We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q3UFM5 (NOM1_MOUSE)
Protein
Nucleolar MIF4G domain-containing protein 1
Gene
Nom1
Organism
Mus musculus (Mouse)
Status
Functioni
Plays a role in targeting PPP1CA to the nucleolus.
By similarityGO - Molecular functioni
- RNA binding Source: GO_Central
GO - Biological processi
- hair follicle maturation Source: MGI
- ribosomal small subunit biogenesis Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Nucleolar MIF4G domain-containing protein 1Alternative name(s): SGD1 homolog |
Gene namesi | Name:Nom1 Synonyms:Gm1040 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1861749, Nom1 |
VEuPathDBi | HostDB:ENSMUSG00000001569 |
Subcellular locationi
Nucleus
- nucleolus By similarity
Nucleus
- nucleolus Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286824 | 1 – 854 | Nucleolar MIF4G domain-containing protein 1Add BLAST | 854 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 60 | PhosphoserineBy similarity | 1 | |
Modified residuei | 311 | PhosphoserineBy similarity | 1 | |
Modified residuei | 314 | PhosphoserineCombined sources | 1 | |
Modified residuei | 315 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q3UFM5 |
MaxQBi | Q3UFM5 |
PaxDbi | Q3UFM5 |
PeptideAtlasi | Q3UFM5 |
PRIDEi | Q3UFM5 |
ProteomicsDBi | 293700 |
PTM databases
iPTMneti | Q3UFM5 |
PhosphoSitePlusi | Q3UFM5 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000001569, Expressed in female gonad and 79 other tissues |
Interactioni
Subunit structurei
May interact with EIF4A1, EIF4A2 and EIF4A3.
Interacts with PPP1CA and PPP1CC (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 241474, 1 interactor |
STRINGi | 10090.ENSMUSP00000001611 |
Miscellaneous databases
RNActi | Q3UFM5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 356 – 553 | MIF4GPROSITE-ProRule annotationAdd BLAST | 198 | |
Domaini | 648 – 764 | MIPROSITE-ProRule annotationAdd BLAST | 117 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 275 | Necessary for nucleolar localization and for targeting PPP1CA to the nucleolusBy similarityAdd BLAST | 274 | |
Regioni | 66 – 215 | DisorderedSequence analysisAdd BLAST | 150 | |
Regioni | 231 – 333 | DisorderedSequence analysisAdd BLAST | 103 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 301 – 304 | Required for efficient binding to PPP1CA and for targeting PPP1CA to the nucleolusBy similarity | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 75 – 98 | Basic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 140 – 154 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 179 – 208 | Basic and acidic residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 277 – 333 | Basic and acidic residuesSequence analysisAdd BLAST | 57 |
Sequence similaritiesi
Belongs to the CWC22 family.Curated
Phylogenomic databases
eggNOGi | KOG2141, Eukaryota |
GeneTreei | ENSGT00940000153458 |
HOGENOMi | CLU_006786_0_1_1 |
InParanoidi | Q3UFM5 |
OMAi | QFKQSIR |
OrthoDBi | 307186at2759 |
PhylomeDBi | Q3UFM5 |
TreeFami | TF312808 |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR003891, Initiation_fac_eIF4g_MI IPR003890, MIF4G-like_typ-3 |
Pfami | View protein in Pfam PF02847, MA3, 1 hit PF02854, MIF4G, 1 hit |
SMARTi | View protein in SMART SM00544, MA3, 1 hit SM00543, MIF4G, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51366, MI, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3UFM5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRNVPEVNG VYRHGACELW CRAMAHALLK RSGVRRGLGG REGPLKRLRL
60 70 80 90 100
AVEDFVRTTS ESEACESRSA VARSRPGGRK SRKELRKEKR HLRKARRLQR
110 120 130 140 150
TVGSGSGDQG GNVGLNDGPE TRRPPTEVRP TPAKATATPA KASAPSTNTK
160 170 180 190 200
ASAAQPKAKA KGAPGKPGPA TATARKRALL AANEEEDREI RKLERCLGLH
210 220 230 240 250
KRKKKGDGSS VPLSFARDGL DYILGALECG SGGGLYESSE EEEEEKLETG
260 270 280 290 300
QTVLESDLES NSKESEEDPD WQVLQEDQED VNSKRRGEAE SGTRGNKGTK
310 320 330 340 350
KVRFAEVVEK SRSSSEDDIE QQESHSVESG EKYIPPRLRN EEVIDVHKKE
360 370 380 390 400
ELDRLKKHVK GLINRLSEPN MASISGQLEE LYMAHSRKDM NDTLTTALMD
410 420 430 440 450
ACVTASAMPS RLMMEHVFLV SILHHTVGIE VGACFLEAVV KKFDAIYRDG
460 470 480 490 500
GEGKELDNLF TMIAHLYNFH VVQSILIFDI LKKLVGTFTE KDIELILLML
510 520 530 540 550
KNVGFALRKD DALSLKELIT EAQTQASGAG NKFQDQNRVR FMLETMLALK
560 570 580 590 600
NNDLRKIPGY NPEPVEKLKK LQRTLVRNAG SGSETRLRIS WDGILNAEQT
610 620 630 640 650
GRWWIVGSAW SGTPMIDNSH HIQLQKPLAG MASSKMLELA RKQRMNTDVR
660 670 680 690 700
RIIFCTLMTS EDFLDAFEKL LKLGLKDQQE REIVHILMDC CLQEKTYNPF
710 720 730 740 750
YAFLASKFCD YERRFQMTFQ FSIWDKFRDL ENLPDTKFSN LVHLLAHLLR
760 770 780 790 800
TKSLPLSVLK VVEFSELDKP RVHFLRRVLT ALLMETEDDD LAVIFSRVSD
810 820 830 840 850
NPKLGMLREG LKLFIGHFLL KHTQAHQSAE EASLLREKAG LASKSLQGKA
ILRM
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 309 | E → D in BAE28535 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK148406 mRNA Translation: BAE28535.1 AC171500 Genomic DNA No translation available. |
CCDSi | CCDS19149.1 |
RefSeqi | NP_001028629.2, NM_001033457.2 |
Genome annotation databases
Ensembli | ENSMUST00000001611; ENSMUSP00000001611; ENSMUSG00000001569 |
GeneIDi | 433864 |
KEGGi | mmu:433864 |
UCSCi | uc008wuj.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK148406 mRNA Translation: BAE28535.1 AC171500 Genomic DNA No translation available. |
CCDSi | CCDS19149.1 |
RefSeqi | NP_001028629.2, NM_001033457.2 |
3D structure databases
AlphaFoldDBi | Q3UFM5 |
SMRi | Q3UFM5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 241474, 1 interactor |
STRINGi | 10090.ENSMUSP00000001611 |
PTM databases
iPTMneti | Q3UFM5 |
PhosphoSitePlusi | Q3UFM5 |
Proteomic databases
EPDi | Q3UFM5 |
MaxQBi | Q3UFM5 |
PaxDbi | Q3UFM5 |
PeptideAtlasi | Q3UFM5 |
PRIDEi | Q3UFM5 |
ProteomicsDBi | 293700 |
Protocols and materials databases
Antibodypediai | 56748, 65 antibodies from 18 providers |
Genome annotation databases
Ensembli | ENSMUST00000001611; ENSMUSP00000001611; ENSMUSG00000001569 |
GeneIDi | 433864 |
KEGGi | mmu:433864 |
UCSCi | uc008wuj.1, mouse |
Organism-specific databases
CTDi | 64434 |
MGIi | MGI:1861749, Nom1 |
VEuPathDBi | HostDB:ENSMUSG00000001569 |
Phylogenomic databases
eggNOGi | KOG2141, Eukaryota |
GeneTreei | ENSGT00940000153458 |
HOGENOMi | CLU_006786_0_1_1 |
InParanoidi | Q3UFM5 |
OMAi | QFKQSIR |
OrthoDBi | 307186at2759 |
PhylomeDBi | Q3UFM5 |
TreeFami | TF312808 |
Miscellaneous databases
BioGRID-ORCSi | 433864, 23 hits in 76 CRISPR screens |
ChiTaRSi | Nom1, mouse |
PROi | PR:Q3UFM5 |
RNActi | Q3UFM5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000001569, Expressed in female gonad and 79 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR003891, Initiation_fac_eIF4g_MI IPR003890, MIF4G-like_typ-3 |
Pfami | View protein in Pfam PF02847, MA3, 1 hit PF02854, MIF4G, 1 hit |
SMARTi | View protein in SMART SM00544, MA3, 1 hit SM00543, MIF4G, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51366, MI, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NOM1_MOUSE | |
Accessioni | Q3UFM5Primary (citable) accession number: Q3UFM5 Secondary accession number(s): E9QPB9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | July 27, 2011 | |
Last modified: | May 25, 2022 | |
This is version 107 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families