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UniProtKB - Q3U8S0 (Q3U8S0_MOUSE)
Protein
Submitted name:
Adaptor-related protein complex 3, sigma 1 subunit
Gene
Ap3s1
Organism
Mus musculus (Mouse)
Status
Functioni
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
ARBA annotationGO - Biological processi
- Golgi to vacuole transport Source: InterPro
- intracellular protein transport Source: InterPro
Keywordsi
Biological process | Protein transportARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: Adaptor-related protein complex 3, sigma 1 subunitImported |
Gene namesi | Name:Ap3s1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:1337062, Ap3s1 |
VEuPathDBi | HostDB:ENSMUSG00000024480 |
Subcellular locationi
Other locations
- Cytoplasmic vesicle membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Cytoplasmic side ARBA annotation
Other locations
- AP-3 adaptor complex Source: Ensembl
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024480, Expressed in pancreas and 76 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 147 | Clat_adaptor_sInterPro annotationAdd BLAST | 147 |
Sequence similaritiesi
Belongs to the adaptor complexes small subunit family.ARBA annotation
Phylogenomic databases
HOGENOMi | CLU_061221_2_2_1 |
OMAi | ERCFKNV |
OrthoDBi | 1458249at2759 |
Family and domain databases
CDDi | cd14834, AP3_sigma, 1 hit |
InterProi | View protein in InterPro IPR016635, AP_complex_ssu IPR022775, AP_mu_sigma_su IPR027155, APS3 IPR000804, Clathrin_sm-chain_CS IPR011012, Longin-like_dom_sf |
PANTHERi | PTHR11753, PTHR11753, 1 hit |
Pfami | View protein in Pfam PF01217, Clat_adaptor_s, 1 hit |
SUPFAMi | SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS00989, CLAT_ADAPTOR_S, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3U8S0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIKAILIFNN HGKPRLSKFY QPYSEDTQQQ IIRETFHLVS KRDENVCNFL
60 70 80 90 100
EGGLLIGGSD NKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC
110 120 130 140 150
FENVCELDLI FHVDKVHNIL AEMVMGGMVL ETNMNEIVTQ IDAQNKLEKS
160 170 180 190
EAGLAGAPAR AVSAVKNMNL PEIPRNINIG DISIKVPNLP SFK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC108327 mRNA Translation: AAI08328.1 BC131985 mRNA Translation: AAI31986.1 AK137489 mRNA Translation: BAE23377.1 AK152100 mRNA Translation: BAE30947.1 |
RefSeqi | NP_001289944.1, NM_001303015.1 NP_033811.1, NM_009681.5 |
Genome annotation databases
GeneIDi | 11777 |
KEGGi | mmu:11777 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC108327 mRNA Translation: AAI08328.1 BC131985 mRNA Translation: AAI31986.1 AK137489 mRNA Translation: BAE23377.1 AK152100 mRNA Translation: BAE30947.1 |
RefSeqi | NP_001289944.1, NM_001303015.1 NP_033811.1, NM_009681.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 25448, 130 antibodies from 22 providers |
DNASUi | 11777 |
Genome annotation databases
GeneIDi | 11777 |
KEGGi | mmu:11777 |
Organism-specific databases
CTDi | 1176 |
MGIi | MGI:1337062, Ap3s1 |
VEuPathDBi | HostDB:ENSMUSG00000024480 |
Phylogenomic databases
HOGENOMi | CLU_061221_2_2_1 |
OMAi | ERCFKNV |
OrthoDBi | 1458249at2759 |
Miscellaneous databases
BioGRID-ORCSi | 11777, 5 hits in 75 CRISPR screens |
ChiTaRSi | Ap3s1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024480, Expressed in pancreas and 76 other tissues |
Family and domain databases
CDDi | cd14834, AP3_sigma, 1 hit |
InterProi | View protein in InterPro IPR016635, AP_complex_ssu IPR022775, AP_mu_sigma_su IPR027155, APS3 IPR000804, Clathrin_sm-chain_CS IPR011012, Longin-like_dom_sf |
PANTHERi | PTHR11753, PTHR11753, 1 hit |
Pfami | View protein in Pfam PF01217, Clat_adaptor_s, 1 hit |
SUPFAMi | SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS00989, CLAT_ADAPTOR_S, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3U8S0_MOUSE | |
Accessioni | Q3U8S0Primary (citable) accession number: Q3U8S0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | May 25, 2022 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |