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Protein

Dual specificity protein phosphatase

Gene

Dusp1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei258Phosphocysteine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation, EC:3.1.3.48UniRule annotation)
Gene namesi
Name:Dusp1Imported
ORF Names:mCG_1582Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:105120 Dusp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000024190 Expressed in 321 organ(s), highest expression level in lung

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 137RhodaneseInterPro annotationAdd BLAST118
Domaini173 – 313Tyrosine-protein phosphataseInterPro annotationAdd BLAST141
Domaini238 – 292TYR_PHOSPHATASE_2InterPro annotationAdd BLAST55

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
HOVERGENiHBG007347
KOiK21278
OMAiMVIMEVP
OrthoDBiEOG091G0249

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.40.250.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR020420 Atypical_DUSP_famB
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR008343 MKP
IPR029021 Prot-tyrosine_phosphatase-like
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF00581 Rhodanese, 1 hit
PIRSFiPIRSF000939 MAPK_Ptase, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01910 ADSPHPHTASEB
PR01764 MAPKPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00450 RHOD, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

Q3U8K3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVMEVGILDA GGLRALLREG AAQCLLLDCR SFFAFNAGHI AGSVNVRFST
60 70 80 90 100
IVRRRAKGAM GLEHIVPNAE LRGRLLAGAY HAVVLLDERS ASLDGAKRDG
110 120 130 140 150
TLALAAGALC REARSTQVFF LQGGYEAFSA SCPELCSKQS TPTGLSLPLS
160 170 180 190 200
TSVPDSAESG CSSCSTPLYD QGGPVEILSF LYLGSAYHAS RKDMLDALGI
210 220 230 240 250
TALINVSANC PNHFEGHYQY KSIPVEDNHK ADISSWFNEA IDFIDSIKDA
260 270 280 290 300
GGRVFVHCQA GISRSATICL AYLMRTNRVK LDEAFEFVKQ RRSIISPNFS
310 320 330 340 350
FMGQLLQFES QVLAPHCSAE AGSPAMAVLD RGTSTTTVFN FPVSIPVHPT
360
NSALNYLKSP ITTSPSC
Length:367
Mass (Da):39,370
Last modified:October 11, 2005 - v1
Checksum:i50B5F90FEBBD19AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149915 mRNA Translation: BAE29163.1
AK152183 mRNA Translation: BAE31014.1
AK152324 mRNA Translation: BAE31126.1
AK159251 mRNA Translation: BAE34932.1
AK159363 mRNA Translation: BAE35021.1
AK159567 mRNA Translation: BAE35190.1
AK159658 mRNA Translation: BAE35267.1
AK159726 mRNA Translation: BAE35320.1
AK167602 mRNA Translation: BAE39659.1
AK168627 mRNA Translation: BAE40487.1
CH466606 Genomic DNA Translation: EDL22508.1
RefSeqiNP_038670.1, NM_013642.3
UniGeneiMm.239041

Genome annotation databases

GeneIDi19252
KEGGimmu:19252

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149915 mRNA Translation: BAE29163.1
AK152183 mRNA Translation: BAE31014.1
AK152324 mRNA Translation: BAE31126.1
AK159251 mRNA Translation: BAE34932.1
AK159363 mRNA Translation: BAE35021.1
AK159567 mRNA Translation: BAE35190.1
AK159658 mRNA Translation: BAE35267.1
AK159726 mRNA Translation: BAE35320.1
AK167602 mRNA Translation: BAE39659.1
AK168627 mRNA Translation: BAE40487.1
CH466606 Genomic DNA Translation: EDL22508.1
RefSeqiNP_038670.1, NM_013642.3
UniGeneiMm.239041

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19252
KEGGimmu:19252

Organism-specific databases

CTDi1843
MGIiMGI:105120 Dusp1

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
HOVERGENiHBG007347
KOiK21278
OMAiMVIMEVP
OrthoDBiEOG091G0249

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024190 Expressed in 321 organ(s), highest expression level in lung

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.40.250.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR020417 Atypical_DUSP
IPR020420 Atypical_DUSP_famB
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR008343 MKP
IPR029021 Prot-tyrosine_phosphatase-like
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF00581 Rhodanese, 1 hit
PIRSFiPIRSF000939 MAPK_Ptase, 1 hit
PRINTSiPR01908 ADSPHPHTASE
PR01910 ADSPHPHTASEB
PR01764 MAPKPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00450 RHOD, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ3U8K3_MOUSE
AccessioniPrimary (citable) accession number: Q3U8K3
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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