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Protein

Lysophospholipase-like protein 1

Gene

Lyplal1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site (By similarity).By similarity

Catalytic activityi

Palmitoyl-protein + H2O = palmitate + protein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei125Charge relay systemBy similarity1
Active sitei180Charge relay systemBy similarity1
Active sitei212Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

  • negative regulation of Golgi to plasma membrane protein transport Source: MGI
  • protein depalmitoylation Source: MGI

Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHERimouse-lypl1 LYsophospholipase_carboxylesterase

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase-like protein 1 (EC:3.1.2.-)
Gene namesi
Name:Lyplal1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2385115 Lyplal1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3259491

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002275582 – 239Lysophospholipase-like protein 1Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ3UFF7
PaxDbiQ3UFF7
PRIDEiQ3UFF7

PTM databases

iPTMnetiQ3UFF7
PhosphoSitePlusiQ3UFF7
SwissPalmiQ3UFF7

Expressioni

Gene expression databases

CleanExiMM_LYPLAL1

Interactioni

Protein-protein interaction databases

BioGridi230556, 14 interactors
IntActiQ3UFF7, 2 interactors
MINTiQ3UFF7
STRINGi10090.ENSMUSP00000048229

Structurei

3D structure databases

ProteinModelPortaliQ3UFF7
SMRiQ3UFF7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2112 Eukaryota
COG0400 LUCA
HOGENOMiHOG000260139
HOVERGENiHBG105375
InParanoidiQ3UFF7
KOiK06999
PhylomeDBiQ3UFF7

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR003140 PLipase/COase/thioEstase
PfamiView protein in Pfam
PF02230 Abhydrolase_2, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UFF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVPSAVHL PRCVVSPTGR HSASLIFLHG SGHSGQGQRE WIKHVLNQDL
60 70 80 90 100
TFQHIKIIYP TAPSRPYTPL KGGLSNVWFD RFKISMDCPE HLESIDSMCQ
110 120 130 140 150
VLSGLIDEEV KTGIQKSRIL IGGFSMGGCM AMHLAYRSHP DVAGVFVLSG
160 170 180 190 200
FLNKASVVYQ DLQQGGRMLP ELFQCHGSAD NLVLHAWGKE TNSKLKSLGV
210 220 230
STTFHSLPNL NHELNKTELE KLKSWILTRL PGETDGQSE
Length:239
Mass (Da):26,354
Last modified:January 23, 2007 - v3
Checksum:iFFAEB2541158E73F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58I → T in AAH27340 (PubMed:15489334).Curated1
Sequence conflicti106I → V in BAE28604 (PubMed:16141072).Curated1
Sequence conflicti184L → Q in BAE28604 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK148533 mRNA Translation: BAE28604.1
BC027340 mRNA Translation: AAH27340.1
CCDSiCCDS15600.1
RefSeqiNP_666218.2, NM_146106.2
UniGeneiMm.257116

Genome annotation databases

GeneIDi226791
KEGGimmu:226791

Similar proteinsi

Entry informationi

Entry nameiLYPL1_MOUSE
AccessioniPrimary (citable) accession number: Q3UFF7
Secondary accession number(s): Q8R065
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 90 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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