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Entry version 96 (16 Oct 2019)
Sequence version 1 (11 Oct 2005)
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Protein

Brefeldin A-inhibited guanine nucleotide-exchange protein 3

Gene

Arfgef3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (PubMed:24711543). Also regulates glucagon granule production in pancreatic alpha cells (PubMed:25737957). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Brefeldin A-inhibited guanine nucleotide-exchange protein 3Curated
Alternative name(s):
ARFGEF family member 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arfgef3Imported
Synonyms:Big3, D10Bwg1379e, Kiaa1244
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:106387 Arfgef3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1488 – 1508HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Viable and fertile with normal body weight gain. Mice exhibit postprandial hyperinsulinemia and hyperglycemia, and impaired glucose tolerance. Three month old animals show severe insulin resistance in liver and muscle tissue, probably due to chronic insulin exposure.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002866721 – 2170Brefeldin A-inhibited guanine nucleotide-exchange protein 3Add BLAST2170

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei471PhosphoserineCombined sources1
Modified residuei628PhosphoserineCombined sources1
Modified residuei632PhosphoserineCombined sources1
Modified residuei1045PhosphoserineCombined sources1
Modified residuei1881PhosphoserineCombined sources1
Modified residuei1975PhosphoserineCombined sources1
Modified residuei1984PhosphoserineBy similarity1
Modified residuei2072PhosphoserineCombined sources1
Modified residuei2074PhosphoserineCombined sources1
Modified residuei2088PhosphoserineCombined sources1
Modified residuei2094PhosphoserineCombined sources1
Modified residuei2096PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3UGY8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3UGY8

PeptideAtlas

More...
PeptideAtlasi
Q3UGY8

PRoteomics IDEntifications database

More...
PRIDEi
Q3UGY8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3UGY8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3UGY8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q3UGY8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in pancreatic islet (insulin granules of islet alpha and beta cells) and brain (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000019852 Expressed in 173 organ(s), highest expression level in supraoptic nucleus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3UGY8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3UGY8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PHB2 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
229664, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q3UGY8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000019999

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3UGY8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini579 – 792SEC7Add BLAST214

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1846 Eukaryota
ENOG410XNND LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064150

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000074183

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3UGY8

KEGG Orthology (KO)

More...
KOi
K17572

Identification of Orthologs from Complete Genome Data

More...
OMAi
TCCWDSM

Database of Orthologous Groups

More...
OrthoDBi
40522at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3UGY8

TreeFam database of animal gene trees

More...
TreeFami
TF300714

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR015403 Sec7_C
IPR000904 Sec7_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00222 Sec7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3UGY8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEILRKLQR DASGSKYKAI KESCTWALET LGGLDTVVKI PPHLLREKCL
60 70 80 90 100
LPLQLALESK NVKLAQHALA GMQKLLSEER FVSMETDSDE KQLLNQILNA
110 120 130 140 150
VKVTPSLNED LQVEVMKVLL CITYTPTFDM NGSAVLKIAE VCIETYTCSC
160 170 180 190 200
HQRSINTAVR ATLSQMLGDL TLQLRQRQEN TIIENPDAPQ EFRSQGLTVE
210 220 230 240 250
ALCDDVISVL AVLCEKLQAS INDSQQLQLL YLECILSVLS SSSSSMHLHR
260 270 280 290 300
GFTDLIWKSL CPALVVILGN PIHDKTITSA HSTSTSTSME SDSASLGVSD
310 320 330 340 350
HGRGSGCSCT APTLSGPVAR TIYYLAAELV RLVGSVDSMK PVLQSLYHRV
360 370 380 390 400
LLYPPPQHRV EAIKIMKEIL GSPQRLYDLA GPSSIESEPR KRSISKRKSH
410 420 430 440 450
LDLLKLIMDG MTEACIKGGI EACYAAVSCV CTLLGALDEL SQGKGLNDTQ
460 470 480 490 500
VQQLLLRLEE LRDGAESSRD SMEINEADFR WQRRVLSSEH TPWESGNERS
510 520 530 540 550
PDISISVTTD TGQTTLEGEL GQTTPEDHKN GLKSPAIQEG KGTMGKVSEP
560 570 580 590 600
EAIDQPDVVQ RSHTVPYPDI TNFLSVDCRT RSYGSRYSES NFSVDDQDLS
610 620 630 640 650
RTEFDSCDQY SMAAEKDSGR SDVSDIGSDN CSLADEEQTP RDYIGHRSLR
660 670 680 690 700
TAALSLKLLK NQEADQHSAR LFIQSLEGLL PRLLALSSVE EVDSALQNFA
710 720 730 740 750
STFCSGMMHS PGFDGGSSLS FQMLMNADSL YTAAHCALLL NLKLSHGDYY
760 770 780 790 800
RKRPTVAPGM MKEFMKQVQT SGVLMVFSQA WLEELYHQVL DRNMLGEAGY
810 820 830 840 850
WGSPEDNSLP LITMLTDIDG LESSAIGGQL MASASVESPF TQSRRLDDST
860 870 880 890 900
VAGVAFARYI LVGCWKNLID TLSTPLTGRM AGSSKGLAFI LGAEGIKEQN
910 920 930 940 950
QKERDAICMS LDGLRKAARL SCALGVAANC ASALAQMAAA SCVQEEKEER
960 970 980 990 1000
QSQEPSDALA QVKLKVEQKL EQMGKVQGVW LHTAHVLCMD AILSVGLEMG
1010 1020 1030 1040 1050
SHNPDCWPHV FRVCEYVGTL EHTHFSDGIS QPPLTIHQPQ KTSGSSGLLG
1060 1070 1080 1090 1100
EIEFKSSSQE QSLEQGPSLN TAPVVQPHSI QELVRECSRG RTSDFRGGSL
1110 1120 1130 1140 1150
SGNSAAKVVL SLSTQADRLF DDATDKLNLT ALGGFLYQLK KASQSQLFHS
1160 1170 1180 1190 1200
VTDTVDYSLT MPGEVKSTQD QKSALHLFRL GDAMLRIVRS KARPLLHVMR
1210 1220 1230 1240 1250
CWSLVAPHLV EAACHKERHV SQKAVSFIHD ILTEVLTDWS EPPHFHFNEA
1260 1270 1280 1290 1300
LFRPFERIMQ LELCDEDVQD QVVTSIGELV EVCSAQIQSG WRPLFSALET
1310 1320 1330 1340 1350
VRSGNKSEVK EYLVGDYSMG KGQAPVFDVF EAFLNTDNIQ VFANAATSYI
1360 1370 1380 1390 1400
MCLMKFVKGL GEVDCKEIGD CVPGAGATST DLCLPALDYL RRCSQLLAKI
1410 1420 1430 1440 1450
YKMPLKPIFL SGRLASLPRR LQEQSASSED GIESVLSDFD DDTGLIEVWI
1460 1470 1480 1490 1500
ILLEQLTAAV SNCPRQHQPP TLDLLFELLR DVTKTPGPGF GIYAVVHLLL
1510 1520 1530 1540 1550
PVMSLWLLRS HKDHSYWDVA SANFKHAIGL SCELVVEHIQ SFLHSDIRYE
1560 1570 1580 1590 1600
SMINTMLKDL FELLVVCVAK PTETISRVGC SCIRYVLVTA GPVFTEEMWR
1610 1620 1630 1640 1650
LACCALQDAF SATLKPVKDL LGCFHGGTEG FSGEGCQVRV AAPSSSPSAE
1660 1670 1680 1690 1700
AEYWRIRAMA QQVFMLDTQC SPKTPNNFDH AQSCQLIIEL PHDEKPNGHA
1710 1720 1730 1740 1750
KKSVSFREIV VSLLSHQVLL QNLYDILLEE FVKGPSPGEE KTVQVPDTKL
1760 1770 1780 1790 1800
AGFLRYISMQ NLAVIFDLLL DSYRTAREFD TSPGLKCLLK KVSGIGGAAN
1810 1820 1830 1840 1850
LYRQSAMSFN IYFHALVCAV LTNQETITAE QVKKVLFEEE ERSSDSSQQC
1860 1870 1880 1890 1900
SSEDEDIFEE TAQVSPPRGK EKRQWRARLP SLSVQPVSNA DWVWLVKRLH
1910 1920 1930 1940 1950
KLCMELCNHY IQMHLDLESS LEEPLTFKSD PFFILPSFQS ESSTPSTGGF
1960 1970 1980 1990 2000
SGKNTPSEDD RREHLSEPQS LRVGSGDMLM LPPSPKTEKK DPGRKKEWWE
2010 2020 2030 2040 2050
SAGNKICTMA ADKTISKLMT EYKKRRQPHN LPPFPKEVKV DKKGEPLGPR
2060 2070 2080 2090 2100
GPDSPLLQRP QHLIDQGQMR HSFSAGPELL RQEKRPRSGS TGSSLSVSVR
2110 2120 2130 2140 2150
DAEAQIQAWT NMVLTVLNQI QILPDQTFTA LQPAVFPCIS QLTCHVTDIR
2160 2170
VRQAVREWLG RVGRVYDIIT
Length:2,170
Mass (Da):240,091
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD759EA53B747F56C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1N9M5I8A0A1N9M5I8_MOUSE
Brefeldin A-inhibited guanine nucle...
Arfgef3
1,709Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK147679 mRNA Translation: BAE28069.1
AK122475 mRNA Translation: BAC65757.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS23712.1

NCBI Reference Sequences

More...
RefSeqi
NP_001028430.1, NM_001033258.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000215836; ENSMUSP00000149210; ENSMUSG00000019852

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
215821

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:215821

UCSC genome browser

More...
UCSCi
uc007emn.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147679 mRNA Translation: BAE28069.1
AK122475 mRNA Translation: BAC65757.1
CCDSiCCDS23712.1
RefSeqiNP_001028430.1, NM_001033258.4

3D structure databases

SMRiQ3UGY8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi229664, 2 interactors
IntActiQ3UGY8, 1 interactor
STRINGi10090.ENSMUSP00000019999

PTM databases

iPTMnetiQ3UGY8
PhosphoSitePlusiQ3UGY8
SwissPalmiQ3UGY8

Proteomic databases

MaxQBiQ3UGY8
PaxDbiQ3UGY8
PeptideAtlasiQ3UGY8
PRIDEiQ3UGY8

Genome annotation databases

EnsembliENSMUST00000215836; ENSMUSP00000149210; ENSMUSG00000019852
GeneIDi215821
KEGGimmu:215821
UCSCiuc007emn.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57221
MGIiMGI:106387 Arfgef3

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1846 Eukaryota
ENOG410XNND LUCA
GeneTreeiENSGT00530000064150
HOGENOMiHOG000074183
InParanoidiQ3UGY8
KOiK17572
OMAiTCCWDSM
OrthoDBi40522at2759
PhylomeDBiQ3UGY8
TreeFamiTF300714

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Arfgef3 mouse

Protein Ontology

More...
PROi
PR:Q3UGY8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000019852 Expressed in 173 organ(s), highest expression level in supraoptic nucleus
ExpressionAtlasiQ3UGY8 baseline and differential
GenevisibleiQ3UGY8 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032629 DCB_dom
IPR015403 Sec7_C
IPR000904 Sec7_dom
PfamiView protein in Pfam
PF16213 DCB, 1 hit
PF09324 DUF1981, 1 hit
SMARTiView protein in SMART
SM00222 Sec7, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBIG3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UGY8
Secondary accession number(s): Q80TH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 11, 2005
Last modified: October 16, 2019
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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