Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Prickle-like protein 1

Gene

Prickle1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure (By similarity). Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-4608870 Asymmetric localization of PCP proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Prickle-like protein 1
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1916034 Prickle1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002830271 – 829Prickle-like protein 1Add BLAST829
PropeptideiPRO_0000396713830 – 832Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei315PhosphoserineCombined sources1
Modified residuei592PhosphoserineCombined sources1
Modified residuei595PhosphoserineCombined sources1
Modified residuei684PhosphoserineCombined sources1
Modified residuei829Cysteine methyl esterBy similarity1
Lipidationi829S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ3U5C7
PaxDbiQ3U5C7
PeptideAtlasiQ3U5C7
PRIDEiQ3U5C7

PTM databases

iPTMnetiQ3U5C7
PhosphoSitePlusiQ3U5C7

Expressioni

Gene expression databases

BgeeiENSMUSG00000036158 Expressed in 322 organ(s), highest expression level in brain
CleanExiMM_PRICKLE1
GenevisibleiQ3U5C7 MM

Interactioni

Subunit structurei

Interacts with REST.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi222980, 1 interactor
STRINGi10090.ENSMUSP00000049204

Structurei

3D structure databases

ProteinModelPortaliQ3U5C7
SMRiQ3U5C7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 122PETPROSITE-ProRule annotationAdd BLAST109
Domaini124 – 188LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST65
Domaini189 – 249LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61
Domaini250 – 313LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi817 – 822Poly-Lys6

Sequence similaritiesi

Belongs to the prickle / espinas / testin family.Curated

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1704 Eukaryota
ENOG410XP0W LUCA
GeneTreeiENSGT00550000074438
HOGENOMiHOG000290649
HOVERGENiHBG053679
InParanoidiQ3U5C7
KOiK04511
OMAiRVEHETP
OrthoDBiEOG091G07C5
PhylomeDBiQ3U5C7
TreeFamiTF313265

Family and domain databases

CDDicd09418 LIM2_Prickle, 1 hit
cd09420 LIM3_Prickle, 1 hit
cd09827 PET_Prickle, 1 hit
InterProiView protein in InterPro
IPR033726 LIM2_prickle
IPR033727 LIM3_prickle
IPR010442 PET_domain
IPR033723 PET_prickle
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 3 hits
PF06297 PET, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 3 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 3 hits
PS51303 PET, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3U5C7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLEMEPKMS KLVFGCQRSS TSDDDSGCAL EEYAWVPPGL RPEQIQLYFA
60 70 80 90 100
CLPEEKVPYV NSPGEKHRIK QLLYQLPPHD NEVRYCQSLS EEEKKELQVF
110 120 130 140 150
SAQRKKEALG RGTIKLLSRA VMHAVCEQCG LQMNGGEVAV FASRAGPGVC
160 170 180 190 200
WHPSCFVCFT CNELLVDLIY FYQDGKIHCG RHHAELLKPR CSACDEIIFA
210 220 230 240 250
DECTEAEGRH WHMKHFCCLE CETVLGGQRY IMKDGRPFCC GCFESLYAEY
260 270 280 290 300
CETCGEHIGV DHAQMTYDGQ HWHATEACFS CAQCKASLLG CPFLPKQGQI
310 320 330 340 350
YCSKTCSLGE DIHASDSSDS AFQSARSRDS RRSVRMGRSS RSADQCRQSL
360 370 380 390 400
LLSPALNYKF PGLSGNADDT LSRKLDDVSL ASRQGAGFAN EEFWKARVEQ
410 420 430 440 450
EASEDPEEWA EHEDYMTQLL LKFGDKNLFQ QQSSEVDPRA SEHWIPDNMV
460 470 480 490 500
TNKPEVKPNH QGLASKKYQS DMYWAQSQDG LGDSAYGSHP GPASSRRLQE
510 520 530 540 550
LDLDHGAAGY THDQSQWYED SLECLSDLKP EQSIRDSMDS LALSNITGAS
560 570 580 590 600
VDGESKPRPS LYSLQNFEEI EAEDCEKMSN MGTLNSSMLH RSAESLQSLN
610 620 630 640 650
SGLCPEKILP EEKPAHLPVL RRSKSQSRPQ QVKFSDDVID NGSYDIEIRQ
660 670 680 690 700
PPMSERTRRR AYHFEERGSR PHHHRHRRSR KSRSDNALNL VTERKYSAKD
710 720 730 740 750
RLRLYTPDNY EKFIQNKSAR ELQAYMQNAN LYSQYAHATS DYALQNPGMN
760 770 780 790 800
RFLGLCGEDD DSWCSSSTSS SDSEEEGYFL GQPIPQPRPQ RFTYYTDDLS
810 820 830
SPASALPTPQ FTQRTTKSKK KKGHKGKNCI IS
Length:832
Mass (Da):94,131
Last modified:October 11, 2005 - v1
Checksum:i8E664AAEA2E23CEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153711 mRNA Translation: BAE32152.1
BC117892 mRNA Translation: AAI17893.1
BC117893 mRNA Translation: AAI17894.1
CCDSiCCDS27769.1
RefSeqiNP_001028389.1, NM_001033217.4
XP_006520327.1, XM_006520264.3
XP_006520328.1, XM_006520265.1
XP_006520329.1, XM_006520266.3
UniGeneiMm.150314

Genome annotation databases

EnsembliENSMUST00000048982; ENSMUSP00000049204; ENSMUSG00000036158
ENSMUST00000109255; ENSMUSP00000104878; ENSMUSG00000036158
GeneIDi106042
KEGGimmu:106042
UCSCiuc007xja.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK153711 mRNA Translation: BAE32152.1
BC117892 mRNA Translation: AAI17893.1
BC117893 mRNA Translation: AAI17894.1
CCDSiCCDS27769.1
RefSeqiNP_001028389.1, NM_001033217.4
XP_006520327.1, XM_006520264.3
XP_006520328.1, XM_006520265.1
XP_006520329.1, XM_006520266.3
UniGeneiMm.150314

3D structure databases

ProteinModelPortaliQ3U5C7
SMRiQ3U5C7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222980, 1 interactor
STRINGi10090.ENSMUSP00000049204

PTM databases

iPTMnetiQ3U5C7
PhosphoSitePlusiQ3U5C7

Proteomic databases

MaxQBiQ3U5C7
PaxDbiQ3U5C7
PeptideAtlasiQ3U5C7
PRIDEiQ3U5C7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048982; ENSMUSP00000049204; ENSMUSG00000036158
ENSMUST00000109255; ENSMUSP00000104878; ENSMUSG00000036158
GeneIDi106042
KEGGimmu:106042
UCSCiuc007xja.1 mouse

Organism-specific databases

CTDi144165
MGIiMGI:1916034 Prickle1

Phylogenomic databases

eggNOGiKOG1704 Eukaryota
ENOG410XP0W LUCA
GeneTreeiENSGT00550000074438
HOGENOMiHOG000290649
HOVERGENiHBG053679
InParanoidiQ3U5C7
KOiK04511
OMAiRVEHETP
OrthoDBiEOG091G07C5
PhylomeDBiQ3U5C7
TreeFamiTF313265

Enzyme and pathway databases

ReactomeiR-MMU-4608870 Asymmetric localization of PCP proteins

Miscellaneous databases

ChiTaRSiPrickle1 mouse
PROiPR:Q3U5C7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036158 Expressed in 322 organ(s), highest expression level in brain
CleanExiMM_PRICKLE1
GenevisibleiQ3U5C7 MM

Family and domain databases

CDDicd09418 LIM2_Prickle, 1 hit
cd09420 LIM3_Prickle, 1 hit
cd09827 PET_Prickle, 1 hit
InterProiView protein in InterPro
IPR033726 LIM2_prickle
IPR033727 LIM3_prickle
IPR010442 PET_domain
IPR033723 PET_prickle
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00412 LIM, 3 hits
PF06297 PET, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 3 hits
PROSITEiView protein in PROSITE
PS00478 LIM_DOMAIN_1, 2 hits
PS50023 LIM_DOMAIN_2, 3 hits
PS51303 PET, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRIC1_MOUSE
AccessioniPrimary (citable) accession number: Q3U5C7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again