UniProtKB - Q3UEF5 (Q3UEF5_MOUSE)
Protein
Fibrinogen C-terminal domain-containing protein
Gene
Angptl3
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- growth factor activity Source: Ensembl
- integrin binding Source: Ensembl
- phospholipase inhibitor activity Source: Ensembl
GO - Biological processi
- cell-matrix adhesion Source: Ensembl
- cholesterol homeostasis Source: Ensembl
- cholesterol metabolic process Source: Ensembl
- fatty acid metabolic process Source: Ensembl
- glycerol metabolic process Source: Ensembl
- lipid storage Source: Ensembl
- negative regulation of lipoprotein lipase activity Source: Ensembl
- negative regulation of phospholipase activity Source: Ensembl
- phospholipid catabolic process Source: Ensembl
- phospholipid homeostasis Source: Ensembl
- positive regulation of angiogenesis Source: Ensembl
- positive regulation of cell migration Source: Ensembl
- positive regulation of lipid catabolic process Source: Ensembl
- response to hormone Source: Ensembl
- triglyceride homeostasis Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: Fibrinogen C-terminal domain-containing proteinInterPro annotation |
Gene namesi | Name:Angptl3Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:1353627, Angptl3 |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: Ensembl
Other locations
- cell surface Source: Ensembl
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_5014309219 | 17 – 455 | Fibrinogen C-terminal domain-containing proteinSequence analysisAdd BLAST | 439 |
Proteomic databases
PeptideAtlasi | Q3UEF5 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028553, Expressed in liver and 92 other tissues |
ExpressionAtlasi | Q3UEF5, baseline and differential |
Interactioni
GO - Molecular functioni
- growth factor activity Source: Ensembl
- integrin binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 237 – 455 | Fibrinogen C-terminalInterPro annotationAdd BLAST | 219 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 202 – 242 | DisorderedSequence analysisAdd BLAST | 41 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 92 – 151 | Sequence analysisAdd BLAST | 60 | |
Coiled coili | 172 – 202 | Sequence analysisAdd BLAST | 31 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 208 – 237 | PolarSequence analysisAdd BLAST | 30 |
Keywords - Domaini
Coiled coilSequence analysis, SignalSequence analysisPhylogenomic databases
HOGENOMi | CLU_038628_2_0_1 |
OMAi | GHFNCPE |
OrthoDBi | 357340at2759 |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
InterProi | View protein in InterPro IPR036056, Fibrinogen-like_C IPR002181, Fibrinogen_a/b/g_C_dom |
Pfami | View protein in Pfam PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS51406, FIBRINOGEN_C_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3UEF5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHTIKLFLFV VPLVIASRVD PDLSSFDSAP SEPKSRFAML DDVKILANGL
60 70 80 90 100
LQLGHGLKDF VHKTKGQIND IFQKLNIFDQ SFYDLSLRTN EIKEEEKELR
110 120 130 140 150
RTTSTLQVKN EEVKNMSVEL NSKLESLLEE KTALQHKVRA LEEQLTNLIL
160 170 180 190 200
SPAGAQEHPE VTSLKSFVEQ QDNSIRELLQ SVEEQYKQLS QQHMQIKEIE
210 220 230 240 250
KQLRKTGIQE PSENSLSSKS RAPRTTPPLQ LNETENTEQD DLPADCSAVY
260 270 280 290 300
NRGEHTSGVY TIKPRNSQGF NVYCDTQSGS PWTLIQHRKD GSQDFNETWE
310 320 330 340 350
NYEKGFGRLD GEFWLGLEKI YAIVQQSNYI LRLELQDWKD SKHYVEYSFH
360 370 380 390 400
LGSHETNYTL HVAEIAGNIP GALPEHTDLM FSTWNHRAKG QLYCPESYSG
410 420 430 440 450
GWWWNDICGE NNLNGKYNKP RTKSRPERRR GIYWRPQSRK LYAIKSSKMM
LQPTT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK149450 mRNA Translation: BAE28886.1 AK149555 mRNA Translation: BAE28956.1 |
RefSeqi | NP_038941.1, NM_013913.4 |
Genome annotation databases
GeneIDi | 30924 |
KEGGi | mmu:30924 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK149450 mRNA Translation: BAE28886.1 AK149555 mRNA Translation: BAE28956.1 |
RefSeqi | NP_038941.1, NM_013913.4 |
3D structure databases
SMRi | Q3UEF5 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | Q3UEF5 |
Protocols and materials databases
Antibodypediai | 19489, 492 antibodies |
DNASUi | 30924 |
Genome annotation databases
GeneIDi | 30924 |
KEGGi | mmu:30924 |
Organism-specific databases
CTDi | 27329 |
MGIi | MGI:1353627, Angptl3 |
Phylogenomic databases
HOGENOMi | CLU_038628_2_0_1 |
OMAi | GHFNCPE |
OrthoDBi | 357340at2759 |
Miscellaneous databases
BioGRID-ORCSi | 30924, 2 hits in 52 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028553, Expressed in liver and 92 other tissues |
ExpressionAtlasi | Q3UEF5, baseline and differential |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
InterProi | View protein in InterPro IPR036056, Fibrinogen-like_C IPR002181, Fibrinogen_a/b/g_C_dom |
Pfami | View protein in Pfam PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS51406, FIBRINOGEN_C_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3UEF5_MOUSE | |
Accessioni | Q3UEF5Primary (citable) accession number: Q3UEF5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | April 7, 2021 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |