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Protein

Transmembrane protein 109

Gene

Tmem109

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (PubMed:20060811). Can form voltage-gated calcium and potassium channels in vitro (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Voltage-gated channel
Biological processIon transport, Transport

Protein family/group databases

TCDBi1.A.74.1.1 the mitsugumin 23 (mg23) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 109
Alternative name(s):
Mitsugumin-23
Short name:
Mg23
Gene namesi
Name:Tmem109
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1915789 Tmem109

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 83LumenalBy similarityAdd BLAST50
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 135CytoplasmicBy similarityAdd BLAST31
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 185LumenalBy similarityAdd BLAST29
Transmembranei186 – 205HelicalSequence analysisAdd BLAST20
Topological domaini206 – 243CytoplasmicBy similarityAdd BLAST38

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus, Sarcoplasmic reticulum

Pathology & Biotechi

Disruption phenotypei

Viable and normal in appearance.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000004461934 – 243Transmembrane protein 109Add BLAST210

Proteomic databases

EPDiQ3UBX0
MaxQBiQ3UBX0
PaxDbiQ3UBX0
PeptideAtlasiQ3UBX0
PRIDEiQ3UBX0

PTM databases

iPTMnetiQ3UBX0
PhosphoSitePlusiQ3UBX0

Expressioni

Gene expression databases

BgeeiENSMUSG00000034659 Expressed in 289 organ(s), highest expression level in ascending aorta
CleanExiMM_TMEM109
ExpressionAtlasiQ3UBX0 baseline and differential
GenevisibleiQ3UBX0 MM

Interactioni

Subunit structurei

Homooligomer. Interacts with CRYAB.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CRYABP025112EBI-2366300,EBI-739060From Homo sapiens.

Protein-protein interaction databases

BioGridi212917, 14 interactors
IntActiQ3UBX0, 16 interactors
MINTiQ3UBX0

Structurei

3D structure databases

SMRiQ3UBX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIBB Eukaryota
ENOG410XXDM LUCA
GeneTreeiENSGT00390000015704
HOGENOMiHOG000126892
HOVERGENiHBG083664
InParanoidiQ3UBX0
OMAiTLSQVMW
OrthoDBiEOG091G0S01
PhylomeDBiQ3UBX0
TreeFamiTF332238

Family and domain databases

InterProiView protein in InterPro
IPR039492 TMEM109
PANTHERiPTHR14550 PTHR14550, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q3UBX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGAHSTPLW SRHLLKAVLM VLVALFLVHS ASAQSHREFA SPGQQKKETS
60 70 80 90 100
ADILTQIGRS LKEMLDTWLG PETMHVISET LLQVMWAISS AISVACFALS
110 120 130 140 150
GIAAQLLSAL GLDGEQLTQG LKLSPSQVQT LLLWGAAALV IYWLLSLLLG
160 170 180 190 200
LVLALLGRIL GGLKLVLFVA GFVALVRSVP DPSTRALMLL ALLTLFALLS
210 220 230 240
RLTGSRSSGS HLEAKVRGLE RQIEELRGRQ RRAAKMPRSM EEE
Length:243
Mass (Da):26,306
Last modified:December 20, 2005 - v2
Checksum:i31376625A07BF587
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YX08D3YX08_MOUSE
Transmembrane protein 109
Tmem109
115Annotation score:
D3Z0I8D3Z0I8_MOUSE
Transmembrane protein 109
Tmem109
213Annotation score:
D3Z7P2D3Z7P2_MOUSE
Transmembrane protein 109
Tmem109
73Annotation score:
D3Z3Z2D3Z3Z2_MOUSE
Transmembrane protein 109
Tmem109
93Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti159I → V in BAE29844 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150779 mRNA Translation: BAE29844.1
AK151850 mRNA Translation: BAE30740.1
AK152419 mRNA Translation: BAE31204.1
AK165990 mRNA Translation: BAE38505.1
BC022997 mRNA Translation: AAH22997.1
BC023901 mRNA Translation: AAH23901.1
BC025033 mRNA Translation: AAH25033.1
BC025815 mRNA Translation: AAH25815.1
CCDSiCCDS29590.1
RefSeqiNP_598903.1, NM_134142.1
XP_006527380.1, XM_006527317.1
UniGeneiMm.251890

Genome annotation databases

EnsembliENSMUST00000038128; ENSMUSP00000039529; ENSMUSG00000034659
GeneIDi68539
KEGGimmu:68539
UCSCiuc008gre.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK150779 mRNA Translation: BAE29844.1
AK151850 mRNA Translation: BAE30740.1
AK152419 mRNA Translation: BAE31204.1
AK165990 mRNA Translation: BAE38505.1
BC022997 mRNA Translation: AAH22997.1
BC023901 mRNA Translation: AAH23901.1
BC025033 mRNA Translation: AAH25033.1
BC025815 mRNA Translation: AAH25815.1
CCDSiCCDS29590.1
RefSeqiNP_598903.1, NM_134142.1
XP_006527380.1, XM_006527317.1
UniGeneiMm.251890

3D structure databases

SMRiQ3UBX0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212917, 14 interactors
IntActiQ3UBX0, 16 interactors
MINTiQ3UBX0

Protein family/group databases

TCDBi1.A.74.1.1 the mitsugumin 23 (mg23) family

PTM databases

iPTMnetiQ3UBX0
PhosphoSitePlusiQ3UBX0

Proteomic databases

EPDiQ3UBX0
MaxQBiQ3UBX0
PaxDbiQ3UBX0
PeptideAtlasiQ3UBX0
PRIDEiQ3UBX0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038128; ENSMUSP00000039529; ENSMUSG00000034659
GeneIDi68539
KEGGimmu:68539
UCSCiuc008gre.2 mouse

Organism-specific databases

CTDi79073
MGIiMGI:1915789 Tmem109

Phylogenomic databases

eggNOGiENOG410IIBB Eukaryota
ENOG410XXDM LUCA
GeneTreeiENSGT00390000015704
HOGENOMiHOG000126892
HOVERGENiHBG083664
InParanoidiQ3UBX0
OMAiTLSQVMW
OrthoDBiEOG091G0S01
PhylomeDBiQ3UBX0
TreeFamiTF332238

Miscellaneous databases

ChiTaRSiTmem109 mouse
PROiPR:Q3UBX0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034659 Expressed in 289 organ(s), highest expression level in ascending aorta
CleanExiMM_TMEM109
ExpressionAtlasiQ3UBX0 baseline and differential
GenevisibleiQ3UBX0 MM

Family and domain databases

InterProiView protein in InterPro
IPR039492 TMEM109
PANTHERiPTHR14550 PTHR14550, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM109_MOUSE
AccessioniPrimary (citable) accession number: Q3UBX0
Secondary accession number(s): Q8R006
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: November 7, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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