UniProtKB - Q3U738 (Q3U738_MOUSE)
Protein
Protein disulfide-isomerase
Gene
P4hb
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
GO - Molecular functioni
- protein disulfide isomerase activity Source: UniProtKB-EC
Keywordsi
Molecular function | IsomeraseUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Protein disulfide-isomeraseUniRule annotationARBA annotation (EC:5.3.4.1UniRule annotationARBA annotation) |
Gene namesi | Name:P4hbImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:97464, P4hb |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum lumen ARBA annotation
Other locations
- Melanosome ARBA annotation
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: UniProtKB-SubCell
Other locations
- melanosome Source: UniProtKB-SubCell
Keywords - Cellular componenti
Endoplasmic reticulumARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | UniRule annotationAdd BLAST | 21 | |
ChainiPRO_5005143187 | 22 – 509 | Protein disulfide-isomeraseUniRule annotationAdd BLAST | 488 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 55 ↔ 58 | Redox-activeUniRule annotation | ||
Disulfide bondi | 399 ↔ 402 | Redox-activeUniRule annotation |
Keywords - PTMi
Disulfide bondUniRule annotationProteomic databases
EPDi | Q3U738 |
PeptideAtlasi | Q3U738 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 136 | ThioredoxinInterPro annotationAdd BLAST | 126 | |
Domaini | 348 – 477 | ThioredoxinInterPro annotationAdd BLAST | 130 |
Sequence similaritiesi
Keywords - Domaini
Redox-active centerUniRule annotationARBA annotation, RepeatARBA annotation, SignalUniRule annotationARBA annotationFamily and domain databases
Gene3Di | 3.40.30.10, 4 hits |
InterProi | View protein in InterPro IPR005788, Disulphide_isomerase IPR005792, Prot_disulphide_isomerase IPR036249, Thioredoxin-like_sf IPR017937, Thioredoxin_CS IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF00085, Thioredoxin, 2 hits |
SUPFAMi | SSF52833, SSF52833, 4 hits |
TIGRFAMsi | TIGR01130, ER_PDI_fam, 1 hit TIGR01126, pdi_dom, 2 hits |
PROSITEi | View protein in PROSITE PS00194, THIOREDOXIN_1, 2 hits PS51352, THIOREDOXIN_2, 2 hits |
i Sequence
Sequence statusi: Complete.
Q3U738-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSRALLCLA LAWAARVGAD ALEEEDNVLV LKKSNFEEAL AAHKYLLVEF
60 70 80 90 100
YAPWCGHCKA LAPEYAKAAA KLKAEGSEIR LAKVDATEES DLAQQYGVRG
110 120 130 140 150
YPTIKFFKNG DTASPKEYTA GREADDIVNW LKKRTGPAAT TLSDTTAAES
160 170 180 190 200
LVDSSEVTVI GFFKDVESDS AKQFLLAAEA IDDIPFGITS NSGVFSKYQL
210 220 230 240 250
DKDGVVLFKK FDEGRNNFEG EITKEKLLDF IKHNQLPLVI EFTEQTAPKI
260 270 280 290 300
FGGEIKTHIL LFLPKSVSDY DGKLSSFKRA AEGFKGKILF IFIDSDHTDN
310 320 330 340 350
QRILEFFGLK KEECPAVRLI TLEEEMTKYK PESDELTAEK ITEFCHRFLE
360 370 380 390 400
GKIKPHLMSQ EVPEDWDKQP VKVLVGANFE EVAFDEKKNV FVEFYAPWCG
410 420 430 440 450
HCKQLAPIWD KLGETYKDHE NIIIAKMDST ANEVEAVKVH SFPTLKFFPA
460 470 480 490 500
SADRTVIDYN GERTLDGFKK FLESGGQDGA GDDEDLDLEE ALEPDMEEED
DQKAVKDEL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK152834 mRNA Translation: BAE31534.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK152834 mRNA Translation: BAE31534.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
EPDi | Q3U738 |
PeptideAtlasi | Q3U738 |
Organism-specific databases
MGIi | MGI:97464, P4hb |
Miscellaneous databases
ChiTaRSi | P4hb, mouse |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 3.40.30.10, 4 hits |
InterProi | View protein in InterPro IPR005788, Disulphide_isomerase IPR005792, Prot_disulphide_isomerase IPR036249, Thioredoxin-like_sf IPR017937, Thioredoxin_CS IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF00085, Thioredoxin, 2 hits |
SUPFAMi | SSF52833, SSF52833, 4 hits |
TIGRFAMsi | TIGR01130, ER_PDI_fam, 1 hit TIGR01126, pdi_dom, 2 hits |
PROSITEi | View protein in PROSITE PS00194, THIOREDOXIN_1, 2 hits PS51352, THIOREDOXIN_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3U738_MOUSE | |
Accessioni | Q3U738Primary (citable) accession number: Q3U738 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |