UniProtKB - Q3UGX2 (Q3UGX2_MOUSE)
Protein
Spectrin beta chain
Gene
Sptb
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- actin filament binding Source: Ensembl
- ankyrin binding Source: Ensembl
- phospholipid binding Source: InterPro
- structural constituent of cytoskeleton Source: UniProtKB-UniRule
GO - Biological processi
- actin filament capping Source: UniProtKB-UniRule
Keywordsi
Molecular function | Actin cappingUniRule annotationARBA annotation, Actin-bindingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Spectrin beta chainUniRule annotation |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:98387, Sptb |
Subcellular locationi
Cytoskeleton
- spectrin Source: InterPro
- spectrin-associated cytoskeleton Source: Ensembl
Cytosol
- cytosol Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, CytoskeletonUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000021061, Expressed in blood and 216 other tissues |
Interactioni
GO - Molecular functioni
- actin filament binding Source: Ensembl
- ankyrin binding Source: Ensembl
Protein-protein interaction databases
IntActi | Q3UGX2, 2 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 158 | Calponin-homology (CH)InterPro annotationAdd BLAST | 105 | |
Domaini | 173 – 278 | Calponin-homology (CH)InterPro annotationAdd BLAST | 106 | |
Domaini | 2179 – 2289 | PHInterPro annotationAdd BLAST | 111 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 30 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 2069 – 2150 | DisorderedSequence analysisAdd BLAST | 82 | |
Regioni | 2157 – 2176 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 2303 – 2329 | DisorderedSequence analysisAdd BLAST | 27 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 113 – 133 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 457 – 498 | Sequence analysisAdd BLAST | 42 | |
Coiled coili | 785 – 805 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 997 – 1017 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1096 – 1116 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1246 – 1266 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1414 – 1441 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 1538 – 1565 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 1977 – 2001 | Sequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 16 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 2070 – 2091 | PolyampholyteSequence analysisAdd BLAST | 22 | |
Compositional biasi | 2131 – 2150 | PolyampholyteSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158908 |
OrthoDBi | 543832at2759 |
TreeFami | TF313446 |
Family and domain databases
CDDi | cd00014, CH, 2 hits |
Gene3Di | 1.10.418.10, 2 hits 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR001589, Actinin_actin-bd_CS IPR001715, CH-domain IPR036872, CH_dom_sf IPR011993, PH-like_dom_sf IPR041681, PH_9 IPR001605, PH_dom-spectrin-type IPR001849, PH_domain IPR018159, Spectrin/alpha-actinin IPR016343, Spectrin_bsu IPR002017, Spectrin_repeat |
Pfami | View protein in Pfam PF00307, CH, 2 hits PF15410, PH_9, 1 hit PF00435, Spectrin, 17 hits |
PIRSFi | PIRSF002297, Spectrin_beta_subunit, 1 hit |
PRINTSi | PR00683, SPECTRINPH |
SMARTi | View protein in SMART SM00033, CH, 2 hits SM00233, PH, 1 hit SM00150, SPEC, 17 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS00019, ACTININ_1, 1 hit PS00020, ACTININ_2, 1 hit PS50021, CH, 2 hits PS50003, PH_DOMAIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q3UGX2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSATEFENV GNQPPFSRIN ARWDAPDDEL DNDNSSARLF ERSRIKALAD
60 70 80 90 100
EREVVQKKTF TKWVNSHLAR VSCRISDLYK DLRDGRMLIK LLEVLSGEML
110 120 130 140 150
PRPTKGKMRI HCLENVDKAL QFLKEQRVHL ENMGSHDIVD GNHRLVLGLI
160 170 180 190 200
WTIILRFQIQ DIVVQTQEGR ETRSAKDALL LWCQMKTAGY PHVNVTNFTS
210 220 230 240 250
SWKDGLAFNA LIHKHRPDLI DFDKLKDSNA RHNLEHAFDV AERQLGIIPL
260 270 280 290 300
LDPEDVFTEN PDEKSIITYV VAFYHYFSKM KVLAVEGKRV GKVIDHAIET
310 320 330 340 350
EKMIEKYSGL ASDLLTWIEQ TISVLNSRKF ANSLSGVQQQ LQAFSTYRTV
360 370 380 390 400
EKPPKFQEKG NLEVLLFTIQ SRMRANNQKV YTPHDGKLVS DINRAWESLE
410 420 430 440 450
EAEYQRELAL RSELIRQEKL EQLARRFDRK AAMRETWLNE NQRLVTQDNF
460 470 480 490 500
GYDLAAVEAA KKKHEAIETD TAAYEERVKA LEDLAQELEK ENYHDQKRII
510 520 530 540 550
ARKDNILRLW SYLQELLRSR RQRLEATLAL QKLFQDMLHS IDWMDEIKAH
560 570 580 590 600
ILSAEFGKHL LEVEDLLQKH KLMEADIAIQ GDKVKAITAA TLQFAEGKGY
610 620 630 640 650
QPCDPQVIQD RVSHLEQCFS ELSNMAAGRK AQLEQSKRLW KFFWEMDEAE
660 670 680 690 700
SWIKEKEQIY SSLDYGKDLT SVLILQRKHK AFEDELRGLD AHLKQIFQEA
710 720 730 740 750
DDMVAQKQFG HPQIETRVKE VSAQWDHLKE LAAFRKKDLQ DAENFFQFQG
760 770 780 790 800
DADDLKAWLQ DAHRLLSGED VGQDEGATRA LGKKHKEFLE ELEESRGVME
810 820 830 840 850
HLEHQAQGFP EEFRDSPDVT NRLQALRKLY QQVLTQAELR GHKLQEALDL
860 870 880 890 900
YTVFGESDAC ELWMTEKGKW LDQMDIPNTL EDLEVVQHRF DILDQEMKTL
910 920 930 940 950
MAQIDGVNLA ANNLVESGHP RSGEVKQYQD RLNKRWQAFQ AVVSEQREAV
960 970 980 990 1000
DSALRVNNYC VDCEETSKWI MDKTKVVEST KDLGQDLAGV IAIQRKLSGL
1010 1020 1030 1040 1050
ERDVLAIRDR VSALERESQY LMESHPEQKE DIGQRQADVE KLWKGLQDAL
1060 1070 1080 1090 1100
QGQELSLGEA SKLQAFLQDL DDFKAWLSMA QKAVASEDMP ESLPEAEQLL
1110 1120 1130 1140 1150
QQHAAIKEEI DAHRDDYHRV KASGEKVIEG QTDPDYQLLG QRLEGLDTDW
1160 1170 1180 1190 1200
DALRRMWESR GNTLTQCLGF QEFQKDAKQA EAILSNQEYT LAHLEPPDSL
1210 1220 1230 1240 1250
AAAEAGIRKF EDFLVSMENN RDKILSPVDS GNKLVAEGNL YSNKIMEKVQ
1260 1270 1280 1290 1300
LIEDRHKKNN EKAQEATVLL KDNLELQNFL QNCKELTLWI NDKLLTSPDV
1310 1320 1330 1340 1350
SYDEARNLHN KWMKHQAFMA ELASHQGWLE NIDAEGRQLM AEKPQFKDVV
1360 1370 1380 1390 1400
SERLEALHKL WEELQSTAKA KAEQLSAARS SDLRLQTHAD LNKWIGAMED
1410 1420 1430 1440 1450
QLRSDDLGKD LTTVNRMLAK LKRVEEQVNL RKEELEELFA DAPSLGAEAG
1460 1470 1480 1490 1500
DTDMSIEKRF LDLLEPLGRR KKQLELSKAK LQISRDLEDE TLWVEERLPL
1510 1520 1530 1540 1550
AQSADYGTNL QTVQLFMKKN QTLQNEILGH APRVEDVLRR GQELVKAAEI
1560 1570 1580 1590 1600
DCQDIEERLG HLQSSWDTLR EAAAGRLQRL RDAHEAQQYY LDAGEAEAWI
1610 1620 1630 1640 1650
SEQELYVFSD EPPKDEEGAI VMLKRHLRQQ RTVEEYGRNI KQLAGRAQSL
1660 1670 1680 1690 1700
LSAGHPEGEQ IIRLQGQVDK QYAGLKDMAE ERRRRLENMY HLFQLKREAD
1710 1720 1730 1740 1750
DLEQWITEKE MVASSQEMGQ DFDHVTMLRD KFRDFARETG AIGQERVDNV
1760 1770 1780 1790 1800
NTIIERLIDA GHSEAATIAE WKDGLNDMWA DLLELIDTRM QLLAASYDLH
1810 1820 1830 1840 1850
RYFYTGTEIL GLIDEKHREL PEDVGLDAST AESFHRVHTA FERELHLLGV
1860 1870 1880 1890 1900
QVQQFQDVAT RLQTAYAGEK ADAIQSKEQE VSAAWQALLD ACAGRRAQLV
1910 1920 1930 1940 1950
DTADKFRFFS MVRDLLSWME SIIRQIETQE RPRDVSSVEL LLKYHQGIKA
1960 1970 1980 1990 2000
EINTRAKNFS TCLELGESLL QRQHQASDEI REKLQQVISR RQEMNDKWEA
2010 2020 2030 2040 2050
RSDRLHMLLE VCQFSRDASV AEAWLIAQEP YLASRDFGHT VDSVEKLIKR
2060 2070 2080 2090 2100
HEAFEKSTAS WAERFAALEK PTTLELKERQ TPERPTEEPG PQEEEGETAG
2110 2120 2130 2140 2150
EAPQVHHAAT ERTSPGEERG PWPQDLQPPP LPGHHKDEQE KSVGDERPAT
2160 2170 2180 2190 2200
EPLFKVLDTP LSEGDEPTTL PAQRDLGHTV QMEGYLGRKH DLEGPNKKAS
2210 2220 2230 2240 2250
NRSWNNLYCV LRNSQLTFYK DAKNLALGVP YHGEEPLALR HAICEIAVNY
2260 2270 2280 2290 2300
KKKKHVFKLR LSNGSEWLFH GKDEEEMLMW LQSMSTAINE SQSIRVKAQS
2310 2320
LPLPSLAGPD ASVGKKEKEK RFSFFPKKK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP15508 | SPTB1_MOUSE | Spectrin beta chain, erythrocytic | Sptb Spnb-1, Spnb1, Sptb1 | 2,128 | Annotation score: | ||
E9Q397 | E9Q397_MOUSE | Spectrin beta chain | Sptb Spnb1 | 2,137 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC132482 Genomic DNA No translation available. AC163033 Genomic DNA No translation available. BC129806 mRNA Translation: AAI29807.1 AK147299 mRNA Translation: BAE27831.1 AK147704 mRNA Translation: BAE28085.1 |
RefSeqi | NP_038703.3, NM_013675.3 |
Genome annotation databases
Ensembli | ENSMUST00000021458; ENSMUSP00000021458; ENSMUSG00000021061 |
GeneIDi | 20741 |
KEGGi | mmu:20741 |
UCSCi | uc007nyo.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC132482 Genomic DNA No translation available. AC163033 Genomic DNA No translation available. BC129806 mRNA Translation: AAI29807.1 AK147299 mRNA Translation: BAE27831.1 AK147704 mRNA Translation: BAE28085.1 |
RefSeqi | NP_038703.3, NM_013675.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q3UGX2, 2 interactors |
Protocols and materials databases
Antibodypediai | 183, 109 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000021458; ENSMUSP00000021458; ENSMUSG00000021061 |
GeneIDi | 20741 |
KEGGi | mmu:20741 |
UCSCi | uc007nyo.1, mouse |
Organism-specific databases
CTDi | 6710 |
MGIi | MGI:98387, Sptb |
Phylogenomic databases
GeneTreei | ENSGT00940000158908 |
OrthoDBi | 543832at2759 |
TreeFami | TF313446 |
Miscellaneous databases
BioGRID-ORCSi | 20741, 1 hit in 17 CRISPR screens |
ChiTaRSi | Sptb, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000021061, Expressed in blood and 216 other tissues |
Family and domain databases
CDDi | cd00014, CH, 2 hits |
Gene3Di | 1.10.418.10, 2 hits 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR001589, Actinin_actin-bd_CS IPR001715, CH-domain IPR036872, CH_dom_sf IPR011993, PH-like_dom_sf IPR041681, PH_9 IPR001605, PH_dom-spectrin-type IPR001849, PH_domain IPR018159, Spectrin/alpha-actinin IPR016343, Spectrin_bsu IPR002017, Spectrin_repeat |
Pfami | View protein in Pfam PF00307, CH, 2 hits PF15410, PH_9, 1 hit PF00435, Spectrin, 17 hits |
PIRSFi | PIRSF002297, Spectrin_beta_subunit, 1 hit |
PRINTSi | PR00683, SPECTRINPH |
SMARTi | View protein in SMART SM00033, CH, 2 hits SM00233, PH, 1 hit SM00150, SPEC, 17 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS00019, ACTININ_1, 1 hit PS00020, ACTININ_2, 1 hit PS50021, CH, 2 hits PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3UGX2_MOUSE | |
Accessioni | Q3UGX2Primary (citable) accession number: Q3UGX2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 10, 2021 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |