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Protein

Protein YIPF3

Gene

Yipf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein YIPF3
Alternative name(s):
Killer lineage protein 1
YIP1 family member 3
Cleaved into the following chain:
Gene namesi
Name:Yipf3
Synonyms:D17Wsu94e, Klip1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:106280 Yipf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 145CytoplasmicBy similarityAdd BLAST144
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 184LumenalCuratedAdd BLAST18
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 211CytoplasmicCurated6
Transmembranei212 – 234HelicalSequence analysisAdd BLAST23
Topological domaini235 – 237LumenalCurated3
Transmembranei238 – 260HelicalSequence analysisAdd BLAST23
Topological domaini261 – 271CytoplasmicCuratedAdd BLAST11
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Topological domaini293 – 347LumenalBy similarityAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002444471 – 347Protein YIPF3Add BLAST347
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00004245232 – 347Protein YIPF3, N-terminally processedAdd BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine; in Protein YIPF3, N-terminally processedBy similarity1
Glycosylationi334N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

EPDiQ3UDR8
MaxQBiQ3UDR8
PaxDbiQ3UDR8
PeptideAtlasiQ3UDR8
PRIDEiQ3UDR8

PTM databases

iPTMnetiQ3UDR8
PhosphoSitePlusiQ3UDR8

Expressioni

Tissue specificityi

Expressed by splenocytes (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000071074 Expressed in 270 organ(s), highest expression level in tracheobronchial tree
CleanExiMM_YIPF3
ExpressionAtlasiQ3UDR8 baseline and differential
GenevisibleiQ3UDR8 MM

Interactioni

Subunit structurei

Interacts with YIPF4 and YIPF5.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092897

Structurei

3D structure databases

ProteinModelPortaliQ3UDR8
SMRiQ3UDR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the YIP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPBK Eukaryota
ENOG4111EUH LUCA
GeneTreeiENSGT00510000047963
HOGENOMiHOG000031450
HOVERGENiHBG055544
InParanoidiQ3UDR8
OMAiTYNIHFH
OrthoDBiEOG091G0ZA9
PhylomeDBiQ3UDR8
TreeFamiTF314073

Family and domain databases

InterProiView protein in InterPro
IPR026637 YIPF3
PANTHERiPTHR15627:SF14 PTHR15627:SF14, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q3UDR8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATPAAPASG VRNGAGPEWG GFEENIQGGG SAVIDMENMD DTSGSSFEDM
60 70 80 90 100
GELHQRLREE EVDADAAAAE EEDGEFLGMK GFKGQLSRQV ADQMWQAGKR
110 120 130 140 150
QASRAFSLYA NIDILRPYFD VEPAQVRSRL LESMIPIKMV NFPQKVAGEL
160 170 180 190 200
YGPLMLVFTL VAILLHGMKT SDTIIREGTL MGTAIGTCFG YWLGVSSFIY
210 220 230 240 250
FLAYLCNAQI TMLQMLALLG YGLFGHCIVL FITYNIHLHA LFYLFWLLVG
260 270 280 290 300
GLSTLRMVAV LVSRTVGPTQ RLLLCGTLAA LHMLFLLYLH FAYHKVVEGI
310 320 330 340
LDTLEGPNIP PMQRVPRDIP AVLPAARLPV AVINATAKAI AVTLQSH
Length:347
Mass (Da):37,998
Last modified:October 11, 2005 - v1
Checksum:iBE3CFD310CD52739
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6YIY0F6YIY0_MOUSE
Protein YIPF
Yipf3
201Annotation score:
D3YXM6D3YXM6_MOUSE
Protein YIPF3
Yipf3
203Annotation score:

Sequence cautioni

The sequence BAC31317 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti333I → V in AAH19384 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149957 mRNA Translation: BAE29193.1
AK042644 mRNA Translation: BAC31317.1 Different initiation.
BC019384 mRNA Translation: AAH19384.1
AF197931 mRNA Translation: AAM21162.1
CCDSiCCDS28823.1
RefSeqiNP_663328.2, NM_145353.2
UniGeneiMm.248769

Genome annotation databases

EnsembliENSMUST00000095263; ENSMUSP00000092897; ENSMUSG00000071074
GeneIDi28064
KEGGimmu:28064
UCSCiuc008csd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149957 mRNA Translation: BAE29193.1
AK042644 mRNA Translation: BAC31317.1 Different initiation.
BC019384 mRNA Translation: AAH19384.1
AF197931 mRNA Translation: AAM21162.1
CCDSiCCDS28823.1
RefSeqiNP_663328.2, NM_145353.2
UniGeneiMm.248769

3D structure databases

ProteinModelPortaliQ3UDR8
SMRiQ3UDR8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092897

PTM databases

iPTMnetiQ3UDR8
PhosphoSitePlusiQ3UDR8

Proteomic databases

EPDiQ3UDR8
MaxQBiQ3UDR8
PaxDbiQ3UDR8
PeptideAtlasiQ3UDR8
PRIDEiQ3UDR8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095263; ENSMUSP00000092897; ENSMUSG00000071074
GeneIDi28064
KEGGimmu:28064
UCSCiuc008csd.2 mouse

Organism-specific databases

CTDi25844
MGIiMGI:106280 Yipf3

Phylogenomic databases

eggNOGiENOG410IPBK Eukaryota
ENOG4111EUH LUCA
GeneTreeiENSGT00510000047963
HOGENOMiHOG000031450
HOVERGENiHBG055544
InParanoidiQ3UDR8
OMAiTYNIHFH
OrthoDBiEOG091G0ZA9
PhylomeDBiQ3UDR8
TreeFamiTF314073

Miscellaneous databases

ChiTaRSiYipf3 mouse
PROiPR:Q3UDR8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071074 Expressed in 270 organ(s), highest expression level in tracheobronchial tree
CleanExiMM_YIPF3
ExpressionAtlasiQ3UDR8 baseline and differential
GenevisibleiQ3UDR8 MM

Family and domain databases

InterProiView protein in InterPro
IPR026637 YIPF3
PANTHERiPTHR15627:SF14 PTHR15627:SF14, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiYIPF3_MOUSE
AccessioniPrimary (citable) accession number: Q3UDR8
Secondary accession number(s): Q8C998, Q8K5D1, Q8VCS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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