Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 89 (16 Oct 2019)
Sequence version 1 (11 Oct 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

UPF0488 protein C8orf33 homolog

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UPF0488 protein C8orf33 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2152337 1110038F14Rik

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003049832 – 222UPF0488 protein C8orf33 homologAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei27Omega-N-methylarginineBy similarity1
Modified residuei75PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3U6N9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3U6N9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3U6N9

PeptideAtlas

More...
PeptideAtlasi
Q3U6N9

PRoteomics IDEntifications database

More...
PRIDEi
Q3U6N9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3U6N9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3U6N9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000063236 Expressed in 280 organ(s), highest expression level in embryo

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3U6N9 MM

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi64 – 69Poly-Lys6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0488 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J09Q Eukaryota
ENOG410XW3G LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000306

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111613

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3U6N9

Identification of Orthologs from Complete Genome Data

More...
OMAi
EFRFSFF

Database of Orthologous Groups

More...
OrthoDBi
1632971at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3U6N9

TreeFam database of animal gene trees

More...
TreeFami
TF326272

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029274 DUF4615

The PANTHER Classification System

More...
PANTHERi
PTHR13602 PTHR13602, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15393 DUF4615, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q3U6N9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEPGRPARE APAASSRKTH RAPRRPRPSR SASGASEPPL RSSVQPACDS
60 70 80 90 100
AAGTHPVGNT VAMKQKKKKT PNRVSGTNGS EKPSEKPAPD EAPPSAEAQA
110 120 130 140 150
EQLARELAWC VEQLELGLKT QRPTPKQKEQ AVGAIRTLRS EKTPLPRKRQ
160 170 180 190 200
LMRSLFGDYR AQMDAEWREA LRALKAATHS AQVQLVSEAT RKKSGRVCRP
210 220
RPAERAKTTP DLTSEEFRFN FF
Length:222
Mass (Da):24,465
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i53D7B2DE0876A60C
GO
Isoform 2 (identifier: Q3U6N9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.
     129-129: Missing.

Note: No experimental confirmation available.
Show »
Length:159
Mass (Da):17,999
Checksum:iC914FAABC27D338A
GO
Isoform 3 (identifier: Q3U6N9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.

Show »
Length:160
Mass (Da):18,128
Checksum:i67B00E6D6E5DB8C4
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0281701 – 62Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST62
Alternative sequenceiVSP_028171129Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK004154 mRNA Translation: BAB23195.1
AK141496 mRNA Translation: BAE24703.1
AK153059 mRNA Translation: BAE31685.1
AK160695 mRNA Translation: BAE35959.1
BC038324 mRNA Translation: AAH38324.1
BC091734 mRNA Translation: AAH91734.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS84175.1 [Q3U6N9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001334469.1, NM_001347540.1 [Q3U6N9-1]
NP_473440.1, NM_054099.2 [Q3U6N9-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000071792; ENSMUSP00000071698; ENSMUSG00000063236 [Q3U6N9-1]
ENSMUST00000229229; ENSMUSP00000155387; ENSMUSG00000063236 [Q3U6N9-2]
ENSMUST00000230274; ENSMUSP00000154907; ENSMUSG00000063236 [Q3U6N9-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
117171

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:117171

UCSC genome browser

More...
UCSCi
uc007wmv.1 mouse [Q3U6N9-1]
uc011zvd.1 mouse [Q3U6N9-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004154 mRNA Translation: BAB23195.1
AK141496 mRNA Translation: BAE24703.1
AK153059 mRNA Translation: BAE31685.1
AK160695 mRNA Translation: BAE35959.1
BC038324 mRNA Translation: AAH38324.1
BC091734 mRNA Translation: AAH91734.1
CCDSiCCDS84175.1 [Q3U6N9-1]
RefSeqiNP_001334469.1, NM_001347540.1 [Q3U6N9-1]
NP_473440.1, NM_054099.2 [Q3U6N9-3]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

iPTMnetiQ3U6N9
PhosphoSitePlusiQ3U6N9

Proteomic databases

EPDiQ3U6N9
MaxQBiQ3U6N9
PaxDbiQ3U6N9
PeptideAtlasiQ3U6N9
PRIDEiQ3U6N9

Genome annotation databases

EnsembliENSMUST00000071792; ENSMUSP00000071698; ENSMUSG00000063236 [Q3U6N9-1]
ENSMUST00000229229; ENSMUSP00000155387; ENSMUSG00000063236 [Q3U6N9-2]
ENSMUST00000230274; ENSMUSP00000154907; ENSMUSG00000063236 [Q3U6N9-3]
GeneIDi117171
KEGGimmu:117171
UCSCiuc007wmv.1 mouse [Q3U6N9-1]
uc011zvd.1 mouse [Q3U6N9-2]

Organism-specific databases

MGIiMGI:2152337 1110038F14Rik

Phylogenomic databases

eggNOGiENOG410J09Q Eukaryota
ENOG410XW3G LUCA
GeneTreeiENSGT00390000000306
HOGENOMiHOG000111613
InParanoidiQ3U6N9
OMAiEFRFSFF
OrthoDBi1632971at2759
PhylomeDBiQ3U6N9
TreeFamiTF326272

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q3U6N9

Gene expression databases

BgeeiENSMUSG00000063236 Expressed in 280 organ(s), highest expression level in embryo
GenevisibleiQ3U6N9 MM

Family and domain databases

InterProiView protein in InterPro
IPR029274 DUF4615
PANTHERiPTHR13602 PTHR13602, 1 hit
PfamiView protein in Pfam
PF15393 DUF4615, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCH033_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3U6N9
Secondary accession number(s): Q3URI5, Q9D0Z5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 11, 2005
Last modified: October 16, 2019
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again