser

More...
UCSCi
uc009hhc.1, mouse [Q3UHC2-2]
uc009hhd.1, mouse [Q3UHC2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK051264 mRNA Translation: BAC34581.1
AK076432 mRNA Translation: BAC36341.1 Different initiation.
AK081849 mRNA Translation: BAC38349.1
AK086795 mRNA Translation: BAC39743.1 Different initiation.
AK147469 mRNA Translation: BAE27935.1
AK154395 mRNA Translation: BAE32558.1
BC027199 mRNA Translation: AAH27199.1 Different initiation.
BC066159 mRNA Translation: AAH66159.1
BC072664 mRNA Translation: AAH72664.1
BC080819 mRNA Translation: AAH80819.1
AK129441 mRNA Translation: BAC98251.1
CCDSiCCDS21344.1 [Q3UHC2-1]
RefSeqiNP_666303.3, NM_146191.3 [Q3UHC2-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi231403, 6 interactors
IntActiQ3UHC2, 3 interactors
MINTiQ3UHC2
STRINGi10090.ENSMUSP00000015277

PTM databases

iPTMnetiQ3UHC2
PhosphoSitePlusiQ3UHC2

Proteomic databases

EPDiQ3UHC2
MaxQBiQ3UHC2
PaxDbiQ3UHC2
PeptideAtlasiQ3UHC2
PRIDEiQ3UHC2

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q3UHC2, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2085, 179 antibodies

Genome annotation databases

EnsembliENSMUST00000015277; ENSMUSP00000015277; ENSMUSG00000015133 [Q3UHC2-1]
GeneIDi233328
KEGGimmu:233328
UCSCiuc009hhc.1, mouse [Q3UHC2-2]
uc009hhd.1, mouse [Q3UHC2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79705
MGIiMGI:2142227, Lrrk1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG0192, Eukaryota
KOG0619, Eukaryota
GeneTreeiENSGT00940000160363
HOGENOMiCLU_001731_0_0_1
InParanoidiQ3UHC2
KOiK08843
OMAiVPCHICA
OrthoDBi14978at2759
PhylomeDBiQ3UHC2
TreeFamiTF313679

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
233328, 0 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Lrrk1, mouse

Protein Ontology

More...
PROi
PR:Q3UHC2
RNActiQ3UHC2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000015133, Expressed in lung and 246 other tissues
GenevisibleiQ3UHC2, MM

Family and domain databases

Gene3Di1.25.40.20, 1 hit
3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR032171, COR
IPR011009, Kinase-like_dom_sf
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR027417, P-loop_NTPase
IPR000719, Prot_kinase_dom
IPR011044, Quino_amine_DH_bsu
IPR020859, ROC_dom
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF16095, COR, 1 hit
PF13855, LRR_8, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 4 hits
SM00369, LRR_TYP, 8 hits
SM00220, S_TKc, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF50969, SSF50969, 1 hit
SSF52540, SSF52540, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS51450, LRR, 11 hits
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS51424, ROC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRRK1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UHC2
Secondary accession number(s): Q3U476
, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 11, 2005
Last modified: August 12, 2020
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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