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Protein

Transforming growth factor beta regulator 1

Gene

Tbrg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.1 Publication

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor beta regulator 1
Alternative name(s):
Nuclear interactor of ARF and Mdm2
Gene namesi
Name:Tbrg1
Synonyms:Niam
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1100877 Tbrg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002742192 – 406Transforming growth factor beta regulator 1Add BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei13PhosphothreonineCombined sources1

Post-translational modificationi

Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ3UB74
MaxQBiQ3UB74
PaxDbiQ3UB74
PeptideAtlasiQ3UB74
PRIDEiQ3UB74

PTM databases

iPTMnetiQ3UB74
PhosphoSitePlusiQ3UB74

Expressioni

Inductioni

Induced in cells undergoing arrest in response to DNA damage and TGFB1 treatment.1 Publication

Gene expression databases

BgeeiENSMUSG00000011114 Expressed in 305 organ(s), highest expression level in placenta
CleanExiMM_TBRG1
ExpressionAtlasiQ3UB74 baseline and differential
GenevisibleiQ3UB74 MM

Interactioni

Subunit structurei

Interacts with CDKN2A and MDM2.1 Publication

Protein-protein interaction databases

BioGridi203980, 5 interactors
IntActiQ3UB74, 1 interactor
MINTiQ3UB74
STRINGi10090.ENSMUSP00000112600

Structurei

3D structure databases

ProteinModelPortaliQ3UB74
SMRiQ3UB74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini177 – 236FYR N-terminalPROSITE-ProRule annotationAdd BLAST60
Domaini237 – 316FYR C-terminalPROSITE-ProRule annotationAdd BLAST80

Sequence similaritiesi

Belongs to the TBRG1 family.Curated

Phylogenomic databases

eggNOGiENOG410ITPM Eukaryota
ENOG410XTBM LUCA
GeneTreeiENSGT00390000013374
HOVERGENiHBG094027
InParanoidiQ3UB74
OMAiGARKCIN
OrthoDBiEOG091G0WMG
PhylomeDBiQ3UB74
TreeFamiTF324736

Family and domain databases

InterProiView protein in InterPro
IPR003889 FYrich_C
IPR003888 FYrich_N
PfamiView protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
SMARTiView protein in SMART
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
PROSITEiView protein in PROSITE
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3UB74-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVLSGLASE PRTPLSSKAR MKRLPRKSQN EKYRLKYLRL RRAAKATVFE
60 70 80 90 100
NASICDEIAR LEEKFLKAKE ERRYLLKKLL QIHALTEGEP QAAAPSHSSS
110 120 130 140 150
LPLPYGVTSS VGTMQGAGPS TGAEEPFAKK SKKEKKEKGK ENSKLEVLKK
160 170 180 190 200
TSKKKKMEGG ARKLVRPIAL DPSGQPVFPI GLGGLTVYSL GEIITNRPGF
210 220 230 240 250
HDENAIYPVG YCSTRVYASM KCPDQKCLYT CQIKDGGVQP QFEIVPEDDP
260 270 280 290 300
QNTIVGSSAD ACYEELLRAI SATTGKLMPN PLSCGADFFG FSHPTIHNLI
310 320 330 340 350
QSCPEAQNCV NYQWVKFDAC KPRKGQLSQE LPENDATMSL EAFQTQTFDD
360 370 380 390 400
DHDDSILPGS LDLPELQHEA FVSSYQPEFL THEPLVDTDL QHLKSPSQCS

PIQSSD
Length:406
Mass (Da):44,881
Last modified:February 6, 2007 - v2
Checksum:iEBF4AED368200625
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1STM2A0A1L1STM2_MOUSE
Transforming growth factor beta reg...
Tbrg1
201Annotation score:

Sequence cautioni

The sequence AAH21331 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH40813 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH43022 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH65795 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32K → M in BAE29651 (PubMed:16141072).Curated1
Sequence conflicti180I → T in BAE30090 (PubMed:16141072).Curated1
Sequence conflicti188Y → C in BAE30090 (PubMed:16141072).Curated1
Sequence conflicti207Y → N in BAE29651 (PubMed:16141072).Curated1
Sequence conflicti228L → P in BAE30090 (PubMed:16141072).Curated1
Sequence conflicti271S → G in BAE38845 (PubMed:16141072).Curated1
Sequence conflicti304P → L in AAH43022 (PubMed:15489334).Curated1
Sequence conflicti382H → Y in BAE38845 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ144541 mRNA Translation: AAZ76015.1
AK150549 mRNA Translation: BAE29651.1
AK151075 mRNA Translation: BAE30090.1
AK151457 mRNA Translation: BAE30416.1
AK151209 mRNA Translation: BAE30204.1
AK166547 mRNA Translation: BAE38845.1
BC021331 mRNA Translation: AAH21331.1 Different initiation.
BC040813 mRNA Translation: AAH40813.3 Different initiation.
BC043022 mRNA Translation: AAH43022.3 Different initiation.
BC065795 mRNA Translation: AAH65795.1 Different initiation.
CCDSiCCDS52771.1
RefSeqiNP_079565.2, NM_025289.3
UniGeneiMm.28689

Genome annotation databases

EnsembliENSMUST00000117654; ENSMUSP00000112600; ENSMUSG00000011114
GeneIDi21376
KEGGimmu:21376
UCSCiuc009ovh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ144541 mRNA Translation: AAZ76015.1
AK150549 mRNA Translation: BAE29651.1
AK151075 mRNA Translation: BAE30090.1
AK151457 mRNA Translation: BAE30416.1
AK151209 mRNA Translation: BAE30204.1
AK166547 mRNA Translation: BAE38845.1
BC021331 mRNA Translation: AAH21331.1 Different initiation.
BC040813 mRNA Translation: AAH40813.3 Different initiation.
BC043022 mRNA Translation: AAH43022.3 Different initiation.
BC065795 mRNA Translation: AAH65795.1 Different initiation.
CCDSiCCDS52771.1
RefSeqiNP_079565.2, NM_025289.3
UniGeneiMm.28689

3D structure databases

ProteinModelPortaliQ3UB74
SMRiQ3UB74
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203980, 5 interactors
IntActiQ3UB74, 1 interactor
MINTiQ3UB74
STRINGi10090.ENSMUSP00000112600

PTM databases

iPTMnetiQ3UB74
PhosphoSitePlusiQ3UB74

Proteomic databases

EPDiQ3UB74
MaxQBiQ3UB74
PaxDbiQ3UB74
PeptideAtlasiQ3UB74
PRIDEiQ3UB74

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000117654; ENSMUSP00000112600; ENSMUSG00000011114
GeneIDi21376
KEGGimmu:21376
UCSCiuc009ovh.1 mouse

Organism-specific databases

CTDi84897
MGIiMGI:1100877 Tbrg1

Phylogenomic databases

eggNOGiENOG410ITPM Eukaryota
ENOG410XTBM LUCA
GeneTreeiENSGT00390000013374
HOVERGENiHBG094027
InParanoidiQ3UB74
OMAiGARKCIN
OrthoDBiEOG091G0WMG
PhylomeDBiQ3UB74
TreeFamiTF324736

Miscellaneous databases

ChiTaRSiTbrg1 mouse
PROiPR:Q3UB74
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000011114 Expressed in 305 organ(s), highest expression level in placenta
CleanExiMM_TBRG1
ExpressionAtlasiQ3UB74 baseline and differential
GenevisibleiQ3UB74 MM

Family and domain databases

InterProiView protein in InterPro
IPR003889 FYrich_C
IPR003888 FYrich_N
PfamiView protein in Pfam
PF05965 FYRC, 1 hit
PF05964 FYRN, 1 hit
SMARTiView protein in SMART
SM00542 FYRC, 1 hit
SM00541 FYRN, 1 hit
PROSITEiView protein in PROSITE
PS51543 FYRC, 1 hit
PS51542 FYRN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBRG1_MOUSE
AccessioniPrimary (citable) accession number: Q3UB74
Secondary accession number(s): Q3TLE7
, Q3UCG2, Q3YBR3, Q6P067, Q80XA1, Q8CGC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: September 12, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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