Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleolar MIF4G domain-containing protein 1

Gene

Nom1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in targeting PPP1CA to the nucleolus.By similarity

GO - Molecular functioni

  • RNA binding Source: GO_Central

GO - Biological processi

  • hair follicle maturation Source: MGI
  • ribosomal small subunit biogenesis Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar MIF4G domain-containing protein 1
Alternative name(s):
SGD1 homolog
Gene namesi
Name:Nom1
Synonyms:Gm1040
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1861749 Nom1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002868241 – 854Nucleolar MIF4G domain-containing protein 1Add BLAST854

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineBy similarity1
Modified residuei311PhosphoserineBy similarity1
Modified residuei314PhosphoserineCombined sources1
Modified residuei315PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3UFM5
MaxQBiQ3UFM5
PaxDbiQ3UFM5
PeptideAtlasiQ3UFM5
PRIDEiQ3UFM5

PTM databases

iPTMnetiQ3UFM5
PhosphoSitePlusiQ3UFM5

Expressioni

Gene expression databases

BgeeiENSMUSG00000001569 Expressed in 28 organ(s), highest expression level in female gonad
CleanExiMM_GM1040

Interactioni

Subunit structurei

May interact with EIF4A1, EIF4A2 and EIF4A3. Interacts with PPP1CA and PPP1CC (By similarity).By similarity

Protein-protein interaction databases

BioGridi241474, 1 interactor
STRINGi10090.ENSMUSP00000001611

Structurei

3D structure databases

ProteinModelPortaliQ3UFM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini356 – 553MIF4GPROSITE-ProRule annotationAdd BLAST198
Domaini648 – 764MIPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 275Necessary for nucleolar localization and for targeting PPP1CA to the nucleolusBy similarityAdd BLAST274

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi301 – 304Required for efficient binding to PPP1CA and for targeting PPP1CA to the nucleolusBy similarity4

Sequence similaritiesi

Belongs to the CWC22 family.Curated

Phylogenomic databases

eggNOGiKOG2141 Eukaryota
ENOG410XNNQ LUCA
GeneTreeiENSGT00550000075087
HOGENOMiHOG000044155
HOVERGENiHBG098839
InParanoidiQ3UFM5
KOiK17583
OMAiQEHMVLL
OrthoDBiEOG091G03TZ
TreeFamiTF312808

Family and domain databases

Gene3Di1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
PfamiView protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit
SMARTiView protein in SMART
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51366 MI, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UFM5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRNVPEVNG VYRHGACELW CRAMAHALLK RSGVRRGLGG REGPLKRLRL
60 70 80 90 100
AVEDFVRTTS ESEACESRSA VARSRPGGRK SRKELRKEKR HLRKARRLQR
110 120 130 140 150
TVGSGSGDQG GNVGLNDGPE TRRPPTEVRP TPAKATATPA KASAPSTNTK
160 170 180 190 200
ASAAQPKAKA KGAPGKPGPA TATARKRALL AANEEEDREI RKLERCLGLH
210 220 230 240 250
KRKKKGDGSS VPLSFARDGL DYILGALECG SGGGLYESSE EEEEEKLETG
260 270 280 290 300
QTVLESDLES NSKESEEDPD WQVLQEDQED VNSKRRGEAE SGTRGNKGTK
310 320 330 340 350
KVRFAEVVEK SRSSSEDDIE QQESHSVESG EKYIPPRLRN EEVIDVHKKE
360 370 380 390 400
ELDRLKKHVK GLINRLSEPN MASISGQLEE LYMAHSRKDM NDTLTTALMD
410 420 430 440 450
ACVTASAMPS RLMMEHVFLV SILHHTVGIE VGACFLEAVV KKFDAIYRDG
460 470 480 490 500
GEGKELDNLF TMIAHLYNFH VVQSILIFDI LKKLVGTFTE KDIELILLML
510 520 530 540 550
KNVGFALRKD DALSLKELIT EAQTQASGAG NKFQDQNRVR FMLETMLALK
560 570 580 590 600
NNDLRKIPGY NPEPVEKLKK LQRTLVRNAG SGSETRLRIS WDGILNAEQT
610 620 630 640 650
GRWWIVGSAW SGTPMIDNSH HIQLQKPLAG MASSKMLELA RKQRMNTDVR
660 670 680 690 700
RIIFCTLMTS EDFLDAFEKL LKLGLKDQQE REIVHILMDC CLQEKTYNPF
710 720 730 740 750
YAFLASKFCD YERRFQMTFQ FSIWDKFRDL ENLPDTKFSN LVHLLAHLLR
760 770 780 790 800
TKSLPLSVLK VVEFSELDKP RVHFLRRVLT ALLMETEDDD LAVIFSRVSD
810 820 830 840 850
NPKLGMLREG LKLFIGHFLL KHTQAHQSAE EASLLREKAG LASKSLQGKA

ILRM
Length:854
Mass (Da):95,960
Last modified:July 27, 2011 - v2
Checksum:i0A9BC99B9F521475
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti309E → D in BAE28535 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148406 mRNA Translation: BAE28535.1
AC171500 Genomic DNA No translation available.
CCDSiCCDS19149.1
RefSeqiNP_001028629.2, NM_001033457.2
UniGeneiMm.262815

Genome annotation databases

EnsembliENSMUST00000001611; ENSMUSP00000001611; ENSMUSG00000001569
GeneIDi433864
KEGGimmu:433864
UCSCiuc008wuj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148406 mRNA Translation: BAE28535.1
AC171500 Genomic DNA No translation available.
CCDSiCCDS19149.1
RefSeqiNP_001028629.2, NM_001033457.2
UniGeneiMm.262815

3D structure databases

ProteinModelPortaliQ3UFM5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi241474, 1 interactor
STRINGi10090.ENSMUSP00000001611

PTM databases

iPTMnetiQ3UFM5
PhosphoSitePlusiQ3UFM5

Proteomic databases

EPDiQ3UFM5
MaxQBiQ3UFM5
PaxDbiQ3UFM5
PeptideAtlasiQ3UFM5
PRIDEiQ3UFM5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001611; ENSMUSP00000001611; ENSMUSG00000001569
GeneIDi433864
KEGGimmu:433864
UCSCiuc008wuj.1 mouse

Organism-specific databases

CTDi64434
MGIiMGI:1861749 Nom1

Phylogenomic databases

eggNOGiKOG2141 Eukaryota
ENOG410XNNQ LUCA
GeneTreeiENSGT00550000075087
HOGENOMiHOG000044155
HOVERGENiHBG098839
InParanoidiQ3UFM5
KOiK17583
OMAiQEHMVLL
OrthoDBiEOG091G03TZ
TreeFamiTF312808

Miscellaneous databases

PROiPR:Q3UFM5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001569 Expressed in 28 organ(s), highest expression level in female gonad
CleanExiMM_GM1040

Family and domain databases

Gene3Di1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
PfamiView protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit
SMARTiView protein in SMART
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51366 MI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNOM1_MOUSE
AccessioniPrimary (citable) accession number: Q3UFM5
Secondary accession number(s): E9QPB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again