UniProtKB - Q3UAG2 (Q3UAG2_MOUSE)
Protein
6-phosphogluconate dehydrogenase, decarboxylating
Gene
Pgd
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.UniRule annotation
Catalytic activityi
- 6-phospho-D-gluconate + NADP+ = CO2 + D-ribulose 5-phosphate + NADPHUniRule annotationARBA annotationEC:1.1.1.44UniRule annotationARBA annotation
: pentose phosphate pathway Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotationARBA annotationProteins known to be involved in the 3 steps of the subpathway in this organism are:
- Glucose-6-phosphate 1-dehydrogenase (G6pd2), Glucose-6-phosphate 1-dehydrogenase X (G6pdx), Glucose-6-phosphate 1-dehydrogenase (G6pdx), Glucose-6-phosphate 1-dehydrogenase 2 (G6pd2), Glucose-6-phosphate 1-dehydrogenase (G6pdx), Glucose-6-phosphate 1-dehydrogenase (G6pd2), Glucose-6-phosphate 1-dehydrogenase (G6pdx)
- 6-phosphogluconolactonase (H6pd), 6-phosphogluconolactonase (Pgls), 6-phosphogluconolactonase (Pgls), 6-phosphogluconolactonase (H6pd), 6-phosphogluconolactonase (Pgls), 6-phosphogluconolactonase (Pgls), 6-phosphogluconolactonase (H6pd), GDH/6PGL endoplasmic bifunctional protein (H6pd)
- 6-phosphogluconate dehydrogenase, decarboxylating (Pgd), 6-phosphogluconate dehydrogenase, decarboxylating (Pgd), 6-phosphogluconate dehydrogenase, decarboxylating (Pgd), 6-phosphogluconate dehydrogenase, decarboxylating (Pgd)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 103 | NADPUniRule annotation | 1 | |
Binding sitei | 103 | SubstrateUniRule annotation | 1 | |
Active sitei | 184 | Proton acceptorUniRule annotation | 1 | |
Active sitei | 191 | Proton donorUniRule annotation | 1 | |
Binding sitei | 192 | SubstrateUniRule annotation | 1 | |
Binding sitei | 261 | Substrate; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 288 | SubstrateUniRule annotation | 1 | |
Binding sitei | 447 | Substrate; shared with dimeric partnerUniRule annotation | 1 | |
Binding sitei | 453 | Substrate; shared with dimeric partnerUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 15 | NADPUniRule annotation | 6 | |
Nucleotide bindingi | 33 – 35 | NADPUniRule annotation | 3 | |
Nucleotide bindingi | 75 – 77 | NADPUniRule annotation | 3 |
GO - Molecular functioni
- NADP binding Source: InterPro
- phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
GO - Biological processi
- D-gluconate metabolic process Source: UniProtKB-KW
- pentose-phosphate shunt Source: UniProtKB-UniPathway
Keywordsi
Molecular function | OxidoreductaseUniRule annotation |
Biological process | Gluconate utilizationUniRule annotationARBA annotation, Pentose shuntUniRule annotationARBA annotation |
Ligand | NADPUniRule annotation |
Enzyme and pathway databases
UniPathwayi | UPA00115;UER00410 |
Names & Taxonomyi
Protein namesi | Recommended name: 6-phosphogluconate dehydrogenase, decarboxylatingUniRule annotation (EC:1.1.1.44UniRule annotation) |
Gene namesi | Name:PgdImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:97553, Pgd |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 180 – 470 | 6PGDInterPro annotationAdd BLAST | 291 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 129 – 131 | Substrate bindingUniRule annotation | 3 | |
Regioni | 187 – 188 | Substrate bindingUniRule annotation | 2 |
Sequence similaritiesi
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR006114, 6PGDH_C IPR006113, 6PGDH_Gnd/GntZ IPR006115, 6PGDH_NADP-bd IPR006184, 6PGdom_BS IPR036291, NAD(P)-bd_dom_sf IPR006183, Pgluconate_DH |
PANTHERi | PTHR11811, PTHR11811, 1 hit |
Pfami | View protein in Pfam PF00393, 6PGD, 1 hit PF03446, NAD_binding_2, 1 hit |
PIRSFi | PIRSF000109, 6PGD, 1 hit |
PRINTSi | PR00076, 6PGDHDRGNASE |
SMARTi | View protein in SMART SM01350, 6PGD, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR00873, gnd, 1 hit |
PROSITEi | View protein in PROSITE PS00461, 6PGD, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3UAG2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQADIALIG LAVMGQNLIL NMNDHGFVVC AFNRTVSKVD DFLANEAKGT
60 70 80 90 100
KVVGAQSLKD MVSKLKKPRR VILLVKAGQA VDDFIEKLVP LLDTGDIIID
110 120 130 140 150
GGNSEYRDTT RRCRDLKAKG ILFVGSGVSG GEEGARYGPS LMPGGNKEAW
160 170 180 190 200
PHIKAIFQAI AAKVGTGEPC CDWVGDEGAG HFVKMVHNGI EYGDMQLICE
210 220 230 240 250
AYHLMKDVLG MRHEEMAQAF EEWNKTELDS FLIEITANIL KYRDTDGKEL
260 270 280 290 300
LPKIRDSAGQ KGTGKWTAIS ALEYGMPVTL IGEAVFARCL SSLKEERVQA
310 320 330 340 350
SQKLKGPKVV QLEGSKKSFL EDIRKALYAS KIISYAQGFM LLRQAATEFG
360 370 380 390 400
WTLNYGGIAL MWRGGCIIRS VFLGKIKDAF ERNPELQNLL LDDFFKSAVD
410 420 430 440 450
NCQDSWRRVI STGVQAGIPM PCFTTALSFY DGYRHEMLPA NLIQAQRDYF
460 470 480
GAHTYELLTK PGEFIHTNWT GHGGSVSSSS YIA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK150490 mRNA Translation: BAE29606.1 AK151380 mRNA Translation: BAE30352.1 AK151993 mRNA Translation: BAE30857.1 AK152758 mRNA Translation: BAE31473.1 AK152894 mRNA Translation: BAE31577.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK150490 mRNA Translation: BAE29606.1 AK151380 mRNA Translation: BAE30352.1 AK151993 mRNA Translation: BAE30857.1 AK152758 mRNA Translation: BAE31473.1 AK152894 mRNA Translation: BAE31577.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PTM databases
SwissPalmi | Q3UAG2 |
Proteomic databases
PeptideAtlasi | Q3UAG2 |
PRIDEi | Q3UAG2 |
Organism-specific databases
MGIi | MGI:97553, Pgd |
Enzyme and pathway databases
UniPathwayi | UPA00115;UER00410 |
Miscellaneous databases
ChiTaRSi | Pgd, mouse |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 1.10.1040.10, 1 hit |
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR013328, 6PGD_dom2 IPR006114, 6PGDH_C IPR006113, 6PGDH_Gnd/GntZ IPR006115, 6PGDH_NADP-bd IPR006184, 6PGdom_BS IPR036291, NAD(P)-bd_dom_sf IPR006183, Pgluconate_DH |
PANTHERi | PTHR11811, PTHR11811, 1 hit |
Pfami | View protein in Pfam PF00393, 6PGD, 1 hit PF03446, NAD_binding_2, 1 hit |
PIRSFi | PIRSF000109, 6PGD, 1 hit |
PRINTSi | PR00076, 6PGDHDRGNASE |
SMARTi | View protein in SMART SM01350, 6PGD, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit SSF51735, SSF51735, 1 hit |
TIGRFAMsi | TIGR00873, gnd, 1 hit |
PROSITEi | View protein in PROSITE PS00461, 6PGD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3UAG2_MOUSE | |
Accessioni | Q3UAG2Primary (citable) accession number: Q3UAG2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | February 10, 2021 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |