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Protein

F-box only protein 7

Gene

Fbxo7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 7
Gene namesi
Name:Fbxo7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1917004 Fbxo7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003077221 – 523F-box only protein 7Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei432Omega-N-methylarginineCombined sources1
Modified residuei452Omega-N-methylarginineCombined sources1
Modified residuei519Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ3U7U3
MaxQBiQ3U7U3
PaxDbiQ3U7U3
PeptideAtlasiQ3U7U3
PRIDEiQ3U7U3

PTM databases

iPTMnetiQ3U7U3
PhosphoSitePlusiQ3U7U3

Expressioni

Gene expression databases

BgeeiENSMUSG00000001786 Expressed in 242 organ(s), highest expression level in bone marrow
CleanExiMM_FBXO7
ExpressionAtlasiQ3U7U3 baseline and differential
GenevisibleiQ3U7U3 MM

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO7) formed of CUL1, SKP1, RBX1 and FBXO7. Interacts via its C-terminal proline-rich region with DLGAP5. Interacts with BIRC2. Interacts with CDK6 and promotes its interaction with D-type cyclin. Interacts (via the N-terminal Ubl domain) with PRKN. Interacts (via N-terminal region) with PINK1. Interacts with PSMF1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120840

Structurei

3D structure databases

ProteinModelPortaliQ3U7U3
SMRiQ3U7U3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini330 – 376F-boxPROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 88Ubiquitin-likeBy similarityAdd BLAST88
Regioni92 – 129Important for interaction with PINK1By similarityAdd BLAST38
Regioni129 – 169Important for interaction with CDK6By similarityAdd BLAST41
Regioni180 – 325Important for dimerization and interaction with PSMF1By similarityAdd BLAST146
Regioni382 – 523Important for interaction with CDK6By similarityAdd BLAST142

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi482 – 485RFDP motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi417 – 510Pro-richAdd BLAST94

Domaini

The ubiquitin-like region mediates interaction with PRKN.By similarity
The proline-rich region is important for protein-protein interactions.By similarity

Phylogenomic databases

eggNOGiENOG410IGV9 Eukaryota
ENOG410XQUZ LUCA
GeneTreeiENSGT00390000006670
HOGENOMiHOG000112551
HOVERGENiHBG005648
InParanoidiQ3U7U3
KOiK10293
OMAiHPIPFYP
OrthoDBiEOG091G0FNN
PhylomeDBiQ3U7U3
TreeFamiTF329830

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR021625 PI31_Prot_N
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF11566 PI31_Prot_N, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q3U7U3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLRVRLQKR TQPLEVPESE PTLGQLRAHL SQVLLPTLGF SSDTRFAITL
60 70 80 90 100
NNKDALTGDE ETLASYGIVS GDLICLVLED DMPAPNLPSS TDTEHSSLQD
110 120 130 140 150
NDQPSLAATP SQTNIPDEQG TDSSQGQATP FDAWTDDSME GPSQNVEAES
160 170 180 190 200
IQDAMSMEEV SGFHPLEPML CNETEDGQVP HSLETLYQSA GCSNISDALI
210 220 230 240 250
VLVHLLMLES GYIPQGTETK AVTMPEKWKS SGVYKLQYTH PLCEGGFAVL
260 270 280 290 300
TCVPLGNLII INATIKVNGG IKNVKSVQLQ PGSYVAAGVE PGESAAKVYK
310 320 330 340 350
DLKKLSRLFK DQLVYPLLAF TRQVLNLPDV FGLVVLPLEL KLRIFRLLDV
360 370 380 390 400
HSVLALSAVC HDLLIASNDP LLWRCLYLRD FRDGTVRGPD TDWKELYRKK
410 420 430 440 450
HIQRKEAQRM RHAMFLPSAH PIPFCPIPVY PRAYLPTSLL PPGIIGGEYD
460 470 480 490 500
ERPILPSVGD PVTSLIPRPG ELPGQFRPLR PRFDPVDPLP GPHSLLPGRA
510 520
IPNNRFPFRP GRGRSADSRL PFL
Length:523
Mass (Da):57,649
Last modified:July 27, 2011 - v2
Checksum:i5FEC744477081929
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UD93Q3UD93_MOUSE
F-box only protein 7
Fbxo7
444Annotation score:
Q3UGI9Q3UGI9_MOUSE
F-box only protein 7
Fbxo7
442Annotation score:
D6RJ76D6RJ76_MOUSE
F-box only protein 7
Fbxo7
49Annotation score:
F8WIP1F8WIP1_MOUSE
F-box only protein 7
Fbxo7
56Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204H → R in BAE29716 (PubMed:16141072).Curated1
Sequence conflicti204H → R in BAE31276 (PubMed:16141072).Curated1
Sequence conflicti227K → N in AAH32153 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147797 mRNA Translation: BAE28145.1
AK151025 mRNA Translation: BAE30043.1
AK150626 mRNA Translation: BAE29716.1
AK152513 mRNA Translation: BAE31276.1
CH466539 Genomic DNA Translation: EDL21433.1
BC032153 mRNA Translation: AAH32153.1
CCDSiCCDS24095.1
RefSeqiNP_001334080.1, NM_001347151.1
NP_694875.2, NM_153195.2
UniGeneiMm.44236

Genome annotation databases

EnsembliENSMUST00000130320; ENSMUSP00000120840; ENSMUSG00000001786
GeneIDi69754
KEGGimmu:69754
UCSCiuc007gnk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147797 mRNA Translation: BAE28145.1
AK151025 mRNA Translation: BAE30043.1
AK150626 mRNA Translation: BAE29716.1
AK152513 mRNA Translation: BAE31276.1
CH466539 Genomic DNA Translation: EDL21433.1
BC032153 mRNA Translation: AAH32153.1
CCDSiCCDS24095.1
RefSeqiNP_001334080.1, NM_001347151.1
NP_694875.2, NM_153195.2
UniGeneiMm.44236

3D structure databases

ProteinModelPortaliQ3U7U3
SMRiQ3U7U3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000120840

PTM databases

iPTMnetiQ3U7U3
PhosphoSitePlusiQ3U7U3

Proteomic databases

EPDiQ3U7U3
MaxQBiQ3U7U3
PaxDbiQ3U7U3
PeptideAtlasiQ3U7U3
PRIDEiQ3U7U3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000130320; ENSMUSP00000120840; ENSMUSG00000001786
GeneIDi69754
KEGGimmu:69754
UCSCiuc007gnk.1 mouse

Organism-specific databases

CTDi25793
MGIiMGI:1917004 Fbxo7

Phylogenomic databases

eggNOGiENOG410IGV9 Eukaryota
ENOG410XQUZ LUCA
GeneTreeiENSGT00390000006670
HOGENOMiHOG000112551
HOVERGENiHBG005648
InParanoidiQ3U7U3
KOiK10293
OMAiHPIPFYP
OrthoDBiEOG091G0FNN
PhylomeDBiQ3U7U3
TreeFamiTF329830

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q3U7U3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001786 Expressed in 242 organ(s), highest expression level in bone marrow
CleanExiMM_FBXO7
ExpressionAtlasiQ3U7U3 baseline and differential
GenevisibleiQ3U7U3 MM

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR021625 PI31_Prot_N
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF11566 PI31_Prot_N, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBX7_MOUSE
AccessioniPrimary (citable) accession number: Q3U7U3
Secondary accession number(s): Q3UBC1, Q8K0A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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