Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

RNA-binding protein MEX3D

Gene

Mex3d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri592 – 632RING-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

GO - Biological processi

  • mRNA catabolic process Source: MGI
  • mRNA destabilization Source: BHF-UCL
  • RNA destabilization Source: MGI

Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein MEX3D
Alternative name(s):
RING finger and KH domain-containing protein 1
Gene namesi
Name:Mex3d
Synonyms:Rkhd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2681847 Mex3d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002816761 – 643RNA-binding protein MEX3DAdd BLAST643

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei491PhosphothreonineBy similarity1
Modified residuei495PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ3UE17
PaxDbiQ3UE17
PRIDEiQ3UE17

PTM databases

iPTMnetiQ3UE17
PhosphoSitePlusiQ3UE17

Expressioni

Gene expression databases

CleanExiMM_MEX3D

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057962

Structurei

3D structure databases

ProteinModelPortaliQ3UE17
SMRiQ3UE17
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini160 – 221KH 1PROSITE-ProRule annotationAdd BLAST62
Domaini253 – 314KH 2PROSITE-ProRule annotationAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi46 – 49Poly-Ala4

Domaini

Binds RNA through its KH domains.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri592 – 632RING-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2113 Eukaryota
ENOG410YCYR LUCA
HOGENOMiHOG000236282
HOVERGENiHBG071698
InParanoidiQ3UE17
KOiK15686
PhylomeDBiQ3UE17

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00013 KH_1, 2 hits
SMARTiView protein in SMART
SM00322 KH, 2 hits
SUPFAMiSSF54791 SSF54791, 2 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 2 hits
PS50089 ZF_RING_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3UE17-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGSTGQPDA GGAGTGTTAG DPGHPHPALA GAEDAAPRPP PEPDDAAAAL
60 70 80 90 100
RLALDQLSAL GLGGARPGDE GMATRSADGA TECGEDEPAP PDELEVAVAP
110 120 130 140 150
PVTASVAPGG LPLLDPDVSP RPSPPDVFAS FAPHPAALGP STLLAEQLNV
160 170 180 190 200
IGSRKKSVNM TECVPVPSSE HVAEIVGRQG CKIKALRAKT NTYIKTPVRG
210 220 230 240 250
EEPVFIVTGR KEDVEMAKRE ILSAEHFSLI RATRSKAGGL SGATPGPPNL
260 270 280 290 300
PGQTTIQVRV PYRVVGLVVG PKGATIKRIQ QRTHTYIVTP GRDKEPVFAV
310 320 330 340 350
TGMPENVDRA REEIEAHITL RTGAFTDSGP DSDFHANGTD VCLDLLGAAA
360 370 380 390 400
SLWAKAPHPG RRPPAATGGL RGDNALGAAS TPEPFYVGSR GGPPLPDPSP
410 420 430 440 450
SSPYGGSGNG GFTFGGDGPS APTGTATPED CDFGFDFLAL DLTVPATATI
460 470 480 490 500
WAPFERAAPL PAFSGCPAVN GAPAQPNTGT RRSSGGGAAT TPRHSPTLPE
510 520 530 540 550
PGGLSLELPL ARRSVPDPVG AVPWRPPQSA LPPFSGSTTF STTPSLPSTT
560 570 580 590 600
LASSTLDTVP SEGNHKPSTT AANSSASTAA PGPPSAALAR ECVVCSEGEA
610 620 630 640
MAALVPCGHN LFCMDCAVRI CGKSEPECPA CRTPATQAIH IFS
Length:643
Mass (Da):65,329
Last modified:March 20, 2007 - v2
Checksum:iEB8EF02F788480F2
GO
Isoform 2 (identifier: Q3UE17-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: MPGSTGQPDA...EVAVAPPVTA → MGVGPSMALA...TLAPTMAVAS

Show »
Length:610
Mass (Da):62,094
Checksum:i3BC2585DA7B18B0D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YTR3D3YTR3_MOUSE
RNA-binding protein MEX3D
Mex3d
718Annotation score:
F6TY75F6TY75_MOUSE
RNA-binding protein MEX3D
Mex3d
268Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0240201 – 104MPGST…PPVTA → MGVGPSMALAPSVTCAPSMA LAPSVTSAPSMALAPSVTCA PCMAVAPSVTVAPSMALTPS VTLAPTMAVAS in isoform 2. 1 PublicationAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAA01108096 Genomic DNA No translation available.
AC152062 Genomic DNA No translation available.
AK149801 mRNA Translation: BAE29094.1
RefSeqiNP_941017.2, NM_198615.2
UniGeneiMm.268389

Genome annotation databases

GeneIDi237400
KEGGimmu:237400

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAA01108096 Genomic DNA No translation available.
AC152062 Genomic DNA No translation available.
AK149801 mRNA Translation: BAE29094.1
RefSeqiNP_941017.2, NM_198615.2
UniGeneiMm.268389

3D structure databases

ProteinModelPortaliQ3UE17
SMRiQ3UE17
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057962

PTM databases

iPTMnetiQ3UE17
PhosphoSitePlusiQ3UE17

Proteomic databases

MaxQBiQ3UE17
PaxDbiQ3UE17
PRIDEiQ3UE17

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi237400
KEGGimmu:237400

Organism-specific databases

CTDi399664
MGIiMGI:2681847 Mex3d

Phylogenomic databases

eggNOGiKOG2113 Eukaryota
ENOG410YCYR LUCA
HOGENOMiHOG000236282
HOVERGENiHBG071698
InParanoidiQ3UE17
KOiK15686
PhylomeDBiQ3UE17

Miscellaneous databases

PROiPR:Q3UE17
SOURCEiSearch...

Gene expression databases

CleanExiMM_MEX3D

Family and domain databases

Gene3Di3.30.1370.10, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00013 KH_1, 2 hits
SMARTiView protein in SMART
SM00322 KH, 2 hits
SUPFAMiSSF54791 SSF54791, 2 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 2 hits
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMEX3D_MOUSE
AccessioniPrimary (citable) accession number: Q3UE17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: February 28, 2018
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again