UniProtKB - Q3UE17 (MEX3D_MOUSE)
Protein
RNA-binding protein MEX3D
Gene
Mex3d
Organism
Mus musculus (Mouse)
Status
Functioni
RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 592 – 632 | RING-typePROSITE-ProRule annotationAdd BLAST | 41 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- mRNA 3'-UTR AU-rich region binding Source: BHF-UCL
- mRNA 3'-UTR binding Source: MGI
GO - Biological processi
- mRNA catabolic process Source: MGI
- mRNA destabilization Source: BHF-UCL
- RNA destabilization Source: MGI
Keywordsi
Molecular function | RNA-binding |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: RNA-binding protein MEX3DAlternative name(s): RING finger and KH domain-containing protein 1 |
Gene namesi | Name:Mex3d Synonyms:Rkhd1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2681847, Mex3d |
Subcellular locationi
Nucleus
- nucleus Source: BHF-UCL
Other locations
- perinuclear region of cytoplasm Source: BHF-UCL
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000281676 | 1 – 643 | RNA-binding protein MEX3DAdd BLAST | 643 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 491 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 495 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | Q3UE17 |
PaxDbi | Q3UE17 |
PRIDEi | Q3UE17 |
PTM databases
iPTMneti | Q3UE17 |
PhosphoSitePlusi | Q3UE17 |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000057962 |
Miscellaneous databases
RNActi | Q3UE17, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 160 – 221 | KH 1PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 253 – 314 | KH 2PROSITE-ProRule annotationAdd BLAST | 62 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 46 – 49 | Poly-Ala | 4 |
Domaini
Binds RNA through its KH domains.By similarity
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 592 – 632 | RING-typePROSITE-ProRule annotationAdd BLAST | 41 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2113, Eukaryota |
InParanoidi | Q3UE17 |
OrthoDBi | 814376at2759 |
PhylomeDBi | Q3UE17 |
Family and domain databases
Gene3Di | 3.30.1370.10, 2 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00013, KH_1, 2 hits |
SMARTi | View protein in SMART SM00322, KH, 2 hits |
SUPFAMi | SSF54791, SSF54791, 2 hits |
PROSITEi | View protein in PROSITE PS50084, KH_TYPE_1, 2 hits PS50089, ZF_RING_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q3UE17-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPGSTGQPDA GGAGTGTTAG DPGHPHPALA GAEDAAPRPP PEPDDAAAAL
60 70 80 90 100
RLALDQLSAL GLGGARPGDE GMATRSADGA TECGEDEPAP PDELEVAVAP
110 120 130 140 150
PVTASVAPGG LPLLDPDVSP RPSPPDVFAS FAPHPAALGP STLLAEQLNV
160 170 180 190 200
IGSRKKSVNM TECVPVPSSE HVAEIVGRQG CKIKALRAKT NTYIKTPVRG
210 220 230 240 250
EEPVFIVTGR KEDVEMAKRE ILSAEHFSLI RATRSKAGGL SGATPGPPNL
260 270 280 290 300
PGQTTIQVRV PYRVVGLVVG PKGATIKRIQ QRTHTYIVTP GRDKEPVFAV
310 320 330 340 350
TGMPENVDRA REEIEAHITL RTGAFTDSGP DSDFHANGTD VCLDLLGAAA
360 370 380 390 400
SLWAKAPHPG RRPPAATGGL RGDNALGAAS TPEPFYVGSR GGPPLPDPSP
410 420 430 440 450
SSPYGGSGNG GFTFGGDGPS APTGTATPED CDFGFDFLAL DLTVPATATI
460 470 480 490 500
WAPFERAAPL PAFSGCPAVN GAPAQPNTGT RRSSGGGAAT TPRHSPTLPE
510 520 530 540 550
PGGLSLELPL ARRSVPDPVG AVPWRPPQSA LPPFSGSTTF STTPSLPSTT
560 570 580 590 600
LASSTLDTVP SEGNHKPSTT AANSSASTAA PGPPSAALAR ECVVCSEGEA
610 620 630 640
MAALVPCGHN LFCMDCAVRI CGKSEPECPA CRTPATQAIH IFS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YTR3 | D3YTR3_MOUSE | RNA-binding protein MEX3D | Mex3d | 718 | Annotation score: | ||
F6TY75 | F6TY75_MOUSE | RNA-binding protein MEX3D | Mex3d | 268 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024020 | 1 – 104 | MPGST…PPVTA → MGVGPSMALAPSVTCAPSMA LAPSVTSAPSMALAPSVTCA PCMAVAPSVTVAPSMALTPS VTLAPTMAVAS in isoform 2. 1 PublicationAdd BLAST | 104 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CAAA01108096 Genomic DNA No translation available. AC152062 Genomic DNA No translation available. AK149801 mRNA Translation: BAE29094.1 |
RefSeqi | NP_941017.2, NM_198615.2 |
Genome annotation databases
GeneIDi | 237400 |
KEGGi | mmu:237400 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CAAA01108096 Genomic DNA No translation available. AC152062 Genomic DNA No translation available. AK149801 mRNA Translation: BAE29094.1 |
RefSeqi | NP_941017.2, NM_198615.2 |
3D structure databases
SMRi | Q3UE17 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000057962 |
PTM databases
iPTMneti | Q3UE17 |
PhosphoSitePlusi | Q3UE17 |
Proteomic databases
MaxQBi | Q3UE17 |
PaxDbi | Q3UE17 |
PRIDEi | Q3UE17 |
Genome annotation databases
GeneIDi | 237400 |
KEGGi | mmu:237400 |
Organism-specific databases
CTDi | 399664 |
MGIi | MGI:2681847, Mex3d |
Phylogenomic databases
eggNOGi | KOG2113, Eukaryota |
InParanoidi | Q3UE17 |
OrthoDBi | 814376at2759 |
PhylomeDBi | Q3UE17 |
Miscellaneous databases
BioGRID-ORCSi | 237400, 0 hits in 17 CRISPR screens |
ChiTaRSi | Mex3d, mouse |
PROi | PR:Q3UE17 |
RNActi | Q3UE17, protein |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 3.30.1370.10, 2 hits 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR004087, KH_dom IPR004088, KH_dom_type_1 IPR036612, KH_dom_type_1_sf IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF00013, KH_1, 2 hits |
SMARTi | View protein in SMART SM00322, KH, 2 hits |
SUPFAMi | SSF54791, SSF54791, 2 hits |
PROSITEi | View protein in PROSITE PS50084, KH_TYPE_1, 2 hits PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MEX3D_MOUSE | |
Accessioni | Q3UE17Primary (citable) accession number: Q3UE17 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | March 20, 2007 | |
Last modified: | December 2, 2020 | |
This is version 105 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot