UniProtKB - Q3U593 (Q3U593_MOUSE)
Protein
C-domain 1
Gene
Tnf
Organism
Mus musculus (Mouse)
Status
Functioni
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.ARBA annotation
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- identical protein binding Source: Ensembl
- protease binding Source: Ensembl
- transcription regulatory region sequence-specific DNA binding Source: Ensembl
- tumor necrosis factor receptor binding Source: Ensembl
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
- activation of MAPK activity Source: Ensembl
- activation of MAPKKK activity Source: Ensembl
- cellular response to nicotine Source: Ensembl
- cellular response to organic cyclic compound Source: Ensembl
- chronic inflammatory response to antigenic stimulus Source: Ensembl
- cortical actin cytoskeleton organization Source: Ensembl
- embryonic digestive tract development Source: Ensembl
- extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
- leukocyte tethering or rolling Source: Ensembl
- lipopolysaccharide-mediated signaling pathway Source: Ensembl
- MAPK cascade Source: Ensembl
- necroptotic signaling pathway Source: Ensembl
- negative regulation of bicellular tight junction assembly Source: Ensembl
- negative regulation of blood vessel endothelial cell migration Source: Ensembl
- negative regulation of branching involved in lung morphogenesis Source: Ensembl
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
- negative regulation of cytokine production involved in immune response Source: Ensembl
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
- negative regulation of interleukin-6 production Source: Ensembl
- negative regulation of lipid catabolic process Source: Ensembl
- negative regulation of myosin-light-chain-phosphatase activity Source: Ensembl
- negative regulation of production of miRNAs involved in gene silencing by miRNA Source: Ensembl
- negative regulation of protein-containing complex disassembly Source: Ensembl
- negative regulation of signaling receptor activity Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- negative regulation of vascular wound healing Source: Ensembl
- negative regulation of viral genome replication Source: Ensembl
- positive regulation of apoptotic process Source: Ensembl
- positive regulation of blood microparticle formation Source: Ensembl
- positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
- positive regulation of calcineurin-NFAT signaling cascade Source: Ensembl
- positive regulation of chemokine (C-X-C motif) ligand 2 production Source: Ensembl
- positive regulation of cytokine production involved in inflammatory response Source: Ensembl
- positive regulation of glial cell proliferation Source: Ensembl
- positive regulation of heterotypic cell-cell adhesion Source: Ensembl
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- positive regulation of I-kappaB phosphorylation Source: Ensembl
- positive regulation of interleukin-1 beta production Source: Ensembl
- positive regulation of interleukin-33 production Source: Ensembl
- positive regulation of interleukin-6 production Source: Ensembl
- positive regulation of interleukin-8 production Source: Ensembl
- positive regulation of JUN kinase activity Source: Ensembl
- positive regulation of leukocyte adhesion to arterial endothelial cell Source: Ensembl
- positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
- positive regulation of NF-kappaB transcription factor activity Source: Ensembl
- positive regulation of NIK/NF-kappaB signaling Source: Ensembl
- positive regulation of nitric oxide biosynthetic process Source: Ensembl
- positive regulation of osteoclast differentiation Source: Ensembl
- positive regulation of peptidyl-serine phosphorylation Source: Ensembl
- positive regulation of phagocytosis Source: Ensembl
- positive regulation of podosome assembly Source: Ensembl
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
- positive regulation of protein-containing complex disassembly Source: Ensembl
- positive regulation of protein localization to cell surface Source: Ensembl
- positive regulation of protein transport Source: Ensembl
- positive regulation of smooth muscle cell proliferation Source: Ensembl
- positive regulation of superoxide dismutase activity Source: Ensembl
- positive regulation of synoviocyte proliferation Source: Ensembl
- positive regulation of vitamin D biosynthetic process Source: Ensembl
- protein kinase B signaling Source: Ensembl
- protein localization to plasma membrane Source: Ensembl
- regulation of endothelial cell apoptotic process Source: Ensembl
- regulation of establishment of endothelial barrier Source: Ensembl
- regulation of insulin secretion Source: Ensembl
- response to glucocorticoid Source: Ensembl
- response to virus Source: Ensembl
- sequestering of triglyceride Source: Ensembl
- tumor necrosis factor-mediated signaling pathway Source: Ensembl
- vascular endothelial growth factor production Source: Ensembl
Keywordsi
Molecular function | CytokineARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: C-domain 1ARBA annotationAlternative name(s): C-domain 2ARBA annotation CachectinARBA annotation Intracellular domain 1ARBA annotation Intracellular domain 2ARBA annotation N-terminal fragmentARBA annotation TNF-alphaARBA annotation Tumor necrosis factorARBA annotation Tumor necrosis factor ligand superfamily member 2ARBA annotation Tumor necrosis factor, membrane formARBA annotation Tumor necrosis factor, soluble formARBA annotation |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:104798, Tnf |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Single-pass type II membrane protein ARBA annotation
Extracellular region or secreted
- Secreted ARBA annotation
Other locations
- Membrane ARBA annotation; Single-pass type II membrane protein ARBA annotation
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Plasma Membrane
- integral component of plasma membrane Source: Ensembl
Other locations
- cell surface Source: Ensembl
- membrane raft Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 30 – 56 | HelicalSequence analysisAdd BLAST | 27 |
Keywords - Cellular componenti
Cell membraneARBA annotation, Membrane, SecretedARBA annotationPTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotation, Lipoprotein, MyristateARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000024401, Expressed in granulocyte and 96 other tissues |
ExpressionAtlasi | Q3U593, baseline and differential |
Interactioni
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- identical protein binding Source: Ensembl
- protease binding Source: Ensembl
- tumor necrosis factor receptor binding Source: Ensembl
Chemistry databases
BindingDBi | Q3U593 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 92 – 235 | TNF_2InterPro annotationAdd BLAST | 144 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 98 – 118 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the tumor necrosis factor family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, Signal-anchorARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_070352_3_1_1 |
OMAi | GATMLFC |
OrthoDBi | 1124938at2759 |
Family and domain databases
CDDi | cd00184, TNF, 1 hit |
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR006053, TNF IPR002959, TNF_alpha IPR021184, TNF_CS IPR006052, TNF_dom IPR008983, Tumour_necrosis_fac-like_dom |
PANTHERi | PTHR11471:SF23, PTHR11471:SF23, 1 hit |
Pfami | View protein in Pfam PF00229, TNF, 1 hit |
PRINTSi | PR01234, TNECROSISFCT PR01235, TNFALPHA |
SMARTi | View protein in SMART SM00207, TNF, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS00251, TNF_1, 1 hit PS50049, TNF_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3U593-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTESMIRDV ELAEEALPQK MGGFQNSRRC LCLSLFSFLL VAGATTLFCL
60 70 80 90 100
LNFGVIGPQR DEKFPNGLPL ISSMAQTLTL RSSSQNSSDK PVAHVVANHQ
110 120 130 140 150
VEEQLEWLSQ RANALLANGM DLKDNQLVVP ADGLYLVYSQ VLFKGQGCPD
160 170 180 190 200
YVLLTHTVSR FAISYQEKVN LLSAVKSPCP KDTPEGAELK PWYEPIYLGG
210 220 230
VFQLEKGDQL SAEVNLPKYL DFAESGQVYF GVIAL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC117057 mRNA Translation: AAI17058.1 BC137720 mRNA Translation: AAI37721.1 AK153319 mRNA Translation: BAE31899.1 AK153800 mRNA Translation: BAE32187.1 AK155964 mRNA Translation: BAE33525.1 AB185894 Genomic DNA Translation: BAF02298.1 |
RefSeqi | NP_038721.1, NM_013693.3 |
Genome annotation databases
GeneIDi | 21926 |
KEGGi | mmu:21926 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC117057 mRNA Translation: AAI17058.1 BC137720 mRNA Translation: AAI37721.1 AK153319 mRNA Translation: BAE31899.1 AK153800 mRNA Translation: BAE32187.1 AK155964 mRNA Translation: BAE33525.1 AB185894 Genomic DNA Translation: BAF02298.1 |
RefSeqi | NP_038721.1, NM_013693.3 |
3D structure databases
SMRi | Q3U593 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q3U593 |
Protocols and materials databases
Antibodypediai | 27196, 4863 antibodies |
DNASUi | 21926 |
Genome annotation databases
GeneIDi | 21926 |
KEGGi | mmu:21926 |
Organism-specific databases
CTDi | 7124 |
MGIi | MGI:104798, Tnf |
Phylogenomic databases
HOGENOMi | CLU_070352_3_1_1 |
OMAi | GATMLFC |
OrthoDBi | 1124938at2759 |
Miscellaneous databases
BioGRID-ORCSi | 21926, 2 hits in 52 CRISPR screens |
ChiTaRSi | Tnf, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024401, Expressed in granulocyte and 96 other tissues |
ExpressionAtlasi | Q3U593, baseline and differential |
Family and domain databases
CDDi | cd00184, TNF, 1 hit |
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR006053, TNF IPR002959, TNF_alpha IPR021184, TNF_CS IPR006052, TNF_dom IPR008983, Tumour_necrosis_fac-like_dom |
PANTHERi | PTHR11471:SF23, PTHR11471:SF23, 1 hit |
Pfami | View protein in Pfam PF00229, TNF, 1 hit |
PRINTSi | PR01234, TNECROSISFCT PR01235, TNFALPHA |
SMARTi | View protein in SMART SM00207, TNF, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS00251, TNF_1, 1 hit PS50049, TNF_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3U593_MOUSE | |
Accessioni | Q3U593Primary (citable) accession number: Q3U593 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | April 7, 2021 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |