UniProtKB - Q3UB06 (Q3UB06_MOUSE)
Protein
Protein kinase domain-containing protein
Gene
Srpk1
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- magnesium ion binding Source: Ensembl
- protein serine/threonine kinase activity Source: Ensembl
GO - Biological processi
- chromosome segregation Source: Ensembl
- intracellular signal transduction Source: Ensembl
- negative regulation of viral genome replication Source: Ensembl
- positive regulation of viral genome replication Source: Ensembl
- regulation of mRNA processing Source: Ensembl
Keywordsi
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Protein kinase domain-containing proteinInterPro annotation |
Gene namesi | Name:Srpk1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:106908, Srpk1 |
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- nuclear speck Source: Ensembl
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- chromatin Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000004865, Expressed in secondary oocyte and 324 other tissues |
ExpressionAtlasi | Q3UB06, baseline and differential |
Genevisiblei | Q3UB06, MM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 80 – 646 | Protein kinaseInterPro annotationAdd BLAST | 567 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 57 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 238 – 354 | DisorderedSequence analysisAdd BLAST | 117 | |
Regioni | 395 – 464 | DisorderedSequence analysisAdd BLAST | 70 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 21 – 43 | PolyampholyteSequence analysisAdd BLAST | 23 | |
Compositional biasi | 276 – 314 | PolyampholyteSequence analysisAdd BLAST | 39 | |
Compositional biasi | 320 – 342 | PolarSequence analysisAdd BLAST | 23 | |
Compositional biasi | 395 – 445 | PolarSequence analysisAdd BLAST | 51 |
Phylogenomic databases
HOGENOMi | CLU_000288_81_9_1 |
OMAi | HEGQRPP |
OrthoDBi | 290680at2759 |
PhylomeDBi | Q3UB06 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 2 hits |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3UB06-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERKVLALQA RKKRTKAKKD KAQRKPETQH RGSAPHSESD IPEQEEEILG
60 70 80 90 100
SDDDEQEDPN DYCKGGYHLV KIGDLFNGRY HVIRKLGWGH FSTVWLSWDI
110 120 130 140 150
QGKKFVAMKV VKSAEHYTET ALDEIRLLKS VRNSDPNDPN GEMVVQLLDD
160 170 180 190 200
FKISGVNGTH ICMVFEVLGH HLLKWIIKSN YQGLPLPCVK KIIQQVLQGL
210 220 230 240 250
DYLHTKCRII HTDIKPENIL LSVNEQYIRR LAAEATEWQR SGAPPPSGSA
260 270 280 290 300
VSTAPQPKPA DKMSKNKKKK LKKKQKRQAE LLEKRMQEIE EMEKESGPGQ
310 320 330 340 350
KRPNKQEESE SPVDRPLTEN PPNKMTQEKL EESNSIGQDQ TLTERGGEGG
360 370 380 390 400
APEINCNGVI GVVNYPENSN NETLRHKEDL HNANDCDVHT LKQEPSFLNS
410 420 430 440 450
SNGDSSPSQD TDSCTPTASE TMVCQSSAEQ SLTRQDITQL EESIRADTPS
460 470 480 490 500
GDEQEPNGAL DSKGKFSAGN FLINPLEPKN AEKLQVKIAD LGNACWVHKH
510 520 530 540 550
FTEDIQTRQY RSLEVLIGSG YNTPADIWST ACMAFELATG DYLFEPHSGE
560 570 580 590 600
DYTRDEDHIA LIIELLGKVP RKLIVAGKYS KEFFTKKGDL KHITKLKPWG
610 620 630 640
LLEVLVEKYE WPQEEAAGFT DFLLPMLELM PEKRATAAEC LRHPWLNS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK151152 mRNA Translation: BAE30158.1 |
RefSeqi | NP_058075.2, NM_016795.4 |
Genome annotation databases
GeneIDi | 20815 |
KEGGi | mmu:20815 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK151152 mRNA Translation: BAE30158.1 |
RefSeqi | NP_058075.2, NM_016795.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Chemistry databases
BindingDBi | Q3UB06 |
Proteomic databases
EPDi | Q3UB06 |
MaxQBi | Q3UB06 |
PRIDEi | Q3UB06 |
Protocols and materials databases
Antibodypediai | 6714, 443 antibodies |
Genome annotation databases
GeneIDi | 20815 |
KEGGi | mmu:20815 |
Organism-specific databases
CTDi | 6732 |
MGIi | MGI:106908, Srpk1 |
Phylogenomic databases
HOGENOMi | CLU_000288_81_9_1 |
OMAi | HEGQRPP |
OrthoDBi | 290680at2759 |
PhylomeDBi | Q3UB06 |
Miscellaneous databases
BioGRID-ORCSi | 20815, 3 hits in 19 CRISPR screens |
ChiTaRSi | Srpk1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000004865, Expressed in secondary oocyte and 324 other tissues |
ExpressionAtlasi | Q3UB06, baseline and differential |
Genevisiblei | Q3UB06, MM |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 2 hits |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3UB06_MOUSE | |
Accessioni | Q3UB06Primary (citable) accession number: Q3UB06 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |