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Entry version 109 (16 Oct 2019)
Sequence version 1 (11 Oct 2005)
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Protein
Submitted name:

Urocanate hydratase

Gene

Uroc1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Urocanate hydrataseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Uroc1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:2385332 Uroc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034456 Expressed in 108 organ(s), highest expression level in left lobe of liver

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini85 – 211Urocanase_NInterPro annotationAdd BLAST127
Domaini214 – 301UrocanaseInterPro annotationAdd BLAST88
Domaini333 – 471UrocanaseInterPro annotationAdd BLAST139
Domaini474 – 680Urocanase_CInterPro annotationAdd BLAST207

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEG2 Eukaryota
COG2987 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015136

KEGG Orthology (KO)

More...
KOi
K01712

Identification of Orthologs from Complete Genome Data

More...
OMAi
LVGDWAN

Database of Orthologous Groups

More...
OrthoDBi
536177at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314306

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10730, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_00577 HutU, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023637 Urocanase
IPR035401 Urocanase_C
IPR038364 Urocanase_central_sf
IPR023636 Urocanase_CS
IPR035400 Urocanase_N
IPR035085 Urocanase_Rossmann-like
IPR036190 Urocanase_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12216 PTHR12216, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01175 Urocanase, 2 hits
PF17392 Urocanase_C, 1 hit
PF17391 Urocanase_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001423 Urocanate_hydrat, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111326 SSF111326, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01233 UROCANASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3UEL5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLQELCSG LPLRPLPENR GRWAGVPHAP VRTPNLSPEE EQLALRNALR
60 70 80 90 100
YFPPDVQKLL ALEFAQELRQ FGHIYMYRFC PSIEMRAYPI DQYPCRTRAA
110 120 130 140 150
AAIMHMIMNN LDPAVAQFPQ ELVTYGGNGQ VFSNWAQFRL TMSYLSKMTE
160 170 180 190 200
EQTLVMYSGH PLGLFPSSPR APRLVITNGM VIPNYSSRTE YEKLFALGVT
210 220 230 240 250
MYGQMTAGSY CYIGPQGIVH GTVLTVLNAG RRYLGIENLA GKVFVTSGLG
260 270 280 290 300
GMSGAQAKAA AIVGCIGVIA EVDKAALVKR HRQGWLMEVT DSLDRCIARL
310 320 330 340 350
RYGLAVWDPE HLTLSTGSRG ESMTWAIQCL MFDHREARKK KEVLSLGYHG
360 370 380 390 400
NVVDLWERLV HELDTTGELL VDLGSDQTSC HNPFNGGYYP VQLSFSEAQS
410 420 430 440 450
LMSSNPAAFK HLVQESLRRH VAAINRLAQE KFFFWDYGNA FLLEAQRAGA
460 470 480 490 500
DVEKKGANKM EFRYPSYVQH IMGDIFSQGF GPFRWVCTSG DPQDLAVTDH
510 520 530 540 550
LATSVLEKAI ADGVKASVKL QYMDNIRWIR EAAKHQLVVG SQARILYSDQ
560 570 580 590 600
KGRVAIAVAI NQAIASGKIK APVVLSRDHH DVSGTDSPFR ETSNIYDGSA
610 620 630 640 650
FCADMAVQNF VGDACRGATW VALHNGGGVG WGEVINGGFG LVLDGTAEAE
660 670 680 690 700
QKARMMLSWD VSNGVARRCW SGNPKAYEII CQTMQENSGL VVTLPHEVAD
710
EQVLQQALRP
Length:710
Mass (Da):78,482
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i947B4061ED3E52CB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8VC12HUTU_MOUSE
Urocanate hydratase
Uroc1
676Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC122521 Genomic DNA No translation available.
AC163346 Genomic DNA No translation available.
AK149464 mRNA Translation: BAE28896.1

NCBI Reference Sequences

More...
RefSeqi
NP_001334258.1, NM_001347329.1
NP_659189.2, NM_144940.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000164761; ENSMUSP00000127114; ENSMUSG00000034456

Database of genes from NCBI RefSeq genomes

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GeneIDi
243537

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:243537

UCSC genome browser

More...
UCSCi
uc012eow.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122521 Genomic DNA No translation available.
AC163346 Genomic DNA No translation available.
AK149464 mRNA Translation: BAE28896.1
RefSeqiNP_001334258.1, NM_001347329.1
NP_659189.2, NM_144940.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSMUST00000164761; ENSMUSP00000127114; ENSMUSG00000034456
GeneIDi243537
KEGGimmu:243537
UCSCiuc012eow.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
131669
MGIiMGI:2385332 Uroc1

Phylogenomic databases

eggNOGiENOG410IEG2 Eukaryota
COG2987 LUCA
GeneTreeiENSGT00390000015136
KOiK01712
OMAiLVGDWAN
OrthoDBi536177at2759
TreeFamiTF314306

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034456 Expressed in 108 organ(s), highest expression level in left lobe of liver

Family and domain databases

Gene3Di3.40.50.10730, 2 hits
HAMAPiMF_00577 HutU, 1 hit
InterProiView protein in InterPro
IPR023637 Urocanase
IPR035401 Urocanase_C
IPR038364 Urocanase_central_sf
IPR023636 Urocanase_CS
IPR035400 Urocanase_N
IPR035085 Urocanase_Rossmann-like
IPR036190 Urocanase_sf
PANTHERiPTHR12216 PTHR12216, 1 hit
PfamiView protein in Pfam
PF01175 Urocanase, 2 hits
PF17392 Urocanase_C, 1 hit
PF17391 Urocanase_N, 1 hit
PIRSFiPIRSF001423 Urocanate_hydrat, 2 hits
SUPFAMiSSF111326 SSF111326, 2 hits
PROSITEiView protein in PROSITE
PS01233 UROCANASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3UEL5_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UEL5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: October 16, 2019
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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