C-domain 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cytokine activity Source: UniProtKB-KW
• identical protein binding Source: Ensembl
• protease binding Source: Ensembl
• transcription regulatory region sequence-specific DNA binding Source: Ensembl
• tumor necrosis factor receptor binding Source: Ensembl

GO - Biological processⁱ

• activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
• activation of MAPK activity Source: Ensembl
• activation of MAPKKK activity Source: Ensembl
• cellular response to nicotine Source: Ensembl
• cellular response to organic cyclic compound Source: Ensembl
• chronic inflammatory response to antigenic stimulus Source: Ensembl
• cortical actin cytoskeleton organization Source: Ensembl
• embryonic digestive tract development Source: Ensembl
• extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
• leukocyte tethering or rolling Source: Ensembl
• lipopolysaccharide-mediated signaling pathway Source: Ensembl
• MAPK cascade Source: Ensembl
• necroptotic signaling pathway Source: Ensembl
• negative regulation of bicellular tight junction assembly Source: Ensembl
• negative regulation of blood vessel endothelial cell migration Source: Ensembl
• negative regulation of branching involved in lung morphogenesis Source: Ensembl
• negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
• negative regulation of cytokine production involved in immune response Source: Ensembl
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
• negative regulation of interleukin-6 production Source: Ensembl
• negative regulation of lipid catabolic process Source: Ensembl
• negative regulation of myosin-light-chain-phosphatase activity Source: Ensembl
• negative regulation of production of miRNAs involved in gene silencing by miRNA Source: Ensembl
• negative regulation of protein-containing complex disassembly Source: Ensembl
• negative regulation of signaling receptor activity Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: Ensembl
• negative regulation of vascular wound healing Source: Ensembl
• negative regulation of viral genome replication Source: Ensembl
• positive regulation of apoptotic process Source: Ensembl
• positive regulation of blood microparticle formation Source: Ensembl
• positive regulation of calcidiol 1-monooxygenase activity Source: Ensembl
• positive regulation of calcineurin-NFAT signaling cascade Source: Ensembl
• positive regulation of chemokine (C-X-C motif) ligand 2 production Source: Ensembl
• positive regulation of cytokine production involved in inflammatory response Source: Ensembl
• positive regulation of glial cell proliferation Source: Ensembl
• positive regulation of heterotypic cell-cell adhesion Source: Ensembl
• positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
• positive regulation of I-kappaB phosphorylation Source: Ensembl
• positive regulation of interleukin-1 beta production Source: Ensembl
• positive regulation of interleukin-33 production Source: Ensembl
• positive regulation of interleukin-6 production Source: Ensembl
• positive regulation of interleukin-8 production Source: Ensembl
• positive regulation of JUN kinase activity Source: Ensembl
• positive regulation of leukocyte adhesion to arterial endothelial cell Source: Ensembl
• positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
• positive regulation of NF-kappaB transcription factor activity Source: Ensembl
• positive regulation of NIK/NF-kappaB signaling Source: Ensembl
• positive regulation of nitric oxide biosynthetic process Source: Ensembl
• positive regulation of osteoclast differentiation Source: Ensembl
• positive regulation of peptidyl-serine phosphorylation Source: Ensembl
• positive regulation of phagocytosis Source: Ensembl
• positive regulation of podosome assembly Source: Ensembl
• positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
• positive regulation of protein-containing complex disassembly Source: Ensembl
• positive regulation of protein localization to cell surface Source: Ensembl
• positive regulation of protein transport Source: Ensembl
• positive regulation of smooth muscle cell proliferation Source: Ensembl
• positive regulation of superoxide dismutase activity Source: Ensembl
• positive regulation of synoviocyte proliferation Source: Ensembl
• positive regulation of vitamin D biosynthetic process Source: Ensembl
• protein kinase B signaling Source: Ensembl
• protein localization to plasma membrane Source: Ensembl
• regulation of endothelial cell apoptotic process Source: Ensembl
• regulation of establishment of endothelial barrier Source: Ensembl
• regulation of insulin secretion Source: Ensembl
• response to glucocorticoid Source: Ensembl
• response to virus Source: Ensembl
• sequestering of triglyceride Source: Ensembl
• tumor necrosis factor-mediated signaling pathway Source: Ensembl
• vascular endothelial growth factor production Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Keywords - PTMⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• cytokine activity Source: UniProtKB-KW
• identical protein binding Source: Ensembl
• protease binding Source: Ensembl
• tumor necrosis factor receptor binding Source: Ensembl

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Coiled coil

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSTESMIRDV ELAEEALPQK MGGFQNSRRC LCLSLFSFLL VAGATTLFCL 
        60         70         80         90        100
LNFGVIGPQR DEKFPNGLPL ISSMAQTLTL RSSSQNSSDK PVAHVVANHQ 
       110        120        130        140        150
VEEQLEWLSQ RANALLANGM DLKDNQLVVP ADGLYLVYSQ VLFKGQGCPD 
       160        170        180        190        200
YVLLTHTVSR FAISYQEKVN LLSAVKSPCP KDTPEGAELK PWYEPIYLGG 
       210        220        230 
VFQLEKGDQL SAEVNLPKYL DFAESGQVYF GVIAL                 

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Chemistry databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ