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Protein

Radial spoke head protein 3 homolog A

Gene

Rsph3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Radial spoke head protein 3 homolog A
Alternative name(s):
A-kinase anchor protein RSPH3A
Radial spoke head-like protein 2A
Gene namesi
Name:Rsph3a
Synonyms:Rshl2, Rshl2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914082 Rsph3a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003137421 – 516Radial spoke head protein 3 homolog AAdd BLAST516

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei270Phosphothreonine; by MAPK1By similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UFY4
PaxDbiQ3UFY4
PRIDEiQ3UFY4

PTM databases

iPTMnetiQ3UFY4
PhosphoSitePlusiQ3UFY4

Expressioni

Gene expression databases

BgeeiENSMUSG00000073471 Expressed in 25 organ(s), highest expression level in testis
CleanExiMM_RSHL2A
GenevisibleiQ3UFY4 MM

Interactioni

Subunit structurei

Interacts with phosphorylated MAPK1. Interacts with MEK1. Interacts with PKA regulatory subunits PRKAR1A and PRKAR1B (By similarity).By similarity

Protein-protein interaction databases

BioGridi211749, 1 interactor
STRINGi10090.ENSMUSP00000095034

Structurei

3D structure databases

ProteinModelPortaliQ3UFY4
SMRiQ3UFY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili333 – 369Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi319 – 322Poly-Glu4

Sequence similaritiesi

Belongs to the flagellar radial spoke RSP3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJ85 Eukaryota
ENOG410ZPSP LUCA
GeneTreeiENSGT00390000004172
HOGENOMiHOG000259276
HOVERGENiHBG067489
InParanoidiQ3UFY4
OMAiVHKHNET
OrthoDBiEOG091G0DQH
PhylomeDBiQ3UFY4
TreeFamiTF324184

Family and domain databases

InterProiView protein in InterPro
IPR009290 Radial_spoke_3
PANTHERiPTHR21648 PTHR21648, 1 hit
PfamiView protein in Pfam
PF06098 Radial_spoke_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q3UFY4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATNIWAAL PAKKRPLHQR ARRPAGGRGR EPEVPFTTDP SGNPAGRNCL
60 70 80 90 100
EFLPPGGTSG CSATDGGATV PLALRPFLRE RRPLGSQHPC PWHYLQVSDY
110 120 130 140 150
DDSLAPTCFR AHLHRRGSSS TLNQASAMTD PNPRTAEASG LYTYSSRPRA
160 170 180 190 200
VACQRRRHRD SILQPVEEPM SYGNIMYDRR VIRGNTYALP TGQVPGQPDP
210 220 230 240 250
LELQRQQQAR RRALARKRAQ EQLKPRTPEP VEGRKHVDIQ TELYLEEIAD
260 270 280 290 300
RIVEVDMECQ TDAFLDRPPT PLFIPAKTGK DVATQILGGE LFDFDLEVKP
310 320 330 340 350
MLEVLVGKTI EQSLLEVMEE EELANLRARQ YAYEEIRNVE LAEVQRLEEQ
360 370 380 390 400
ERRHREEKER RKKQQWEIVH KRNETLQKIS ALIFARQYLA NLLPSVFDKL
410 420 430 440 450
RNSGFFYDPI ERDIEVGFLP WLMNEVEKSM EHSMVGRTVL DMLIRDVVER
460 470 480 490 500
RINDYEHKEA MPPGQKTNVI NGPNTVTDPS VTTLHTQKPV LDRVSSQPAP
510
SQERKPVEEG GHLMAE
Length:516
Mass (Da):58,786
Last modified:October 11, 2005 - v1
Checksum:i50B579E28D5C0FD2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A338P7J7A0A338P7J7_MOUSE
Radial spoke head protein 3 homolog...
Rsph3a
515Annotation score:
A0A338P6Z9A0A338P6Z9_MOUSE
Radial spoke head protein 3 homolog...
Rsph3a
133Annotation score:

Sequence cautioni

The sequence BAB25385 differs from that shown. Reason: Frameshift at position 65.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti297E → G in BAB25385 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007979 mRNA Translation: BAB25385.1 Frameshift.
AK148230 mRNA Translation: BAE28425.1
CCDSiCCDS49943.1
RefSeqiNP_080065.4, NM_025789.5
UniGeneiMm.29830
Mm.359991

Genome annotation databases

EnsembliENSMUST00000097423; ENSMUSP00000095034; ENSMUSG00000073471
GeneIDi66832
KEGGimmu:66832
UCSCiuc008ait.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007979 mRNA Translation: BAB25385.1 Frameshift.
AK148230 mRNA Translation: BAE28425.1
CCDSiCCDS49943.1
RefSeqiNP_080065.4, NM_025789.5
UniGeneiMm.29830
Mm.359991

3D structure databases

ProteinModelPortaliQ3UFY4
SMRiQ3UFY4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211749, 1 interactor
STRINGi10090.ENSMUSP00000095034

PTM databases

iPTMnetiQ3UFY4
PhosphoSitePlusiQ3UFY4

Proteomic databases

MaxQBiQ3UFY4
PaxDbiQ3UFY4
PRIDEiQ3UFY4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097423; ENSMUSP00000095034; ENSMUSG00000073471
GeneIDi66832
KEGGimmu:66832
UCSCiuc008ait.2 mouse

Organism-specific databases

CTDi66832
MGIiMGI:1914082 Rsph3a

Phylogenomic databases

eggNOGiENOG410IJ85 Eukaryota
ENOG410ZPSP LUCA
GeneTreeiENSGT00390000004172
HOGENOMiHOG000259276
HOVERGENiHBG067489
InParanoidiQ3UFY4
OMAiVHKHNET
OrthoDBiEOG091G0DQH
PhylomeDBiQ3UFY4
TreeFamiTF324184

Miscellaneous databases

PROiPR:Q3UFY4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000073471 Expressed in 25 organ(s), highest expression level in testis
CleanExiMM_RSHL2A
GenevisibleiQ3UFY4 MM

Family and domain databases

InterProiView protein in InterPro
IPR009290 Radial_spoke_3
PANTHERiPTHR21648 PTHR21648, 1 hit
PfamiView protein in Pfam
PF06098 Radial_spoke_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRSH3A_MOUSE
AccessioniPrimary (citable) accession number: Q3UFY4
Secondary accession number(s): Q9D8J2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: September 12, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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