UniProtKB - Q3UE17 (MEX3D_MOUSE)

BLAST

>sp|Q3UE17|MEX3D_MOUSE RNA-binding protein MEX3D OS=Mus musculus OX=10090 GN=Mex3d PE=1 SV=2
MPGSTGQPDAGGAGTGTTAGDPGHPHPALAGAEDAAPRPPPEPDDAAAALRLALDQLSAL
GLGGARPGDEGMATRSADGATECGEDEPAPPDELEVAVAPPVTASVAPGGLPLLDPDVSP
RPSPPDVFASFAPHPAALGPSTLLAEQLNVIGSRKKSVNMTECVPVPSSEHVAEIVGRQG
CKIKALRAKTNTYIKTPVRGEEPVFIVTGRKEDVEMAKREILSAEHFSLIRATRSKAGGL
SGATPGPPNLPGQTTIQVRVPYRVVGLVVGPKGATIKRIQQRTHTYIVTPGRDKEPVFAV
TGMPENVDRAREEIEAHITLRTGAFTDSGPDSDFHANGTDVCLDLLGAAASLWAKAPHPG
RRPPAATGGLRGDNALGAASTPEPFYVGSRGGPPLPDPSPSSPYGGSGNGGFTFGGDGPS
APTGTATPEDCDFGFDFLALDLTVPATATIWAPFERAAPLPAFSGCPAVNGAPAQPNTGT
RRSSGGGAATTPRHSPTLPEPGGLSLELPLARRSVPDPVGAVPWRPPQSALPPFSGSTTF
STTPSLPSTTLASSTLDTVPSEGNHKPSTTAANSSASTAAPGPPSAALARECVVCSEGEA
MAALVPCGHNLFCMDCAVRICGKSEPECPACRTPATQAIHIFS

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History
Entry version 94 (28 Feb 2018)
Sequence version 2 (20 Mar 2007)
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Protein

RNA-binding protein MEX3D

Gene

Mex3d

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	592 – 632	RING-typePROSITE-ProRule annotationAdd BLAST		41

GO - Molecular functionⁱ

AU-rich element binding Source: BHF-UCL
metal ion binding Source: UniProtKB-KW
mRNA 3'-UTR binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA catabolic process Source: MGI
mRNA destabilization
Source: BHF-UCL
Non-traceable author statementⁱ
- 14769789
RNA destabilization Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: RNA-binding protein MEX3D Alternative name(s): RING finger and KH domain-containing protein 1
Gene namesⁱ	Name:Mex3d Synonyms:Rkhd1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:2681847 Mex3d

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000281676	1 – 643	RNA-binding protein MEX3DAdd BLAST		643

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	491	PhosphothreonineBy similarity		1
Modified residueⁱ	495	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3UE17
PaxDbⁱ	Q3UE17
PRIDEⁱ	Q3UE17

PTM databases

iPTMnetⁱ	Q3UE17
PhosphoSitePlusⁱ	Q3UE17

Expressionⁱ

Gene expression databases

CleanExⁱ	MM_MEX3D

CleanExⁱ

MM_MEX3D

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000057962

STRINGⁱ

10090.ENSMUSP00000057962

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3UE17
SMRⁱ	Q3UE17
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	160 – 221	KH 1PROSITE-ProRule annotationAdd BLAST		62
Domainⁱ	253 – 314	KH 2PROSITE-ProRule annotationAdd BLAST		62

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	46 – 49	Poly-Ala		4

Domainⁱ

Binds RNA through its KH domains.By similarity

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	592 – 632	RING-typePROSITE-ProRule annotationAdd BLAST		41

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG2113 Eukaryota ENOG410YCYR LUCA
HOGENOMⁱ	HOG000236282
HOVERGENⁱ	HBG071698
InParanoidⁱ	Q3UE17
KEGG Orthology (KO) More...KOⁱ	K15686
PhylomeDBⁱ	Q3UE17

Family and domain databases

Gene3Dⁱ	3.30.1370.10, 2 hits 3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR004087 KH_dom IPR004088 KH_dom_type_1 IPR036612 KH_dom_type_1_sf IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00013 KH_1, 2 hits
SMARTⁱ	View protein in SMART SM00322 KH, 2 hits
SUPFAMⁱ	SSF54791 SSF54791, 2 hits
PROSITEⁱ	View protein in PROSITE PS50084 KH_TYPE_1, 2 hits PS50089 ZF_RING_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q3UE17-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGSTGQPDA GGAGTGTTAG DPGHPHPALA GAEDAAPRPP PEPDDAAAAL 
        60         70         80         90        100
RLALDQLSAL GLGGARPGDE GMATRSADGA TECGEDEPAP PDELEVAVAP 
       110        120        130        140        150
PVTASVAPGG LPLLDPDVSP RPSPPDVFAS FAPHPAALGP STLLAEQLNV 
       160        170        180        190        200
IGSRKKSVNM TECVPVPSSE HVAEIVGRQG CKIKALRAKT NTYIKTPVRG 
       210        220        230        240        250
EEPVFIVTGR KEDVEMAKRE ILSAEHFSLI RATRSKAGGL SGATPGPPNL 
       260        270        280        290        300
PGQTTIQVRV PYRVVGLVVG PKGATIKRIQ QRTHTYIVTP GRDKEPVFAV 
       310        320        330        340        350
TGMPENVDRA REEIEAHITL RTGAFTDSGP DSDFHANGTD VCLDLLGAAA 
       360        370        380        390        400
SLWAKAPHPG RRPPAATGGL RGDNALGAAS TPEPFYVGSR GGPPLPDPSP 
       410        420        430        440        450
SSPYGGSGNG GFTFGGDGPS APTGTATPED CDFGFDFLAL DLTVPATATI 
       460        470        480        490        500
WAPFERAAPL PAFSGCPAVN GAPAQPNTGT RRSSGGGAAT TPRHSPTLPE 
       510        520        530        540        550
PGGLSLELPL ARRSVPDPVG AVPWRPPQSA LPPFSGSTTF STTPSLPSTT 
       560        570        580        590        600
LASSTLDTVP SEGNHKPSTT AANSSASTAA PGPPSAALAR ECVVCSEGEA 
       610        620        630        640 
MAALVPCGHN LFCMDCAVRI CGKSEPECPA CRTPATQAIH IFS

Length:643

Mass (Da):65,329

Last modified:March 20, 2007 - v2

Checksum:ⁱEB8EF02F788480F2

Isoform 2 (identifier: Q3UE17-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-104: MPGSTGQPDA...EVAVAPPVTA → MGVGPSMALA...TLAPTMAVAS

« Hide

        10         20         30         40         50
MGVGPSMALA PSVTCAPSMA LAPSVTSAPS MALAPSVTCA PCMAVAPSVT 
        60         70         80         90        100
VAPSMALTPS VTLAPTMAVA SSVAPGGLPL LDPDVSPRPS PPDVFASFAP 
       110        120        130        140        150
HPAALGPSTL LAEQLNVIGS RKKSVNMTEC VPVPSSEHVA EIVGRQGCKI 
       160        170        180        190        200
KALRAKTNTY IKTPVRGEEP VFIVTGRKED VEMAKREILS AEHFSLIRAT 
       210        220        230        240        250
RSKAGGLSGA TPGPPNLPGQ TTIQVRVPYR VVGLVVGPKG ATIKRIQQRT 
       260        270        280        290        300
HTYIVTPGRD KEPVFAVTGM PENVDRAREE IEAHITLRTG AFTDSGPDSD 
       310        320        330        340        350
FHANGTDVCL DLLGAAASLW AKAPHPGRRP PAATGGLRGD NALGAASTPE 
       360        370        380        390        400
PFYVGSRGGP PLPDPSPSSP YGGSGNGGFT FGGDGPSAPT GTATPEDCDF 
       410        420        430        440        450
GFDFLALDLT VPATATIWAP FERAAPLPAF SGCPAVNGAP AQPNTGTRRS 
       460        470        480        490        500
SGGGAATTPR HSPTLPEPGG LSLELPLARR SVPDPVGAVP WRPPQSALPP 
       510        520        530        540        550
FSGSTTFSTT PSLPSTTLAS STLDTVPSEG NHKPSTTAAN SSASTAAPGP 
       560        570        580        590        600
PSAALARECV VCSEGEAMAA LVPCGHNLFC MDCAVRICGK SEPECPACRT 
       610
PATQAIHIFS

Show »

Length:610

Mass (Da):62,094

Checksum:ⁱ3BC2585DA7B18B0D

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3YTR3	D3YTR3_MOUSE	RNA-binding protein MEX3D RNA-binding protein MEX3D	Mex3d	718	Annotation score:
F6TY75	F6TY75_MOUSE	RNA-binding protein MEX3D RNA-binding protein MEX3D	Mex3d	268	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_024020	1 – 104	MPGST…PPVTA → MGVGPSMALAPSVTCAPSMA LAPSVTSAPSMALAPSVTCA PCMAVAPSVTVAPSMALTPS VTLAPTMAVAS in isoform 2. 1 PublicationAdd BLAST		104

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CAAA01108096 Genomic DNA No translation available. AC152062 Genomic DNA No translation available. AK149801 mRNA Translation: BAE29094.1
NCBI Reference Sequences More...RefSeqⁱ	NP_941017.2, NM_198615.2
UniGeneⁱ	Mm.268389

Genome annotation databases

GeneIDⁱ	237400
KEGGⁱ	mmu:237400

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q3UE17-2	RNA-binding protein MEX3D		MOUSE		718	UniRef90_Q3UE17-2
Mex-3 RNA-binding family member D		RAT		662
RNA-binding protein MEX3D		MESAU		648
RNA-binding protein MEX3D		CRIGR		598
Uncharacterized protein (Fragment)		NEOLE		598
+9

Protein	Similar proteins		Species	Score	Length	Source
Q3UE17	RNA-binding protein MEX3D	)	HUMAN		651	UniRef50_Q86XN8
Mex-3 RNA binding family member D		CALJA		653
MEX3D isoform 1		PANTR		652
MEX3D isoform 1		PONAB		651
Mex-3 RNA binding family member D		CERAT		619
+37
Q3UE17-2	RNA-binding protein MEX3D		MOUSE		718	UniRef50_Q3UE17-2
Mex-3 RNA-binding family member D		RAT		662
RNA-binding protein MEX3D		MESAU		648
Uncharacterized protein (Fragment)		NEOLE		598
RNA-binding protein MEX3D		CRIGR		598
+36

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CAAA01108096 Genomic DNA No translation available. AC152062 Genomic DNA No translation available. AK149801 mRNA Translation: BAE29094.1
RefSeqⁱ	NP_941017.2, NM_198615.2
UniGeneⁱ	Mm.268389

3D structure databases

ProteinModelPortalⁱ	Q3UE17
SMRⁱ	Q3UE17
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000057962

STRINGⁱ

10090.ENSMUSP00000057962

PTM databases

iPTMnetⁱ	Q3UE17
PhosphoSitePlusⁱ	Q3UE17

Proteomic databases

MaxQBⁱ	Q3UE17
PaxDbⁱ	Q3UE17
PRIDEⁱ	Q3UE17

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	237400
KEGGⁱ	mmu:237400

Organism-specific databases

CTDⁱ	399664
MGIⁱ	MGI:2681847 Mex3d

Phylogenomic databases

eggNOGⁱ	KOG2113 Eukaryota ENOG410YCYR LUCA
HOGENOMⁱ	HOG000236282
HOVERGENⁱ	HBG071698
InParanoidⁱ	Q3UE17
KOⁱ	K15686
PhylomeDBⁱ	Q3UE17

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q3UE17
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	MM_MEX3D

CleanExⁱ

MM_MEX3D

Family and domain databases

Gene3Dⁱ	3.30.1370.10, 2 hits 3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR004087 KH_dom IPR004088 KH_dom_type_1 IPR036612 KH_dom_type_1_sf IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
Pfamⁱ	View protein in Pfam PF00013 KH_1, 2 hits
SMARTⁱ	View protein in SMART SM00322 KH, 2 hits
SUPFAMⁱ	SSF54791 SSF54791, 2 hits
PROSITEⁱ	View protein in PROSITE PS50084 KH_TYPE_1, 2 hits PS50089 ZF_RING_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MEX3D_MOUSE
Accessionⁱ	Q3UE17Primary (citable) accession number: Q3UE17
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
	Last sequence update:	March 20, 2007
	Last modified:	February 28, 2018
	This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3UE17 (MEX3D_MOUSE)

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RNA-binding protein MEX3D

Mex3d

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ