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Protein

Histone H2A

Gene

H2afz

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2AUniRule annotation
Gene namesi
Name:H2afzImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1888388 H2afz

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome coreUniRule annotationSAAS annotation, NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000037894 Expressed in 265 organ(s), highest expression level in primitive streak

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotationSAAS annotation

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 67HistoneInterPro annotationAdd BLAST61
Domaini72 – 103Histone_H2A_CInterPro annotationAdd BLAST32

Sequence similaritiesi

Belongs to the histone H2A family.UniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00900000140979
HOVERGENiHBG009342

Family and domain databases

Gene3Di1.10.20.10, 2 hits
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q3UA95-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGGKAGKDS GKAKTKAVSR SQRAGLQFPV GRIHRHLKSR TTSHGRVGAT
60 70 80 90 100
AAVYSAAILE YLTAELAIRG DEELDSLIKA TIAGGGVIPH IHKSLIGKKG

QQKTV
Length:105
Mass (Da):10,984
Last modified:October 11, 2005 - v1
Checksum:i6BA47ED2F71536DB
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P0C0S6H2AZ_MOUSE
Histone H2A.Z
H2afz H2az
128Annotation score:
G3UWL7G3UWL7_MOUSE
Histone H2A
H2afz
87Annotation score:
G3UX40G3UX40_MOUSE
Histone H2A.Z
H2afz
54Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125154 Genomic DNA No translation available.
AK151462 mRNA Translation: BAE30420.1
RefSeqiNP_001303924.1, NM_001316995.1
UniGeneiMm.117541
Mm.372513
Mm.465508

Genome annotation databases

EnsembliENSMUST00000174561; ENSMUSP00000134059; ENSMUSG00000037894
GeneIDi51788
UCSCiuc008rmp.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125154 Genomic DNA No translation available.
AK151462 mRNA Translation: BAE30420.1
RefSeqiNP_001303924.1, NM_001316995.1
UniGeneiMm.117541
Mm.372513
Mm.465508

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000174561; ENSMUSP00000134059; ENSMUSG00000037894
GeneIDi51788
UCSCiuc008rmp.2 mouse

Organism-specific databases

CTDi3015
MGIiMGI:1888388 H2afz

Phylogenomic databases

GeneTreeiENSGT00900000140979
HOVERGENiHBG009342

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037894 Expressed in 265 organ(s), highest expression level in primitive streak

Family and domain databases

Gene3Di1.10.20.10, 2 hits
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
IPR032458 Histone_H2A_CS
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00046 HISTONE_H2A, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ3UA95_MOUSE
AccessioniPrimary (citable) accession number: Q3UA95
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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