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Entry version 135 (29 Sep 2021)
Sequence version 1 (11 Oct 2005)
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Protein

Protein sidekick-1

Gene

Sdk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-373756, SDK interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein sidekick-11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sdk11 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444413, Sdk1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000039683

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini? – 1991ExtracellularSequence analysis
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1992 – 2012HelicalSequence analysisAdd BLAST21
Topological domaini2013 – 2193CytoplasmicSequence analysisAdd BLAST181

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi227 – 232Missing : Abolishes homophilic interactions. 1 Publication6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – ?Sequence analysis
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000226976? – 2193Protein sidekick-1

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi108 ↔ 151PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi253N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi297 ↔ 344PROSITE-ProRule annotation
Disulfide bondi390 ↔ 440PROSITE-ProRule annotation
Disulfide bondi483 ↔ 535PROSITE-ProRule annotation
Glycosylationi532N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi545N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi554N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi577 ↔ 629PROSITE-ProRule annotation
Glycosylationi764N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi803N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi864N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi997N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1006N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1264N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1315N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1636N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1730N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1801N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1875N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3UH53

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3UH53

PeptideAtlas

More...
PeptideAtlasi
Q3UH53

PRoteomics IDEntifications database

More...
PRIDEi
Q3UH53

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
257111 [Q3UH53-1]
257112 [Q3UH53-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2644, 1 N-Linked glycan (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q3UH53, 17 sites, 1 N-linked glycan (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3UH53

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3UH53

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by non-overlapping subsets of retinal neurons. Sdk1 and Sdk2 are expressed in non-overlapping subsets of interneurons and retinal ganglion cells (RGCs) that form synapses in distinct inner plexiform layer (IPL) sublaminae (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in many fetal tissues, inlcuding kidney but shows markedly lower expression in adult organs. Expression in kidney is high throughout development with maximal expression occurring near birth.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039683, Expressed in embryo and 158 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3UH53, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; mediates homophilic interactions to promote cell adhesion (PubMed:15703275).

Interacts (via PDZ-binding motif) with MAGI1, MAGI2, DLG2, DLG3 and DLG4 (PubMed:20219992).

2 Publications

Does not mediate homophilic interactions (PubMed:15703275).

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
236924, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000082928

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3UH53, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3UH53

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini86 – 168Ig-like C2-type 1Add BLAST83
Domaini173 – 259Ig-like C2-type 2Add BLAST87
Domaini275 – 363Ig-like C2-type 3Add BLAST89
Domaini368 – 458Ig-like C2-type 4Add BLAST91
Domaini462 – 551Ig-like C2-type 5Add BLAST90
Domaini556 – 645Ig-like C2-type 6Add BLAST90
Domaini652 – 748Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST97
Domaini753 – 849Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini854 – 952Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST99
Domaini956 – 1050Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST95
Domaini1054 – 1153Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST100
Domaini1158 – 1256Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST99
Domaini1261 – 1358Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST98
Domaini1362 – 1456Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST95
Domaini1461 – 1558Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST98
Domaini1563 – 1681Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST119
Domaini1686 – 1782Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST97
Domaini1786 – 1881Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST96
Domaini1884 – 1982Fibronectin type-III 13PROSITE-ProRule annotationAdd BLAST99

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 56DisorderedSequence analysisAdd BLAST56
Regioni2057 – 2080DisorderedSequence analysisAdd BLAST24

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2187 – 2193PDZ-bindingBy similarity7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi22 – 36Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

the PDZ-binding motif mediates interaction with PDZ domain-containing proteins MAGI1, MAGI2, DLG2, DLG3 and DLG4 and is required for is required for synaptic localization in photoreceptors.By similarity
Ig-like C2-type domains 1 and 2 mediate homophilic interactions.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sidekick family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3510, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157747

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001875_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3UH53

Identification of Orthologs from Complete Genome Data

More...
OMAi
CSKYNGA

Database of Orthologous Groups

More...
OrthoDBi
134749at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3UH53

TreeFam database of animal gene trees

More...
TreeFami
TF316846

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 13 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 19 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041, fn3, 13 hits
PF07679, I-set, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 13 hits
SM00409, IG, 6 hits
SM00408, IGc2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 5 hits
SSF49265, SSF49265, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 13 hits
PS50835, IG_LIKE, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q3UH53-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARARPSVAG GGVAAPPERA GPGRPRRSRT GHHCDPECPG LRAAPRTPGP
60 70 80 90 100
GAGRRAAKLR PGRGWWALLL LQLHLLRALA QDDVAPYFKT EPGLPQIHLE
110 120 130 140 150
GNRLVLTCLA EGSWPLEFKW IRNDSELTTY SSEYKYIIPS LQKLDAGFYR
160 170 180 190 200
CVVRNRMGAL LQRKSEIQVA YMGNFMDTDQ RKTVSQGHAA LLNLLPIVSC
210 220 230 240 250
PQPQVTWFRE GHKIIPSSRI AITLENQLVI LATTASDAGA YYVQAVNEKN
260 270 280 290 300
GENKTSPFIH LSVARDTGTH EAMAPIIVVA PGNRSVVAGS SETTLECIAN
310 320 330 340 350
ARPVEELSVH WKRNGVRLTS GLHSYGRRLT ITNPTSADTG MYVCEATLRG
360 370 380 390 400
STFEPARARA FLSIIEPPYF TAEPESRILG EVEETMDIPC RAMGVPLPTL
410 420 430 440 450
QWYKDAVPLS KLQNPRYKVL PSGGLHIQKL SPEDSGIFQC FASNEGGEVQ
460 470 480 490 500
THTYLDVTNI APAFTQRPVD TTVTDGMTAV LRCEVSGAPK PAITWKRGNH
510 520 530 540 550
ILASGSVRIP RFMLLESGGL RIAPVFIQDA GNYTCYAANT EASVNASAML
560 570 580 590 600
TVWNRTSIVH PPEDRVVIKG TTATLCCGAT HDPRTSLRYV WKKDNVVITA
610 620 630 640 650
SSSSRIVVEK DGSLVISQTW SGDIGDYTCE IISEGGSDSR TARLEVIELP
660 670 680 690 700
HPPQNLLASL SPARSHSVTL SWVRPFDGNS PVLYYIVQVS ENNSPWKVHL
710 720 730 740 750
SNVGPEMTGV TVSGLTPART YQFRVCAVNQ VGKGQYSTET SRLMLPEEPP
760 770 780 790 800
SAPPKNIVAS GRTNQSIMVQ WQPPPETEHN GVLRGYILRY RLAGLPGEHQ
810 820 830 840 850
QRNISSPEVN YCLVTDLIIW TQYEIQVAAY NGAGLGVFSR AVTEYTLQGV
860 870 880 890 900
PTAPPQNVQA EAVNSTTVHF LWNPPPQQFI NGINQGYKLL AWPADAPETV
910 920 930 940 950
TVVTIAPDFH GIHHGYITNL KKFTAYFTSV LCFTTPGDGP PSSPQLVWTH
960 970 980 990 1000
EDKPGAVGHL SFTEILDTSL KVSWQEPLER NGIIMGYQIS WEVYGRNDSR
1010 1020 1030 1040 1050
LTHTLNSTMH EYKIQGLSSL TTYTIDVAAL TAAGVGVTTS STISSGVPPD
1060 1070 1080 1090 1100
LPGAPSNLVI SNISPRSATL QFRPGYDGKT AICRWIVEGQ VGAIGDEEEW
1110 1120 1130 1140 1150
VTLYEEENEP DAQMLEIPNL TPYTHYRFRM RQVNIVGPSP FSQSSRVIQT
1160 1170 1180 1190 1200
LQAPPDVAPT SLTVRTASET SLRLRWVPLP DSQYNGNPES VGYRVKYWRS
1210 1220 1230 1240 1250
DQPSSALAQV VSDRLERELT IEELEEWTEY ELRMQAFNAI GAGPWSELVR
1260 1270 1280 1290 1300
GRTRESVPSA APENVSAEAV SSTQILLTWA SVPEQDQNGL ILGYKVLYCA
1310 1320 1330 1340 1350
KDLDPEPRSH VVRGNHTQSA LLAGLRKFVV YELQVLAFTR IGNGVPSSPL
1360 1370 1380 1390 1400
ILERTKDDTP GPPVRLVFPE VRLTAVRIVW QPPEEPNGVI LGYQIAYRLA
1410 1420 1430 1440 1450
SGSPHTFTTV EVGATVRQFT ATELAPESAY IFRLSAKTRQ GWGEPLEATV
1460 1470 1480 1490 1500
ITTEKRERPA PPRELLVPQA EVTARSLRLQ WVPGSDGASP IRYFTVQVRE
1510 1520 1530 1540 1550
LPGGEWQTYS SSISHEATAC AVERLRPFTS YKLRLKATND IGDSDFSAET
1560 1570 1580 1590 1600
EAVTTLQDVP GEPPGSVSAT PHTTSSVLIQ WQPPRDESLN GLLQGYRIYY
1610 1620 1630 1640 1650
RELESETGMS PEPKTLKSPS ALRAELTAQS SFKTVNSSSS LTTYELTHLK
1660 1670 1680 1690 1700
KYRRYEVIMT AYNIIGESPA SVPVEVFVGE AAPAMAPQNV QVTPLTASQL
1710 1720 1730 1740 1750
EVTWDPPPPE SQNGNIQGYK VYYWEADSRN ETEKMKVLFL PEPVVKIKDL
1760 1770 1780 1790 1800
TSHTKYLISI SAFNAAGDGP KSDPCQGRTH QAAPGPPSFL AFSEITSTTL
1810 1820 1830 1840 1850
NVSWGEPSAA NGILQGYRVV YEPLAPVQGV SKVVTVDVKG NWQRWLKVRD
1860 1870 1880 1890 1900
LTKGVTYFFR VQARTIAYGP ELQANVTAGP AEGSPGSPRN VLVTKSASEL
1910 1920 1930 1940 1950
TLQWTEGNAG TTPTTGYVIE ARPSDEGLWD MFAKDIPRSA TSYTVDLDKL
1960 1970 1980 1990 2000
RQGVTYEFRV VAVNKAGFGE PSRPSIAVSA QAEAPFYEEW WFLLVMALSS
2010 2020 2030 2040 2050
LLLILLVVFV LVLHGQSKKY KSCSTGKGIS NMEETVTLDN GGFAALELNS
2060 2070 2080 2090 2100
RHLNVKSTFS KKNGTRSPPR PSPGGLHYSD EDICNKYNGA VLTESVNLKE
2110 2120 2130 2140 2150
KSVDGSESEA SDSDYEEALP KHSFVNHYMS DPTYYNSWKR RPPAAAPHRY
2160 2170 2180 2190
EAVAGAEAGP HLHTVITTQS AGGVYTPAGP GARAPLTGFS SFV
Length:2,193
Mass (Da):240,306
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC22752D48DC4B137
GO
Isoform 2 (identifier: Q3UH53-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-260: Missing.
     261-265: LSVAR → MDRSG

Show »
Length:1,933
Mass (Da):211,606
Checksum:iB8AEF51A28AAC145
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC28069 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC28986 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1009M → T in AAQ57662 (PubMed:15213259).Curated1
Sequence conflicti1888P → L in BAE28630 (PubMed:16141072).Curated1
Sequence conflicti1957E → G in BAC28986 (PubMed:16141072).Curated1
Sequence conflicti2038L → Q in BAE28630 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0175201 – 260Missing in isoform 2. 1 PublicationAdd BLAST260
Alternative sequenceiVSP_017521261 – 265LSVAR → MDRSG in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY353236 mRNA Translation: AAQ57662.1
AK032883 mRNA Translation: BAC28069.1 Different initiation.
AK035225 mRNA Translation: BAC28986.1 Different initiation.
AK147578 mRNA Translation: BAE28004.1
AK148648 mRNA Translation: BAE28630.1
BC060237 mRNA Translation: AAH60237.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS39360.2 [Q3UH53-1]

NCBI Reference Sequences

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RefSeqi
NP_808547.3, NM_177879.5 [Q3UH53-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000074546; ENSMUSP00000074133; ENSMUSG00000039683 [Q3UH53-2]
ENSMUST00000085774; ENSMUSP00000082928; ENSMUSG00000039683 [Q3UH53-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
330222

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:330222

UCSC genome browser

More...
UCSCi
uc009ail.2, mouse [Q3UH53-1]
uc009ain.2, mouse [Q3UH53-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY353236 mRNA Translation: AAQ57662.1
AK032883 mRNA Translation: BAC28069.1 Different initiation.
AK035225 mRNA Translation: BAC28986.1 Different initiation.
AK147578 mRNA Translation: BAE28004.1
AK148648 mRNA Translation: BAE28630.1
BC060237 mRNA Translation: AAH60237.1
CCDSiCCDS39360.2 [Q3UH53-1]
RefSeqiNP_808547.3, NM_177879.5 [Q3UH53-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5K6UX-ray2.20A78-459[»]
5K6VX-ray3.21A78-459[»]
5K6WX-ray3.50A/B78-556[»]
5K6ZX-ray2.70A/B268-459[»]
5XWXX-ray1.55A/B1-458[»]
SMRiQ3UH53
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi236924, 1 interactor
STRINGi10090.ENSMUSP00000082928

PTM databases

GlyConnecti2644, 1 N-Linked glycan (2 sites)
GlyGeniQ3UH53, 17 sites, 1 N-linked glycan (2 sites)
iPTMnetiQ3UH53
PhosphoSitePlusiQ3UH53

Proteomic databases

jPOSTiQ3UH53
PaxDbiQ3UH53
PeptideAtlasiQ3UH53
PRIDEiQ3UH53
ProteomicsDBi257111 [Q3UH53-1]
257112 [Q3UH53-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2506, 30 antibodies

The DNASU plasmid repository

More...
DNASUi
330222

Genome annotation databases

EnsembliENSMUST00000074546; ENSMUSP00000074133; ENSMUSG00000039683 [Q3UH53-2]
ENSMUST00000085774; ENSMUSP00000082928; ENSMUSG00000039683 [Q3UH53-1]
GeneIDi330222
KEGGimmu:330222
UCSCiuc009ail.2, mouse [Q3UH53-1]
uc009ain.2, mouse [Q3UH53-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
221935
MGIiMGI:2444413, Sdk1
VEuPathDBiHostDB:ENSMUSG00000039683

Phylogenomic databases

eggNOGiKOG3510, Eukaryota
GeneTreeiENSGT00940000157747
HOGENOMiCLU_001875_1_0_1
InParanoidiQ3UH53
OMAiCSKYNGA
OrthoDBi134749at2759
PhylomeDBiQ3UH53
TreeFamiTF316846

Enzyme and pathway databases

ReactomeiR-MMU-373756, SDK interactions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
330222, 0 hits in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sdk1, mouse

Protein Ontology

More...
PROi
PR:Q3UH53
RNActiQ3UH53, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039683, Expressed in embryo and 158 other tissues
GenevisibleiQ3UH53, MM

Family and domain databases

CDDicd00063, FN3, 13 hits
Gene3Di2.60.40.10, 19 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
PfamiView protein in Pfam
PF00041, fn3, 13 hits
PF07679, I-set, 3 hits
SMARTiView protein in SMART
SM00060, FN3, 13 hits
SM00409, IG, 6 hits
SM00408, IGc2, 5 hits
SUPFAMiSSF48726, SSF48726, 5 hits
SSF49265, SSF49265, 7 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 13 hits
PS50835, IG_LIKE, 5 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSDK1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UH53
Secondary accession number(s): Q3UFD1
, Q6PAL2, Q6V3A4, Q8BMC2, Q8BZI1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 11, 2005
Last modified: September 29, 2021
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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