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Entry version 105 (29 Sep 2021)
Sequence version 1 (11 Oct 2005)
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Protein

AP-5 complex subunit zeta-1

Gene

Ap5z1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair, Protein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AP-5 complex subunit zeta-1
Alternative name(s):
Adaptor-related protein complex 5 zeta subunit
Short name:
Zeta5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ap5z1
Synonyms:Kiaa0415
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1924908, Ap5z1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000039623

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002613581 – 807AP-5 complex subunit zeta-1Add BLAST807

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3U829

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3U829

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3U829

PeptideAtlas

More...
PeptideAtlasi
Q3U829

PRoteomics IDEntifications database

More...
PRIDEi
Q3U829

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
281789

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3U829

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3U829

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039623, Expressed in blastocyst and 202 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3U829, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

Interacts with ZFYVE26 and SPG11 (By similarity).

By similarity

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-5182, AP-5 Adaptor complex

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000041863

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3U829, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVBK, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017592

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3U829

Identification of Orthologs from Complete Genome Data

More...
OMAi
GQHYTED

Database of Orthologous Groups

More...
OrthoDBi
414014at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3U829

TreeFam database of animal gene trees

More...
TreeFami
TF331050

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028222, AP5Z1
IPR016024, ARM-type_fold

The PANTHER Classification System

More...
PANTHERi
PTHR46488, PTHR46488, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14764, SPG48, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q3U829-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSAGAESLL HQAREIQDEE LRRFCSRVTK LLQEAPGPAT VDALQRLFLI
60 70 80 90 100
VSATKYPRRL EKMCVDLLQT TLCLPASPEQ LQVLCAAILR EMSPFNDLAL
110 120 130 140 150
SCDHTPNTRQ LSLVASVLLA QGDRKGEIRC VSQRIFKILE NRQPEGPSVR
160 170 180 190 200
PLLPILSKVI GLAPGILMED QTNLLSKRLV DWLRYASIQQ GLPYSGGFFS
210 220 230 240 250
TPRTRQPGPI TEVDGAVASD FFTVLSTGQH FTEDQWVNMQ AFSMLRKWLL
260 270 280 290 300
HSGPEDPCSP DADDKSELEG STLSVLSAAS TASRLLPPRE RLREVAFEYC
310 320 330 340 350
QRLLEQSNRR ALRKGDSDLQ KACLVEAVSV LDVLCRQDPS FLYRTLSCLK
360 370 380 390 400
ALHRRLGEDP GSERALVPLA QFFLNHGEAA AMDAEAVYGQ LLRGLPSERF
410 420 430 440 450
HSPTLAFEVI HFCTHNLALF DSHFLSLLRL SFPSLFKFLA WNSPPLTAEF
460 470 480 490 500
VVLLPALVDA GTAVEMLHAL LDLPCLTAAL DLQLRSTQTP SERLLWDISL
510 520 530 540 550
RVPSCLEAFQ DPQFQGLFRH LLRTKASGST ERLTPLHQVL KPMASCARVT
560 570 580 590 600
QCAEAVPVLL QAFFSAVTQT ADGALINQLA LLLLERSDSL YPVPQYEARV
610 620 630 640 650
HGVLSSQLLV LCKLKPSLVV ELSRELLEFV GSVSSIHSRA SVFTCVVWAI
660 670 680 690 700
GEYLSVTWDK RCTAEQINKF FEALEALLFE VTQSRPLADL PCCPPEVVTA
710 720 730 740 750
LMTTLTKLAS RSQDLIPRVS LFLSKMRTLA QNPATSSVHS EEGAESIRTR
760 770 780 790 800
ASELLTLLKM PSVAQFVFTP PAGVCQPRYH RDTNVALPLA LRTVSRLVEK

EAGLLPG
Length:807
Mass (Da):89,407
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDAFDB2B325A0FA40
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JF65A0A0G2JF65_MOUSE
AP-5 complex subunit zeta-1
Ap5z1
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFH9A0A0G2JFH9_MOUSE
AP-5 complex subunit zeta-1
Ap5z1
791Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JEH7A0A0G2JEH7_MOUSE
AP-5 complex subunit zeta-1
Ap5z1
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC30747 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti323C → G in AAH82786 (PubMed:15489334).Curated1
Sequence conflicti338D → N in BAC30747 (PubMed:16141072).Curated1
Sequence conflicti428L → I in BAE27165 (PubMed:16141072).Curated1
Sequence conflicti558V → I in BAC38605 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK040924 mRNA Translation: BAC30747.1 Different initiation.
AK082759 mRNA Translation: BAC38605.1
AK146431 mRNA Translation: BAE27165.1
AK152402 mRNA Translation: BAE31190.1
BC082786 mRNA Translation: AAH82786.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS39361.1

NCBI Reference Sequences

More...
RefSeqi
NP_766313.2, NM_172725.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000038699; ENSMUSP00000041863; ENSMUSG00000039623

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
231855

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:231855

UCSC genome browser

More...
UCSCi
uc009aiq.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK040924 mRNA Translation: BAC30747.1 Different initiation.
AK082759 mRNA Translation: BAC38605.1
AK146431 mRNA Translation: BAE27165.1
AK152402 mRNA Translation: BAE31190.1
BC082786 mRNA Translation: AAH82786.1
CCDSiCCDS39361.1
RefSeqiNP_766313.2, NM_172725.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

ComplexPortaliCPX-5182, AP-5 Adaptor complex
STRINGi10090.ENSMUSP00000041863

PTM databases

iPTMnetiQ3U829
PhosphoSitePlusiQ3U829

Proteomic databases

EPDiQ3U829
MaxQBiQ3U829
PaxDbiQ3U829
PeptideAtlasiQ3U829
PRIDEiQ3U829
ProteomicsDBi281789

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
48203, 71 antibodies

The DNASU plasmid repository

More...
DNASUi
231855

Genome annotation databases

EnsembliENSMUST00000038699; ENSMUSP00000041863; ENSMUSG00000039623
GeneIDi231855
KEGGimmu:231855
UCSCiuc009aiq.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9907
MGIiMGI:1924908, Ap5z1
VEuPathDBiHostDB:ENSMUSG00000039623

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG502QVBK, Eukaryota
GeneTreeiENSGT00390000017592
InParanoidiQ3U829
OMAiGQHYTED
OrthoDBi414014at2759
PhylomeDBiQ3U829
TreeFamiTF331050

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
231855, 2 hits in 98 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ap5z1, mouse

Protein Ontology

More...
PROi
PR:Q3U829
RNActiQ3U829, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039623, Expressed in blastocyst and 202 other tissues
GenevisibleiQ3U829, MM

Family and domain databases

InterProiView protein in InterPro
IPR028222, AP5Z1
IPR016024, ARM-type_fold
PANTHERiPTHR46488, PTHR46488, 1 hit
PfamiView protein in Pfam
PF14764, SPG48, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAP5Z1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3U829
Secondary accession number(s): Q3UJJ0
, Q63ZW8, Q8BS06, Q8C488
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 11, 2005
Last modified: September 29, 2021
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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