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Entry version 92 (11 Dec 2019)
Sequence version 1 (11 Oct 2005)
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Protein

Arginine/serine-rich protein 1

Gene

Rsrp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

It is uncertain whether Met-1 or Met-6 is the initiator.Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arginine/serine-rich protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rsrp1
Synonyms:D4Wsu53e
ORF Names:MNCb-0169
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:106498 Rsrp1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002976191 – 298Arginine/serine-rich protein 1Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17PhosphoserineCombined sources1
Modified residuei145Omega-N-methylarginineCombined sources1
Modified residuei282PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3UC65

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3UC65

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3UC65

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3UC65

PeptideAtlas

More...
PeptideAtlasi
Q3UC65

PRoteomics IDEntifications database

More...
PRIDEi
Q3UC65

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3UC65

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3UC65

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000037266 Expressed in 295 organ(s), highest expression level in sciatic nerve

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3UC65 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000077226

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3UC65 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi23 – 181Arg/Ser-richAdd BLAST159

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RSRP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JBP1 Eukaryota
ENOG410Z5YZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111390

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111225

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3UC65

Identification of Orthologs from Complete Genome Data

More...
OMAi
PYGHWIP

Database of Orthologous Groups

More...
OrthoDBi
1527220at2759

TreeFam database of animal gene trees

More...
TreeFami
TF338669

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029656 RSRP1

The PANTHER Classification System

More...
PANTHERi
PTHR47622 PTHR47622, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q3UC65-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSAAMSKYV NDMWPGSPQE KASPSTSGSG RSSRLSSRSR SRSSSRSSRR
60 70 80 90 100
DSRSSSRSSS RSHSRPRRSR RSRSRSRRRH QRKYRRYSRS YSRSRSRSRS
110 120 130 140 150
HRYHRDSRYE RPRRYYKSPS PYRSRSRSRS RGRSQHRWSY YAITRGRRYY
160 170 180 190 200
GFGRTVYPED RPRWRERSRT RSRSRSRTPF RLSEKDRMEL LEIAKANAAK
210 220 230 240 250
ALGTANFDLP ASLRAKEASQ GTAVSSSGPK VEHSEKQTED ATKNTSEKSS
260 270 280 290
TQRNIAFSSN NSVAKPLQKT TKAAVEEKSS GSPKIDKKKS PYGLWIPV
Length:298
Mass (Da):34,539
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B44F3F9AA4E6CDC
GO
Isoform 2 (identifier: Q3UC65-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-298: HSEKQTEDAT...KSPYGLWIPV → VSAFRKLLPAFITLCQ

Note: May be due to intron retention.Curated
Show »
Length:248
Mass (Da):29,126
Checksum:i24D1BCC779344031
GO
Isoform 3 (identifier: Q3UC65-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-234: HS → KS
     235-298: Missing.

Show »
Length:234
Mass (Da):27,552
Checksum:iABCE001BB799885D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti158P → T in BAB28190 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027308233 – 298HSEKQ…LWIPV → VSAFRKLLPAFITLCQ in isoform 2. 2 PublicationsAdd BLAST66
Alternative sequenceiVSP_027309233 – 234HS → KS in isoform 3. 2 Publications2
Alternative sequenceiVSP_027310235 – 298Missing in isoform 3. 2 PublicationsAdd BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB041555 mRNA Translation: BAA95040.1
AK003799 mRNA Translation: BAB23002.1
AK012363 mRNA Translation: BAB28190.3
AK028145 mRNA Translation: BAC25773.1
AK029529 mRNA Translation: BAC26498.1
AK150024 mRNA Translation: BAE29249.1
AK150665 mRNA Translation: BAE29749.1
AK152736 mRNA Translation: BAE31456.1
AK160993 mRNA Translation: BAE36138.1
AK169598 mRNA Translation: BAE41249.1
AK169760 mRNA Translation: BAE41350.1
AL611963 Genomic DNA No translation available.
BC043057 mRNA Translation: AAH43057.1
BC046231 mRNA Translation: AAH46231.2
BC054728 mRNA Translation: AAH54728.1
BC056986 mRNA Translation: AAH56986.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS51328.1 [Q3UC65-1]

NCBI Reference Sequences

More...
RefSeqi
NP_076154.3, NM_023665.3 [Q3UC65-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000078084; ENSMUSP00000077226; ENSMUSG00000037266 [Q3UC65-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27981

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:27981

UCSC genome browser

More...
UCSCi
uc008vfx.1 mouse [Q3UC65-1]
uc008vfz.1 mouse [Q3UC65-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041555 mRNA Translation: BAA95040.1
AK003799 mRNA Translation: BAB23002.1
AK012363 mRNA Translation: BAB28190.3
AK028145 mRNA Translation: BAC25773.1
AK029529 mRNA Translation: BAC26498.1
AK150024 mRNA Translation: BAE29249.1
AK150665 mRNA Translation: BAE29749.1
AK152736 mRNA Translation: BAE31456.1
AK160993 mRNA Translation: BAE36138.1
AK169598 mRNA Translation: BAE41249.1
AK169760 mRNA Translation: BAE41350.1
AL611963 Genomic DNA No translation available.
BC043057 mRNA Translation: AAH43057.1
BC046231 mRNA Translation: AAH46231.2
BC054728 mRNA Translation: AAH54728.1
BC056986 mRNA Translation: AAH56986.1
CCDSiCCDS51328.1 [Q3UC65-1]
RefSeqiNP_076154.3, NM_023665.3 [Q3UC65-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077226

PTM databases

iPTMnetiQ3UC65
PhosphoSitePlusiQ3UC65

Proteomic databases

EPDiQ3UC65
jPOSTiQ3UC65
MaxQBiQ3UC65
PaxDbiQ3UC65
PeptideAtlasiQ3UC65
PRIDEiQ3UC65

Genome annotation databases

EnsembliENSMUST00000078084; ENSMUSP00000077226; ENSMUSG00000037266 [Q3UC65-1]
GeneIDi27981
KEGGimmu:27981
UCSCiuc008vfx.1 mouse [Q3UC65-1]
uc008vfz.1 mouse [Q3UC65-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57035
MGIiMGI:106498 Rsrp1

Phylogenomic databases

eggNOGiENOG410JBP1 Eukaryota
ENOG410Z5YZ LUCA
GeneTreeiENSGT00730000111390
HOGENOMiHOG000111225
InParanoidiQ3UC65
OMAiPYGHWIP
OrthoDBi1527220at2759
TreeFamiTF338669

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rsrp1 mouse

Protein Ontology

More...
PROi
PR:Q3UC65
RNActiQ3UC65 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000037266 Expressed in 295 organ(s), highest expression level in sciatic nerve
GenevisibleiQ3UC65 MM

Family and domain databases

InterProiView protein in InterPro
IPR029656 RSRP1
PANTHERiPTHR47622 PTHR47622, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRSRP1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UC65
Secondary accession number(s): Q80Y97
, Q9CSN6, Q9D194, Q9JJF1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 11, 2005
Last modified: December 11, 2019
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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