UniProtKB - Q3U6G0 (Q3U6G0_MOUSE)
Protein
Submitted name:
Nox2
Gene
Cybb
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- electron transfer activity Source: Ensembl
- flavin adenine dinucleotide binding Source: Ensembl
- heme binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
- superoxide-generating NADPH oxidase activity Source: Ensembl
GO - Biological processi
- cellular response to cadmium ion Source: Ensembl
- cellular response to ethanol Source: Ensembl
- cellular response to L-glutamine Source: Ensembl
- hypoxia-inducible factor-1alpha signaling pathway Source: Ensembl
- innate immune response Source: Ensembl
- positive regulation of angiogenesis Source: Ensembl
- positive regulation of tumor necrosis factor biosynthetic process Source: Ensembl
- respiratory burst Source: Ensembl
- response to aldosterone Source: Ensembl
- response to angiotensin Source: Ensembl
- response to drug Source: Ensembl
- response to nutrient Source: Ensembl
- superoxide anion generation Source: Ensembl
Keywordsi
Molecular function | OxidoreductaseARBA annotation |
Protein family/group databases
PeroxiBasei | 5957, MmNOx02 |
Names & Taxonomyi
Protein namesi | Submitted name: Nox2Imported |
Gene namesi | Name:CybbImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:88574, Cybb |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Endoplasmic reticulum
- perinuclear endoplasmic reticulum Source: Ensembl
- rough endoplasmic reticulum Source: Ensembl
Golgi apparatus
- Golgi apparatus Source: Ensembl
Nucleus
- nuclear envelope Source: Ensembl
Plasma Membrane
- NADPH oxidase complex Source: Ensembl
Other locations
- dendrite Source: Ensembl
- neuronal cell body Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 30 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 99 – 121 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 167 – 192 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 204 – 224 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSMUSG00000015340, Expressed in mesenteric lymph node and 158 other tissues |
ExpressionAtlasi | Q3U6G0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 287 – 397 | FAD-binding FR-typeInterPro annotationAdd BLAST | 111 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_005646_3_1_1 |
OMAi | GHVMLLC |
OrthoDBi | 936110at2759 |
Family and domain databases
Gene3Di | 3.40.50.80, 1 hit |
InterProi | View protein in InterPro IPR000778, Cyt_b245_heavy_chain IPR013112, FAD-bd_8 IPR017927, FAD-bd_FR_type IPR013130, Fe3_Rdtase_TM_dom IPR013121, Fe_red_NAD-bd_6 IPR039261, FNR_nucleotide-bd IPR017938, Riboflavin_synthase-like_b-brl |
Pfami | View protein in Pfam PF08022, FAD_binding_8, 1 hit PF01794, Ferric_reduct, 1 hit PF08030, NAD_binding_6, 1 hit |
PRINTSi | PR00466, GP91PHOX |
SUPFAMi | SSF52343, SSF52343, 1 hit SSF63380, SSF63380, 1 hit |
PROSITEi | View protein in PROSITE PS51384, FAD_FR, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3U6G0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGNWAVNEGL SIFVILVWLG LNVFLFINYY KVYDDGPKYN YTRKLLGSAL
60 70 80 90 100
ALARAPAACL NFNCMLILLP VCRNLLSFLR GSSACCSTRI RRQLDRNLTF
110 120 130 140 150
HKMVAWMIAL HTAIHTIAHL FNVEWCVNAR VGISDRYSIA LSDIGDNENE
160 170 180 190 200
EYLNFAREKI KNPEGGLYVA VTRLAGITGI VITLCLILII TSSTKTIRRS
210 220 230 240 250
YFEVFWYTHH LFVIFFIGLA IHGAERIVRG QTAESLEEHN LDICADKIEE
260 270 280 290 300
WGKIKECPVP KFAGNPPMTW KWIVGPMFLY LCERLVRFWR SQQKVVITKV
310 320 330 340 350
VTHPFKTIEL QMKKKGFKME VGQYIFVKCP KVSKLEWHPF TLTSAPEEDF
360 370 380 390 400
FSIHIRIVGD WTEGLFNACG CDKQEFQDAW KLPKIAVDGP FGTASEDVFS
410 420 430 440 450
YEVVMLVGAG IGVTPFASIL KSVWYKYCDN ATSLKLKKIY FYWLCRDTHA
460 470 480 490 500
FEWFADLLQL LETQMQERNN ANFLSYNIYL TGWDESQANH FAVHHDEEKD
510 520 530 540 550
VITGLKQKTL YGRPNWDNEF KTIASEHPNT TIGVFLCGPE ALAETLSKQS
560 570
ISNSESGPRG VHFIFNKENF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ168469 mRNA Translation: ACI04541.1 AK152257 mRNA Translation: BAE31076.1 AK153154 mRNA Translation: BAE31764.1 AK153259 mRNA Translation: BAE31850.1 AK171526 mRNA Translation: BAE42507.1 |
RefSeqi | NP_031833.3, NM_007807.5 XP_006527628.1, XM_006527565.3 |
Genome annotation databases
GeneIDi | 13058 |
KEGGi | mmu:13058 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FJ168469 mRNA Translation: ACI04541.1 AK152257 mRNA Translation: BAE31076.1 AK153154 mRNA Translation: BAE31764.1 AK153259 mRNA Translation: BAE31850.1 AK171526 mRNA Translation: BAE42507.1 |
RefSeqi | NP_031833.3, NM_007807.5 XP_006527628.1, XM_006527565.3 |
3D structure databases
SMRi | Q3U6G0 |
ModBasei | Search... |
Protein family/group databases
PeroxiBasei | 5957, MmNOx02 |
Proteomic databases
PeptideAtlasi | Q3U6G0 |
Protocols and materials databases
Antibodypediai | 24864, 484 antibodies |
Genome annotation databases
GeneIDi | 13058 |
KEGGi | mmu:13058 |
Organism-specific databases
CTDi | 1536 |
MGIi | MGI:88574, Cybb |
Phylogenomic databases
HOGENOMi | CLU_005646_3_1_1 |
OMAi | GHVMLLC |
OrthoDBi | 936110at2759 |
Miscellaneous databases
BioGRID-ORCSi | 13058, 0 hits in 17 CRISPR screens |
ChiTaRSi | Cybb, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000015340, Expressed in mesenteric lymph node and 158 other tissues |
ExpressionAtlasi | Q3U6G0, baseline and differential |
Family and domain databases
Gene3Di | 3.40.50.80, 1 hit |
InterProi | View protein in InterPro IPR000778, Cyt_b245_heavy_chain IPR013112, FAD-bd_8 IPR017927, FAD-bd_FR_type IPR013130, Fe3_Rdtase_TM_dom IPR013121, Fe_red_NAD-bd_6 IPR039261, FNR_nucleotide-bd IPR017938, Riboflavin_synthase-like_b-brl |
Pfami | View protein in Pfam PF08022, FAD_binding_8, 1 hit PF01794, Ferric_reduct, 1 hit PF08030, NAD_binding_6, 1 hit |
PRINTSi | PR00466, GP91PHOX |
SUPFAMi | SSF52343, SSF52343, 1 hit SSF63380, SSF63380, 1 hit |
PROSITEi | View protein in PROSITE PS51384, FAD_FR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3U6G0_MOUSE | |
Accessioni | Q3U6G0Primary (citable) accession number: Q3U6G0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |