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Protein

Alanine--glyoxylate aminotransferase 2, mitochondrial

Gene

Agxt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.1 Publication

Catalytic activityi

L-alanine + glyoxylate = pyruvate + glycine.
(R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-MMU-389661 Glyoxylate metabolism and glycine degradation
SABIO-RKiQ3UEG6

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine--glyoxylate aminotransferase 2, mitochondrial (EC:2.6.1.44)
Short name:
AGT 2
Alternative name(s):
(R)-3-amino-2-methylpropionate--pyruvate transaminase (EC:2.6.1.40)
Beta-ALAAT II
Beta-alanine-pyruvate aminotransferase
D-AIBAT
Gene namesi
Name:Agxt2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2146052 Agxt2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Knockout mice are hypertensive.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 40MitochondrionBy similarityAdd BLAST40
ChainiPRO_000028375341 – 513Alanine--glyoxylate aminotransferase 2, mitochondrialAdd BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56N6-acetyllysineCombined sources1
Modified residuei70N6-acetyllysine; alternateCombined sources1
Modified residuei70N6-succinyllysine; alternateCombined sources1
Modified residuei83N6-acetyllysineCombined sources1
Modified residuei261N6-acetyllysine; alternateCombined sources1
Modified residuei261N6-succinyllysine; alternateCombined sources1
Modified residuei303N6-succinyllysineCombined sources1
Modified residuei349N6-(pyridoxal phosphate)lysineBy similarity1
Modified residuei416N6-acetyllysine; alternateCombined sources1
Modified residuei416N6-succinyllysine; alternateCombined sources1
Modified residuei419N6-acetyllysine; alternateCombined sources1
Modified residuei419N6-succinyllysine; alternateCombined sources1
Modified residuei453N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ3UEG6
PRIDEiQ3UEG6

PTM databases

iPTMnetiQ3UEG6
PhosphoSitePlusiQ3UEG6
SwissPalmiQ3UEG6

Expressioni

Gene expression databases

BgeeiENSMUSG00000089678 Expressed in 32 organ(s), highest expression level in liver
CleanExiMM_AGXT2
ExpressionAtlasiQ3UEG6 baseline and differential
GenevisibleiQ3UEG6 MM

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ3UEG6
SMRiQ3UEG6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00530000062907
HOGENOMiHOG000020206
HOVERGENiHBG004196
InParanoidiQ3UEG6
KOiK00827
OMAiGIATCTL

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q3UEG6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLAWRNLQK PFYLETSLRI LQMRPSLSLG ASRIAVPKLT LHTKHSMPPC
60 70 80 90 100
DFSPEKYQSL AYSRVLAIHK QHLSPVDTAY FRKPLLLHQG HMEWLFDSEG
110 120 130 140 150
NRYLDFFSGI VTVSVGHCHP KVSAVAKKQI DRLWHTSSVF FHSPMHEYAE
160 170 180 190 200
KLSALLPEPL KVIFLVNSGS EANDLAMVMA RAHSNHTDII SFRGAYHGCS
210 220 230 240 250
PYTLGLTNVG IYKMEVPGGI GCQSTMCPDV FRGPWGGIHC RDSPVQTVRD
260 270 280 290 300
CSCAPDCCQA KERYIEQFKD TLNTSVATSI AGFFAEPIQG VNGVVQYPKE
310 320 330 340 350
FLKEAFALVR ERGGVCIADE VQTGFGRLGS HFWGFQTHDV LPDIVTMAKG
360 370 380 390 400
IGNGFPMAAV VTTPEIAKSL AKRLLHFSTF GGNPLACAIG SAVLEVIEEE
410 420 430 440 450
NLQRNSQEVG TYMLLKFAKL RDEFDIVGDV RGKGLMVGIE MVQDKISRQP
460 470 480 490 500
LPKTEVNQIH EDCKDMGLLV GRGGNFSQTF RIVPPMCVTK MEVDFAYEVF
510
RAALIQHMER RAK
Length:513
Mass (Da):57,115
Last modified:October 11, 2005 - v1
Checksum:i055D10974BA46A25
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BWY3H7BWY3_MOUSE
Alanine--glyoxylate aminotransferas...
Agxt2
541Annotation score:
D3YZ49D3YZ49_MOUSE
Alanine--glyoxylate aminotransferas...
Agxt2
234Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149538 mRNA Translation: BAE28945.1
BC141248 mRNA Translation: AAI41249.1
CCDSiCCDS79362.1
RefSeqiNP_001297664.1, NM_001310735.1
NP_001297665.1, NM_001310736.1
UniGeneiMm.482244

Genome annotation databases

EnsembliENSMUST00000110542; ENSMUSP00000106171; ENSMUSG00000089678
GeneIDi268782
KEGGimmu:268782
UCSCiuc007vga.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149538 mRNA Translation: BAE28945.1
BC141248 mRNA Translation: AAI41249.1
CCDSiCCDS79362.1
RefSeqiNP_001297664.1, NM_001310735.1
NP_001297665.1, NM_001310736.1
UniGeneiMm.482244

3D structure databases

ProteinModelPortaliQ3UEG6
SMRiQ3UEG6
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ3UEG6
PhosphoSitePlusiQ3UEG6
SwissPalmiQ3UEG6

Proteomic databases

MaxQBiQ3UEG6
PRIDEiQ3UEG6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110542; ENSMUSP00000106171; ENSMUSG00000089678
GeneIDi268782
KEGGimmu:268782
UCSCiuc007vga.1 mouse

Organism-specific databases

CTDi64902
MGIiMGI:2146052 Agxt2

Phylogenomic databases

GeneTreeiENSGT00530000062907
HOGENOMiHOG000020206
HOVERGENiHBG004196
InParanoidiQ3UEG6
KOiK00827
OMAiGIATCTL

Enzyme and pathway databases

ReactomeiR-MMU-389661 Glyoxylate metabolism and glycine degradation
SABIO-RKiQ3UEG6

Miscellaneous databases

PROiPR:Q3UEG6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000089678 Expressed in 32 organ(s), highest expression level in liver
CleanExiMM_AGXT2
ExpressionAtlasiQ3UEG6 baseline and differential
GenevisibleiQ3UEG6 MM

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
PIRSFiPIRSF000521 Transaminase_4ab_Lys_Orn, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAGT2_MOUSE
AccessioniPrimary (citable) accession number: Q3UEG6
Secondary accession number(s): B9EIZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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