UniProtKB - Q3UGQ1 (Q3UGQ1_MOUSE)
Protein
Cellular tumor antigen p53
Gene
Trp53
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.UniRule annotation
Cofactori
Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- transcription regulatory region sequence-specific DNA binding Source: InterPro
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell cycle Source: UniProtKB-KW
- protein tetramerization Source: InterPro
- rhythmic process Source: UniProtKB-KW
Keywordsi
Molecular function | ActivatorUniRule annotationARBA annotation, DNA-bindingUniRule annotationARBA annotation, RepressorARBA annotation |
Biological process | ApoptosisUniRule annotationARBA annotation, Biological rhythmsARBA annotation, Cell cycleUniRule annotationARBA annotation, NecrosisARBA annotation, Transcription, Transcription regulationUniRule annotation |
Ligand | Metal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Cellular tumor antigen p53UniRule annotationARBA annotation |
Gene namesi | Name:Trp53Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:98834, Trp53 |
Subcellular locationi
Nucleus
- PML body ARBA annotation
Endoplasmic reticulum
- Endoplasmic reticulum ARBA annotation
Mitochondrion
- Mitochondrion matrix ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
Nucleus
- PML body Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationARBA annotation, Endoplasmic reticulumARBA annotation, NucleusUniRule annotationPTM / Processingi
Keywords - PTMi
Isopeptide bondARBA annotation, PhosphoproteinARBA annotation, Ubl conjugationARBA annotationInteractioni
Subunit structurei
Binds DNA as a homotetramer.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 31 | P53_TADInterPro annotationAdd BLAST | 23 | |
Domaini | 97 – 285 | P53InterPro annotationAdd BLAST | 189 | |
Domaini | 316 – 353 | P53_tetramerInterPro annotationAdd BLAST | 38 |
Sequence similaritiesi
Phylogenomic databases
OrthoDBi | 257530at2759 |
Family and domain databases
CDDi | cd08367, P53, 1 hit |
Gene3Di | 2.60.40.720, 1 hit 4.10.170.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR011615, p53_DNA-bd IPR036674, p53_tetramer_sf IPR010991, p53_tetrameristn IPR013872, p53_transactivation_domain IPR002117, p53_tumour_suppressor |
PANTHERi | PTHR11447, PTHR11447, 1 hit |
Pfami | View protein in Pfam PF00870, P53, 1 hit PF08563, P53_TAD, 1 hit PF07710, P53_tetramer, 1 hit |
PRINTSi | PR00386, P53SUPPRESSR |
SUPFAMi | SSF47719, SSF47719, 1 hit SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS00348, P53, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q3UGQ1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTAMEESQSD ISLELPLSQE TFSGLWKLLP PEDILPSPHC MDDLLLPQDV
60 70 80 90 100
EEFFEGPSEA LRVSGAPAAQ DPVTETPGPV APAPATPWPL SSFVPSQKTY
110 120 130 140 150
QGNYGFHLGF LQSGTAKSVM CTYSPPLNKL FCQLAKTCPV QLWVSATPPA
160 170 180 190 200
GSRVRAMAIY KKSQHMTEVV RRCPHHERCS DGDGLAPPQH LIRVEGNLYP
210 220 230 240 250
EYLEDRQTFR HSVVVPYEPP EAGSEYTTIH YKYMCNSSCM GGMNRRPILT
260 270 280 290 300
IITLEDSSGN LLGRDSFEVR VCACPGRDRR TEEENFRKKE VLCPELPPGS
310 320 330 340 350
AKRALPTCTS ASPPQKKKPL DGEYFTLKIR GRKRFEMFRE LNEALELKDA
HATEESG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 357 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK147815 mRNA Translation: BAE28156.1 |
RefSeqi | NP_035770.2, NM_011640.3 |
Genome annotation databases
GeneIDi | 22059 |
KEGGi | mmu:22059 |
UCSCi | uc011xww.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK147815 mRNA Translation: BAE28156.1 |
RefSeqi | NP_035770.2, NM_011640.3 |
3D structure databases
SMRi | Q3UGQ1 |
ModBasei | Search... |
Protocols and materials databases
DNASUi | 22059 |
Genome annotation databases
GeneIDi | 22059 |
KEGGi | mmu:22059 |
UCSCi | uc011xww.1, mouse |
Organism-specific databases
CTDi | 22059 |
MGIi | MGI:98834, Trp53 |
Phylogenomic databases
OrthoDBi | 257530at2759 |
Miscellaneous databases
BioGRID-ORCSi | 22059, 7 hits in 55 CRISPR screens |
ChiTaRSi | Trp53, mouse |
SOURCEi | Search... |
Gene expression databases
Genevisiblei | Q3UGQ1, MM |
Family and domain databases
CDDi | cd08367, P53, 1 hit |
Gene3Di | 2.60.40.720, 1 hit 4.10.170.10, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR011615, p53_DNA-bd IPR036674, p53_tetramer_sf IPR010991, p53_tetrameristn IPR013872, p53_transactivation_domain IPR002117, p53_tumour_suppressor |
PANTHERi | PTHR11447, PTHR11447, 1 hit |
Pfami | View protein in Pfam PF00870, P53, 1 hit PF08563, P53_TAD, 1 hit PF07710, P53_tetramer, 1 hit |
PRINTSi | PR00386, P53SUPPRESSR |
SUPFAMi | SSF47719, SSF47719, 1 hit SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS00348, P53, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3UGQ1_MOUSE | |
Accessioni | Q3UGQ1Primary (citable) accession number: Q3UGQ1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | April 7, 2021 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |