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Entry version 115 (08 May 2019)
Sequence version 2 (16 May 2006)
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Protein

Extended synaptotagmin-1

Gene

Esyt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi334Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi335Calcium 1By similarity1
Metal bindingi335Calcium 2By similarity1
Metal bindingi347Calcium 2By similarity1
Metal bindingi394Calcium 1By similarity1
Metal bindingi394Calcium 2By similarity1
Metal bindingi396Calcium 1By similarity1
Metal bindingi396Calcium 2By similarity1
Metal bindingi396Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi398Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi400Calcium 3By similarity1
Metal bindingi401Calcium 1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport
LigandCalcium, Lipid-binding, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1660662 Glycosphingolipid metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Extended synaptotagmin-1
Short name:
E-Syt1
Alternative name(s):
Membrane-bound C2 domain-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Esyt1
Synonyms:Fam62a, Mbc2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1344426 Esyt1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Topological domaini50 – 52LumenalSequence analysis3
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 1092CytoplasmicSequence analysisAdd BLAST1019

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi314S → A: Abolished phosphorylation by CDK5. 1 Publication1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3621032

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002343451 – 1092Extended synaptotagmin-1Add BLAST1092

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei314Phosphoserine; by CDK51 Publication1
Modified residuei804N6-acetyllysineBy similarity1
Modified residuei807PhosphoserineBy similarity1
Modified residuei937PhosphoserineBy similarity1
Modified residuei951PhosphoserineCombined sources1
Modified residuei997PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Ser residues in insulin-treated adipocytes (in vitro); this promotes interaction with SLC2A4.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q3U7R1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q3U7R1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3U7R1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3U7R1

PeptideAtlas

More...
PeptideAtlasi
Q3U7R1

PRoteomics IDEntifications database

More...
PRIDEi
Q3U7R1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3U7R1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3U7R1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q3U7R1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025366 Expressed in 72 organ(s), highest expression level in white adipose tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3U7R1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3U7R1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ESYT2 and ESYT3 (By similarity). Interacts (phosphorylated form) with SLC2A4.By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Slc2a4P141422EBI-8398881,EBI-7540210

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
204808, 2 interactors

Database of interacting proteins

More...
DIPi
DIP-48746N

Protein interaction database and analysis system

More...
IntActi
Q3U7R1, 5 interactors

Molecular INTeraction database

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MINTi
Q3U7R1

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000026427

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q3U7R1

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini125 – 303SMP-LTDPROSITE-ProRule annotationAdd BLAST179
Domaini306 – 407C2 1PROSITE-ProRule annotationAdd BLAST102
Domaini455 – 548C2 2PROSITE-ProRule annotationAdd BLAST94
Domaini621 – 722C2 3PROSITE-ProRule annotationAdd BLAST102
Domaini772 – 864C2 4PROSITE-ProRule annotationAdd BLAST93
Domaini950 – 1065C2 5PROSITE-ProRule annotationAdd BLAST116

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1006 – 1013Required for phosphatidylinositol 4,5-bisphosphate-dependent location at the cell membraneBy similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi910 – 921Poly-SerAdd BLAST12

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Anchored to the endoplasmic reticulum membrane by a transmembrane hairpin structure; both N-terminus and C-terminus are cytoplasmic.By similarity
The C2 domains mediate lipid and calcium binding. The N-terminal C2 domain binds calcium ions and is important for calcium-dependent lipid binding and interaction with membranes. Two calcium ions are bound at a high-affinity site and a third calcium ion is bound with lower affinity. May bind up to four calcium ions. In contrast, the second C2 domain apparently does not bind calcium. The third C2 domain mediates interaction with membranes enriched in phosphatidylinositol 4,5-bisphosphate and is required for translocation to the cell membrane in response to increased cytosolic calcium levels (By similarity).By similarity
The SMP-LTD domain is a barrel-like domain that binds glycerophospholipids in its interior (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the extended synaptotagmin family.Curated

Keywords - Domaini

Coiled coil, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1012 Eukaryota
COG5038 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000156561

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000043080

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3U7R1

Identification of Orthologs from Complete Genome Data

More...
OMAi
GAAQWYD

Database of Orthologous Groups

More...
OrthoDBi
52746at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3U7R1

TreeFam database of animal gene trees

More...
TreeFami
TF324255

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08391 C2A_C2C_Synaptotagmin_like, 2 hits
cd04050 C2B_Synaptotagmin-like, 2 hits
cd04030 C2C_KIAA1228, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037752 C2C_KIAA1228
IPR037733 Ext_Synaptotagmin_C2A
IPR037749 Ext_Synaptotagmin_C2B
IPR031468 SMP_LBD
IPR039010 Synaptotagmin_SMP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 5 hits
PF17047 SMP_LBD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00360 C2DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239 C2, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 5 hits
PS51847 SMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3U7R1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEHSPEEGAS PEPSGQPPAT DSTRDGGSGV PPAGPGAASE ALAVLTSFGR
60 70 80 90 100
RLLVLVPVYL AGAAGLSVGF VLFGLALYLG WRRVRDGKER SLRAARQLLD
110 120 130 140 150
DEERITAETL YMSHRELPAW VSFPDVEKAE WLNKIVAQVW PFLGQYMEKL
160 170 180 190 200
LAETVAPAVR GANPHLQTFT FTRVELGEKP LRIIGVKVHP SQRKDQILLD
210 220 230 240 250
LNVSYVGDVQ IDVEVKKYFC KAGVKGMQLH GVLRVILEPL TGDLPIVGAV
260 270 280 290 300
SMFFIKRPTL DINWTGMTNL LDIPGLSSLS DTMIMDSIAA FLVLPNRLLV
310 320 330 340 350
PLVPDLQDVA QLRSPLPRGI IRIHLLAARG LSSKDKYVKG LIEGKSDPYA
360 370 380 390 400
LVRVGTQTFC SRVIDEELNP HWGETYEVIV HEVPGQEIEV EVFDKDPDKD
410 420 430 440 450
DFLGRMKLDV GKVLQAGVLD NWYPLQGGQG QVHLRLEWLS LLPDAEKLDQ
460 470 480 490 500
VLQWNRGITS RPEPPSAAIL VVYLDRAQDL PLKKGNKEPN PMVQLSVQDV
510 520 530 540 550
TRESKATYST NSPVWEEAFR FFLQDPRSQE LDVQVKDDSR ALTLGALTLP
560 570 580 590 600
LARLLTASEL TLDQWFQLSS SGPNSRLYMK LVMRILYLDY SEIRFPTVPG
610 620 630 640 650
AQDWDRESLE TGSSVDAPPR PYHTTPNSHF GTENVLRIHV LEAQDLIAKD
660 670 680 690 700
RFLGGLVKGK SDPYVKLKVA GKSFRTHVVR EDLNPRWNEV FEVIVTSIPG
710 720 730 740 750
QELEIEVFDK DLDKDDFLGR YKVSLTTVLN SGFLDEWLTL EDVPSGRLHL
760 770 780 790 800
RLERLTPRPT AAELEEVLQV NSLIQTQKSS ELAAALLSVF LERAEDLPLR
810 820 830 840 850
KGTKPPSPYA TITVGETSHK TKTVSQSSAP VWEESASFLI RKPHAESLEL
860 870 880 890 900
QVRGEGTGTL GSVSLPLSEL LQEDQLCLDH WFALSGQGQV LMRAQLGILV
910 920 930 940 950
SQHSGVEAHS HSYSHSHSSS SLNDEPEALG GPTHPASPVL EVRHRLTHGD
960 970 980 990 1000
SPSEAPVGPL GQVKLTVWYH SDEQKLISII HSCRALRQNG RDLPDPYVSV
1010 1020 1030 1040 1050
LLLPDKNRST KRKTPQKKRT LNPEFNERFE WDLPLDGTLR RKLDVSVKSN
1060 1070 1080 1090
SSFMSREREL LGKVQLDLAE IDLSQGAAQW YDLMDDRDKG GS
Length:1,092
Mass (Da):121,554
Last modified:May 16, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71A397EC52DE6DA9
GO
Isoform 2 (identifier: Q3U7R1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     852-893: VRGEGTGTLG...LSGQGQVLMR → ACFIHLLFLF...CGNLWATAHS
     894-1092: Missing.

Note: No experimental confirmation available.
Show »
Length:893
Mass (Da):99,673
Checksum:i956808B5CD6450E3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P784A0A1W2P784_MOUSE
Extended synaptotagmin-1
Esyt1
528Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti385G → R in BAC32020 (PubMed:15489334).Curated1
Sequence conflicti392 – 394VFD → IQH in AAD10190 (PubMed:10350628).Curated3
Sequence conflicti829 – 841APVWE…SFLIR → GFGLEAKIRHEGG in AAD10189 (PubMed:10350628).CuratedAdd BLAST13

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_018278852 – 893VRGEG…QVLMR → ACFIHLLFLFERGREQRTVF EFEVFGVNSFPPCGNLWATA HS in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_018279894 – 1092Missing in isoform 2. 1 PublicationAdd BLAST199

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK008224 mRNA Translation: BAB25542.1
AK044656 mRNA Translation: BAC32020.1
AK152482 mRNA Translation: BAE31254.1
AK152554 mRNA Translation: BAE31308.1
BC011482 mRNA Translation: AAH11482.1
AF098633 mRNA Translation: AAD10189.1
AF098634 mRNA Translation: AAD10190.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS24280.1 [Q3U7R1-1]

NCBI Reference Sequences

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RefSeqi
NP_035973.1, NM_011843.2 [Q3U7R1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000026427; ENSMUSP00000026427; ENSMUSG00000025366 [Q3U7R1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23943

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:23943

UCSC genome browser

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UCSCi
uc007hng.1 mouse [Q3U7R1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008224 mRNA Translation: BAB25542.1
AK044656 mRNA Translation: BAC32020.1
AK152482 mRNA Translation: BAE31254.1
AK152554 mRNA Translation: BAE31308.1
BC011482 mRNA Translation: AAH11482.1
AF098633 mRNA Translation: AAD10189.1
AF098634 mRNA Translation: AAD10190.1
CCDSiCCDS24280.1 [Q3U7R1-1]
RefSeqiNP_035973.1, NM_011843.2 [Q3U7R1-1]

3D structure databases

SMRiQ3U7R1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204808, 2 interactors
DIPiDIP-48746N
IntActiQ3U7R1, 5 interactors
MINTiQ3U7R1
STRINGi10090.ENSMUSP00000026427

Chemistry databases

ChEMBLiCHEMBL3621032

PTM databases

iPTMnetiQ3U7R1
PhosphoSitePlusiQ3U7R1
SwissPalmiQ3U7R1

Proteomic databases

EPDiQ3U7R1
jPOSTiQ3U7R1
MaxQBiQ3U7R1
PaxDbiQ3U7R1
PeptideAtlasiQ3U7R1
PRIDEiQ3U7R1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026427; ENSMUSP00000026427; ENSMUSG00000025366 [Q3U7R1-1]
GeneIDi23943
KEGGimmu:23943
UCSCiuc007hng.1 mouse [Q3U7R1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23344
MGIiMGI:1344426 Esyt1

Phylogenomic databases

eggNOGiKOG1012 Eukaryota
COG5038 LUCA
GeneTreeiENSGT00940000156561
HOGENOMiHOG000043080
InParanoidiQ3U7R1
OMAiGAAQWYD
OrthoDBi52746at2759
PhylomeDBiQ3U7R1
TreeFamiTF324255

Enzyme and pathway databases

ReactomeiR-MMU-1660662 Glycosphingolipid metabolism

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Esyt1 mouse

Protein Ontology

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PROi
PR:Q3U7R1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000025366 Expressed in 72 organ(s), highest expression level in white adipose tissue
ExpressionAtlasiQ3U7R1 baseline and differential
GenevisibleiQ3U7R1 MM

Family and domain databases

CDDicd08391 C2A_C2C_Synaptotagmin_like, 2 hits
cd04050 C2B_Synaptotagmin-like, 2 hits
cd04030 C2C_KIAA1228, 1 hit
Gene3Di2.60.40.150, 5 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037752 C2C_KIAA1228
IPR037733 Ext_Synaptotagmin_C2A
IPR037749 Ext_Synaptotagmin_C2B
IPR031468 SMP_LBD
IPR039010 Synaptotagmin_SMP
PfamiView protein in Pfam
PF00168 C2, 5 hits
PF17047 SMP_LBD, 1 hit
PRINTSiPR00360 C2DOMAIN
SMARTiView protein in SMART
SM00239 C2, 5 hits
PROSITEiView protein in PROSITE
PS50004 C2, 5 hits
PS51847 SMP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiESYT1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3U7R1
Secondary accession number(s): Q8C8R1
, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: May 8, 2019
This is version 115 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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