UniProtKB - Q3UD61 (MX1_MOUSE)
Protein
Protein Mx1
Gene
Mx1
Organism
Mus musculus (Mouse)
Status
Functioni
Caution
Could be the product of a pseudogene. The sequence shown in this entry is that of an non-functional Mx1 gene product, as it is encoded by the C57BL/6J reference genome (PubMed:19468303). The expression of this gene, if it occurs, would result in a non-functional gene product. Mx1 gene corruption, by a deletion or a nonsense mutation, is also observed in other inbred strains. The functional Mx1 gene is found in some feral mouse strains. Its product is involved in the innate immunity system (PubMed:2903437).Curated2 Publications
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: InterPro
- microtubule binding Source: GO_Central
GO - Biological processi
- dynamin family protein polymerization involved in mitochondrial fission Source: GO_Central
- membrane fusion Source: GO_Central
- mitochondrial fission Source: GO_Central
- postsynaptic neurotransmitter receptor internalization Source: GO_Central
- receptor internalization Source: GO_Central
- regulation of synapse structure or activity Source: GO_Central
- synaptic vesicle budding from presynaptic endocytic zone membrane Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Protein Mx1 |
Gene namesi | Name:Mx1 Synonyms:Mx1 Publication |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97243, Mx1 |
Subcellular locationi
Cytoskeleton
- microtubule cytoskeleton Source: GO_Central
Mitochondrion
- mitochondrial membrane Source: GO_Central
Nucleus
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
- postsynaptic endocytic zone membrane Source: GO_Central
Other locations
- axon Source: GO_Central
- cytoplasm Source: GO_Central
- cytoplasmic vesicle Source: GO_Central
- dendritic spine head Source: GO_Central
- membrane Source: GO_Central
- postsynaptic density Source: GO_Central
- presynapse Source: GOC
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000451089 | 1 – 397 | Protein Mx1Add BLAST | 397 |
Proteomic databases
jPOSTi | Q3UD61 |
MaxQBi | Q3UD61 |
ProteomicsDBi | 330322 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000000386, Expressed in mucous cell of stomach and 132 other tissues |
ExpressionAtlasi | Q3UD61, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation
Phylogenomic databases
GeneTreei | ENSGT00940000155686 |
HOGENOMi | CLU_008964_8_2_1 |
TreeFami | TF331484 |
Family and domain databases
CDDi | cd08771, DLP_1, 1 hit |
InterProi | View protein in InterPro IPR001401, Dynamin_GTPase IPR019762, Dynamin_GTPase_CS IPR022812, Dynamin_SF IPR000375, Dynamin_stalk IPR030381, G_DYNAMIN_dom IPR003130, GED IPR020850, GED_dom IPR027417, P-loop_NTPase |
PANTHERi | PTHR11566, PTHR11566, 2 hits |
Pfami | View protein in Pfam PF01031, Dynamin_M, 1 hit PF00350, Dynamin_N, 1 hit PF02212, GED, 1 hit |
PRINTSi | PR00195, DYNAMIN |
SMARTi | View protein in SMART SM00053, DYNc, 1 hit SM00302, GED, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00410, G_DYNAMIN_1, 1 hit PS51718, G_DYNAMIN_2, 1 hit PS51388, GED, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q3UD61-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSVNNLCRH YEEKVRPCID LIDTLRALGV EQDLALPAIA VIGDQSSGKS
60 70 80 90 100
SVLEALSGVA LPRGSGIVTR CPLVLKLRKL KEGEEWRGKV SYDDIEVELS
110 120 130 140 150
DPSEVEEAIN KGQNFIAGVG LGISDKLISL DVSSPNVPDL TLIDLPGITR
160 170 180 190 200
VAVGNQPADI GRQIKRLIKT YIQKQETINL VVVPSNVDIA TTEALSMAQE
210 220 230 240 250
VDPEGDRTIE MVQTAFVKIL SNDFGDFLNL CCTAKSKIKE IRLNQEKEAE
260 270 280 290 300
NLIRLHFQME QIVYCQDQVY KETLKTIREK EAEKEKTKAL INPATFQNNS
310 320 330 340 350
QFPQKGLTTT EMTQHLKAYY QECRRNIGRQ IPLIIQYFIL KTFGEEIEKT
360 370 380 390
MLQLLQDTSK CSWFLEEQSD TREKKKFLKR RLLRLDEARQ KLAKFSD
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q0J3 | E9Q0J3_MOUSE | Interferon-induced GTP-binding prot... | Mx1 | 627 | Annotation score: | ||
A0A338P7J0 | A0A338P7J0_MOUSE | Interferon-induced GTP-binding prot... | Mx1 | 298 | Annotation score: | ||
A0A338P725 | A0A338P725_MOUSE | Interferon-induced GTP-binding prot... | Mx1 | 287 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK150023 mRNA Translation: BAE29248.1 AK150236 mRNA Translation: BAE29400.1 AC164088 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000113768; ENSMUSP00000109397; ENSMUSG00000000386 |
UCSCi | uc008adh.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK150023 mRNA Translation: BAE29248.1 AK150236 mRNA Translation: BAE29400.1 AC164088 Genomic DNA No translation available. |
3D structure databases
SMRi | Q3UD61 |
ModBasei | Search... |
Proteomic databases
jPOSTi | Q3UD61 |
MaxQBi | Q3UD61 |
ProteomicsDBi | 330322 |
Genome annotation databases
Ensembli | ENSMUST00000113768; ENSMUSP00000109397; ENSMUSG00000000386 |
UCSCi | uc008adh.1, mouse |
Organism-specific databases
MGIi | MGI:97243, Mx1 |
Phylogenomic databases
GeneTreei | ENSGT00940000155686 |
HOGENOMi | CLU_008964_8_2_1 |
TreeFami | TF331484 |
Miscellaneous databases
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000000386, Expressed in mucous cell of stomach and 132 other tissues |
ExpressionAtlasi | Q3UD61, baseline and differential |
Family and domain databases
CDDi | cd08771, DLP_1, 1 hit |
InterProi | View protein in InterPro IPR001401, Dynamin_GTPase IPR019762, Dynamin_GTPase_CS IPR022812, Dynamin_SF IPR000375, Dynamin_stalk IPR030381, G_DYNAMIN_dom IPR003130, GED IPR020850, GED_dom IPR027417, P-loop_NTPase |
PANTHERi | PTHR11566, PTHR11566, 2 hits |
Pfami | View protein in Pfam PF01031, Dynamin_M, 1 hit PF00350, Dynamin_N, 1 hit PF02212, GED, 1 hit |
PRINTSi | PR00195, DYNAMIN |
SMARTi | View protein in SMART SM00053, DYNc, 1 hit SM00302, GED, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00410, G_DYNAMIN_1, 1 hit PS51718, G_DYNAMIN_2, 1 hit PS51388, GED, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MX1_MOUSE | |
Accessioni | Q3UD61Primary (citable) accession number: Q3UD61 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 7, 2020 |
Last sequence update: | October 11, 2005 | |
Last modified: | April 7, 2021 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families