UniProtKB - Q3UG89 (Q3UG89_MOUSE)
Protein
Major prion protein
Gene
Prnp
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Biological processi
- protein homooligomerization Source: InterPro
Keywordsi
Molecular function | PrionUniRule annotationARBA annotation |
Ligand | CopperARBA annotation, ZincARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Major prion proteinUniRule annotationARBA annotation |
Gene namesi | Name:PrnpImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:97769, Prnp |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; GPI-anchor ARBA annotation
Golgi apparatus
- Golgi apparatus ARBA annotation
Other locations
- Membrane ARBA annotation; GPI-anchor ARBA annotation
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- anchored component of membrane Source: UniProtKB-KW
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 111 – 130 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 234 – 253 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Amyloid, Cell membraneUniRule annotation, Golgi apparatusARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_5004230118 | 23 – 254 | Major prion proteinSequence analysisAdd BLAST | 232 |
Keywords - PTMi
Glycoprotein, GPI-anchorARBA annotation, LipoproteinFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 112 – 127 | Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST | 16 | |
Domaini | 199 – 217 | Prion/Doppel_prot_b-ribbon_domInterPro annotationAdd BLAST | 19 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 104 | DisorderedSequence analysisAdd BLAST | 80 |
Sequence similaritiesi
Keywords - Domaini
RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
OrthoDBi | 1403854at2759 |
Family and domain databases
Gene3Di | 1.10.790.10, 1 hit |
InterProi | View protein in InterPro IPR000817, Prion IPR036924, Prion/Doppel_b-ribbon_dom_sf IPR022416, Prion/Doppel_prot_b-ribbon_dom IPR025860, Prion_N_dom |
Pfami | View protein in Pfam PF00377, Prion, 1 hit PF11587, Prion_bPrPp, 1 hit |
PRINTSi | PR00341, PRION |
SMARTi | View protein in SMART SM00157, PRP, 1 hit |
SUPFAMi | SSF54098, SSF54098, 1 hit |
PROSITEi | View protein in PROSITE PS00291, PRION_1, 1 hit PS00706, PRION_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3UG89-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANLGYWLLA LFVTMWTDVG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP
60 70 80 90 100
PQGGTWGQPH GGGWGQPHGG SWGQPHGGSW GQPHGGGWGQ GGGTHNQWNK
110 120 130 140 150
PSKPKTNLKH VAGAAAAGAV VGGLGGYMLG SAMSRPMVHF GNDWEDRYYR
160 170 180 190 200
ENMYRYPNQV YYRPVDQYSN QNNFVHDCVN ITIKQHTVTT TTKGENFTET
210 220 230 240 250
DVKMMERVVE QMCVTQYQKE SQAYYDGRRS SSTVLFSSPP VILLISFLIF
LIVG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK148061 mRNA Translation: BAE28320.1 |
RefSeqi | NP_035300.1, NM_011170.3 |
Genome annotation databases
GeneIDi | 19122 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK148061 mRNA Translation: BAE28320.1 |
RefSeqi | NP_035300.1, NM_011170.3 |
3D structure databases
SMRi | Q3UG89 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 19122 |
Organism-specific databases
CTDi | 5621 |
MGIi | MGI:97769, Prnp |
Phylogenomic databases
OrthoDBi | 1403854at2759 |
Miscellaneous databases
BioGRID-ORCSi | 19122, 0 hits in 17 CRISPR screens |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 1.10.790.10, 1 hit |
InterProi | View protein in InterPro IPR000817, Prion IPR036924, Prion/Doppel_b-ribbon_dom_sf IPR022416, Prion/Doppel_prot_b-ribbon_dom IPR025860, Prion_N_dom |
Pfami | View protein in Pfam PF00377, Prion, 1 hit PF11587, Prion_bPrPp, 1 hit |
PRINTSi | PR00341, PRION |
SMARTi | View protein in SMART SM00157, PRP, 1 hit |
SUPFAMi | SSF54098, SSF54098, 1 hit |
PROSITEi | View protein in PROSITE PS00291, PRION_1, 1 hit PS00706, PRION_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3UG89_MOUSE | |
Accessioni | Q3UG89Primary (citable) accession number: Q3UG89 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 116 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |