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Entry version 115 (16 Oct 2019)
Sequence version 1 (11 Oct 2005)
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Protein

Plexin-D1

Gene

Plxnd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Mediates anti-angiogenic signaling in response to SEMA3E. Required for normal development of the heart and vasculature.6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processAngiogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-416700 Other semaphorin interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plexin-D1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Plxnd1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2154244 Plxnd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini49 – 1271ExtracellularSequence analysisAdd BLAST1223
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1272 – 1292HelicalSequence analysisAdd BLAST21
Topological domaini1293 – 1925CytoplasmicSequence analysisAdd BLAST633

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Neonate lethality, due to defects in the development of the heart outflow tract and in aortic arch patterning, plus defects in peripheral vasculature. Mice also display skeletal defects, but these may be caused by defects in the embryonic vasculature.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 48Sequence analysisAdd BLAST48
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000041589049 – 1925Plexin-D1Add BLAST1877

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi106 ↔ 116PROSITE-ProRule annotation
Disulfide bondi142 ↔ 150PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi324 ↔ 447PROSITE-ProRule annotation
Disulfide bondi347 ↔ 391PROSITE-ProRule annotation
Glycosylationi483N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi551 ↔ 568PROSITE-ProRule annotation
Disulfide bondi557 ↔ 602PROSITE-ProRule annotation
Disulfide bondi560 ↔ 577PROSITE-ProRule annotation
Disulfide bondi571 ↔ 583PROSITE-ProRule annotation
Disulfide bondi639 ↔ 663PROSITE-ProRule annotation
Glycosylationi967N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1120N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3UH93

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3UH93

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3UH93

PeptideAtlas

More...
PeptideAtlasi
Q3UH93

PRoteomics IDEntifications database

More...
PRIDEi
Q3UH93

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2597

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3UH93

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3UH93

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in embryonic heart and vascular endothelium, brain, dorsal root ganglia, adrenal gland, lung mesenchyme, small intestine and in the ossification centers of vertebral bodies.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030123 Expressed in 242 organ(s), highest expression level in pancreas

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3UH93 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3UH93 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NRP1 and SEMA4A (PubMed:15239958, PubMed:17318185).

Interacts with SH3BP1; they dissociate upon SEMA3E binding to PLXND1 allowing SH3BP1 to transduce downstream signal through RAC1 inactivation (By similarity).

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
212439, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q3UH93

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000015511

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11925
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3UH93

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 548SemaPROSITE-ProRule annotationAdd BLAST500
Domaini893 – 977IPT/TIG 1Add BLAST85
Domaini983 – 1065IPT/TIG 2Add BLAST83
Domaini1071 – 1145IPT/TIG 3Add BLAST75

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3610 Eukaryota
ENOG410ZUMY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00970000193384

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231376

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3UH93

KEGG Orthology (KO)

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KOi
K06822

Identification of Orthologs from Complete Genome Data

More...
OMAi
DVRQEYP

Database of Orthologous Groups

More...
OrthoDBi
484727at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3UH93

TreeFam database of animal gene trees

More...
TreeFami
TF312962

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11247 Sema_plexin_D1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
2.60.40.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR042719 Plexin-D1_Sema
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR041019 TIG1_plexin
IPR015943 WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22625 PTHR22625, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
PF17960 TIG_plexin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51004 SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3UH93-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARRAAGGAP PSARAAAAVP LRPRPHSRGP GLLPLPLLLL LGAARAGALE
60 70 80 90 100
IQRRFPSPTP TNNFALDGTA GTVYLAAVNR LYQLSSANLS LEAEATVGPV
110 120 130 140 150
PDSPLCHAPQ LPQASCEHPR RLTDNYNKIL QLDPGQGLVV ACGSIYQGLC
160 170 180 190 200
QLRRRGNISA LAVSFPPAAP TAEPVTVFPS MLNVAANHPN ASTVGLVLPP
210 220 230 240 250
TSGTGGSRLL VGATYTGFGS AFFPRNRSLE DHRFENTPEI AIRSLDARGD
260 270 280 290 300
LAKLFTFDLN PSDDNILKIK QGAKEQHKLG FVRAFLHPAV PPHSAQPYAY
310 320 330 340 350
LALNSEARAG DKDSQARSLL ARICLPRGAG GDAKKLTESY IQLGLQCAGG
360 370 380 390 400
AGRGDLYSRL VSVFPAREQF FAVFERPQGA PGARNAPAAL CAFRFDDVQA
410 420 430 440 450
AIRAARTACF VEPAPDVVAV LDSVVQGTGP ACESKRNIQL QPEQLDCGAA
460 470 480 490 500
HLQHPLTILQ PLRASPVFRA PGLTAVAVAS ANNYTAVFLG TATGRLLKIS
510 520 530 540 550
LNESMQVVSR RVLTVAYGEP VHHVMQFDPM DPGYLYLMTS HQMARVKVAA
560 570 580 590 600
CEVHSTCGDC VGAADAYCGW CTLETRCTLQ QDCTNSSQPH FWTSASEGPS
610 620 630 640 650
RCPAMTVLPS EIDVHRDYTG MILQISGSLP SLSGMEMACD YGNGVRTVAR
660 670 680 690 700
VPGPAYDHQI AYCNLLPRAQ FPSFPAGQDH VTVEMSVRVK GHNIVSANFT
710 720 730 740 750
IYDCSRIGQV YPHTACTSCL STQWPCSWCI QLHSCVSNQS QCQDSPNPTS
760 770 780 790 800
PQDCPQILPS PLAPVPTGGS QDILVPLTKA TFFHGSSLEC SFGLEESFEA
810 820 830 840 850
VWANNSLVRC NQVVLHTTQK SQVFPLSLKL KGPPDRFLDS PNPMTVVVYN
860 870 880 890 900
CAMGSPDCSQ CLGREDLGHL CVWNDGCRLR GPLQPLPGTC PAPEIRAIEP
910 920 930 940 950
LSGPLDGGTL LTIRGRNLGR RLSDVAHGVW IGSVACEPLA DRYTVSEEIV
960 970 980 990 1000
CATGPAAGAF SDVVTVNVSK EGRSREQFSY VLPTVHSLEP SMGPKAGGTR
1010 1020 1030 1040 1050
ITIHGSDLNV GSMLQVLVND TDPCTDLTRT ATSITCTVPG GTLPSPVPVC
1060 1070 1080 1090 1100
VRFESRGCVH GNLTFWYMQN PVITAISPGR SPVSGGRTIT VAGERFHMVQ
1110 1120 1130 1140 1150
NVSMAVHHIG REPTFCKVLN STLITCPSPG ALSNASAPVD FFINGRAYAD
1160 1170 1180 1190 1200
EAAEELLDPA EAQRGSRFRL DYLPNPQFST AKREKWIKHH PGEPLTLVIH
1210 1220 1230 1240 1250
KEQDSLGLES HEYHIKIGQV SCDIQIISDR VIHCSVNESL GTAEGQLPIT
1260 1270 1280 1290 1300
IQVGNFNQTI ATLQLGGSET AIVVSIVICS VLLLLSVVAL FVFCTKSRRA
1310 1320 1330 1340 1350
ERYWQKTLLQ MEEMESQIRE EIRKGFAELQ TDMTDLTKEL NRSQGIPFLE
1360 1370 1380 1390 1400
YKHFVTRTFF PKCSSLYEER YVLPSKTLNS QGGSPPQETH PLLGEWNIPE
1410 1420 1430 1440 1450
HCRPSMEEGI SLFSSLLNNK HFLIVFVHAL EQQKDFAVRD RCSLASLLTI
1460 1470 1480 1490 1500
ALHGKLEYYT SIMKELLVDL IDASAAKNPK LMLRRTESVV EKMLTNWMSI
1510 1520 1530 1540 1550
CMYGCLRETV GEPFFLLLCA IKQQINKGSI DAITGKARYT LNEEWLLREN
1560 1570 1580 1590 1600
IEAKPRNLNV SFQGCGMDSL SVRAMDTDTL TQVKEKILEA FCKNVPYSQW
1610 1620 1630 1640 1650
PRAEDVDLEW FASSTQSYVL RDLDDTSVVE DGRKKLNTLA HYKIPEGASL
1660 1670 1680 1690 1700
AMSLTDKKDS TLGRVKDLDT EKYFHLVLPT DELVEPKKSH RQSHRKKVLP
1710 1720 1730 1740 1750
EIYLTRLLST KGTLQKFLDD LFKAILSIRE DKPPLAVKYF FDFLEEQAEK
1760 1770 1780 1790 1800
RGISDPDTLH IWKTNSLPLR FWVNILKNPQ FVFDIEKTDH IDACLSVIAQ
1810 1820 1830 1840 1850
AFIDACSISD LQLGKDSPTN KLLYAKEIPE YRKTVQRYYK QIQDMTPLSE
1860 1870 1880 1890 1900
QEMNAHLAEE SRKYQNEFNT NVAMAEIYKY AKRYRPQIMA ALEANPTARR
1910 1920
TQLQHKFEQV VALMENNIYE CYSEA
Length:1,925
Mass (Da):211,608
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7385B372DC53AF2E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6T0L5F6T0L5_MOUSE
Plexin-D1
Plxnd1
233Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14R → W in AAT99561 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY688678 mRNA Translation: AAT99561.1
AK147513 mRNA Translation: BAE27964.1
AC139761 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS20448.1

NCBI Reference Sequences

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RefSeqi
NP_080652.2, NM_026376.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000015511; ENSMUSP00000015511; ENSMUSG00000030123

Database of genes from NCBI RefSeq genomes

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GeneIDi
67784

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:67784

UCSC genome browser

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UCSCi
uc009djn.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY688678 mRNA Translation: AAT99561.1
AK147513 mRNA Translation: BAE27964.1
AC139761 Genomic DNA No translation available.
CCDSiCCDS20448.1
RefSeqiNP_080652.2, NM_026376.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5V6RX-ray2.70A/B1339-1925[»]
5V6TX-ray3.19A1339-1925[»]
SMRiQ3UH93
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi212439, 4 interactors
CORUMiQ3UH93
STRINGi10090.ENSMUSP00000015511

PTM databases

GlyConnecti2597
iPTMnetiQ3UH93
PhosphoSitePlusiQ3UH93

Proteomic databases

jPOSTiQ3UH93
MaxQBiQ3UH93
PaxDbiQ3UH93
PeptideAtlasiQ3UH93
PRIDEiQ3UH93

Genome annotation databases

EnsembliENSMUST00000015511; ENSMUSP00000015511; ENSMUSG00000030123
GeneIDi67784
KEGGimmu:67784
UCSCiuc009djn.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23129
MGIiMGI:2154244 Plxnd1

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410ZUMY LUCA
GeneTreeiENSGT00970000193384
HOGENOMiHOG000231376
InParanoidiQ3UH93
KOiK06822
OMAiDVRQEYP
OrthoDBi484727at2759
PhylomeDBiQ3UH93
TreeFamiTF312962

Enzyme and pathway databases

ReactomeiR-MMU-416700 Other semaphorin interactions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Plxnd1 mouse

Protein Ontology

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PROi
PR:Q3UH93

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000030123 Expressed in 242 organ(s), highest expression level in pancreas
ExpressionAtlasiQ3UH93 baseline and differential
GenevisibleiQ3UH93 MM

Family and domain databases

CDDicd11247 Sema_plexin_D1, 1 hit
Gene3Di2.130.10.10, 1 hit
2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR042719 Plexin-D1_Sema
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR041019 TIG1_plexin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 1 hit
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
PF17960 TIG_plexin, 1 hit
SMARTiView protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLXD1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UH93
Secondary accession number(s): Q68HV1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: October 11, 2005
Last modified: October 16, 2019
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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