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Protein

Protein zyg-11 homolog B

Gene

Zyg11b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC.By similarity

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein zyg-11 homolog B
Gene namesi
Name:Zyg11b
Synonyms:Kiaa1730
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2685277 Zyg11b

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003050881 – 744Protein zyg-11 homolog BAdd BLAST744

Proteomic databases

EPDiQ3UFS0
MaxQBiQ3UFS0
PaxDbiQ3UFS0
PeptideAtlasiQ3UFS0
PRIDEiQ3UFS0

PTM databases

iPTMnetiQ3UFS0
PhosphoSitePlusiQ3UFS0

Expressioni

Gene expression databases

BgeeiENSMUSG00000034636 Expressed in 272 organ(s), highest expression level in brain
CleanExiMM_ZYG11B
GenevisibleiQ3UFS0 MM

Interactioni

Subunit structurei

Interacts with TCEB1/Elongin C. Part of an E3 ubiquitin ligase complex including ZYG11B, CUL2 and Elongin BC (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043844

Structurei

3D structure databases

ProteinModelPortaliQ3UFS0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati185 – 208LRR 1Add BLAST24
Repeati216 – 236LRR 2Add BLAST21
Repeati237 – 261LRR 3Add BLAST25

Sequence similaritiesi

Belongs to the zyg-11 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG3665 Eukaryota
ENOG410XPSX LUCA
GeneTreeiENSGT00530000063187
HOVERGENiHBG108780
InParanoidiQ3UFS0
KOiK10350
OMAiHVCSKNA
OrthoDBiEOG091G031E
PhylomeDBiQ3UFS0
TreeFamiTF313007

Family and domain databases

Gene3Di1.25.10.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q3UFS0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPEDQAHAAM EEASPYSLLD ICLSFLTTNL EKFCSARQDG TLCLQEPGVF
60 70 80 90 100
PQEVADRLLQ TIAFHGLLND GTVGIFRGNQ MRLKRACIRK AKISAVAFRK
110 120 130 140 150
AFCHHKLVEL DATGVNADIT ITDIISGLGS NKWIQQNLQC LVLNSLTLSL
160 170 180 190 200
EDPYERCFSR LSGLRALSIT NVLFYNEDLA EVASLPRLES LDISNTSITD
210 220 230 240 250
ITALLACKDR LKSLTMHHLK CLKMTTTQIL DVVRELKHLN HLDISDDKQF
260 270 280 290 300
TSDIALRLLE QKDILPNLVS LDVSGRKHVT DKAVEAFIQQ RPSMQFVGLL
310 320 330 340 350
ATDAGYSEFL MGKGHLKVSG EANETQIAEA LRRYSERAFF VREALFHLFS
360 370 380 390 400
LTHVMEKTKP DILKLVVTGM RNHPMNLPVQ LAASACVFNL TKQDLALGMP
410 420 430 440 450
VRLLADVTHL LLKAMEHFPN HQQLQKNCLL SLCSDRILQD VPFNRFEAAK
460 470 480 490 500
LVMQWLCNHE DQNMQRMAVA IISILAAKLS TEQTAQLGAE LFIVRQLLQI
510 520 530 540 550
VKQKTNQNSV DTTLKFTLSA LWNLTDESPT TCRHFIENQG LELFMRVLES
560 570 580 590 600
FPTESSIQQK VLGLLNNIAE VQELHSELMW KDFIDHISSL LHSVEVEVSY
610 620 630 640 650
FAAGIIAHLI SRGEQAWTLS RSQRNSLLDD LHSAILKWPT PECEMVAYRS
660 670 680 690 700
FNPFFPLLGC FTTPGVQLWA VWAMQHVCSK NPSRYCSMLI EEGGLQHLYN
710 720 730 740
IKEHEQTDPY VQQIAVAILD SLEKHIVRHG RPPPCKKQPQ ARLN
Length:744
Mass (Da):83,991
Last modified:October 2, 2007 - v2
Checksum:iC08B0CF8381622F6
GO
Isoform 2 (identifier: Q3UFS0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-447: FE → QV
     448-744: Missing.

Note: No experimental confirmation available.
Show »
Length:447
Mass (Da):50,102
Checksum:i17FA70C01D4776E0
GO
Isoform 3 (identifier: Q3UFS0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     471-477: IISILAA → LALNSKH
     478-744: Missing.

Note: No experimental confirmation available.
Show »
Length:477
Mass (Da):53,585
Checksum:iC7E56DEE045D714F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263D → G in BAE28490 (PubMed:16141072).Curated1
Sequence conflicti289Q → K in BAE37005 (PubMed:16141072).Curated1
Sequence conflicti311M → T in BAE38609 (PubMed:16141072).Curated1
Sequence conflicti532C → S in BAE28658 (PubMed:16141072).Curated1
Sequence conflicti576S → P in BAE28490 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028225446 – 447FE → QV in isoform 2. 1 Publication2
Alternative sequenceiVSP_028226448 – 744Missing in isoform 2. 1 PublicationAdd BLAST297
Alternative sequenceiVSP_028227471 – 477IISILAA → LALNSKH in isoform 3. 1 Publication7
Alternative sequenceiVSP_028228478 – 744Missing in isoform 3. 1 PublicationAdd BLAST267

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148335 mRNA Translation: BAE28490.1
AK148760 mRNA Translation: BAE28658.1
AK162646 mRNA Translation: BAE37005.1
AK166031 mRNA Translation: BAE38532.1
AK166174 mRNA Translation: BAE38609.1
BX293563, AL627238 Genomic DNA Translation: CAM22563.1
AL627238, BX293563 Genomic DNA Translation: CAM25320.1
BC117977 mRNA Translation: AAI17978.1
BC117978 mRNA Translation: AAI17979.1
BC139383 mRNA Translation: AAI39384.1
BC139384 mRNA Translation: AAI39385.1
AK122545 mRNA Translation: BAC65827.1
CCDSiCCDS18448.1 [Q3UFS0-1]
RefSeqiNP_001028806.2, NM_001033634.3 [Q3UFS0-1]
UniGeneiMm.426241

Genome annotation databases

EnsembliENSMUST00000043616; ENSMUSP00000043844; ENSMUSG00000034636 [Q3UFS0-1]
GeneIDi414872
KEGGimmu:414872
UCSCiuc008uax.2 mouse [Q3UFS0-1]
uc008uay.2 mouse [Q3UFS0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148335 mRNA Translation: BAE28490.1
AK148760 mRNA Translation: BAE28658.1
AK162646 mRNA Translation: BAE37005.1
AK166031 mRNA Translation: BAE38532.1
AK166174 mRNA Translation: BAE38609.1
BX293563, AL627238 Genomic DNA Translation: CAM22563.1
AL627238, BX293563 Genomic DNA Translation: CAM25320.1
BC117977 mRNA Translation: AAI17978.1
BC117978 mRNA Translation: AAI17979.1
BC139383 mRNA Translation: AAI39384.1
BC139384 mRNA Translation: AAI39385.1
AK122545 mRNA Translation: BAC65827.1
CCDSiCCDS18448.1 [Q3UFS0-1]
RefSeqiNP_001028806.2, NM_001033634.3 [Q3UFS0-1]
UniGeneiMm.426241

3D structure databases

ProteinModelPortaliQ3UFS0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043844

PTM databases

iPTMnetiQ3UFS0
PhosphoSitePlusiQ3UFS0

Proteomic databases

EPDiQ3UFS0
MaxQBiQ3UFS0
PaxDbiQ3UFS0
PeptideAtlasiQ3UFS0
PRIDEiQ3UFS0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043616; ENSMUSP00000043844; ENSMUSG00000034636 [Q3UFS0-1]
GeneIDi414872
KEGGimmu:414872
UCSCiuc008uax.2 mouse [Q3UFS0-1]
uc008uay.2 mouse [Q3UFS0-2]

Organism-specific databases

CTDi79699
MGIiMGI:2685277 Zyg11b
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3665 Eukaryota
ENOG410XPSX LUCA
GeneTreeiENSGT00530000063187
HOVERGENiHBG108780
InParanoidiQ3UFS0
KOiK10350
OMAiHVCSKNA
OrthoDBiEOG091G031E
PhylomeDBiQ3UFS0
TreeFamiTF313007

Miscellaneous databases

ChiTaRSiZyg11b mouse
PROiPR:Q3UFS0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034636 Expressed in 272 organ(s), highest expression level in brain
CleanExiMM_ZYG11B
GenevisibleiQ3UFS0 MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZY11B_MOUSE
AccessioniPrimary (citable) accession number: Q3UFS0
Secondary accession number(s): B9EID5
, Q148T6, Q3TM33, Q3TMB0, Q3TRM3, Q3UFA3, Q80TA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 7, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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