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Entry version 98 (08 May 2019)
Sequence version 2 (29 Apr 2008)
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Protein

UMP-CMP kinase 2, mitochondrial

Gene

Cmpk2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi259 – 266ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processPyrimidine biosynthesis
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UMP-CMP kinase 2, mitochondrial (EC:2.7.4.14)
Alternative name(s):
Nucleoside-diphosphate kinase (EC:2.7.4.6)
Thymidylate kinase LPS-inducible member
Short name:
TYKi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cmpk2
Synonyms:Tyki
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:99830 Cmpk2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 73MitochondrionSequence analysisAdd BLAST73
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000033152574 – 447UMP-CMP kinase 2, mitochondrialAdd BLAST374

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3U5Q7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3U5Q7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3U5Q7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3U5Q7

PeptideAtlas

More...
PeptideAtlasi
Q3U5Q7

PRoteomics IDEntifications database

More...
PRIDEi
Q3U5Q7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3U5Q7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3U5Q7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q3U5Q7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By lipopolysaccharides in macrophages and in primary microglia.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020638 Expressed in 255 organ(s), highest expression level in blood

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3U5Q7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000020969

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili380 – 412Sequence analysisAdd BLAST33

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thymidylate kinase family.Curated

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3327 Eukaryota
COG0125 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154030

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082499

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3U5Q7

KEGG Orthology (KO)

More...
KOi
K13809

Identification of Orthologs from Complete Genome Data

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OMAi
HHPVYQW

Database of Orthologous Groups

More...
OrthoDBi
1450196at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3U5Q7

TreeFam database of animal gene trees

More...
TreeFami
TF328875

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR039430 Thymidylate_kin-like_dom
IPR014505 UMP-CMP_kinase_2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02223 Thymidylate_kin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF019736 dTMP_TKRP1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q3U5Q7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALISRPRAP LWLGRLSRRL CGRHQACMGT MARPRRFTVE LPDCSLTHFV
60 70 80 90 100
LGDATDHRDA RLAELLGPPG RSYALCVPLA PGEGCGPRVQ AARVHHRLLQ
110 120 130 140 150
QLRRGPLQRC QLSKLLGYGP GDQAGEAQHG FLLRDPCDHP DTRRDLLQLL
160 170 180 190 200
GSCQEAARPQ LAEFQADSQG LLWQRLWELQ GDRQVQVDCA CVLPAQEPHL
210 220 230 240 250
HPLLPDLLNS AVFQDRDAAR AVLEECTSFI PEARAVLDLV DQCPKEVQKG
260 270 280 290 300
KFQVIAIEGL DATGKTTLTQ SVSESLKAVL LQSPPPCISQ WRKIFDDEPT
310 320 330 340 350
IIRRAFYSLG NYLVASEIAK ESTNFPVIVD RYWHSTATYA IATEVSGGLQ
360 370 380 390 400
YLPPAHHPVY QWPGDLLKPD LVLLLTVNSE ERVRRLQGRG QEKTKEEAEL
410 420 430 440
EANNVFRQKV EMTYQRMENP SCHLVDASPS RETVLQKVLE LIQSSGR
Length:447
Mass (Da):50,036
Last modified:April 29, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37CBACA251A40CFC
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA58770 differs from that shown. Sequence differs due to frameshifts, sequencing errors and other discrepancies.Curated
The sequence AAH27329 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH57565 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB23396 differs from that shown. Reason: Frameshift at position 74.Curated
The sequence BAE29625 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE29646 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE29803 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE29932 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE31987 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14G → R in BAE29625 (PubMed:16141072).Curated1
Sequence conflicti183R → K in BAE32020 (PubMed:16141072).Curated1
Sequence conflicti225E → G in BAE32020 (PubMed:16141072).Curated1
Sequence conflicti317E → G in BAE29625 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK004595 mRNA Translation: BAB23396.1 Frameshift.
AK153469 mRNA Translation: BAE32020.1
AK150512 mRNA Translation: BAE29625.1 Different initiation.
AK150543 mRNA Translation: BAE29646.1 Different initiation.
AK150725 mRNA Translation: BAE29803.1 Different initiation.
AK150885 mRNA Translation: BAE29932.1 Different initiation.
AK153429 mRNA Translation: BAE31987.1 Different initiation.
BC027329 mRNA Translation: AAH27329.1 Different initiation.
BC057565 mRNA Translation: AAH57565.1 Different initiation.
L32973 mRNA Translation: AAA58770.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS49039.1

NCBI Reference Sequences

More...
RefSeqi
NP_065582.3, NM_020557.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000020969; ENSMUSP00000020969; ENSMUSG00000020638

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22169

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:22169

UCSC genome browser

More...
UCSCi
uc007nfj.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004595 mRNA Translation: BAB23396.1 Frameshift.
AK153469 mRNA Translation: BAE32020.1
AK150512 mRNA Translation: BAE29625.1 Different initiation.
AK150543 mRNA Translation: BAE29646.1 Different initiation.
AK150725 mRNA Translation: BAE29803.1 Different initiation.
AK150885 mRNA Translation: BAE29932.1 Different initiation.
AK153429 mRNA Translation: BAE31987.1 Different initiation.
BC027329 mRNA Translation: AAH27329.1 Different initiation.
BC057565 mRNA Translation: AAH57565.1 Different initiation.
L32973 mRNA Translation: AAA58770.1 Sequence problems.
CCDSiCCDS49039.1
RefSeqiNP_065582.3, NM_020557.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020969

PTM databases

iPTMnetiQ3U5Q7
PhosphoSitePlusiQ3U5Q7
SwissPalmiQ3U5Q7

Proteomic databases

EPDiQ3U5Q7
jPOSTiQ3U5Q7
MaxQBiQ3U5Q7
PaxDbiQ3U5Q7
PeptideAtlasiQ3U5Q7
PRIDEiQ3U5Q7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020969; ENSMUSP00000020969; ENSMUSG00000020638
GeneIDi22169
KEGGimmu:22169
UCSCiuc007nfj.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
129607
MGIiMGI:99830 Cmpk2

Phylogenomic databases

eggNOGiKOG3327 Eukaryota
COG0125 LUCA
GeneTreeiENSGT00940000154030
HOGENOMiHOG000082499
InParanoidiQ3U5Q7
KOiK13809
OMAiHHPVYQW
OrthoDBi1450196at2759
PhylomeDBiQ3U5Q7
TreeFamiTF328875

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q3U5Q7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020638 Expressed in 255 organ(s), highest expression level in blood
GenevisibleiQ3U5Q7 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR039430 Thymidylate_kin-like_dom
IPR014505 UMP-CMP_kinase_2
PfamiView protein in Pfam
PF02223 Thymidylate_kin, 1 hit
PIRSFiPIRSF019736 dTMP_TKRP1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCMPK2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3U5Q7
Secondary accession number(s): Q3UCI7
, Q5XKG5, Q62316, Q6PFG7, Q9DC34
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: May 8, 2019
This is version 98 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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