UniProtKB - Q3UF95 (Q3UF95_MOUSE)
Protein
BCL2-associated athanogene 6
Gene
Bag6
Organism
Mus musculus (Mouse)
Status
Functioni
Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).ARBA annotation
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell differentiation Source: UniProtKB-KW
- chromatin organization Source: UniProtKB-KW
- immune system process Source: UniProtKB-KW
- spermatogenesis Source: UniProtKB-KW
Keywordsi
Molecular function | Chromatin regulatorARBA annotation |
Biological process | ApoptosisARBA annotation, Differentiation, ImmunityARBA annotation, SpermatogenesisARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: BCL2-associated athanogene 6ARBA annotationAlternative name(s): HLA-B-associated transcript 3ARBA annotation Large proline-rich protein BAG6ARBA annotation |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1919439, Bag6 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Cytosol
- cytosol ARBA annotation
Extracellular region or secreted
- extracellular exosome ARBA annotation
Cytosol
- cytosol Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000024392, Expressed in cerebral cortex and 313 other tissues |
ExpressionAtlasi | Q3UF95, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 77 | Ubiquitin-likeInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 87 – 125 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 168 – 256 | DisorderedSequence analysisAdd BLAST | 89 | |
Regioni | 369 – 424 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 445 – 513 | DisorderedSequence analysisAdd BLAST | 69 | |
Regioni | 550 – 608 | DisorderedSequence analysisAdd BLAST | 59 | |
Regioni | 655 – 701 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 950 – 1136 | DisorderedSequence analysisAdd BLAST | 187 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 92 – 107 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 168 – 202 | PolarSequence analysisAdd BLAST | 35 | |
Compositional biasi | 205 – 221 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 225 – 251 | Pro-richSequence analysisAdd BLAST | 27 | |
Compositional biasi | 388 – 408 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 576 – 591 | PolarSequence analysisAdd BLAST | 16 | |
Compositional biasi | 658 – 687 | Pro-richSequence analysisAdd BLAST | 30 |
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000016199 |
OrthoDBi | 1233552at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR021925, BAG6 IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR019954, Ubiquitin_CS |
Pfami | View protein in Pfam PF12057, BAG6, 1 hit PF00240, ubiquitin, 1 hit |
SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00299, UBIQUITIN_1, 1 hit PS50053, UBIQUITIN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
Q3UF95-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPSDSASTA MEEPDSLEVL VKTLDSQTRT FIVGAQMNVK EFKEHIAASV
60 70 80 90 100
SIPSEKQRLI YQGRVLQDDK KLQEYNVGGK VIHLVERAPP QTQLPSGASS
110 120 130 140 150
GTGSASATHG GAPLPGTRGP GASVHDRNAN SYVMVGTFNL PSEPRVRLVM
160 170 180 190 200
AQHMIRDIQT LLSRMECRGG TQAQASQPPP QTPQTVASET VALNSQTSEP
210 220 230 240 250
VESEAPPREP MESEEMEERP PTQTPELAPS GPAPAGPAPA GPAPAPETNA
260 270 280 290 300
PNHPSPAEHV EVLQELQRLQ RRLQPFLQRY CEVLGAAATT DYNNNHEGRE
310 320 330 340 350
EDQRLINLVG ESLRLLGNTF VALSDLRCNL ACAPPRHLHV VRPMSHYTTP
360 370 380 390 400
MVLQQAAIPI QINVGTTVTM TGNGARPPPA PGAEAATPGS AQATSLPPSS
410 420 430 440 450
TTVDSSTEGA PPPGPAPPPA SSHPRVIRIS HQSVEPVVMM HMNIQDSGAQ
460 470 480 490 500
PGGVPSAPTG PLGPPGHGQT LGQQVPGFPT APTRVVIARP TPPQARPSHP
510 520 530 540 550
GGPPVSGALQ GAGLGTNTSL AQMVSGLVGQ LLMQPVLVAQ GTPGMAQAQA
560 570 580 590 600
QAQAQAQAQA QAPAPAPAPA PAPATASASA GTTNTATTAG PAPGGPAQPP
610 620 630 640 650
PPQPSAADLQ FSQLLGNLLG PAGPGAGGPG MASPTITVAM PGVPAFLQGM
660 670 680 690 700
TDFLQASQTA PPPPPPPPPP PPAPEQQSTP PPGSPSGGTA SPGGLGPESL
710 720 730 740 750
PPEFFTSVVQ GVLSSLLGSL GARAGSSESI AAFIQRLSGS SNIFEPGADG
760 770 780 790 800
ALGFFGALLS LLCQNFSMVD VVMLLHGHFQ PLQRLQPQLR SFFHQHYLGG
810 820 830 840 850
QEPTPSNIRM ATHTLITGLE EYVRESFSLV QVQPGVDIIR TNLEFLQEQF
860 870 880 890 900
NSIAAHVLHC TDSGFGARLL ELCNQGLFEC LALNLHCLGG QQMELAAVIN
910 920 930 940 950
GRIRRMSRGV NPSLVSWLTT MMGLRLQVVL EHMPVGPDAI LRYVRRVGDP
960 970 980 990 1000
PQTLPEEPME VQGAERTSPE PQRENASPAP GTTAEEAMSR GPPPAPEGGS
1010 1020 1030 1040 1050
RDEQDGASAD AEPWAAAVPP EWVPIIQQDI QSQRKVKPQP PLSDAYLSGM
1060 1070 1080 1090 1100
PAKRRKTMQG EGPQLLLSEA VSRAAKAAGA RPLTSPESLS RDLEAPEVQE
1110 1120 1130
SYRQQLRSDI QKRLQEDPNY SPQRFPNAHR AFADDP
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9Z1R2 | BAG6_MOUSE | Large proline-rich protein BAG6 | Bag6 Bat3 | 1,154 | Annotation score: | ||
G3UXT8 | G3UXT8_MOUSE | BCL2-associated athanogene 6 | Bag6 | 563 | Annotation score: | ||
G3UZT6 | G3UZT6_MOUSE | BCL2-associated athanogene 6 | Bag6 | 1,122 | Annotation score: | ||
G3UYQ2 | G3UYQ2_MOUSE | BCL2-associated athanogene 6 | Bag6 | 1,082 | Annotation score: | ||
A0A1B0GX81 | A0A1B0GX81_MOUSE | BCL2-associated athanogene 6 | Bag6 | 1,107 | Annotation score: | ||
G3V013 | G3V013_MOUSE | Large proline-rich protein BAG6 | Bag6 | 253 | Annotation score: | ||
S4R183 | S4R183_MOUSE | Large proline-rich protein BAG6 | Bag6 | 115 | Annotation score: | ||
G3UYZ0 | G3UYZ0_MOUSE | Large proline-rich protein BAG6 | Bag6 | 209 | Annotation score: | ||
S4R224 | S4R224_MOUSE | Large proline-rich protein BAG6 | Bag6 | 120 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR974444 Genomic DNA No translation available. AK148796 mRNA Translation: BAE28666.1 |
RefSeqi | NP_001239397.1, NM_001252468.1 NP_476512.1, NM_057171.2 |
Genome annotation databases
Ensembli | ENSMUST00000166426; ENSMUSP00000129324; ENSMUSG00000024392 |
GeneIDi | 224727 |
KEGGi | mmu:224727 |
UCSCi | uc008cgc.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR974444 Genomic DNA No translation available. AK148796 mRNA Translation: BAE28666.1 |
RefSeqi | NP_001239397.1, NM_001252468.1 NP_476512.1, NM_057171.2 |
3D structure databases
SMRi | Q3UF95 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q3UF95 |
Protocols and materials databases
Antibodypediai | 27346, 283 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000166426; ENSMUSP00000129324; ENSMUSG00000024392 |
GeneIDi | 224727 |
KEGGi | mmu:224727 |
UCSCi | uc008cgc.2, mouse |
Organism-specific databases
CTDi | 7917 |
MGIi | MGI:1919439, Bag6 |
Phylogenomic databases
GeneTreei | ENSGT00390000016199 |
OrthoDBi | 1233552at2759 |
Miscellaneous databases
BioGRID-ORCSi | 224727, 3 hits in 19 CRISPR screens |
ChiTaRSi | Bag6, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024392, Expressed in cerebral cortex and 313 other tissues |
ExpressionAtlasi | Q3UF95, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR021925, BAG6 IPR000626, Ubiquitin-like_dom IPR029071, Ubiquitin-like_domsf IPR019954, Ubiquitin_CS |
Pfami | View protein in Pfam PF12057, BAG6, 1 hit PF00240, ubiquitin, 1 hit |
SMARTi | View protein in SMART SM00213, UBQ, 1 hit |
SUPFAMi | SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS00299, UBIQUITIN_1, 1 hit PS50053, UBIQUITIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3UF95_MOUSE | |
Accessioni | Q3UF95Primary (citable) accession number: Q3UF95 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 10, 2021 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |